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Fusion gene ID: 8202 |
FusionGeneSummary for CPB1_ANXA1 |
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Fusion gene information | Fusion gene name: CPB1_ANXA1 | Fusion gene ID: 8202 | Hgene | Tgene | Gene symbol | CPB1 | ANXA1 | Gene ID | 1360 | 301 |
Gene name | carboxypeptidase B1 | annexin A1 | |
Synonyms | CPB|PASP|PCPB | ANX1|LPC1 | |
Cytomap | 3q24 | 9q21.13 | |
Type of gene | protein-coding | protein-coding | |
Description | carboxypeptidase Bcarboxypeptidase B1 (tissue)pancreas-specific proteinpancreatic carboxypeptidase Bprocarboxypeptidase Bprotaminasetissue carboxypeptidase B | annexin A1annexin I (lipocortin I)annexin-1calpactin IIcalpactin-2chromobindin-9phospholipase A2 inhibitory protein | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P15086 | P04083 | |
Ensembl transtripts involved in fusion gene | ENST00000491148, ENST00000282957, ENST00000498639, | ENST00000257497, ENST00000376911, ENST00000491192, | |
Fusion gene scores | * DoF score | 7 X 7 X 3=147 | 19 X 2 X 7=266 |
# samples | 12 | 19 | |
** MAII score | log2(12/147*10)=-0.292781749227846 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/266*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CPB1 [Title/Abstract] AND ANXA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ANXA1 | GO:0002548 | monocyte chemotaxis | 15187149 |
Tgene | ANXA1 | GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 25664854 |
Tgene | ANXA1 | GO:0008360 | regulation of cell shape | 15187149 |
Tgene | ANXA1 | GO:0018149 | peptide cross-linking | 10908733 |
Tgene | ANXA1 | GO:0030216 | keratinocyte differentiation | 10908733 |
Tgene | ANXA1 | GO:0031340 | positive regulation of vesicle fusion | 2138016 |
Tgene | ANXA1 | GO:0031532 | actin cytoskeleton reorganization | 15187149 |
Tgene | ANXA1 | GO:0032743 | positive regulation of interleukin-2 production | 17008549 |
Tgene | ANXA1 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 22773844 |
Tgene | ANXA1 | GO:0042102 | positive regulation of T cell proliferation | 17008549 |
Tgene | ANXA1 | GO:0045627 | positive regulation of T-helper 1 cell differentiation | 17008549 |
Tgene | ANXA1 | GO:0045629 | negative regulation of T-helper 2 cell differentiation | 17008549 |
Tgene | ANXA1 | GO:0071385 | cellular response to glucocorticoid stimulus | 2936963 |
Tgene | ANXA1 | GO:0071621 | granulocyte chemotaxis | 15187149 |
Tgene | ANXA1 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis | 22773844 |
Tgene | ANXA1 | GO:0090303 | positive regulation of wound healing | 25664854 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-AR-A252-01A | CPB1 | chr3 | 148577970 | + | ANXA1 | chr9 | 75772570 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000491148 | ENST00000257497 | CPB1 | chr3 | 148577970 | + | ANXA1 | chr9 | 75772570 | + |
5CDS-intron | ENST00000491148 | ENST00000376911 | CPB1 | chr3 | 148577970 | + | ANXA1 | chr9 | 75772570 | + |
5CDS-intron | ENST00000491148 | ENST00000491192 | CPB1 | chr3 | 148577970 | + | ANXA1 | chr9 | 75772570 | + |
5CDS-intron | ENST00000282957 | ENST00000257497 | CPB1 | chr3 | 148577970 | + | ANXA1 | chr9 | 75772570 | + |
5CDS-intron | ENST00000282957 | ENST00000376911 | CPB1 | chr3 | 148577970 | + | ANXA1 | chr9 | 75772570 | + |
5CDS-intron | ENST00000282957 | ENST00000491192 | CPB1 | chr3 | 148577970 | + | ANXA1 | chr9 | 75772570 | + |
5CDS-intron | ENST00000498639 | ENST00000257497 | CPB1 | chr3 | 148577970 | + | ANXA1 | chr9 | 75772570 | + |
5CDS-intron | ENST00000498639 | ENST00000376911 | CPB1 | chr3 | 148577970 | + | ANXA1 | chr9 | 75772570 | + |
5CDS-intron | ENST00000498639 | ENST00000491192 | CPB1 | chr3 | 148577970 | + | ANXA1 | chr9 | 75772570 | + |
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FusionProtFeatures for CPB1_ANXA1 |
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Hgene | Tgene |
CPB1 | ANXA1 |
Plays important roles in the innate immune response aseffector of glucocorticoid-mediated responses and regulator of theinflammatory process. Has anti-inflammatory activity(PubMed:8425544). Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response (Bysimilarity). Promotes resolution of inflammation and wound healing(PubMed:25664854). Functions at least in part by activating theformyl peptide receptors and downstream signaling cascades(PubMed:15187149, PubMed:25664854). Promotes chemotaxis ofgranulocytes and monocytes via activation of the formyl peptidereceptors (PubMed:15187149). Contributes to the adaptive immuneresponse by enhancing signaling cascades that are triggered by T-cell activation, regulates differentiation and proliferation ofactivated T-cells (PubMed:17008549). Promotes the differentiationof T-cells into Th1 cells and negatively regulates differentiationinto Th2 cells (PubMed:17008549). Has no effect on unstimulated Tcells (PubMed:17008549). Promotes rearrangement of the actincytoskeleton, cell polarization and cell migration(PubMed:15187149). Negatively regulates hormone exocytosis viaactivation of the formyl peptide receptors and reorganization ofthe actin cytoskeleton (PubMed:19625660). Has high affinity forCa(2+) and can bind up to eight Ca(2+) ions (By similarity).Displays Ca(2+)-dependent binding to phospholipid membranes(PubMed:2532504, PubMed:8557678). Plays a role in the formation ofphagocytic cups and phagosomes. Plays a role in phagocytosis bymediating the Ca(2+)-dependent interaction between phagosomes andthe actin cytoskeleton (By similarity).{ECO:0000250|UniProtKB:P10107, ECO:0000250|UniProtKB:P19619,ECO:0000269|PubMed:15187149, ECO:0000269|PubMed:17008549,ECO:0000269|PubMed:19625660, ECO:0000269|PubMed:2532504,ECO:0000269|PubMed:25664854, ECO:0000269|PubMed:2936963,ECO:0000269|PubMed:8425544, ECO:0000269|PubMed:8557678}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CPB1_ANXA1 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CPB1_ANXA1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CPB1 | ANXA1 | PPM1B, DLG3, S100A11, KRT8, USP25, USPL1, SLX1B, ATG4B, MGMT, UCHL5, UBE3A, CD4, UBE2I, GAPDH, KLHL23, APBB1, CSAD, C1orf123, RPA1, UNC119, OTUB1, C14orf1, XRCC6, KMT2B, CCT7, UBE2D1, COPS6, LRIF1, FAF1, ANXA1, ANXA5, SIRT7, CUL5, CDK2, IKBKG, RIPK1, RELA, ANXA4, FN1, VCAM1, ATF2, ITGA4, HMGA1, BAG3, ATP4A, YWHAQ, HECW2, WWOX, ZBTB1, MEIS2, ENO1, MOV10, NXF1, CUL7, OBSL1, SUMO2, NSL1, UCP2, SOX2, KIR2DS2, DDX19B, UGT1A10, ZSCAN20, TP53BP2, MAP1S, STK4, RASSF10, HNRNPA1, HSPB1, CEP152, CEP128, CEP89, DCTN1, KIF11, PPIA, TFG, GOLT1B, CCDC88A, USP7, MCM2, EGFR, U2AF2, ACTA1, PLA2G4A, CDC73, CDH1, GNB2, FRMD1, RPUSD3, SOD1, TRIM25, G3BP1, BRCA1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CPB1_ANXA1 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | CPB1 | P15086 | DB04272 | Citric Acid | Carboxypeptidase B | small molecule | approved|nutraceutical|vet_approved |
Tgene | ANXA1 | P04083 | DB00288 | Amcinonide | Annexin A1 | small molecule | approved |
Tgene | ANXA1 | P04083 | DB01234 | Dexamethasone | Annexin A1 | small molecule | approved|investigational|vet_approved |
Tgene | ANXA1 | P04083 | DB00741 | Hydrocortisone | Annexin A1 | small molecule | approved|vet_approved |
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RelatedDiseases for CPB1_ANXA1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | ANXA1 | C0024667 | Animal Mammary Neoplasms | 3 | CTD_human |
Tgene | ANXA1 | C0024668 | Mammary Neoplasms, Experimental | 2 | CTD_human |
Tgene | ANXA1 | C0007137 | Squamous cell carcinoma | 1 | CTD_human |
Tgene | ANXA1 | C0020538 | Hypertensive disease | 1 | CTD_human |
Tgene | ANXA1 | C0022658 | Kidney Diseases | 1 | CTD_human |
Tgene | ANXA1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Tgene | ANXA1 | C0024232 | Lymphatic Metastasis | 1 | CTD_human |
Tgene | ANXA1 | C0026640 | Mouth Neoplasms | 1 | CTD_human |
Tgene | ANXA1 | C0027626 | Neoplasm Invasiveness | 1 | CTD_human |
Tgene | ANXA1 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Tgene | ANXA1 | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Tgene | ANXA1 | C0038354 | Stomach Diseases | 1 | CTD_human |
Tgene | ANXA1 | C0152013 | Adenocarcinoma of lung (disorder) | 1 | CTD_human |
Tgene | ANXA1 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
Tgene | ANXA1 | C0376634 | Craniofacial Abnormalities | 1 | CTD_human |