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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8204

FusionGeneSummary for CPB1_CPB1

check button Fusion gene summary
Fusion gene informationFusion gene name: CPB1_CPB1
Fusion gene ID: 8204
HgeneTgene
Gene symbol

CPB1

CPB1

Gene ID

1360

1360

Gene namecarboxypeptidase B1carboxypeptidase B1
SynonymsCPB|PASP|PCPBCPB|PASP|PCPB
Cytomap

3q24

3q24

Type of geneprotein-codingprotein-coding
Descriptioncarboxypeptidase Bcarboxypeptidase B1 (tissue)pancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase Bcarboxypeptidase Bcarboxypeptidase B1 (tissue)pancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase B
Modification date2018052320180523
UniProtAcc

P15086

P15086

Ensembl transtripts involved in fusion geneENST00000491148, ENST00000282957, 
ENST00000498639, 		ENST00000491148, 
ENST00000282957, ENST00000498639, 
Fusion gene scores* DoF score7 X 7 X 3=14721 X 24 X 3=1512
# samples 1219
** MAII scorelog2(12/147*10)=-0.292781749227846
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(19/1512*10)=-2.99238681589013
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CPB1 [Title/Abstract] AND CPB1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1T10370CPB1chr3

148577906

-CPB1chr3

148577880

+
ChiTaRS3.1BP325131CPB1chr3

148562318

+CPB1chr3

148545598

+
ChiTaRS3.1T10608CPB1chr3

148577906

-CPB1chr3

148577880

+
ChiTaRS3.1T11417CPB1chr3

148577906

-CPB1chr3

148577880

+
ChiTaRS3.1BP325294CPB1chr3

148563073

+CPB1chr3

148545596

+
ChiTaRS3.1BM263604CPB1chr3

148577649

-CPB1chr3

148577696

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000491148ENST00000491148CPB1chr3

148577906

-CPB1chr3

148577880

+
3UTR-3UTRENST00000491148ENST00000282957CPB1chr3

148577906

-CPB1chr3

148577880

+
3UTR-3UTRENST00000491148ENST00000498639CPB1chr3

148577906

-CPB1chr3

148577880

+
3UTR-3UTRENST00000282957ENST00000491148CPB1chr3

148577906

-CPB1chr3

148577880

+
3UTR-3UTRENST00000282957ENST00000282957CPB1chr3

148577906

-CPB1chr3

148577880

+
3UTR-3UTRENST00000282957ENST00000498639CPB1chr3

148577906

-CPB1chr3

148577880

+
3UTR-3UTRENST00000498639ENST00000491148CPB1chr3

148577906

-CPB1chr3

148577880

+
3UTR-3UTRENST00000498639ENST00000282957CPB1chr3

148577906

-CPB1chr3

148577880

+
3UTR-3UTRENST00000498639ENST00000498639CPB1chr3

148577906

-CPB1chr3

148577880

+
5CDS-5UTRENST00000491148ENST00000491148CPB1chr3

148562318

+CPB1chr3

148545598

+
5CDS-5UTRENST00000491148ENST00000282957CPB1chr3

148562318

+CPB1chr3

148545598

+
5CDS-intronENST00000491148ENST00000498639CPB1chr3

148562318

+CPB1chr3

148545598

+
5CDS-5UTRENST00000282957ENST00000491148CPB1chr3

148562318

+CPB1chr3

148545598

+
5CDS-5UTRENST00000282957ENST00000282957CPB1chr3

148562318

+CPB1chr3

148545598

+
5CDS-intronENST00000282957ENST00000498639CPB1chr3

148562318

+CPB1chr3

148545598

+
intron-5UTRENST00000498639ENST00000491148CPB1chr3

148562318

+CPB1chr3

148545598

+
intron-5UTRENST00000498639ENST00000282957CPB1chr3

148562318

+CPB1chr3

148545598

+
intron-intronENST00000498639ENST00000498639CPB1chr3

148562318

+CPB1chr3

148545598

+
intron-5UTRENST00000491148ENST00000491148CPB1chr3

148563073

+CPB1chr3

148545596

+
intron-5UTRENST00000491148ENST00000282957CPB1chr3

148563073

+CPB1chr3

148545596

+
intron-intronENST00000491148ENST00000498639CPB1chr3

148563073

+CPB1chr3

148545596

+
intron-5UTRENST00000282957ENST00000491148CPB1chr3

148563073

+CPB1chr3

148545596

+
intron-5UTRENST00000282957ENST00000282957CPB1chr3

148563073

+CPB1chr3

148545596

+
intron-intronENST00000282957ENST00000498639CPB1chr3

148563073

+CPB1chr3

148545596

+
intron-5UTRENST00000498639ENST00000491148CPB1chr3

148563073

+CPB1chr3

148545596

+
intron-5UTRENST00000498639ENST00000282957CPB1chr3

148563073

+CPB1chr3

148545596

+
intron-intronENST00000498639ENST00000498639CPB1chr3

148563073

+CPB1chr3

148545596

+
Frame-shiftENST00000491148ENST00000491148CPB1chr3

148577649

-CPB1chr3

148577696

+
In-frameENST00000491148ENST00000282957CPB1chr3

148577649

-CPB1chr3

148577696

+
5CDS-3UTRENST00000491148ENST00000498639CPB1chr3

148577649

-CPB1chr3

148577696

+
In-frameENST00000282957ENST00000491148CPB1chr3

148577649

-CPB1chr3

148577696

+
Frame-shiftENST00000282957ENST00000282957CPB1chr3

148577649

-CPB1chr3

148577696

+
5CDS-3UTRENST00000282957ENST00000498639CPB1chr3

148577649

-CPB1chr3

148577696

+
3UTR-3CDSENST00000498639ENST00000491148CPB1chr3

148577649

-CPB1chr3

148577696

+
3UTR-3CDSENST00000498639ENST00000282957CPB1chr3

148577649

-CPB1chr3

148577696

+
3UTR-3UTRENST00000498639ENST00000498639CPB1chr3

148577649

-CPB1chr3

148577696

+

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FusionProtFeatures for CPB1_CPB1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CPB1

P15086

CPB1

P15086


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CPB1_CPB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CPB1_CPB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CPB1_CPB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneCPB1P15086DB04272Citric AcidCarboxypeptidase Bsmall moleculeapproved|nutraceutical|vet_approved
TgeneCPB1P15086DB04272Citric AcidCarboxypeptidase Bsmall moleculeapproved|nutraceutical|vet_approved

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RelatedDiseases for CPB1_CPB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource