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Fusion gene ID: 8195 |
FusionGeneSummary for CPA1_SCYL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CPA1_SCYL1 | Fusion gene ID: 8195 | Hgene | Tgene | Gene symbol | CPA1 | SCYL1 | Gene ID | 1357 | 57410 |
| Gene name | carboxypeptidase A1 | SCY1 like pseudokinase 1 | |
| Synonyms | CPA | GKLP|HT019|NKTL|NTKL|P105|SCAR21|TAPK|TEIF|TRAP | |
| Cytomap | 7q32.2 | 11q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | carboxypeptidase A1carboxypeptidase A1 (pancreatic)pancreatic carboxypeptidase A | N-terminal kinase-like proteinSCY1-like protein 1SCY1-like, kinase-like 1coated vesicle-associated kinase of 90 kDalikely ortholog of mouse N-terminal kinase-like proteintelomerase regulation-associated proteintelomerase transcriptional elements-int | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P15085 | Q96KG9 | |
| Ensembl transtripts involved in fusion gene | ENST00000011292, ENST00000484324, | ENST00000525364, ENST00000270176, ENST00000420247, ENST00000533862, ENST00000279270, ENST00000524944, ENST00000527009, ENST00000534462, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: CPA1 [Title/Abstract] AND SCYL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SCYL1 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER | 18556652 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PAAD | TCGA-HZ-8003-01A | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000011292 | ENST00000525364 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| Frame-shift | ENST00000011292 | ENST00000270176 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| Frame-shift | ENST00000011292 | ENST00000420247 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| Frame-shift | ENST00000011292 | ENST00000533862 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| Frame-shift | ENST00000011292 | ENST00000279270 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| Frame-shift | ENST00000011292 | ENST00000524944 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| 5CDS-5UTR | ENST00000011292 | ENST00000527009 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| 5CDS-intron | ENST00000011292 | ENST00000534462 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| 3UTR-3CDS | ENST00000484324 | ENST00000525364 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| 3UTR-3CDS | ENST00000484324 | ENST00000270176 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| 3UTR-3CDS | ENST00000484324 | ENST00000420247 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| 3UTR-3CDS | ENST00000484324 | ENST00000533862 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| 3UTR-3CDS | ENST00000484324 | ENST00000279270 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| 3UTR-3CDS | ENST00000484324 | ENST00000524944 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| 3UTR-5UTR | ENST00000484324 | ENST00000527009 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
| 3UTR-intron | ENST00000484324 | ENST00000534462 | CPA1 | chr7 | 130027929 | + | SCYL1 | chr11 | 65293392 | + |
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FusionProtFeatures for CPA1_SCYL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CPA1 | SCYL1 |
| Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu,-Arg, -Lys or -Pro. {ECO:0000269|PubMed:8806703}. | Regulates COPI-mediated retrograde protein traffic atthe interface between the Golgi apparatus and the endoplasmicreticulum (PubMed:18556652). Involved in the maintenance of theGolgi apparatus morphology (PubMed:26581903). Has no detectablekinase activity in vitro (PubMed:18556652).{ECO:0000269|PubMed:18556652, ECO:0000269|PubMed:26581903}. Isoform 6 acts as transcriptional activator. It binds tothree different types of GC-rich DNA binding sites (box-A, -B and-C) in the beta-polymerase promoter region. It also binds to theTERT promoter region. {ECO:0000269|PubMed:18556652}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CPA1_SCYL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CPA1_SCYL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CPA1 | ARRB1 | SCYL1 | MYC, COIL, APP, SPTY2D1, CWC27, CD93, CDC25A, CHD1L, GORAB, CRTC3, SEC31A, AURKA, REST, ACTR1B, POLA2, NTRK1, TMEM17, XPO1, CTDSPL2, CCNF, SMURF1, CDH1, EGFR, KLHL2, AVIL, AGPAT3, DUSP23, UBR3, NEK7, P4HA2, TES |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CPA1_SCYL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CPA1_SCYL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | CPA1 | C0149521 | Pancreatitis, Chronic | 1 | CTD_human |
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