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Fusion gene ID: 8206 |
FusionGeneSummary for CPB1_MGP |
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Fusion gene information | Fusion gene name: CPB1_MGP | Fusion gene ID: 8206 | Hgene | Tgene | Gene symbol | CPB1 | MGP | Gene ID | 1360 | 4256 |
Gene name | carboxypeptidase B1 | matrix Gla protein | |
Synonyms | CPB|PASP|PCPB | GIG36|MGLAP|NTI | |
Cytomap | 3q24 | 12p12.3 | |
Type of gene | protein-coding | protein-coding | |
Description | carboxypeptidase Bcarboxypeptidase B1 (tissue)pancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase B | matrix Gla proteincell growth-inhibiting gene 36 protein | |
Modification date | 20180523 | 20180527 | |
UniProtAcc | P15086 | P08493 | |
Ensembl transtripts involved in fusion gene | ENST00000491148, ENST00000282957, ENST00000498639, | ENST00000539261, ENST00000228938, | |
Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 10 X 7 X 2=140 |
# samples | 12 | 18 | |
** MAII score | log2(12/147*10)=-0.292781749227846 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(18/140*10)=0.362570079384708 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: CPB1 [Title/Abstract] AND MGP [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-E9-A228-01A | CPB1 | chr3 | 148559711 | + | MGP | chr12 | 15035214 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000491148 | ENST00000539261 | CPB1 | chr3 | 148559711 | + | MGP | chr12 | 15035214 | - |
Frame-shift | ENST00000491148 | ENST00000228938 | CPB1 | chr3 | 148559711 | + | MGP | chr12 | 15035214 | - |
Frame-shift | ENST00000282957 | ENST00000539261 | CPB1 | chr3 | 148559711 | + | MGP | chr12 | 15035214 | - |
Frame-shift | ENST00000282957 | ENST00000228938 | CPB1 | chr3 | 148559711 | + | MGP | chr12 | 15035214 | - |
intron-3CDS | ENST00000498639 | ENST00000539261 | CPB1 | chr3 | 148559711 | + | MGP | chr12 | 15035214 | - |
intron-3CDS | ENST00000498639 | ENST00000228938 | CPB1 | chr3 | 148559711 | + | MGP | chr12 | 15035214 | - |
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FusionProtFeatures for CPB1_MGP |
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Hgene | Tgene |
CPB1 | MGP |
Associates with the organic matrix of bone andcartilage. Thought to act as an inhibitor of bone formation. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CPB1_MGP |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CPB1_MGP |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CPB1 | MGP | BMP2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CPB1_MGP |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CPB1 | P15086 | DB04272 | Citric Acid | Carboxypeptidase B | small molecule | approved|nutraceutical|vet_approved |
Tgene | MGP | P08493 | DB01373 | Calcium | Matrix Gla protein | small molecule | approved|nutraceutical |
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RelatedDiseases for CPB1_MGP |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | MGP | C0024667 | Animal Mammary Neoplasms | 2 | CTD_human |
Tgene | MGP | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
Tgene | MGP | C0000786 | Spontaneous abortion | 1 | CTD_human;HPO |
Tgene | MGP | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | MGP | C0041948 | Uremia | 1 | CTD_human |
Tgene | MGP | C0042345 | Varicosity | 1 | CTD_human |
Tgene | MGP | C0342649 | Vascular calcification | 1 | CTD_human |
Tgene | MGP | C1855607 | Keutel syndrome | 1 | CTD_human;ORPHANET |