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Fusion gene ID: 8207 |
FusionGeneSummary for CPB1_NDUFV1 |
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Fusion gene information | Fusion gene name: CPB1_NDUFV1 | Fusion gene ID: 8207 | Hgene | Tgene | Gene symbol | CPB1 | NDUFV1 | Gene ID | 1360 | 4723 |
Gene name | carboxypeptidase B1 | NADH:ubiquinone oxidoreductase core subunit V1 | |
Synonyms | CPB|PASP|PCPB | CI-51K|CI51KD|UQOR1 | |
Cytomap | 3q24 | 11q13.2 | |
Type of gene | protein-coding | protein-coding | |
Description | carboxypeptidase Bcarboxypeptidase B1 (tissue)pancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase B | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrialNADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDaNADH-ubiquinone oxidoreductase 51 kDa subunitcomplex I 51 kda subunitcomplex I 51kDa subunitcomplex I, mitochondrial respiratory chainm | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P15086 | P49821 | |
Ensembl transtripts involved in fusion gene | ENST00000491148, ENST00000282957, ENST00000498639, | ENST00000322776, ENST00000532303, ENST00000529927, ENST00000415352, ENST00000526169, | |
Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 35 X 6 X 14=2940 |
# samples | 12 | 37 | |
** MAII score | log2(12/147*10)=-0.292781749227846 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(37/2940*10)=-2.99021897920741 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CPB1 [Title/Abstract] AND NDUFV1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-AO-A0JI-01A | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000491148 | ENST00000322776 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000491148 | ENST00000532303 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000491148 | ENST00000529927 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000491148 | ENST00000415352 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000491148 | ENST00000526169 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000282957 | ENST00000322776 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000282957 | ENST00000532303 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000282957 | ENST00000529927 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000282957 | ENST00000415352 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000282957 | ENST00000526169 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000498639 | ENST00000322776 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000498639 | ENST00000532303 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000498639 | ENST00000529927 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000498639 | ENST00000415352 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
5CDS-intron | ENST00000498639 | ENST00000526169 | CPB1 | chr3 | 148577970 | + | NDUFV1 | chr11 | 67375697 | + |
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FusionProtFeatures for CPB1_NDUFV1 |
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Hgene | Tgene |
CPB1 | NDUFV1 |
Core subunit of the mitochondrial membrane respiratorychain NADH dehydrogenase (Complex I) that is believed to belong tothe minimal assembly required for catalysis. Complex I functionsin the transfer of electrons from NADH to the respiratory chain.The immediate electron acceptor for the enzyme is believed to beubiquinone (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CPB1_NDUFV1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CPB1_NDUFV1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CPB1 | NDUFV1 | EWSR1, ICT1, COPS5, NDUFS8, NDUFS3, NDUFS7, NDUFS2, NDUFV2, NDUFS1, NDUFA9, NDUFB6, NDUFB10, TCOF1, VPS29, TMEM189, RRM1, NOTCH2, STMN1, TIMM9, HNRNPR, PNP, ABCD3, MPST, TOR1AIP1, ILF3, ERGIC1, DNAJB11, CPT1A, HTRA2, PAICS, HSPA1L, PALLD, SDHA, RNASET2, ADRB2, NDUFA8, COX5A, EEF2, MRPL45, ANXA11, ATP1A1, ATP1B1, ATP5F1, ATP6V0D1, FH, MTCH1, NDUFA10, NDUFA2, NDUFB8, NDUFS4, POR, SLC9A3R2, TOMM40, TPI1, UQCRB, VDAC2, PDHA1, PHB2, PSMD7, SDHB, STXBP1, UQCRFS1, NPHP1, NDUFA12, NDUFS5, NDUFA11, NDUFA13, NDUFS6, OXCT1, NDUFV3, ND1, ND5, NDUFB4, TIMMDC1, VAPA, GOLT1B, FOXQ1, NDUFA4, C15orf48, OCIAD1, COQ2, PAK7, COX6B1, C7orf55, C6orf203, COA3, NDUFB11, TRIM25 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CPB1_NDUFV1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CPB1 | P15086 | DB04272 | Citric Acid | Carboxypeptidase B | small molecule | approved|nutraceutical|vet_approved |
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RelatedDiseases for CPB1_NDUFV1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | NDUFV1 | C1838979 | MITOCHONDRIAL COMPLEX I DEFICIENCY | 2 | CTD_human;UNIPROT |
Tgene | NDUFV1 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
Tgene | NDUFV1 | C0023264 | Leigh Disease | 1 | CTD_human;ORPHANET;UNIPROT |
Tgene | NDUFV1 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
Tgene | NDUFV1 | C0036341 | Schizophrenia | 1 | PSYGENET |
Tgene | NDUFV1 | C0038356 | Stomach Neoplasms | 1 | CTD_human |
Tgene | NDUFV1 | C0041696 | Unipolar Depression | 1 | PSYGENET |
Tgene | NDUFV1 | C1269683 | Major Depressive Disorder | 1 | PSYGENET |