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Fusion gene ID: 8218 |
FusionGeneSummary for CPD_NF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CPD_NF1 | Fusion gene ID: 8218 | Hgene | Tgene | Gene symbol | CPD | NF1 | Gene ID | 9455 | 4763 |
| Gene name | homer scaffold protein 2 | neurofibromin 1 | |
| Synonyms | ACPD|CPD|DFNA68|HOMER-2|VESL-2 | NFNS|VRNF|WSS | |
| Cytomap | 15q25.2 | 17q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | homer protein homolog 2cupidinhomer homolog 2homer homolog 3homer scaffolding protein 2homer, neuronal immediate early gene, 2 | neurofibrominneurofibromatosis 1neurofibromatosis-related protein NF-1truncated neurofibromin 1 | |
| Modification date | 20180523 | 20180527 | |
| UniProtAcc | O75976 | P21359 | |
| Ensembl transtripts involved in fusion gene | ENST00000225719, ENST00000543464, ENST00000584051, | ENST00000356175, ENST00000358273, ENST00000431387, ENST00000581113, ENST00000417592, ENST00000444181, | |
| Fusion gene scores | * DoF score | 19 X 10 X 9=1710 | 15 X 13 X 12=2340 |
| # samples | 16 | 16 | |
| ** MAII score | log2(16/1710*10)=-3.4178525148859 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/2340*10)=-3.8703647195834 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CPD [Title/Abstract] AND NF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | NF1 | GO:0043547 | positive regulation of GTPase activity | 2121371 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-60-2704-01A | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000225719 | ENST00000356175 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| In-frame | ENST00000225719 | ENST00000358273 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| 5CDS-intron | ENST00000225719 | ENST00000431387 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| 5CDS-intron | ENST00000225719 | ENST00000581113 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| 5CDS-intron | ENST00000225719 | ENST00000417592 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| 5CDS-intron | ENST00000225719 | ENST00000444181 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| In-frame | ENST00000543464 | ENST00000356175 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| In-frame | ENST00000543464 | ENST00000358273 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| 5CDS-intron | ENST00000543464 | ENST00000431387 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| 5CDS-intron | ENST00000543464 | ENST00000581113 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| 5CDS-intron | ENST00000543464 | ENST00000417592 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| 5CDS-intron | ENST00000543464 | ENST00000444181 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| intron-3CDS | ENST00000584051 | ENST00000356175 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| intron-3CDS | ENST00000584051 | ENST00000358273 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| intron-intron | ENST00000584051 | ENST00000431387 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| intron-intron | ENST00000584051 | ENST00000581113 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| intron-intron | ENST00000584051 | ENST00000417592 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
| intron-intron | ENST00000584051 | ENST00000444181 | CPD | chr17 | 28766095 | + | NF1 | chr17 | 29676138 | + |
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FusionProtFeatures for CPD_NF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CPD | NF1 |
| Stimulates the GTPase activity of Ras. NF1 shows greateraffinity for Ras GAP, but lower specific activity. May be aregulator of Ras activity. {ECO:0000269|PubMed:2121371,ECO:0000269|PubMed:8417346}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | CPD | chr17:28766095 | chr17:29676138 | ENST00000225719 | + | 9 | 21 | 162_164 | 743 | 1381 | Motif | Cell attachment site |
| Hgene | CPD | chr17:28766095 | chr17:29676138 | ENST00000543464 | + | 9 | 21 | 162_164 | 496 | 1134 | Motif | Cell attachment site |
| Hgene | CPD | chr17:28766095 | chr17:29676138 | ENST00000225719 | + | 9 | 21 | 32_493 | 743 | 1381 | Region | Note=Carboxypeptidase-like 1 |
| Hgene | CPD | chr17:28766095 | chr17:29676138 | ENST00000543464 | + | 9 | 21 | 32_493 | 496 | 1134 | Region | Note=Carboxypeptidase-like 1 |
| Tgene | >NF1 | chr17:28766095 | chr17:29676138 | ENST00000431387 | + | 0 | 15 | 1352_1355 | -111 | 594 | Compositional bias | Note=Poly-Ser |
| Tgene | >NF1 | chr17:28766095 | chr17:29676138 | ENST00000431387 | + | 0 | 15 | 1235_1451 | -111 | 594 | Domain | Ras-GAP |
| Tgene | >NF1 | chr17:28766095 | chr17:29676138 | ENST00000431387 | + | 0 | 15 | 1580_1738 | -111 | 594 | Domain | CRAL-TRIO |
| Tgene | >NF1 | chr17:28766095 | chr17:29676138 | ENST00000356175 | + | 46 | 57 | 2555_2571 | 2375 | 2819 | Motif | Note=Bipartite nuclear localization signal |
| Tgene | >NF1 | chr17:28766095 | chr17:29676138 | ENST00000358273 | + | 47 | 58 | 2555_2571 | 2396 | 2840 | Motif | Note=Bipartite nuclear localization signal |
| Tgene | >NF1 | chr17:28766095 | chr17:29676138 | ENST00000431387 | + | 0 | 15 | 2555_2571 | -111 | 594 | Motif | Note=Bipartite nuclear localization signal |
| Tgene | >NF1 | chr17:28766095 | chr17:29676138 | ENST00000431387 | + | 0 | 15 | 1580_1837 | -111 | 594 | Region | Note=Lipid binding |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CPD | chr17:28766095 | chr17:29676138 | ENST00000225719 | + | 9 | 21 | 494_897 | 743 | 1381 | Region | Note=Carboxypeptidase-like 2 |
| Hgene | >CPD | chr17:28766095 | chr17:29676138 | ENST00000225719 | + | 9 | 21 | 898_1299 | 743 | 1381 | Region | Note=Carboxypeptidase-like 3 |
| Hgene | >CPD | chr17:28766095 | chr17:29676138 | ENST00000543464 | + | 9 | 21 | 494_897 | 496 | 1134 | Region | Note=Carboxypeptidase-like 2 |
| Hgene | >CPD | chr17:28766095 | chr17:29676138 | ENST00000543464 | + | 9 | 21 | 898_1299 | 496 | 1134 | Region | Note=Carboxypeptidase-like 3 |
| Hgene | >CPD | chr17:28766095 | chr17:29676138 | ENST00000225719 | + | 9 | 21 | 1321_1380 | 743 | 1381 | Topological domain | Cytoplasmic |
| Hgene | >CPD | chr17:28766095 | chr17:29676138 | ENST00000225719 | + | 9 | 21 | 32_1299 | 743 | 1381 | Topological domain | Extracellular |
| Hgene | >CPD | chr17:28766095 | chr17:29676138 | ENST00000543464 | + | 9 | 21 | 1321_1380 | 496 | 1134 | Topological domain | Cytoplasmic |
| Hgene | >CPD | chr17:28766095 | chr17:29676138 | ENST00000543464 | + | 9 | 21 | 32_1299 | 496 | 1134 | Topological domain | Extracellular |
| Hgene | >CPD | chr17:28766095 | chr17:29676138 | ENST00000225719 | + | 9 | 21 | 1300_1320 | 743 | 1381 | Transmembrane | Helical |
| Hgene | >CPD | chr17:28766095 | chr17:29676138 | ENST00000543464 | + | 9 | 21 | 1300_1320 | 496 | 1134 | Transmembrane | Helical |
| Tgene | NF1 | chr17:28766095 | chr17:29676138 | ENST00000356175 | + | 46 | 57 | 1352_1355 | 2375 | 2819 | Compositional bias | Note=Poly-Ser |
| Tgene | NF1 | chr17:28766095 | chr17:29676138 | ENST00000358273 | + | 47 | 58 | 1352_1355 | 2396 | 2840 | Compositional bias | Note=Poly-Ser |
| Tgene | NF1 | chr17:28766095 | chr17:29676138 | ENST00000356175 | + | 46 | 57 | 1235_1451 | 2375 | 2819 | Domain | Ras-GAP |
| Tgene | NF1 | chr17:28766095 | chr17:29676138 | ENST00000356175 | + | 46 | 57 | 1580_1738 | 2375 | 2819 | Domain | CRAL-TRIO |
| Tgene | NF1 | chr17:28766095 | chr17:29676138 | ENST00000358273 | + | 47 | 58 | 1235_1451 | 2396 | 2840 | Domain | Ras-GAP |
| Tgene | NF1 | chr17:28766095 | chr17:29676138 | ENST00000358273 | + | 47 | 58 | 1580_1738 | 2396 | 2840 | Domain | CRAL-TRIO |
| Tgene | NF1 | chr17:28766095 | chr17:29676138 | ENST00000356175 | + | 46 | 57 | 1580_1837 | 2375 | 2819 | Region | Note=Lipid binding |
| Tgene | NF1 | chr17:28766095 | chr17:29676138 | ENST00000358273 | + | 47 | 58 | 1580_1837 | 2396 | 2840 | Region | Note=Lipid binding |
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FusionGeneSequence for CPD_NF1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CPD_ENST00000225719_chr17_28766095_+_NF1_ENST00000356175_chr17_29676138_+_1187aa MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVE GRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLP SLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDS PEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPAS QLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEG PATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYV MEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNN FDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPC KNMYPNEYFPHGITNGASWYNVPGYRHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLL TDISMENVPMDTYPIHHGDPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKA PKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYL AEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVK FLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQK >In-frame_CPD_ENST00000225719_chr17_28766095_+_NF1_ENST00000358273_chr17_29676138_+_1187aa MASGRDERPPWRLGRLLLLMCLLLLGSSARAAHIKKAEATTTTTSAGAEAAEGQFDRYYHEEELESALREAAAAGLPGLARLFSIGRSVE GRPLWVLRLTAGLGSLIPEGDAGPDAAGPDAAGPLLPGRPQVKLVGNMHGDETVSRQVLIYLARELAAGYRRGDPRLVRLLNTTDVYLLP SLNPDGFERAREGDCGFGDGGPSGASGRDNSRGRDLNRSFPDQFSTGEPPALDEVPEVRALIEWIRRNKFVLSGNLHGGSVVASYPFDDS PEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDYNYVWANCFEITLELSCCKYPPAS QLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGTYNLTVVLTGYMPLTVTNVVVKEG PATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFANEYPNITRLYSLGKSVESRELYV MEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMNPDGYEKSQEGDSISVIGRNNSNN FDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDDAVFQQIALSYSKENSQMFQGRPC KNMYPNEYFPHGITNGASWYNVPGYRHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLAALLTVSEEVRSRCSLKHRKSLLL TDISMENVPMDTYPIHHGDPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARKSMSLDMGQPSQANTKKLLGTRKSFDHLISDTKA PKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLLTVLATLVKYTTDEFDQRILYEYL AEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNGLWRFAGPFSKQTQIPDYAELIVK FLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVELSPTTGHCNSGRTRHGSASQVQK >In-frame_CPD_ENST00000543464_chr17_28766095_+_NF1_ENST00000356175_chr17_29676138_+_940aa MRFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDY NYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGT YNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFA NEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMN PDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDD AVFQQIALSYSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGYRHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLA ALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARKSMSLDMGQPS QANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLL TVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNG LWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVE >In-frame_CPD_ENST00000543464_chr17_28766095_+_NF1_ENST00000358273_chr17_29676138_+_940aa MRFVLSGNLHGGSVVASYPFDDSPEHKATGIYSKTSDDEVFKYLAKAYASNHPIMKTGEPHCPGDEDETFKDGITNGAHWYDVEGGMQDY NYVWANCFEITLELSCCKYPPASQLRQEWENNRESLITLIEKVHIGVKGFVKDSITGSGLENATISVAGINHNITTGRFGDFYRLLVPGT YNLTVVLTGYMPLTVTNVVVKEGPATEVDFSLRPTVTSVIPDTTEAVSTASTVAIPNILSGTSSSYQPIQPKDFHHHHFPDMEIFLRRFA NEYPNITRLYSLGKSVESRELYVMEISDNPGVHEPGEPEFKYIGNMHGNEVVGRELLLNLIEYLCKNFGTDPEVTDLVHNTRIHLMPSMN PDGYEKSQEGDSISVIGRNNSNNFDLNRNFPDQFVQITDPTQPETIAVMSWMKSYPFVLSANLHGGSLVVNYPFDDDEQGLATYSKSPDD AVFQQIALSYSKENSQMFQGRPCKNMYPNEYFPHGITNGASWYNVPGYRHPSPAIVARTVRILHTLLTLVNKHRNCDKFEVNTQSVAYLA ALLTVSEEVRSRCSLKHRKSLLLTDISMENVPMDTYPIHHGDPSYRTLKETQPWSSPKGSEGYLAATYPTVGQTSPRARKSMSLDMGQPS QANTKKLLGTRKSFDHLISDTKAPKRQEMESGITTPPKMRRVAETDYEMETQRISSSQQHPHLRKVSVSESNVLLDEEVLTDPKIQALLL TVLATLVKYTTDEFDQRILYEYLAEASVVFPKVFPVVHNLLDSKINTLLSLCQDPNLLNPIHGIVQSVVYHEESPPQYQTSYLQSFGFNG LWRFAGPFSKQTQIPDYAELIVKFLDALIDTYLPGIDEETSEESLLTPTSPYPPALQSQLSITANLNLSNSMTSLATSQHSPGIDKENVE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CPD_ENST00000225719_chr17_28766095_+_NF1_ENST00000356175_chr17_29676138_+_3561nt ATGGCGAGCGGCCGGGACGAGCGGCCGCCTTGGCGGCTAGGGCGGCTCCTGTTGCTCATGTGCCTGCTGCTGCTGGGGAGCTCGGCCCGG GCGGCTCACATCAAGAAGGCGGAGGCGACTACCACAACTACGAGCGCGGGCGCCGAGGCGGCCGAGGGCCAGTTCGACCGCTACTACCAC GAAGAGGAGTTGGAGTCGGCGCTGAGGGAGGCGGCGGCCGCGGGCCTCCCCGGCCTGGCCCGCCTCTTTAGCATCGGCCGCTCGGTGGAA GGCCGGCCGCTGTGGGTGCTTCGCCTCACCGCCGGCCTGGGGTCGCTAATCCCTGAGGGCGACGCGGGGCCTGACGCTGCCGGGCCCGAC GCTGCGGGGCCGCTGCTGCCCGGCCGGCCCCAGGTGAAGCTGGTGGGCAACATGCATGGCGACGAGACCGTGTCGCGCCAGGTGTTGATC TACTTGGCCCGCGAGCTGGCGGCCGGCTACCGCCGCGGGGACCCGCGCCTGGTCCGCCTGCTCAACACCACCGACGTGTACCTGCTGCCC AGCCTCAACCCCGATGGCTTCGAGCGTGCCCGCGAGGGCGACTGTGGCTTCGGCGACGGCGGCCCGTCCGGGGCCAGCGGCCGCGACAAT AGTCGCGGCCGCGACCTCAACCGAAGCTTTCCCGACCAGTTTAGCACCGGCGAACCCCCCGCCCTGGACGAGGTGCCCGAGGTGCGCGCC CTCATCGAGTGGATCCGCAGGAACAAGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTTGATGATTCT CCAGAACATAAGGCCACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCC ATAATGAAAACTGGTGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGGTATGATGTG GAAGGTGGTATGCAAGATTACAATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGTTGCAAGTACCCACCTGCTTCA CAGCTTCGACAGGAATGGGAGAACAATCGTGAGTCTTTGATCACATTGATTGAAAAGGTTCACATTGGAGTGAAAGGATTTGTTAAAGAT TCCATAACAGGATCTGGGTTAGAGAATGCAACCATCTCAGTGGCTGGTATTAATCATAATATCACAACAGGCAGATTTGGTGATTTCTAC CGATTACTTGTTCCTGGAACTTACAACCTTACAGTAGTTTTAACTGGGTATATGCCATTGACTGTTACTAATGTAGTGGTGAAAGAAGGA CCAGCCACAGAGGTGGATTTTTCTCTTAGGCCAACTGTAACTTCAGTAATCCCTGACACGACAGAGGCTGTATCAACTGCTAGCACAGTT GCTATACCTAATATTCTTTCTGGAACATCATCCTCCTACCAGCCAATTCAGCCAAAGGACTTTCACCACCACCATTTCCCTGATATGGAA ATCTTCTTGAGAAGGTTTGCCAATGAATATCCTAACATTACCCGGCTTTATTCCTTGGGAAAATCAGTAGAGTCAAGAGAACTTTATGTG ATGGAGATATCTGATAATCCGGGTGTCCATGAACCAGGTGAACCAGAATTTAAGTACATTGGAAATATGCATGGAAATGAAGTGGTTGGA AGAGAACTGCTGTTGAACCTCATAGAATACCTTTGTAAGAACTTTGGAACAGACCCTGAAGTCACAGATTTGGTTCATAACACTAGAATT CACCTTATGCCATCCATGAATCCTGATGGGTATGAAAAGTCCCAGGAAGGAGATTCAATAAGTGTAATTGGCAGAAACAACAGCAACAAC TTTGACCTGAACCGAAATTTCCCAGACCAGTTTGTTCAGATCACAGATCCTACGCAACCAGAAACTATTGCTGTAATGAGCTGGATGAAG TCCTATCCATTTGTACTTTCAGCAAACCTGCATGGAGGTTCTTTGGTGGTTAACTACCCTTTTGATGATGATGAACAAGGACTTGCCACA TATAGTAAATCACCAGATGATGCTGTGTTCCAACAAATAGCACTTTCTTATTCCAAGGAAAATTCCCAGATGTTTCAAGGTAGACCTTGC AAGAATATGTATCCTAATGAATATTTTCCTCATGGAATAACAAATGGAGCTAGTTGGTATAATGTGCCAGGGTACAGGCATCCTTCACCT GCTATTGTTGCAAGAACAGTCAGAATTTTACATACACTACTAACTCTGGTTAACAAACACAGAAATTGTGACAAATTTGAAGTGAATACA CAGAGCGTGGCCTACTTAGCAGCTTTACTTACAGTGTCTGAAGAAGTTCGAAGTCGCTGCAGCCTAAAACATAGAAAGTCACTTCTTCTT ACTGATATTTCAATGGAAAATGTTCCTATGGATACATATCCCATTCATCATGGTGACCCTTCCTATAGGACACTAAAGGAGACTCAGCCA TGGTCCTCTCCCAAAGGTTCTGAAGGATACCTTGCAGCCACCTATCCAACTGTCGGCCAGACCAGTCCCCGAGCCAGGAAATCCATGAGC CTGGACATGGGGCAACCTTCTCAGGCCAACACTAAGAAGTTGCTTGGAACAAGGAAAAGTTTTGATCACTTGATATCAGACACAAAGGCT CCTAAAAGGCAAGAAATGGAATCAGGGATCACAACACCCCCCAAAATGAGGAGAGTAGCAGAAACTGATTATGAAATGGAAACTCAGAGG ATTTCCTCATCACAACAGCACCCACATTTACGTAAAGTTTCAGTGTCTGAATCAAATGTTCTCTTGGATGAAGAAGTACTTACTGATCCG AAGATCCAGGCGCTGCTTCTTACTGTTCTAGCTACACTGGTAAAATATACCACAGATGAGTTTGATCAACGAATTCTTTATGAATACTTA GCAGAGGCCAGTGTTGTGTTTCCCAAAGTCTTTCCTGTTGTGCATAATTTGTTGGACTCTAAGATCAACACCCTGTTATCATTGTGCCAA GATCCAAATTTGTTAAATCCAATCCATGGAATTGTGCAGAGTGTGGTGTACCATGAAGAATCCCCACCACAATACCAAACATCTTACCTG CAAAGTTTTGGTTTTAATGGCTTGTGGCGGTTTGCAGGACCGTTTTCAAAGCAAACACAAATTCCAGACTATGCTGAGCTTATTGTTAAG TTTCTTGATGCCTTGATTGACACGTACCTGCCTGGAATTGATGAAGAAACCAGTGAAGAATCCCTCCTGACTCCCACATCTCCTTACCCT CCTGCACTGCAGAGCCAGCTTAGTATCACTGCCAACCTTAACCTTTCTAATTCCATGACCTCACTTGCAACTTCCCAGCATTCCCCAGGA ATCGACAAGGAGAACGTTGAACTCTCCCCTACCACTGGCCACTGTAACAGTGGACGAACTCGCCACGGATCCGCAAGCCAAGTGCAGAAG >In-frame_CPD_ENST00000225719_chr17_28766095_+_NF1_ENST00000358273_chr17_29676138_+_3561nt ATGGCGAGCGGCCGGGACGAGCGGCCGCCTTGGCGGCTAGGGCGGCTCCTGTTGCTCATGTGCCTGCTGCTGCTGGGGAGCTCGGCCCGG GCGGCTCACATCAAGAAGGCGGAGGCGACTACCACAACTACGAGCGCGGGCGCCGAGGCGGCCGAGGGCCAGTTCGACCGCTACTACCAC GAAGAGGAGTTGGAGTCGGCGCTGAGGGAGGCGGCGGCCGCGGGCCTCCCCGGCCTGGCCCGCCTCTTTAGCATCGGCCGCTCGGTGGAA GGCCGGCCGCTGTGGGTGCTTCGCCTCACCGCCGGCCTGGGGTCGCTAATCCCTGAGGGCGACGCGGGGCCTGACGCTGCCGGGCCCGAC GCTGCGGGGCCGCTGCTGCCCGGCCGGCCCCAGGTGAAGCTGGTGGGCAACATGCATGGCGACGAGACCGTGTCGCGCCAGGTGTTGATC TACTTGGCCCGCGAGCTGGCGGCCGGCTACCGCCGCGGGGACCCGCGCCTGGTCCGCCTGCTCAACACCACCGACGTGTACCTGCTGCCC AGCCTCAACCCCGATGGCTTCGAGCGTGCCCGCGAGGGCGACTGTGGCTTCGGCGACGGCGGCCCGTCCGGGGCCAGCGGCCGCGACAAT AGTCGCGGCCGCGACCTCAACCGAAGCTTTCCCGACCAGTTTAGCACCGGCGAACCCCCCGCCCTGGACGAGGTGCCCGAGGTGCGCGCC CTCATCGAGTGGATCCGCAGGAACAAGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTTGATGATTCT CCAGAACATAAGGCCACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCC ATAATGAAAACTGGTGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGGTATGATGTG GAAGGTGGTATGCAAGATTACAATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGTTGCAAGTACCCACCTGCTTCA CAGCTTCGACAGGAATGGGAGAACAATCGTGAGTCTTTGATCACATTGATTGAAAAGGTTCACATTGGAGTGAAAGGATTTGTTAAAGAT TCCATAACAGGATCTGGGTTAGAGAATGCAACCATCTCAGTGGCTGGTATTAATCATAATATCACAACAGGCAGATTTGGTGATTTCTAC CGATTACTTGTTCCTGGAACTTACAACCTTACAGTAGTTTTAACTGGGTATATGCCATTGACTGTTACTAATGTAGTGGTGAAAGAAGGA CCAGCCACAGAGGTGGATTTTTCTCTTAGGCCAACTGTAACTTCAGTAATCCCTGACACGACAGAGGCTGTATCAACTGCTAGCACAGTT GCTATACCTAATATTCTTTCTGGAACATCATCCTCCTACCAGCCAATTCAGCCAAAGGACTTTCACCACCACCATTTCCCTGATATGGAA ATCTTCTTGAGAAGGTTTGCCAATGAATATCCTAACATTACCCGGCTTTATTCCTTGGGAAAATCAGTAGAGTCAAGAGAACTTTATGTG ATGGAGATATCTGATAATCCGGGTGTCCATGAACCAGGTGAACCAGAATTTAAGTACATTGGAAATATGCATGGAAATGAAGTGGTTGGA AGAGAACTGCTGTTGAACCTCATAGAATACCTTTGTAAGAACTTTGGAACAGACCCTGAAGTCACAGATTTGGTTCATAACACTAGAATT CACCTTATGCCATCCATGAATCCTGATGGGTATGAAAAGTCCCAGGAAGGAGATTCAATAAGTGTAATTGGCAGAAACAACAGCAACAAC TTTGACCTGAACCGAAATTTCCCAGACCAGTTTGTTCAGATCACAGATCCTACGCAACCAGAAACTATTGCTGTAATGAGCTGGATGAAG TCCTATCCATTTGTACTTTCAGCAAACCTGCATGGAGGTTCTTTGGTGGTTAACTACCCTTTTGATGATGATGAACAAGGACTTGCCACA TATAGTAAATCACCAGATGATGCTGTGTTCCAACAAATAGCACTTTCTTATTCCAAGGAAAATTCCCAGATGTTTCAAGGTAGACCTTGC AAGAATATGTATCCTAATGAATATTTTCCTCATGGAATAACAAATGGAGCTAGTTGGTATAATGTGCCAGGGTACAGGCATCCTTCACCT GCTATTGTTGCAAGAACAGTCAGAATTTTACATACACTACTAACTCTGGTTAACAAACACAGAAATTGTGACAAATTTGAAGTGAATACA CAGAGCGTGGCCTACTTAGCAGCTTTACTTACAGTGTCTGAAGAAGTTCGAAGTCGCTGCAGCCTAAAACATAGAAAGTCACTTCTTCTT ACTGATATTTCAATGGAAAATGTTCCTATGGATACATATCCCATTCATCATGGTGACCCTTCCTATAGGACACTAAAGGAGACTCAGCCA TGGTCCTCTCCCAAAGGTTCTGAAGGATACCTTGCAGCCACCTATCCAACTGTCGGCCAGACCAGTCCCCGAGCCAGGAAATCCATGAGC CTGGACATGGGGCAACCTTCTCAGGCCAACACTAAGAAGTTGCTTGGAACAAGGAAAAGTTTTGATCACTTGATATCAGACACAAAGGCT CCTAAAAGGCAAGAAATGGAATCAGGGATCACAACACCCCCCAAAATGAGGAGAGTAGCAGAAACTGATTATGAAATGGAAACTCAGAGG ATTTCCTCATCACAACAGCACCCACATTTACGTAAAGTTTCAGTGTCTGAATCAAATGTTCTCTTGGATGAAGAAGTACTTACTGATCCG AAGATCCAGGCGCTGCTTCTTACTGTTCTAGCTACACTGGTAAAATATACCACAGATGAGTTTGATCAACGAATTCTTTATGAATACTTA GCAGAGGCCAGTGTTGTGTTTCCCAAAGTCTTTCCTGTTGTGCATAATTTGTTGGACTCTAAGATCAACACCCTGTTATCATTGTGCCAA GATCCAAATTTGTTAAATCCAATCCATGGAATTGTGCAGAGTGTGGTGTACCATGAAGAATCCCCACCACAATACCAAACATCTTACCTG CAAAGTTTTGGTTTTAATGGCTTGTGGCGGTTTGCAGGACCGTTTTCAAAGCAAACACAAATTCCAGACTATGCTGAGCTTATTGTTAAG TTTCTTGATGCCTTGATTGACACGTACCTGCCTGGAATTGATGAAGAAACCAGTGAAGAATCCCTCCTGACTCCCACATCTCCTTACCCT CCTGCACTGCAGAGCCAGCTTAGTATCACTGCCAACCTTAACCTTTCTAATTCCATGACCTCACTTGCAACTTCCCAGCATTCCCCAGGA ATCGACAAGGAGAACGTTGAACTCTCCCCTACCACTGGCCACTGTAACAGTGGACGAACTCGCCACGGATCCGCAAGCCAAGTGCAGAAG >In-frame_CPD_ENST00000543464_chr17_28766095_+_NF1_ENST00000356175_chr17_29676138_+_2820nt ATGAGGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTTGATGATTCTCCAGAACATAAGGCCACTGGA ATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCCATAATGAAAACTGGTGAGCCT CATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGGTATGATGTGGAAGGTGGTATGCAAGATTAC AATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGTTGCAAGTACCCACCTGCTTCACAGCTTCGACAGGAATGGGAG AACAATCGTGAGTCTTTGATCACATTGATTGAAAAGGTTCACATTGGAGTGAAAGGATTTGTTAAAGATTCCATAACAGGATCTGGGTTA GAGAATGCAACCATCTCAGTGGCTGGTATTAATCATAATATCACAACAGGCAGATTTGGTGATTTCTACCGATTACTTGTTCCTGGAACT TACAACCTTACAGTAGTTTTAACTGGGTATATGCCATTGACTGTTACTAATGTAGTGGTGAAAGAAGGACCAGCCACAGAGGTGGATTTT TCTCTTAGGCCAACTGTAACTTCAGTAATCCCTGACACGACAGAGGCTGTATCAACTGCTAGCACAGTTGCTATACCTAATATTCTTTCT GGAACATCATCCTCCTACCAGCCAATTCAGCCAAAGGACTTTCACCACCACCATTTCCCTGATATGGAAATCTTCTTGAGAAGGTTTGCC AATGAATATCCTAACATTACCCGGCTTTATTCCTTGGGAAAATCAGTAGAGTCAAGAGAACTTTATGTGATGGAGATATCTGATAATCCG GGTGTCCATGAACCAGGTGAACCAGAATTTAAGTACATTGGAAATATGCATGGAAATGAAGTGGTTGGAAGAGAACTGCTGTTGAACCTC ATAGAATACCTTTGTAAGAACTTTGGAACAGACCCTGAAGTCACAGATTTGGTTCATAACACTAGAATTCACCTTATGCCATCCATGAAT CCTGATGGGTATGAAAAGTCCCAGGAAGGAGATTCAATAAGTGTAATTGGCAGAAACAACAGCAACAACTTTGACCTGAACCGAAATTTC CCAGACCAGTTTGTTCAGATCACAGATCCTACGCAACCAGAAACTATTGCTGTAATGAGCTGGATGAAGTCCTATCCATTTGTACTTTCA GCAAACCTGCATGGAGGTTCTTTGGTGGTTAACTACCCTTTTGATGATGATGAACAAGGACTTGCCACATATAGTAAATCACCAGATGAT GCTGTGTTCCAACAAATAGCACTTTCTTATTCCAAGGAAAATTCCCAGATGTTTCAAGGTAGACCTTGCAAGAATATGTATCCTAATGAA TATTTTCCTCATGGAATAACAAATGGAGCTAGTTGGTATAATGTGCCAGGGTACAGGCATCCTTCACCTGCTATTGTTGCAAGAACAGTC AGAATTTTACATACACTACTAACTCTGGTTAACAAACACAGAAATTGTGACAAATTTGAAGTGAATACACAGAGCGTGGCCTACTTAGCA GCTTTACTTACAGTGTCTGAAGAAGTTCGAAGTCGCTGCAGCCTAAAACATAGAAAGTCACTTCTTCTTACTGATATTTCAATGGAAAAT GTTCCTATGGATACATATCCCATTCATCATGGTGACCCTTCCTATAGGACACTAAAGGAGACTCAGCCATGGTCCTCTCCCAAAGGTTCT GAAGGATACCTTGCAGCCACCTATCCAACTGTCGGCCAGACCAGTCCCCGAGCCAGGAAATCCATGAGCCTGGACATGGGGCAACCTTCT CAGGCCAACACTAAGAAGTTGCTTGGAACAAGGAAAAGTTTTGATCACTTGATATCAGACACAAAGGCTCCTAAAAGGCAAGAAATGGAA TCAGGGATCACAACACCCCCCAAAATGAGGAGAGTAGCAGAAACTGATTATGAAATGGAAACTCAGAGGATTTCCTCATCACAACAGCAC CCACATTTACGTAAAGTTTCAGTGTCTGAATCAAATGTTCTCTTGGATGAAGAAGTACTTACTGATCCGAAGATCCAGGCGCTGCTTCTT ACTGTTCTAGCTACACTGGTAAAATATACCACAGATGAGTTTGATCAACGAATTCTTTATGAATACTTAGCAGAGGCCAGTGTTGTGTTT CCCAAAGTCTTTCCTGTTGTGCATAATTTGTTGGACTCTAAGATCAACACCCTGTTATCATTGTGCCAAGATCCAAATTTGTTAAATCCA ATCCATGGAATTGTGCAGAGTGTGGTGTACCATGAAGAATCCCCACCACAATACCAAACATCTTACCTGCAAAGTTTTGGTTTTAATGGC TTGTGGCGGTTTGCAGGACCGTTTTCAAAGCAAACACAAATTCCAGACTATGCTGAGCTTATTGTTAAGTTTCTTGATGCCTTGATTGAC ACGTACCTGCCTGGAATTGATGAAGAAACCAGTGAAGAATCCCTCCTGACTCCCACATCTCCTTACCCTCCTGCACTGCAGAGCCAGCTT AGTATCACTGCCAACCTTAACCTTTCTAATTCCATGACCTCACTTGCAACTTCCCAGCATTCCCCAGGAATCGACAAGGAGAACGTTGAA CTCTCCCCTACCACTGGCCACTGTAACAGTGGACGAACTCGCCACGGATCCGCAAGCCAAGTGCAGAAGCAAAGAAGCGCTGGCAGTTTC >In-frame_CPD_ENST00000543464_chr17_28766095_+_NF1_ENST00000358273_chr17_29676138_+_2820nt ATGAGGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTTGATGATTCTCCAGAACATAAGGCCACTGGA ATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCCATAATGAAAACTGGTGAGCCT CATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGGTATGATGTGGAAGGTGGTATGCAAGATTAC AATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGTTGCAAGTACCCACCTGCTTCACAGCTTCGACAGGAATGGGAG AACAATCGTGAGTCTTTGATCACATTGATTGAAAAGGTTCACATTGGAGTGAAAGGATTTGTTAAAGATTCCATAACAGGATCTGGGTTA GAGAATGCAACCATCTCAGTGGCTGGTATTAATCATAATATCACAACAGGCAGATTTGGTGATTTCTACCGATTACTTGTTCCTGGAACT TACAACCTTACAGTAGTTTTAACTGGGTATATGCCATTGACTGTTACTAATGTAGTGGTGAAAGAAGGACCAGCCACAGAGGTGGATTTT TCTCTTAGGCCAACTGTAACTTCAGTAATCCCTGACACGACAGAGGCTGTATCAACTGCTAGCACAGTTGCTATACCTAATATTCTTTCT GGAACATCATCCTCCTACCAGCCAATTCAGCCAAAGGACTTTCACCACCACCATTTCCCTGATATGGAAATCTTCTTGAGAAGGTTTGCC AATGAATATCCTAACATTACCCGGCTTTATTCCTTGGGAAAATCAGTAGAGTCAAGAGAACTTTATGTGATGGAGATATCTGATAATCCG GGTGTCCATGAACCAGGTGAACCAGAATTTAAGTACATTGGAAATATGCATGGAAATGAAGTGGTTGGAAGAGAACTGCTGTTGAACCTC ATAGAATACCTTTGTAAGAACTTTGGAACAGACCCTGAAGTCACAGATTTGGTTCATAACACTAGAATTCACCTTATGCCATCCATGAAT CCTGATGGGTATGAAAAGTCCCAGGAAGGAGATTCAATAAGTGTAATTGGCAGAAACAACAGCAACAACTTTGACCTGAACCGAAATTTC CCAGACCAGTTTGTTCAGATCACAGATCCTACGCAACCAGAAACTATTGCTGTAATGAGCTGGATGAAGTCCTATCCATTTGTACTTTCA GCAAACCTGCATGGAGGTTCTTTGGTGGTTAACTACCCTTTTGATGATGATGAACAAGGACTTGCCACATATAGTAAATCACCAGATGAT GCTGTGTTCCAACAAATAGCACTTTCTTATTCCAAGGAAAATTCCCAGATGTTTCAAGGTAGACCTTGCAAGAATATGTATCCTAATGAA TATTTTCCTCATGGAATAACAAATGGAGCTAGTTGGTATAATGTGCCAGGGTACAGGCATCCTTCACCTGCTATTGTTGCAAGAACAGTC AGAATTTTACATACACTACTAACTCTGGTTAACAAACACAGAAATTGTGACAAATTTGAAGTGAATACACAGAGCGTGGCCTACTTAGCA GCTTTACTTACAGTGTCTGAAGAAGTTCGAAGTCGCTGCAGCCTAAAACATAGAAAGTCACTTCTTCTTACTGATATTTCAATGGAAAAT GTTCCTATGGATACATATCCCATTCATCATGGTGACCCTTCCTATAGGACACTAAAGGAGACTCAGCCATGGTCCTCTCCCAAAGGTTCT GAAGGATACCTTGCAGCCACCTATCCAACTGTCGGCCAGACCAGTCCCCGAGCCAGGAAATCCATGAGCCTGGACATGGGGCAACCTTCT CAGGCCAACACTAAGAAGTTGCTTGGAACAAGGAAAAGTTTTGATCACTTGATATCAGACACAAAGGCTCCTAAAAGGCAAGAAATGGAA TCAGGGATCACAACACCCCCCAAAATGAGGAGAGTAGCAGAAACTGATTATGAAATGGAAACTCAGAGGATTTCCTCATCACAACAGCAC CCACATTTACGTAAAGTTTCAGTGTCTGAATCAAATGTTCTCTTGGATGAAGAAGTACTTACTGATCCGAAGATCCAGGCGCTGCTTCTT ACTGTTCTAGCTACACTGGTAAAATATACCACAGATGAGTTTGATCAACGAATTCTTTATGAATACTTAGCAGAGGCCAGTGTTGTGTTT CCCAAAGTCTTTCCTGTTGTGCATAATTTGTTGGACTCTAAGATCAACACCCTGTTATCATTGTGCCAAGATCCAAATTTGTTAAATCCA ATCCATGGAATTGTGCAGAGTGTGGTGTACCATGAAGAATCCCCACCACAATACCAAACATCTTACCTGCAAAGTTTTGGTTTTAATGGC TTGTGGCGGTTTGCAGGACCGTTTTCAAAGCAAACACAAATTCCAGACTATGCTGAGCTTATTGTTAAGTTTCTTGATGCCTTGATTGAC ACGTACCTGCCTGGAATTGATGAAGAAACCAGTGAAGAATCCCTCCTGACTCCCACATCTCCTTACCCTCCTGCACTGCAGAGCCAGCTT AGTATCACTGCCAACCTTAACCTTTCTAATTCCATGACCTCACTTGCAACTTCCCAGCATTCCCCAGGAATCGACAAGGAGAACGTTGAA CTCTCCCCTACCACTGGCCACTGTAACAGTGGACGAACTCGCCACGGATCCGCAAGCCAAGTGCAGAAGCAAAGAAGCGCTGGCAGTTTC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CPD_ENST00000225719_chr17_28766095_+_NF1_ENST00000356175_chr17_29676138_+_7159nt GGGGATCCGGCGGGCCCCCGCCGCCCGGAGCGCTGAGCCGCGGGAGCGGAGCCGGGGTTAGCGGCGCTGCTGGAAGATGGCGAGCGGCCG GGACGAGCGGCCGCCTTGGCGGCTAGGGCGGCTCCTGTTGCTCATGTGCCTGCTGCTGCTGGGGAGCTCGGCCCGGGCGGCTCACATCAA GAAGGCGGAGGCGACTACCACAACTACGAGCGCGGGCGCCGAGGCGGCCGAGGGCCAGTTCGACCGCTACTACCACGAAGAGGAGTTGGA GTCGGCGCTGAGGGAGGCGGCGGCCGCGGGCCTCCCCGGCCTGGCCCGCCTCTTTAGCATCGGCCGCTCGGTGGAAGGCCGGCCGCTGTG GGTGCTTCGCCTCACCGCCGGCCTGGGGTCGCTAATCCCTGAGGGCGACGCGGGGCCTGACGCTGCCGGGCCCGACGCTGCGGGGCCGCT GCTGCCCGGCCGGCCCCAGGTGAAGCTGGTGGGCAACATGCATGGCGACGAGACCGTGTCGCGCCAGGTGTTGATCTACTTGGCCCGCGA GCTGGCGGCCGGCTACCGCCGCGGGGACCCGCGCCTGGTCCGCCTGCTCAACACCACCGACGTGTACCTGCTGCCCAGCCTCAACCCCGA TGGCTTCGAGCGTGCCCGCGAGGGCGACTGTGGCTTCGGCGACGGCGGCCCGTCCGGGGCCAGCGGCCGCGACAATAGTCGCGGCCGCGA CCTCAACCGAAGCTTTCCCGACCAGTTTAGCACCGGCGAACCCCCCGCCCTGGACGAGGTGCCCGAGGTGCGCGCCCTCATCGAGTGGAT CCGCAGGAACAAGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTTGATGATTCTCCAGAACATAAGGC CACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCCATAATGAAAACTGG TGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGGTATGATGTGGAAGGTGGTATGCA AGATTACAATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGTTGCAAGTACCCACCTGCTTCACAGCTTCGACAGGA ATGGGAGAACAATCGTGAGTCTTTGATCACATTGATTGAAAAGGTTCACATTGGAGTGAAAGGATTTGTTAAAGATTCCATAACAGGATC TGGGTTAGAGAATGCAACCATCTCAGTGGCTGGTATTAATCATAATATCACAACAGGCAGATTTGGTGATTTCTACCGATTACTTGTTCC TGGAACTTACAACCTTACAGTAGTTTTAACTGGGTATATGCCATTGACTGTTACTAATGTAGTGGTGAAAGAAGGACCAGCCACAGAGGT GGATTTTTCTCTTAGGCCAACTGTAACTTCAGTAATCCCTGACACGACAGAGGCTGTATCAACTGCTAGCACAGTTGCTATACCTAATAT TCTTTCTGGAACATCATCCTCCTACCAGCCAATTCAGCCAAAGGACTTTCACCACCACCATTTCCCTGATATGGAAATCTTCTTGAGAAG GTTTGCCAATGAATATCCTAACATTACCCGGCTTTATTCCTTGGGAAAATCAGTAGAGTCAAGAGAACTTTATGTGATGGAGATATCTGA TAATCCGGGTGTCCATGAACCAGGTGAACCAGAATTTAAGTACATTGGAAATATGCATGGAAATGAAGTGGTTGGAAGAGAACTGCTGTT GAACCTCATAGAATACCTTTGTAAGAACTTTGGAACAGACCCTGAAGTCACAGATTTGGTTCATAACACTAGAATTCACCTTATGCCATC CATGAATCCTGATGGGTATGAAAAGTCCCAGGAAGGAGATTCAATAAGTGTAATTGGCAGAAACAACAGCAACAACTTTGACCTGAACCG AAATTTCCCAGACCAGTTTGTTCAGATCACAGATCCTACGCAACCAGAAACTATTGCTGTAATGAGCTGGATGAAGTCCTATCCATTTGT ACTTTCAGCAAACCTGCATGGAGGTTCTTTGGTGGTTAACTACCCTTTTGATGATGATGAACAAGGACTTGCCACATATAGTAAATCACC AGATGATGCTGTGTTCCAACAAATAGCACTTTCTTATTCCAAGGAAAATTCCCAGATGTTTCAAGGTAGACCTTGCAAGAATATGTATCC TAATGAATATTTTCCTCATGGAATAACAAATGGAGCTAGTTGGTATAATGTGCCAGGGTACAGGCATCCTTCACCTGCTATTGTTGCAAG AACAGTCAGAATTTTACATACACTACTAACTCTGGTTAACAAACACAGAAATTGTGACAAATTTGAAGTGAATACACAGAGCGTGGCCTA CTTAGCAGCTTTACTTACAGTGTCTGAAGAAGTTCGAAGTCGCTGCAGCCTAAAACATAGAAAGTCACTTCTTCTTACTGATATTTCAAT GGAAAATGTTCCTATGGATACATATCCCATTCATCATGGTGACCCTTCCTATAGGACACTAAAGGAGACTCAGCCATGGTCCTCTCCCAA AGGTTCTGAAGGATACCTTGCAGCCACCTATCCAACTGTCGGCCAGACCAGTCCCCGAGCCAGGAAATCCATGAGCCTGGACATGGGGCA ACCTTCTCAGGCCAACACTAAGAAGTTGCTTGGAACAAGGAAAAGTTTTGATCACTTGATATCAGACACAAAGGCTCCTAAAAGGCAAGA AATGGAATCAGGGATCACAACACCCCCCAAAATGAGGAGAGTAGCAGAAACTGATTATGAAATGGAAACTCAGAGGATTTCCTCATCACA ACAGCACCCACATTTACGTAAAGTTTCAGTGTCTGAATCAAATGTTCTCTTGGATGAAGAAGTACTTACTGATCCGAAGATCCAGGCGCT GCTTCTTACTGTTCTAGCTACACTGGTAAAATATACCACAGATGAGTTTGATCAACGAATTCTTTATGAATACTTAGCAGAGGCCAGTGT TGTGTTTCCCAAAGTCTTTCCTGTTGTGCATAATTTGTTGGACTCTAAGATCAACACCCTGTTATCATTGTGCCAAGATCCAAATTTGTT AAATCCAATCCATGGAATTGTGCAGAGTGTGGTGTACCATGAAGAATCCCCACCACAATACCAAACATCTTACCTGCAAAGTTTTGGTTT TAATGGCTTGTGGCGGTTTGCAGGACCGTTTTCAAAGCAAACACAAATTCCAGACTATGCTGAGCTTATTGTTAAGTTTCTTGATGCCTT GATTGACACGTACCTGCCTGGAATTGATGAAGAAACCAGTGAAGAATCCCTCCTGACTCCCACATCTCCTTACCCTCCTGCACTGCAGAG CCAGCTTAGTATCACTGCCAACCTTAACCTTTCTAATTCCATGACCTCACTTGCAACTTCCCAGCATTCCCCAGGAATCGACAAGGAGAA CGTTGAACTCTCCCCTACCACTGGCCACTGTAACAGTGGACGAACTCGCCACGGATCCGCAAGCCAAGTGCAGAAGCAAAGAAGCGCTGG CAGTTTCAAACGTAATAGCATTAAGAAGATCGTGTGAAGCTTGCTTGCTTTCTTTTTTAAAATCAACTTAACATGGGCTCTTCACTAGTG ACCCCTTCCCTGTCCTTGCCCTTTCCCCCCATGTTGTAATGCTGCACTTCCTGTTTTATAATGAACCCATCCGGTTTGCCATGTTGCCAG ATGATCAACTCTTCGAAGCCTTGCCTAAATTTAATGCTGCCTTTTCTTTAACTTTTTTTCTTCTACTTTTGGCGTGTATCTGGTATATGT AAGTGTTCAGAACAACTGCAAAGAAAGTGGGAGGTCAGGAAACTTTTAACTGAGAAATCTCAATTGTAAGAGAGGATGAATTCTTGAATA CTGCTACTACTGGCCAGTGATGAAAGCCATTTGCACAGAGCTCTGCCTTCTGTGGTTTTCCCTTCTTCATCCTACAGAGTAAAGTGTTAG TCCTATTTATACATTTTTCAAGATACAAGTTTATGAGAGAAATAGTATTATAACCCCAGTATGTTTAATCTTTTAGCTGTGGACTTTTTT TTTAACCGTACAAAACTGAAAGAACCATAGAGGTCAAGCCTCAGTGACTTGACACCATAAAGCCACAGACAAGGTACTTGGGGGGGAGGG CAGGGAAATTTCATATTTTATAGTGGATTCTTAAGAAATACTAACACTTGAGTATTAGCAATAATTACAGGAAAATAAGTGCGACCACAT ATATCTTAACATTACTGAATTAAAACTATGGCTTCTAAGTCCTTATCCAAACTCAGTCATCCAAACTAGTTTATTTTTTTCTCCAGTTGA TTATCTTTTAATTTTTAATTTTGCTAAAGGTGGTTTTTTTGTGTTTTGTTTTTTGTAAACCAAAACTATACTAAGTATAGTAATTATATA TATATATATATTTTTTCCCCTCCCCCTCTTCTTTCCTAACTAATTCTGAGCAGGGTAATCAGTGAACAAAGTGTTGAAAATTGTTCCCAG AAGGTAATTTTCATAGATGTTTGCATTAGCTCCATAGCAAAATGGAATGGTACGTGACATTTAGGGTAGCTGATATTTTTATTTTGTTAA ATAATTTCCAAGAATAGAGTATGGTGTATATTATAAATTTCTTTGATAAGATGTATTTTGAATGTCTTTTAATCTTCCTCCTCCTCTCCA AAAAAATCAGAAACCTCTTTAAGAAAACATGTAGGTTATATATGCTAGAATTGCATTTAATCACTGTGAAAAGACTGGTCAGCCTGCATT AGTATGACAGTAGGGGGGCTGTTAGAATTGCTGCTATACTGGTGGTATGGATTATCATGGCATTGGAATTTTCATAGTAATGCAGATCCA ATTTCTTTGTGGTACCTGCAGTTTACAAAATAATTTGACTTCAGTGAGCATATTGGTATCTGGATGTTCCAATTTAGAACTAAACCATAT TTATTACAAAAAGATATTAATCCCTCTACTCCCAGGTTCCCTTTATATGTTAAGATATAATGGCTTTGAGGGGGGAAAAAATAAACCTAG GGGAGAGGGGAGTTTCCTGTAGTGCTGTTTCATTAGAGGATTTCAGTAAATTAAATTCCACAGCTAATTCAATAAATAATGGTACATTTA AGTGTTCTGATTTTAATAATATATTTCACATTTATCCACACAGTAACAATGTAATATGTTAATGTAAATAAAATTGGTTTTGATACTCAG AAATAACAAGAATTTAATTTTTTAAATTTGTTTACAGTCCTGGGAAAAGTAAGAATTATTTGCCAAAATAAGAGGAAAGAAAACCTTAGT ATTATTAATGAGTTTACCATAGAATTGTTGGAAATACTGAAGACAGGTGCAATTTACTAAACTTTTGTTTTTAAACTATTGTAGAGGCTG CATTAGAAGAAAATGTTTATAATGACAGAGCAACTATGACTATATAAAAAAGCTGAAATTAGAACTGTGTTTAGAAATAGATCAGTAACC CAGTGCCAAGGATGCCAAGCTGCCACCATGGTCTTGGCTCTCCCACAACCCAGTGTTTCTGGGGTAAGTTTCACAGTTTCTAGGCCCTGG AATAGCAGGCAGTGTAAGCCTTTGATAACTTTAGTTCGATGTTTTTCTTGTTTTTGTTTGTTGGTTTGGTGCATATGATAGTGGGTGTTA TGCTATTTTGCTCTTCCCATCAAAATAAAGAAACTTCCAGAGGTTTACTGTTAAAAATACTGATATTTCCATAAACGGGTTTACCAAGGG TGTAGTATTTCATACCGCCTGAAATGATCAGCATTGGCACAAATCAAAATTCAGCCGCCTTTGAAATGCAAAAATACCTTTGACTAGTAA GTACATCCTAGGAGTTTGAAAACTTAACTAAGGTTTAAAATTTACCTTGTTTAAAGAACTTCTGACTTTTGAGGAAAATCTAGCTTTCCA AGTAACTAAAATGTACATGAGATAAACCTCTCACCACTATGTGTCCCTTGAGAAATGCAACACTTTTTTAGTCTTCATACTTGTAATCTA TAAAAGAAATTCTGAAGTTTAGACCAAGTTGCCCATTTCTGCGTAATTGACATAAGTTCTGTTAAAAATATTATAAGTAATTCGTTTCGG TTTGTAGATGTTTCCCCTGACTTGTTAAAGAGGAAACCAGGAACTCAGTCATGTTTTTGTCCTGGATAATCTACCTGTTATGCCAGTACT CCCATCCGAGGGGCATGCCCTTAGTTGCCCAGATGGAGATGCAGTTCAGTAGATTTGGGGCAAAGTGGCTACAGCTCTGTCTTCCATTCA CTCAACACCTGTTCATGACTGAGCCAGGTGCCCAGGACACATCCTAAACAGTCAGCTTCTATCCTGTGTCCTAGTTGGGGAGACAGAGTG CCAGCCAGCAACCCTCCCAGGTTTGTAGGTTTTAGGGGTTTTCAGTTTTGTTTGGGTTTTTTGTTTTTTGTTTTTGTTTCTACATCCTTC CCCGACTCCCAGGCATAATGAGGCATGTCTTACTCAATGTTATGCAATGGATTTAGGCAAAAATTCATTCTTAGTGTCAGCCACACAATT TTTTTTAATGCAGTATATTCACCTGTAAATAGTTTGTGTAAAATTTGACAAAAAAAGTATATTTACTATACTGTAAATATATGTGATGAT ATATTGTATTATTTTGCTTTTTTGTAAAGCAGTTAGTTGCTGCACATGGATAACAACAAAAATTTGATTATTCTCGTGTTAGTATTGTTA ACTTCTTTTTGCGACTGCGTTACATCATTTAAAGAAAATGCTGTGTATTGTAAACTTAAATTGTATATGATAACTTACTGTCCTTTCCAT CCGGGCCTAAACTTTGGCAGTTCCTTTGTCTACAACCTTGTTAATACTGTAAACAGTTGTACGCCAGCAGGAAAAATACTGCCCAACAGA CAAAATCGATCATTGTAGGGGAAAATCATAGAAATCCATTTCAGATCTTTATTGTTCCTCACCCCATTTTCCTCCTTGTGTATGTACTTC >In-frame_CPD_ENST00000225719_chr17_28766095_+_NF1_ENST00000358273_chr17_29676138_+_7159nt GGGGATCCGGCGGGCCCCCGCCGCCCGGAGCGCTGAGCCGCGGGAGCGGAGCCGGGGTTAGCGGCGCTGCTGGAAGATGGCGAGCGGCCG GGACGAGCGGCCGCCTTGGCGGCTAGGGCGGCTCCTGTTGCTCATGTGCCTGCTGCTGCTGGGGAGCTCGGCCCGGGCGGCTCACATCAA GAAGGCGGAGGCGACTACCACAACTACGAGCGCGGGCGCCGAGGCGGCCGAGGGCCAGTTCGACCGCTACTACCACGAAGAGGAGTTGGA GTCGGCGCTGAGGGAGGCGGCGGCCGCGGGCCTCCCCGGCCTGGCCCGCCTCTTTAGCATCGGCCGCTCGGTGGAAGGCCGGCCGCTGTG GGTGCTTCGCCTCACCGCCGGCCTGGGGTCGCTAATCCCTGAGGGCGACGCGGGGCCTGACGCTGCCGGGCCCGACGCTGCGGGGCCGCT GCTGCCCGGCCGGCCCCAGGTGAAGCTGGTGGGCAACATGCATGGCGACGAGACCGTGTCGCGCCAGGTGTTGATCTACTTGGCCCGCGA GCTGGCGGCCGGCTACCGCCGCGGGGACCCGCGCCTGGTCCGCCTGCTCAACACCACCGACGTGTACCTGCTGCCCAGCCTCAACCCCGA TGGCTTCGAGCGTGCCCGCGAGGGCGACTGTGGCTTCGGCGACGGCGGCCCGTCCGGGGCCAGCGGCCGCGACAATAGTCGCGGCCGCGA CCTCAACCGAAGCTTTCCCGACCAGTTTAGCACCGGCGAACCCCCCGCCCTGGACGAGGTGCCCGAGGTGCGCGCCCTCATCGAGTGGAT CCGCAGGAACAAGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCAAGCTATCCTTTTGATGATTCTCCAGAACATAAGGC CACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAAGCTTATGCTTCAAACCACCCCATAATGAAAACTGG TGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAACGGCGCACATTGGTATGATGTGGAAGGTGGTATGCA AGATTACAATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGTTGCAAGTACCCACCTGCTTCACAGCTTCGACAGGA ATGGGAGAACAATCGTGAGTCTTTGATCACATTGATTGAAAAGGTTCACATTGGAGTGAAAGGATTTGTTAAAGATTCCATAACAGGATC TGGGTTAGAGAATGCAACCATCTCAGTGGCTGGTATTAATCATAATATCACAACAGGCAGATTTGGTGATTTCTACCGATTACTTGTTCC TGGAACTTACAACCTTACAGTAGTTTTAACTGGGTATATGCCATTGACTGTTACTAATGTAGTGGTGAAAGAAGGACCAGCCACAGAGGT GGATTTTTCTCTTAGGCCAACTGTAACTTCAGTAATCCCTGACACGACAGAGGCTGTATCAACTGCTAGCACAGTTGCTATACCTAATAT TCTTTCTGGAACATCATCCTCCTACCAGCCAATTCAGCCAAAGGACTTTCACCACCACCATTTCCCTGATATGGAAATCTTCTTGAGAAG GTTTGCCAATGAATATCCTAACATTACCCGGCTTTATTCCTTGGGAAAATCAGTAGAGTCAAGAGAACTTTATGTGATGGAGATATCTGA TAATCCGGGTGTCCATGAACCAGGTGAACCAGAATTTAAGTACATTGGAAATATGCATGGAAATGAAGTGGTTGGAAGAGAACTGCTGTT GAACCTCATAGAATACCTTTGTAAGAACTTTGGAACAGACCCTGAAGTCACAGATTTGGTTCATAACACTAGAATTCACCTTATGCCATC CATGAATCCTGATGGGTATGAAAAGTCCCAGGAAGGAGATTCAATAAGTGTAATTGGCAGAAACAACAGCAACAACTTTGACCTGAACCG AAATTTCCCAGACCAGTTTGTTCAGATCACAGATCCTACGCAACCAGAAACTATTGCTGTAATGAGCTGGATGAAGTCCTATCCATTTGT ACTTTCAGCAAACCTGCATGGAGGTTCTTTGGTGGTTAACTACCCTTTTGATGATGATGAACAAGGACTTGCCACATATAGTAAATCACC AGATGATGCTGTGTTCCAACAAATAGCACTTTCTTATTCCAAGGAAAATTCCCAGATGTTTCAAGGTAGACCTTGCAAGAATATGTATCC TAATGAATATTTTCCTCATGGAATAACAAATGGAGCTAGTTGGTATAATGTGCCAGGGTACAGGCATCCTTCACCTGCTATTGTTGCAAG AACAGTCAGAATTTTACATACACTACTAACTCTGGTTAACAAACACAGAAATTGTGACAAATTTGAAGTGAATACACAGAGCGTGGCCTA CTTAGCAGCTTTACTTACAGTGTCTGAAGAAGTTCGAAGTCGCTGCAGCCTAAAACATAGAAAGTCACTTCTTCTTACTGATATTTCAAT GGAAAATGTTCCTATGGATACATATCCCATTCATCATGGTGACCCTTCCTATAGGACACTAAAGGAGACTCAGCCATGGTCCTCTCCCAA AGGTTCTGAAGGATACCTTGCAGCCACCTATCCAACTGTCGGCCAGACCAGTCCCCGAGCCAGGAAATCCATGAGCCTGGACATGGGGCA ACCTTCTCAGGCCAACACTAAGAAGTTGCTTGGAACAAGGAAAAGTTTTGATCACTTGATATCAGACACAAAGGCTCCTAAAAGGCAAGA AATGGAATCAGGGATCACAACACCCCCCAAAATGAGGAGAGTAGCAGAAACTGATTATGAAATGGAAACTCAGAGGATTTCCTCATCACA ACAGCACCCACATTTACGTAAAGTTTCAGTGTCTGAATCAAATGTTCTCTTGGATGAAGAAGTACTTACTGATCCGAAGATCCAGGCGCT GCTTCTTACTGTTCTAGCTACACTGGTAAAATATACCACAGATGAGTTTGATCAACGAATTCTTTATGAATACTTAGCAGAGGCCAGTGT TGTGTTTCCCAAAGTCTTTCCTGTTGTGCATAATTTGTTGGACTCTAAGATCAACACCCTGTTATCATTGTGCCAAGATCCAAATTTGTT AAATCCAATCCATGGAATTGTGCAGAGTGTGGTGTACCATGAAGAATCCCCACCACAATACCAAACATCTTACCTGCAAAGTTTTGGTTT TAATGGCTTGTGGCGGTTTGCAGGACCGTTTTCAAAGCAAACACAAATTCCAGACTATGCTGAGCTTATTGTTAAGTTTCTTGATGCCTT GATTGACACGTACCTGCCTGGAATTGATGAAGAAACCAGTGAAGAATCCCTCCTGACTCCCACATCTCCTTACCCTCCTGCACTGCAGAG CCAGCTTAGTATCACTGCCAACCTTAACCTTTCTAATTCCATGACCTCACTTGCAACTTCCCAGCATTCCCCAGGAATCGACAAGGAGAA CGTTGAACTCTCCCCTACCACTGGCCACTGTAACAGTGGACGAACTCGCCACGGATCCGCAAGCCAAGTGCAGAAGCAAAGAAGCGCTGG CAGTTTCAAACGTAATAGCATTAAGAAGATCGTGTGAAGCTTGCTTGCTTTCTTTTTTAAAATCAACTTAACATGGGCTCTTCACTAGTG ACCCCTTCCCTGTCCTTGCCCTTTCCCCCCATGTTGTAATGCTGCACTTCCTGTTTTATAATGAACCCATCCGGTTTGCCATGTTGCCAG ATGATCAACTCTTCGAAGCCTTGCCTAAATTTAATGCTGCCTTTTCTTTAACTTTTTTTCTTCTACTTTTGGCGTGTATCTGGTATATGT AAGTGTTCAGAACAACTGCAAAGAAAGTGGGAGGTCAGGAAACTTTTAACTGAGAAATCTCAATTGTAAGAGAGGATGAATTCTTGAATA CTGCTACTACTGGCCAGTGATGAAAGCCATTTGCACAGAGCTCTGCCTTCTGTGGTTTTCCCTTCTTCATCCTACAGAGTAAAGTGTTAG TCCTATTTATACATTTTTCAAGATACAAGTTTATGAGAGAAATAGTATTATAACCCCAGTATGTTTAATCTTTTAGCTGTGGACTTTTTT TTTAACCGTACAAAACTGAAAGAACCATAGAGGTCAAGCCTCAGTGACTTGACACCATAAAGCCACAGACAAGGTACTTGGGGGGGAGGG CAGGGAAATTTCATATTTTATAGTGGATTCTTAAGAAATACTAACACTTGAGTATTAGCAATAATTACAGGAAAATAAGTGCGACCACAT ATATCTTAACATTACTGAATTAAAACTATGGCTTCTAAGTCCTTATCCAAACTCAGTCATCCAAACTAGTTTATTTTTTTCTCCAGTTGA TTATCTTTTAATTTTTAATTTTGCTAAAGGTGGTTTTTTTGTGTTTTGTTTTTTGTAAACCAAAACTATACTAAGTATAGTAATTATATA TATATATATATTTTTTCCCCTCCCCCTCTTCTTTCCTAACTAATTCTGAGCAGGGTAATCAGTGAACAAAGTGTTGAAAATTGTTCCCAG AAGGTAATTTTCATAGATGTTTGCATTAGCTCCATAGCAAAATGGAATGGTACGTGACATTTAGGGTAGCTGATATTTTTATTTTGTTAA ATAATTTCCAAGAATAGAGTATGGTGTATATTATAAATTTCTTTGATAAGATGTATTTTGAATGTCTTTTAATCTTCCTCCTCCTCTCCA AAAAAATCAGAAACCTCTTTAAGAAAACATGTAGGTTATATATGCTAGAATTGCATTTAATCACTGTGAAAAGACTGGTCAGCCTGCATT AGTATGACAGTAGGGGGGCTGTTAGAATTGCTGCTATACTGGTGGTATGGATTATCATGGCATTGGAATTTTCATAGTAATGCAGATCCA ATTTCTTTGTGGTACCTGCAGTTTACAAAATAATTTGACTTCAGTGAGCATATTGGTATCTGGATGTTCCAATTTAGAACTAAACCATAT TTATTACAAAAAGATATTAATCCCTCTACTCCCAGGTTCCCTTTATATGTTAAGATATAATGGCTTTGAGGGGGGAAAAAATAAACCTAG GGGAGAGGGGAGTTTCCTGTAGTGCTGTTTCATTAGAGGATTTCAGTAAATTAAATTCCACAGCTAATTCAATAAATAATGGTACATTTA AGTGTTCTGATTTTAATAATATATTTCACATTTATCCACACAGTAACAATGTAATATGTTAATGTAAATAAAATTGGTTTTGATACTCAG AAATAACAAGAATTTAATTTTTTAAATTTGTTTACAGTCCTGGGAAAAGTAAGAATTATTTGCCAAAATAAGAGGAAAGAAAACCTTAGT ATTATTAATGAGTTTACCATAGAATTGTTGGAAATACTGAAGACAGGTGCAATTTACTAAACTTTTGTTTTTAAACTATTGTAGAGGCTG CATTAGAAGAAAATGTTTATAATGACAGAGCAACTATGACTATATAAAAAAGCTGAAATTAGAACTGTGTTTAGAAATAGATCAGTAACC CAGTGCCAAGGATGCCAAGCTGCCACCATGGTCTTGGCTCTCCCACAACCCAGTGTTTCTGGGGTAAGTTTCACAGTTTCTAGGCCCTGG AATAGCAGGCAGTGTAAGCCTTTGATAACTTTAGTTCGATGTTTTTCTTGTTTTTGTTTGTTGGTTTGGTGCATATGATAGTGGGTGTTA TGCTATTTTGCTCTTCCCATCAAAATAAAGAAACTTCCAGAGGTTTACTGTTAAAAATACTGATATTTCCATAAACGGGTTTACCAAGGG TGTAGTATTTCATACCGCCTGAAATGATCAGCATTGGCACAAATCAAAATTCAGCCGCCTTTGAAATGCAAAAATACCTTTGACTAGTAA GTACATCCTAGGAGTTTGAAAACTTAACTAAGGTTTAAAATTTACCTTGTTTAAAGAACTTCTGACTTTTGAGGAAAATCTAGCTTTCCA AGTAACTAAAATGTACATGAGATAAACCTCTCACCACTATGTGTCCCTTGAGAAATGCAACACTTTTTTAGTCTTCATACTTGTAATCTA TAAAAGAAATTCTGAAGTTTAGACCAAGTTGCCCATTTCTGCGTAATTGACATAAGTTCTGTTAAAAATATTATAAGTAATTCGTTTCGG TTTGTAGATGTTTCCCCTGACTTGTTAAAGAGGAAACCAGGAACTCAGTCATGTTTTTGTCCTGGATAATCTACCTGTTATGCCAGTACT CCCATCCGAGGGGCATGCCCTTAGTTGCCCAGATGGAGATGCAGTTCAGTAGATTTGGGGCAAAGTGGCTACAGCTCTGTCTTCCATTCA CTCAACACCTGTTCATGACTGAGCCAGGTGCCCAGGACACATCCTAAACAGTCAGCTTCTATCCTGTGTCCTAGTTGGGGAGACAGAGTG CCAGCCAGCAACCCTCCCAGGTTTGTAGGTTTTAGGGGTTTTCAGTTTTGTTTGGGTTTTTTGTTTTTTGTTTTTGTTTCTACATCCTTC CCCGACTCCCAGGCATAATGAGGCATGTCTTACTCAATGTTATGCAATGGATTTAGGCAAAAATTCATTCTTAGTGTCAGCCACACAATT TTTTTTAATGCAGTATATTCACCTGTAAATAGTTTGTGTAAAATTTGACAAAAAAAGTATATTTACTATACTGTAAATATATGTGATGAT ATATTGTATTATTTTGCTTTTTTGTAAAGCAGTTAGTTGCTGCACATGGATAACAACAAAAATTTGATTATTCTCGTGTTAGTATTGTTA ACTTCTTTTTGCGACTGCGTTACATCATTTAAAGAAAATGCTGTGTATTGTAAACTTAAATTGTATATGATAACTTACTGTCCTTTCCAT CCGGGCCTAAACTTTGGCAGTTCCTTTGTCTACAACCTTGTTAATACTGTAAACAGTTGTACGCCAGCAGGAAAAATACTGCCCAACAGA CAAAATCGATCATTGTAGGGGAAAATCATAGAAATCCATTTCAGATCTTTATTGTTCCTCACCCCATTTTCCTCCTTGTGTATGTACTTC >In-frame_CPD_ENST00000543464_chr17_28766095_+_NF1_ENST00000356175_chr17_29676138_+_6744nt AGTGTGGCTGGGACTTAGAATTAGGCAATCTGATTCCCGATAGTCCTCTTAGCCACGGAGGGACACTGGAGCCCAAAAATGGCAGATGAT ATTCCCAGGATCTTCCCCTTGCCTATTTGACAGAAGCTGATTTTTCTCCAATTTTTACCTCTGACTCAGCTTAAGAAGATATGGACTTAG CTGGAGAACTTGCACAGATCTGTGAGCCGCTTCATTTTAGACTCTGAAGGGTTTGTGATGTCATTTGTGCACCTTATTAGCCTGGGCAGA ATGGCTAATGGTCACACTTCTAATACACACTTTAAGTGTTATTAAGCATTGCATGAGGTTTAAAAAATTACAAAGTAGAAGAAGGAGGAC CTCAAGAAATTAGTATAAAACAAGAGAATGTTATAAATATTTATGAGGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCA AGCTATCCTTTTGATGATTCTCCAGAACATAAGGCCACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAA GCTTATGCTTCAAACCACCCCATAATGAAAACTGGTGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAAC GGCGCACATTGGTATGATGTGGAAGGTGGTATGCAAGATTACAATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGT TGCAAGTACCCACCTGCTTCACAGCTTCGACAGGAATGGGAGAACAATCGTGAGTCTTTGATCACATTGATTGAAAAGGTTCACATTGGA GTGAAAGGATTTGTTAAAGATTCCATAACAGGATCTGGGTTAGAGAATGCAACCATCTCAGTGGCTGGTATTAATCATAATATCACAACA GGCAGATTTGGTGATTTCTACCGATTACTTGTTCCTGGAACTTACAACCTTACAGTAGTTTTAACTGGGTATATGCCATTGACTGTTACT AATGTAGTGGTGAAAGAAGGACCAGCCACAGAGGTGGATTTTTCTCTTAGGCCAACTGTAACTTCAGTAATCCCTGACACGACAGAGGCT GTATCAACTGCTAGCACAGTTGCTATACCTAATATTCTTTCTGGAACATCATCCTCCTACCAGCCAATTCAGCCAAAGGACTTTCACCAC CACCATTTCCCTGATATGGAAATCTTCTTGAGAAGGTTTGCCAATGAATATCCTAACATTACCCGGCTTTATTCCTTGGGAAAATCAGTA GAGTCAAGAGAACTTTATGTGATGGAGATATCTGATAATCCGGGTGTCCATGAACCAGGTGAACCAGAATTTAAGTACATTGGAAATATG CATGGAAATGAAGTGGTTGGAAGAGAACTGCTGTTGAACCTCATAGAATACCTTTGTAAGAACTTTGGAACAGACCCTGAAGTCACAGAT TTGGTTCATAACACTAGAATTCACCTTATGCCATCCATGAATCCTGATGGGTATGAAAAGTCCCAGGAAGGAGATTCAATAAGTGTAATT GGCAGAAACAACAGCAACAACTTTGACCTGAACCGAAATTTCCCAGACCAGTTTGTTCAGATCACAGATCCTACGCAACCAGAAACTATT GCTGTAATGAGCTGGATGAAGTCCTATCCATTTGTACTTTCAGCAAACCTGCATGGAGGTTCTTTGGTGGTTAACTACCCTTTTGATGAT GATGAACAAGGACTTGCCACATATAGTAAATCACCAGATGATGCTGTGTTCCAACAAATAGCACTTTCTTATTCCAAGGAAAATTCCCAG ATGTTTCAAGGTAGACCTTGCAAGAATATGTATCCTAATGAATATTTTCCTCATGGAATAACAAATGGAGCTAGTTGGTATAATGTGCCA GGGTACAGGCATCCTTCACCTGCTATTGTTGCAAGAACAGTCAGAATTTTACATACACTACTAACTCTGGTTAACAAACACAGAAATTGT GACAAATTTGAAGTGAATACACAGAGCGTGGCCTACTTAGCAGCTTTACTTACAGTGTCTGAAGAAGTTCGAAGTCGCTGCAGCCTAAAA CATAGAAAGTCACTTCTTCTTACTGATATTTCAATGGAAAATGTTCCTATGGATACATATCCCATTCATCATGGTGACCCTTCCTATAGG ACACTAAAGGAGACTCAGCCATGGTCCTCTCCCAAAGGTTCTGAAGGATACCTTGCAGCCACCTATCCAACTGTCGGCCAGACCAGTCCC CGAGCCAGGAAATCCATGAGCCTGGACATGGGGCAACCTTCTCAGGCCAACACTAAGAAGTTGCTTGGAACAAGGAAAAGTTTTGATCAC TTGATATCAGACACAAAGGCTCCTAAAAGGCAAGAAATGGAATCAGGGATCACAACACCCCCCAAAATGAGGAGAGTAGCAGAAACTGAT TATGAAATGGAAACTCAGAGGATTTCCTCATCACAACAGCACCCACATTTACGTAAAGTTTCAGTGTCTGAATCAAATGTTCTCTTGGAT GAAGAAGTACTTACTGATCCGAAGATCCAGGCGCTGCTTCTTACTGTTCTAGCTACACTGGTAAAATATACCACAGATGAGTTTGATCAA CGAATTCTTTATGAATACTTAGCAGAGGCCAGTGTTGTGTTTCCCAAAGTCTTTCCTGTTGTGCATAATTTGTTGGACTCTAAGATCAAC ACCCTGTTATCATTGTGCCAAGATCCAAATTTGTTAAATCCAATCCATGGAATTGTGCAGAGTGTGGTGTACCATGAAGAATCCCCACCA CAATACCAAACATCTTACCTGCAAAGTTTTGGTTTTAATGGCTTGTGGCGGTTTGCAGGACCGTTTTCAAAGCAAACACAAATTCCAGAC TATGCTGAGCTTATTGTTAAGTTTCTTGATGCCTTGATTGACACGTACCTGCCTGGAATTGATGAAGAAACCAGTGAAGAATCCCTCCTG ACTCCCACATCTCCTTACCCTCCTGCACTGCAGAGCCAGCTTAGTATCACTGCCAACCTTAACCTTTCTAATTCCATGACCTCACTTGCA ACTTCCCAGCATTCCCCAGGAATCGACAAGGAGAACGTTGAACTCTCCCCTACCACTGGCCACTGTAACAGTGGACGAACTCGCCACGGA TCCGCAAGCCAAGTGCAGAAGCAAAGAAGCGCTGGCAGTTTCAAACGTAATAGCATTAAGAAGATCGTGTGAAGCTTGCTTGCTTTCTTT TTTAAAATCAACTTAACATGGGCTCTTCACTAGTGACCCCTTCCCTGTCCTTGCCCTTTCCCCCCATGTTGTAATGCTGCACTTCCTGTT TTATAATGAACCCATCCGGTTTGCCATGTTGCCAGATGATCAACTCTTCGAAGCCTTGCCTAAATTTAATGCTGCCTTTTCTTTAACTTT TTTTCTTCTACTTTTGGCGTGTATCTGGTATATGTAAGTGTTCAGAACAACTGCAAAGAAAGTGGGAGGTCAGGAAACTTTTAACTGAGA AATCTCAATTGTAAGAGAGGATGAATTCTTGAATACTGCTACTACTGGCCAGTGATGAAAGCCATTTGCACAGAGCTCTGCCTTCTGTGG TTTTCCCTTCTTCATCCTACAGAGTAAAGTGTTAGTCCTATTTATACATTTTTCAAGATACAAGTTTATGAGAGAAATAGTATTATAACC CCAGTATGTTTAATCTTTTAGCTGTGGACTTTTTTTTTAACCGTACAAAACTGAAAGAACCATAGAGGTCAAGCCTCAGTGACTTGACAC CATAAAGCCACAGACAAGGTACTTGGGGGGGAGGGCAGGGAAATTTCATATTTTATAGTGGATTCTTAAGAAATACTAACACTTGAGTAT TAGCAATAATTACAGGAAAATAAGTGCGACCACATATATCTTAACATTACTGAATTAAAACTATGGCTTCTAAGTCCTTATCCAAACTCA GTCATCCAAACTAGTTTATTTTTTTCTCCAGTTGATTATCTTTTAATTTTTAATTTTGCTAAAGGTGGTTTTTTTGTGTTTTGTTTTTTG TAAACCAAAACTATACTAAGTATAGTAATTATATATATATATATATTTTTTCCCCTCCCCCTCTTCTTTCCTAACTAATTCTGAGCAGGG TAATCAGTGAACAAAGTGTTGAAAATTGTTCCCAGAAGGTAATTTTCATAGATGTTTGCATTAGCTCCATAGCAAAATGGAATGGTACGT GACATTTAGGGTAGCTGATATTTTTATTTTGTTAAATAATTTCCAAGAATAGAGTATGGTGTATATTATAAATTTCTTTGATAAGATGTA TTTTGAATGTCTTTTAATCTTCCTCCTCCTCTCCAAAAAAATCAGAAACCTCTTTAAGAAAACATGTAGGTTATATATGCTAGAATTGCA TTTAATCACTGTGAAAAGACTGGTCAGCCTGCATTAGTATGACAGTAGGGGGGCTGTTAGAATTGCTGCTATACTGGTGGTATGGATTAT CATGGCATTGGAATTTTCATAGTAATGCAGATCCAATTTCTTTGTGGTACCTGCAGTTTACAAAATAATTTGACTTCAGTGAGCATATTG GTATCTGGATGTTCCAATTTAGAACTAAACCATATTTATTACAAAAAGATATTAATCCCTCTACTCCCAGGTTCCCTTTATATGTTAAGA TATAATGGCTTTGAGGGGGGAAAAAATAAACCTAGGGGAGAGGGGAGTTTCCTGTAGTGCTGTTTCATTAGAGGATTTCAGTAAATTAAA TTCCACAGCTAATTCAATAAATAATGGTACATTTAAGTGTTCTGATTTTAATAATATATTTCACATTTATCCACACAGTAACAATGTAAT ATGTTAATGTAAATAAAATTGGTTTTGATACTCAGAAATAACAAGAATTTAATTTTTTAAATTTGTTTACAGTCCTGGGAAAAGTAAGAA TTATTTGCCAAAATAAGAGGAAAGAAAACCTTAGTATTATTAATGAGTTTACCATAGAATTGTTGGAAATACTGAAGACAGGTGCAATTT ACTAAACTTTTGTTTTTAAACTATTGTAGAGGCTGCATTAGAAGAAAATGTTTATAATGACAGAGCAACTATGACTATATAAAAAAGCTG AAATTAGAACTGTGTTTAGAAATAGATCAGTAACCCAGTGCCAAGGATGCCAAGCTGCCACCATGGTCTTGGCTCTCCCACAACCCAGTG TTTCTGGGGTAAGTTTCACAGTTTCTAGGCCCTGGAATAGCAGGCAGTGTAAGCCTTTGATAACTTTAGTTCGATGTTTTTCTTGTTTTT GTTTGTTGGTTTGGTGCATATGATAGTGGGTGTTATGCTATTTTGCTCTTCCCATCAAAATAAAGAAACTTCCAGAGGTTTACTGTTAAA AATACTGATATTTCCATAAACGGGTTTACCAAGGGTGTAGTATTTCATACCGCCTGAAATGATCAGCATTGGCACAAATCAAAATTCAGC CGCCTTTGAAATGCAAAAATACCTTTGACTAGTAAGTACATCCTAGGAGTTTGAAAACTTAACTAAGGTTTAAAATTTACCTTGTTTAAA GAACTTCTGACTTTTGAGGAAAATCTAGCTTTCCAAGTAACTAAAATGTACATGAGATAAACCTCTCACCACTATGTGTCCCTTGAGAAA TGCAACACTTTTTTAGTCTTCATACTTGTAATCTATAAAAGAAATTCTGAAGTTTAGACCAAGTTGCCCATTTCTGCGTAATTGACATAA GTTCTGTTAAAAATATTATAAGTAATTCGTTTCGGTTTGTAGATGTTTCCCCTGACTTGTTAAAGAGGAAACCAGGAACTCAGTCATGTT TTTGTCCTGGATAATCTACCTGTTATGCCAGTACTCCCATCCGAGGGGCATGCCCTTAGTTGCCCAGATGGAGATGCAGTTCAGTAGATT TGGGGCAAAGTGGCTACAGCTCTGTCTTCCATTCACTCAACACCTGTTCATGACTGAGCCAGGTGCCCAGGACACATCCTAAACAGTCAG CTTCTATCCTGTGTCCTAGTTGGGGAGACAGAGTGCCAGCCAGCAACCCTCCCAGGTTTGTAGGTTTTAGGGGTTTTCAGTTTTGTTTGG GTTTTTTGTTTTTTGTTTTTGTTTCTACATCCTTCCCCGACTCCCAGGCATAATGAGGCATGTCTTACTCAATGTTATGCAATGGATTTA GGCAAAAATTCATTCTTAGTGTCAGCCACACAATTTTTTTTAATGCAGTATATTCACCTGTAAATAGTTTGTGTAAAATTTGACAAAAAA AGTATATTTACTATACTGTAAATATATGTGATGATATATTGTATTATTTTGCTTTTTTGTAAAGCAGTTAGTTGCTGCACATGGATAACA ACAAAAATTTGATTATTCTCGTGTTAGTATTGTTAACTTCTTTTTGCGACTGCGTTACATCATTTAAAGAAAATGCTGTGTATTGTAAAC TTAAATTGTATATGATAACTTACTGTCCTTTCCATCCGGGCCTAAACTTTGGCAGTTCCTTTGTCTACAACCTTGTTAATACTGTAAACA GTTGTACGCCAGCAGGAAAAATACTGCCCAACAGACAAAATCGATCATTGTAGGGGAAAATCATAGAAATCCATTTCAGATCTTTATTGT >In-frame_CPD_ENST00000543464_chr17_28766095_+_NF1_ENST00000358273_chr17_29676138_+_6744nt AGTGTGGCTGGGACTTAGAATTAGGCAATCTGATTCCCGATAGTCCTCTTAGCCACGGAGGGACACTGGAGCCCAAAAATGGCAGATGAT ATTCCCAGGATCTTCCCCTTGCCTATTTGACAGAAGCTGATTTTTCTCCAATTTTTACCTCTGACTCAGCTTAAGAAGATATGGACTTAG CTGGAGAACTTGCACAGATCTGTGAGCCGCTTCATTTTAGACTCTGAAGGGTTTGTGATGTCATTTGTGCACCTTATTAGCCTGGGCAGA ATGGCTAATGGTCACACTTCTAATACACACTTTAAGTGTTATTAAGCATTGCATGAGGTTTAAAAAATTACAAAGTAGAAGAAGGAGGAC CTCAAGAAATTAGTATAAAACAAGAGAATGTTATAAATATTTATGAGGTTTGTGCTTTCTGGAAATCTGCATGGTGGCTCAGTGGTAGCA AGCTATCCTTTTGATGATTCTCCAGAACATAAGGCCACTGGAATCTATAGCAAAACCTCAGATGATGAAGTATTTAAATACTTGGCAAAA GCTTATGCTTCAAACCACCCCATAATGAAAACTGGTGAGCCTCATTGTCCAGGAGATGAAGACGAGACTTTCAAAGATGGAATCACAAAC GGCGCACATTGGTATGATGTGGAAGGTGGTATGCAAGATTACAATTATGTGTGGGCCAACTGTTTTGAGATCACATTAGAACTGTCTTGT TGCAAGTACCCACCTGCTTCACAGCTTCGACAGGAATGGGAGAACAATCGTGAGTCTTTGATCACATTGATTGAAAAGGTTCACATTGGA GTGAAAGGATTTGTTAAAGATTCCATAACAGGATCTGGGTTAGAGAATGCAACCATCTCAGTGGCTGGTATTAATCATAATATCACAACA GGCAGATTTGGTGATTTCTACCGATTACTTGTTCCTGGAACTTACAACCTTACAGTAGTTTTAACTGGGTATATGCCATTGACTGTTACT AATGTAGTGGTGAAAGAAGGACCAGCCACAGAGGTGGATTTTTCTCTTAGGCCAACTGTAACTTCAGTAATCCCTGACACGACAGAGGCT GTATCAACTGCTAGCACAGTTGCTATACCTAATATTCTTTCTGGAACATCATCCTCCTACCAGCCAATTCAGCCAAAGGACTTTCACCAC CACCATTTCCCTGATATGGAAATCTTCTTGAGAAGGTTTGCCAATGAATATCCTAACATTACCCGGCTTTATTCCTTGGGAAAATCAGTA GAGTCAAGAGAACTTTATGTGATGGAGATATCTGATAATCCGGGTGTCCATGAACCAGGTGAACCAGAATTTAAGTACATTGGAAATATG CATGGAAATGAAGTGGTTGGAAGAGAACTGCTGTTGAACCTCATAGAATACCTTTGTAAGAACTTTGGAACAGACCCTGAAGTCACAGAT TTGGTTCATAACACTAGAATTCACCTTATGCCATCCATGAATCCTGATGGGTATGAAAAGTCCCAGGAAGGAGATTCAATAAGTGTAATT GGCAGAAACAACAGCAACAACTTTGACCTGAACCGAAATTTCCCAGACCAGTTTGTTCAGATCACAGATCCTACGCAACCAGAAACTATT GCTGTAATGAGCTGGATGAAGTCCTATCCATTTGTACTTTCAGCAAACCTGCATGGAGGTTCTTTGGTGGTTAACTACCCTTTTGATGAT GATGAACAAGGACTTGCCACATATAGTAAATCACCAGATGATGCTGTGTTCCAACAAATAGCACTTTCTTATTCCAAGGAAAATTCCCAG ATGTTTCAAGGTAGACCTTGCAAGAATATGTATCCTAATGAATATTTTCCTCATGGAATAACAAATGGAGCTAGTTGGTATAATGTGCCA GGGTACAGGCATCCTTCACCTGCTATTGTTGCAAGAACAGTCAGAATTTTACATACACTACTAACTCTGGTTAACAAACACAGAAATTGT GACAAATTTGAAGTGAATACACAGAGCGTGGCCTACTTAGCAGCTTTACTTACAGTGTCTGAAGAAGTTCGAAGTCGCTGCAGCCTAAAA CATAGAAAGTCACTTCTTCTTACTGATATTTCAATGGAAAATGTTCCTATGGATACATATCCCATTCATCATGGTGACCCTTCCTATAGG ACACTAAAGGAGACTCAGCCATGGTCCTCTCCCAAAGGTTCTGAAGGATACCTTGCAGCCACCTATCCAACTGTCGGCCAGACCAGTCCC CGAGCCAGGAAATCCATGAGCCTGGACATGGGGCAACCTTCTCAGGCCAACACTAAGAAGTTGCTTGGAACAAGGAAAAGTTTTGATCAC TTGATATCAGACACAAAGGCTCCTAAAAGGCAAGAAATGGAATCAGGGATCACAACACCCCCCAAAATGAGGAGAGTAGCAGAAACTGAT TATGAAATGGAAACTCAGAGGATTTCCTCATCACAACAGCACCCACATTTACGTAAAGTTTCAGTGTCTGAATCAAATGTTCTCTTGGAT GAAGAAGTACTTACTGATCCGAAGATCCAGGCGCTGCTTCTTACTGTTCTAGCTACACTGGTAAAATATACCACAGATGAGTTTGATCAA CGAATTCTTTATGAATACTTAGCAGAGGCCAGTGTTGTGTTTCCCAAAGTCTTTCCTGTTGTGCATAATTTGTTGGACTCTAAGATCAAC ACCCTGTTATCATTGTGCCAAGATCCAAATTTGTTAAATCCAATCCATGGAATTGTGCAGAGTGTGGTGTACCATGAAGAATCCCCACCA CAATACCAAACATCTTACCTGCAAAGTTTTGGTTTTAATGGCTTGTGGCGGTTTGCAGGACCGTTTTCAAAGCAAACACAAATTCCAGAC TATGCTGAGCTTATTGTTAAGTTTCTTGATGCCTTGATTGACACGTACCTGCCTGGAATTGATGAAGAAACCAGTGAAGAATCCCTCCTG ACTCCCACATCTCCTTACCCTCCTGCACTGCAGAGCCAGCTTAGTATCACTGCCAACCTTAACCTTTCTAATTCCATGACCTCACTTGCA ACTTCCCAGCATTCCCCAGGAATCGACAAGGAGAACGTTGAACTCTCCCCTACCACTGGCCACTGTAACAGTGGACGAACTCGCCACGGA TCCGCAAGCCAAGTGCAGAAGCAAAGAAGCGCTGGCAGTTTCAAACGTAATAGCATTAAGAAGATCGTGTGAAGCTTGCTTGCTTTCTTT TTTAAAATCAACTTAACATGGGCTCTTCACTAGTGACCCCTTCCCTGTCCTTGCCCTTTCCCCCCATGTTGTAATGCTGCACTTCCTGTT TTATAATGAACCCATCCGGTTTGCCATGTTGCCAGATGATCAACTCTTCGAAGCCTTGCCTAAATTTAATGCTGCCTTTTCTTTAACTTT TTTTCTTCTACTTTTGGCGTGTATCTGGTATATGTAAGTGTTCAGAACAACTGCAAAGAAAGTGGGAGGTCAGGAAACTTTTAACTGAGA AATCTCAATTGTAAGAGAGGATGAATTCTTGAATACTGCTACTACTGGCCAGTGATGAAAGCCATTTGCACAGAGCTCTGCCTTCTGTGG TTTTCCCTTCTTCATCCTACAGAGTAAAGTGTTAGTCCTATTTATACATTTTTCAAGATACAAGTTTATGAGAGAAATAGTATTATAACC CCAGTATGTTTAATCTTTTAGCTGTGGACTTTTTTTTTAACCGTACAAAACTGAAAGAACCATAGAGGTCAAGCCTCAGTGACTTGACAC CATAAAGCCACAGACAAGGTACTTGGGGGGGAGGGCAGGGAAATTTCATATTTTATAGTGGATTCTTAAGAAATACTAACACTTGAGTAT TAGCAATAATTACAGGAAAATAAGTGCGACCACATATATCTTAACATTACTGAATTAAAACTATGGCTTCTAAGTCCTTATCCAAACTCA GTCATCCAAACTAGTTTATTTTTTTCTCCAGTTGATTATCTTTTAATTTTTAATTTTGCTAAAGGTGGTTTTTTTGTGTTTTGTTTTTTG TAAACCAAAACTATACTAAGTATAGTAATTATATATATATATATATTTTTTCCCCTCCCCCTCTTCTTTCCTAACTAATTCTGAGCAGGG TAATCAGTGAACAAAGTGTTGAAAATTGTTCCCAGAAGGTAATTTTCATAGATGTTTGCATTAGCTCCATAGCAAAATGGAATGGTACGT GACATTTAGGGTAGCTGATATTTTTATTTTGTTAAATAATTTCCAAGAATAGAGTATGGTGTATATTATAAATTTCTTTGATAAGATGTA TTTTGAATGTCTTTTAATCTTCCTCCTCCTCTCCAAAAAAATCAGAAACCTCTTTAAGAAAACATGTAGGTTATATATGCTAGAATTGCA TTTAATCACTGTGAAAAGACTGGTCAGCCTGCATTAGTATGACAGTAGGGGGGCTGTTAGAATTGCTGCTATACTGGTGGTATGGATTAT CATGGCATTGGAATTTTCATAGTAATGCAGATCCAATTTCTTTGTGGTACCTGCAGTTTACAAAATAATTTGACTTCAGTGAGCATATTG GTATCTGGATGTTCCAATTTAGAACTAAACCATATTTATTACAAAAAGATATTAATCCCTCTACTCCCAGGTTCCCTTTATATGTTAAGA TATAATGGCTTTGAGGGGGGAAAAAATAAACCTAGGGGAGAGGGGAGTTTCCTGTAGTGCTGTTTCATTAGAGGATTTCAGTAAATTAAA TTCCACAGCTAATTCAATAAATAATGGTACATTTAAGTGTTCTGATTTTAATAATATATTTCACATTTATCCACACAGTAACAATGTAAT ATGTTAATGTAAATAAAATTGGTTTTGATACTCAGAAATAACAAGAATTTAATTTTTTAAATTTGTTTACAGTCCTGGGAAAAGTAAGAA TTATTTGCCAAAATAAGAGGAAAGAAAACCTTAGTATTATTAATGAGTTTACCATAGAATTGTTGGAAATACTGAAGACAGGTGCAATTT ACTAAACTTTTGTTTTTAAACTATTGTAGAGGCTGCATTAGAAGAAAATGTTTATAATGACAGAGCAACTATGACTATATAAAAAAGCTG AAATTAGAACTGTGTTTAGAAATAGATCAGTAACCCAGTGCCAAGGATGCCAAGCTGCCACCATGGTCTTGGCTCTCCCACAACCCAGTG TTTCTGGGGTAAGTTTCACAGTTTCTAGGCCCTGGAATAGCAGGCAGTGTAAGCCTTTGATAACTTTAGTTCGATGTTTTTCTTGTTTTT GTTTGTTGGTTTGGTGCATATGATAGTGGGTGTTATGCTATTTTGCTCTTCCCATCAAAATAAAGAAACTTCCAGAGGTTTACTGTTAAA AATACTGATATTTCCATAAACGGGTTTACCAAGGGTGTAGTATTTCATACCGCCTGAAATGATCAGCATTGGCACAAATCAAAATTCAGC CGCCTTTGAAATGCAAAAATACCTTTGACTAGTAAGTACATCCTAGGAGTTTGAAAACTTAACTAAGGTTTAAAATTTACCTTGTTTAAA GAACTTCTGACTTTTGAGGAAAATCTAGCTTTCCAAGTAACTAAAATGTACATGAGATAAACCTCTCACCACTATGTGTCCCTTGAGAAA TGCAACACTTTTTTAGTCTTCATACTTGTAATCTATAAAAGAAATTCTGAAGTTTAGACCAAGTTGCCCATTTCTGCGTAATTGACATAA GTTCTGTTAAAAATATTATAAGTAATTCGTTTCGGTTTGTAGATGTTTCCCCTGACTTGTTAAAGAGGAAACCAGGAACTCAGTCATGTT TTTGTCCTGGATAATCTACCTGTTATGCCAGTACTCCCATCCGAGGGGCATGCCCTTAGTTGCCCAGATGGAGATGCAGTTCAGTAGATT TGGGGCAAAGTGGCTACAGCTCTGTCTTCCATTCACTCAACACCTGTTCATGACTGAGCCAGGTGCCCAGGACACATCCTAAACAGTCAG CTTCTATCCTGTGTCCTAGTTGGGGAGACAGAGTGCCAGCCAGCAACCCTCCCAGGTTTGTAGGTTTTAGGGGTTTTCAGTTTTGTTTGG GTTTTTTGTTTTTTGTTTTTGTTTCTACATCCTTCCCCGACTCCCAGGCATAATGAGGCATGTCTTACTCAATGTTATGCAATGGATTTA GGCAAAAATTCATTCTTAGTGTCAGCCACACAATTTTTTTTAATGCAGTATATTCACCTGTAAATAGTTTGTGTAAAATTTGACAAAAAA AGTATATTTACTATACTGTAAATATATGTGATGATATATTGTATTATTTTGCTTTTTTGTAAAGCAGTTAGTTGCTGCACATGGATAACA ACAAAAATTTGATTATTCTCGTGTTAGTATTGTTAACTTCTTTTTGCGACTGCGTTACATCATTTAAAGAAAATGCTGTGTATTGTAAAC TTAAATTGTATATGATAACTTACTGTCCTTTCCATCCGGGCCTAAACTTTGGCAGTTCCTTTGTCTACAACCTTGTTAATACTGTAAACA GTTGTACGCCAGCAGGAAAAATACTGCCCAACAGACAAAATCGATCATTGTAGGGGAAAATCATAGAAATCCATTTCAGATCTTTATTGT |
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FusionGenePPI for CPD_NF1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CPD | ELAVL1, TCF3, KIAA0368, RAD18, UBL4A, ATP4A, AATF, FBXO6, ASB17, LGR4, CD1B, TNF, NTRK1, TMEM17, TMEM216, PPM1H, DEFA1, UFSP2, FOXK2, AP1M1 | NF1 | HRAS, SMARCA4, POLR2A, TIRAP, SIRT7, VCP, NSFL1C, CAV1, YWHAB, FAF2, NXF1, CCDC8, HLA-DPA1, EFNB2, CD274, TNFSF13B, CA14, SLAMF1, VSIG4, TGOLN2, HTR6, NOSIP, KRAS, CLK1, CDC5L, APP, YWHAH, PML, TRAF6, PTEN, SDC2, EGFR, CD79B, P4HA3, SCN3B, VSIG1, SIGLECL1, EPHA1, FAM174A, KCTD3, KIF13B, ZBTB21, KSR1, CGN, GIGYF1, LRFN1, RTKN, MAST3, DENND1A, SH3PXD2A, SRGAP2, DENND4C, PPM1H, EIF4E2, SIPA1L1, LIMA1, RALGPS2, MAGI1, CBY1, TESK2, CDC25C, DCLK1, GIGYF2, HDAC4, LPIN3, ZNF638, CAMSAP2, NADK, MAPKAP1, SRSF12, RASAL2, SYDE1, KIAA1804, TIAM1, AGAP1, CDC25B, CDK16, SH3RF3, PHLDB2, PLEKHA7, KIF1C, OSBPL6, FAM110B, USP21, NAV1, TANC2, PTPN13, FAM53C, ANKRD34A, STARD13, PTPN14, GAB2, DENND4A, INPP5E, TOP1, TOP2A, TOP3A, NRAS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CPD_NF1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CPD_NF1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | NF1 | C0027831 | Neurofibromatosis 1 | 34 | CTD_human;ORPHANET;UNIPROT |
| Tgene | NF1 | C2931482 | Neurofibromatosis-Noonan syndrome | 5 | CTD_human;ORPHANET;UNIPROT |
| Tgene | NF1 | C0349639 | Juvenile Myelomonocytic Leukemia | 3 | CTD_human;HPO;ORPHANET |
| Tgene | NF1 | C0004114 | Astrocytoma | 2 | CTD_human;HPO |
| Tgene | NF1 | C0023467 | Leukemia, Myelocytic, Acute | 2 | CTD_human |
| Tgene | NF1 | C0025202 | melanoma | 2 | CTD_human |
| Tgene | NF1 | C0206727 | Nerve Sheath Tumors | 2 | CTD_human |
| Tgene | NF1 | C0001430 | Adenoma | 1 | CTD_human |
| Tgene | NF1 | C0004352 | Autistic Disorder | 1 | CTD_human |
| Tgene | NF1 | C0016057 | Fibrosarcoma | 1 | CTD_human |
| Tgene | NF1 | C0017636 | Glioblastoma | 1 | CTD_human |
| Tgene | NF1 | C0017638 | Glioma | 1 | CTD_human |
| Tgene | NF1 | C0023186 | Learning Disorders | 1 | CTD_human |
| Tgene | NF1 | C0023827 | liposarcoma | 1 | CTD_human |
| Tgene | NF1 | C0027809 | Neurilemmoma | 1 | CTD_human |
| Tgene | NF1 | C0027830 | neurofibroma | 1 | CTD_human |
| Tgene | NF1 | C0027962 | Melanocytic nevus | 1 | CTD_human |
| Tgene | NF1 | C0031511 | Pheochromocytoma | 1 | CTD_human |
| Tgene | NF1 | C0162678 | Neurofibromatoses | 1 | CTD_human;HPO |
| Tgene | NF1 | C1261473 | Sarcoma | 1 | CTD_human |
| Tgene | NF1 | C1834235 | NEUROFIBROMATOSIS, FAMILIAL SPINAL | 1 | CTD_human;UNIPROT |
| Tgene | NF1 | C3714756 | Intellectual Disability | 1 | CTD_human;HPO |
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