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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 819

FusionGeneSummary for ADCY2_LARP1B

check button Fusion gene summary
Fusion gene informationFusion gene name: ADCY2_LARP1B
Fusion gene ID: 819
HgeneTgene
Gene symbol

ADCY2

LARP1B

Gene ID

108

55132

Gene nameadenylate cyclase 2La ribonucleoprotein domain family member 1B
SynonymsAC2|HBAC2LARP2
Cytomap

5p15.31

4q28.2

Type of geneprotein-codingprotein-coding
Descriptionadenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclasela-related protein 1BLa ribonucleoprotein domain family, member 2la-related protein 2
Modification date2018052220180519
UniProtAcc

Q08462

Q659C4

Ensembl transtripts involved in fusion geneENST00000338316, ENST00000537121, 
ENST00000513693, 
ENST00000326639, 
ENST00000264584, ENST00000441387, 
ENST00000354456, ENST00000506199, 
ENST00000512292, ENST00000394288, 
ENST00000432347, ENST00000427266, 
Fusion gene scores* DoF score20 X 19 X 5=19003 X 4 X 2=24
# samples 217
** MAII scorelog2(21/1900*10)=-3.17753818555219
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/24*10)=1.54432051622381
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ADCY2 [Title/Abstract] AND LARP1B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AA303012ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
ChiTaRS3.1AW962618ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000338316ENST00000326639ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000338316ENST00000264584ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000338316ENST00000441387ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000338316ENST00000354456ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000338316ENST00000506199ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000338316ENST00000512292ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-3UTRENST00000338316ENST00000394288ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-3UTRENST00000338316ENST00000432347ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000338316ENST00000427266ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000537121ENST00000326639ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000537121ENST00000264584ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000537121ENST00000441387ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000537121ENST00000354456ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000537121ENST00000506199ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000537121ENST00000512292ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-3UTRENST00000537121ENST00000394288ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-3UTRENST00000537121ENST00000432347ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000537121ENST00000427266ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000513693ENST00000326639ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000513693ENST00000264584ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000513693ENST00000441387ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000513693ENST00000354456ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000513693ENST00000506199ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000513693ENST00000512292ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-3UTRENST00000513693ENST00000394288ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-3UTRENST00000513693ENST00000432347ADCY2chr1

152005172

+LARP1Bchr4

129029795

-
intron-intronENST00000513693ENST00000427266ADCY2chr1

152005172

+LARP1Bchr4

129029795

-

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FusionProtFeatures for ADCY2_LARP1B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADCY2

Q08462

LARP1B

Q659C4

Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling (PubMed:15385642). Down-streamsignaling cascades mediate changes in gene expression patterns andlead to increased IL6 production. Functions in signaling cascadesdownstream of the muscarinic acetylcholine receptors (Bysimilarity). {ECO:0000250|UniProtKB:P26769,ECO:0000269|PubMed:15385642}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADCY2_LARP1B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADCY2_LARP1B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADCY2_LARP1B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneADCY2Q08462DB09121AurothioglucoseAdenylate cyclase type 2small moleculeapproved|withdrawn

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RelatedDiseases for ADCY2_LARP1B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADCY2C0004096Asthma1CTD_human
HgeneADCY2C0005586Bipolar Disorder1PSYGENET