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Fusion gene ID: 817 |
FusionGeneSummary for ADCY2_HSDL2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADCY2_HSDL2 | Fusion gene ID: 817 | Hgene | Tgene | Gene symbol | ADCY2 | HSDL2 | Gene ID | 108 | 84263 |
| Gene name | adenylate cyclase 2 | hydroxysteroid dehydrogenase like 2 | |
| Synonyms | AC2|HBAC2 | C9orf99|SDR13C1 | |
| Cytomap | 5p15.31 | 9q32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | adenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase | hydroxysteroid dehydrogenase-like protein 2short chain dehydrogenase/reductase family 13C member 1 | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q08462 | Q6YN16 | |
| Ensembl transtripts involved in fusion gene | ENST00000338316, ENST00000537121, ENST00000513693, | ENST00000398805, ENST00000398803, ENST00000488101, ENST00000262542, ENST00000539114, | |
| Fusion gene scores | * DoF score | 20 X 19 X 5=1900 | 5 X 6 X 5=150 |
| # samples | 21 | 6 | |
| ** MAII score | log2(21/1900*10)=-3.17753818555219 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/150*10)=-1.32192809488736 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADCY2 [Title/Abstract] AND HSDL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-DX-A1KZ-01A | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000338316 | ENST00000398805 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| 5CDS-intron | ENST00000338316 | ENST00000398803 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| 5CDS-3UTR | ENST00000338316 | ENST00000488101 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| 5CDS-3UTR | ENST00000338316 | ENST00000262542 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| 5CDS-intron | ENST00000338316 | ENST00000539114 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| In-frame | ENST00000537121 | ENST00000398805 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| 5CDS-intron | ENST00000537121 | ENST00000398803 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| 5CDS-3UTR | ENST00000537121 | ENST00000488101 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| 5CDS-3UTR | ENST00000537121 | ENST00000262542 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| 5CDS-intron | ENST00000537121 | ENST00000539114 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| intron-3CDS | ENST00000513693 | ENST00000398805 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| intron-intron | ENST00000513693 | ENST00000398803 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| intron-3UTR | ENST00000513693 | ENST00000488101 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| intron-3UTR | ENST00000513693 | ENST00000262542 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
| intron-intron | ENST00000513693 | ENST00000539114 | ADCY2 | chr5 | 7773214 | + | HSDL2 | chr9 | 115179121 | + |
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FusionProtFeatures for ADCY2_HSDL2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADCY2 | HSDL2 |
| Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling (PubMed:15385642). Down-streamsignaling cascades mediate changes in gene expression patterns andlead to increased IL6 production. Functions in signaling cascadesdownstream of the muscarinic acetylcholine receptors (Bysimilarity). {ECO:0000250|UniProtKB:P26769,ECO:0000269|PubMed:15385642}. | Has apparently no steroid dehydrogenase activity.{ECO:0000269|PubMed:19703561}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 295_300 | 794 | 1092 | Nucleotide binding | ATP |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 337_339 | 794 | 1092 | Nucleotide binding | ATP |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 1_45 | 794 | 1092 | Topological domain | Cytoplasmic |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 208_601 | 794 | 1092 | Topological domain | Cytoplasmic |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 108_128 | 794 | 1092 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 133_153 | 794 | 1092 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 159_179 | 794 | 1092 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 187_207 | 794 | 1092 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 46_66 | 794 | 1092 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 602_622 | 794 | 1092 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 628_652 | 794 | 1092 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 680_701 | 794 | 1092 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 734_755 | 794 | 1092 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 763_780 | 794 | 1092 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 76_96 | 794 | 1092 | Transmembrane | Helical |
| Tgene | >HSDL2 | chr5:7773214 | chr9:115179121 | ENST00000398803 | + | 0 | 9 | 306_415 | -28 | 346 | Domain | Note=SCP2 |
| Tgene | >HSDL2 | chr5:7773214 | chr9:115179121 | ENST00000398805 | + | 3 | 11 | 306_415 | 131 | 419 | Domain | Note=SCP2 |
| Tgene | >HSDL2 | chr5:7773214 | chr9:115179121 | ENST00000398803 | + | 0 | 9 | 17_23 | -28 | 346 | Nucleotide binding | NADP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 1019_1021 | 794 | 1092 | Nucleotide binding | ATP |
| Hgene | >ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 1026_1030 | 794 | 1092 | Nucleotide binding | ATP |
| Hgene | >ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 822_1091 | 794 | 1092 | Topological domain | Cytoplasmic |
| Hgene | >ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 801_821 | 794 | 1092 | Transmembrane | Helical |
| Tgene | HSDL2 | chr5:7773214 | chr9:115179121 | ENST00000398805 | + | 3 | 11 | 17_23 | 131 | 419 | Nucleotide binding | NADP |
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FusionGeneSequence for ADCY2_HSDL2 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ADCY2_ENST00000338316_chr5_7773214_+_HSDL2_ENST00000398805_chr9_115179121_+_1082aa MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFF AIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT PGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRD PYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGI SFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERSKACIPYLKKSKVAH ILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKS FTGNFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQLQPKPRSGAVEETFRIVKDSLSDDVVK ATQAIYLFELSGEDGGTWFLDLKSKGGNVGYGEPSDQADVVMSMTTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLEKLMNQMNAR >In-frame_ADCY2_ENST00000537121_chr5_7773214_+_HSDL2_ENST00000398805_chr9_115179121_+_902aa MDLRWARDLHLREASRSVAFTTLRLGAVTTGLLTFREPGDKEKSGKGLGKRWRIQREESQERLLLSLLPAHIAMEMKAEIIQRLQGPKAG QMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRD PYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGI SFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFS ASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERSKACIPYLKKSKVAH ILNISPPLNLNPVWFKQHCAYTIAKYGMSMYVLGMAEEFKGEIAVNALWPKTAIHTAAMDMLGGPGIESQCRKVDIIADAAYSIFQKPKS FTGNFVIDENILKEEGIENFDVYAIKPGHPLQPDFFLDEYPEAVSKKVESTGAVPEFKEEKLQLQPKPRSGAVEETFRIVKDSLSDDVVK ATQAIYLFELSGEDGGTWFLDLKSKGGNVGYGEPSDQADVVMSMTTDDFVKMFSGKLKPTMAFMSGKLKIKGNMALAIKLEKLMNQMNAR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ADCY2_ENST00000338316_chr5_7773214_+_HSDL2_ENST00000398805_chr9_115179121_+_3246nt ATGTGGCAGGAGGCGATGCGGCGCCGCCGCTACCTGCGGGACCGCTCCGAGGAGGCGGCGGGCGGCGGAGACGGGCTGCCGCGGTCCCGG GACTGGCTCTACGAGTCCTACTACTGCATGAGCCAGCAGCACCCGCTCATCGTCTTCCTGCTGCTCATCGTCATGGGCTCCTGCCTCGCC CTGCTCGCCGTCTTCTTCGCGCTCGGGCTGGAAGTTGAAGACCATGTGGCGTTTCTAATAACAGTTCCAACTGCCCTGGCGATTTTCTTT GCGATATTTATCCTGGTCTGCATCGAGTCTGTGTTTAAGAAGCTGCTGCGCCTCTTCTCGTTGGTGATATGGATATGCCTTGTTGCCATG GGATACCTGTTCATGTGTTTTGGAGGCACCGTCTCTCCCTGGGACCAGGTATCGTTCTTCCTCTTCATCATCTTCGTGGTGTACACCATG CTGCCCTTCAACATGCGAGACGCCATCATTGCCAGCGTCCTCACCTCCTCCTCCCACACCATCGTGCTTAGCGTCTGCCTGTCTGCAACA CCGGGAGGCAAGGAGCACCTGGTCTGGCAGATCCTGGCCAATGTGATCATTTTCATCTGTGGGAACCTGGCGGGAGCCTACCATAAGCAC CTCATGGAACTCGCTCTTCAGCAAACATATCAGGACACCTGTAATTGCATCAAGTCGCGGATCAAGTTGGAATTTGAAAAACGTCAACAG GAGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGC CAGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACC CGGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAA TGCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAA ATGGGGCTGGACATGTGTGAAGCCATAAAGAAAGTGAGGGATGCTACTGGAGTTGATATCAACATGCGCGTGGGCGTGCATTCTGGGAAT GTCCTGTGTGGCGTGATTGGTCTGCAGAAGTGGCAATATGATGTGTGGTCACATGATGTGACCTTGGCCAACCACATGGAAGCTGGAGGG GTCCCTGGACGTGTTCACATTTCTTCTGTCACCCTGGAGCACTTGAATGGCGCTTATAAAGTGGAGGAGGGAGATGGTGACATTAGGGAC CCATATTTAAAACAGCACCTGGTGAAAACCTACTTTGTGATCAACCCCAAGGGAGAACGACGGAGCCCCCAGCATCTCTTCAGACCTCGC CACACCCTTGATGGAGCCAAAATGAGGGCCTCGGTCCGCATGACCCGGTACTTGGAGTCCTGGGGGGCAGCCAAGCCCTTTGCACACCTA CATCACAGGGACAGCATGACCACAGAGAACGGCAAGATCAGCACCACGGATGTACCCATGGGTCAGCATAATTTTCAAAATCGCACCTTA AGAACCAAGTCACAAAAGAAGAGATTTGAAGAAGAATTGAATGAAAGGATGATTCAAGCAATTGATGGGATTAATGCACAGAAGCAATGG CTCAAGTCTGAAGACATTCAGAGAATCTCACTGCTTTTCTATAACAAAGTACTAGAAAAAGAGTACCGGGCCACGGCACTGCCAGCGTTC AAGTATTATGTGACTTGTGCCTGTCTCATATTCTTCTGCATCTTCATTGTGCAGATTCTCGTGCTGCCAAAAACGTCCGTCCTGGGCATC TCCTTTGGGGCTGCGTTTCTCTTGCTGGCCTTCATCCTCTTCGTCTGCTTTGCTGGACAGCTTCTGCAATGCAGCAAAAAAGCCTCTCCC CTGCTCATGTGGCTTTTGAAGTCCTCGGGCATCATTGCCAACCGCCCCTGGCCACGGATCTCTCTCACGATCATCACCACAGCCATCATA TTAATGATGGCCGTGTTCAACATGTTTTTCCTGAGTGACTCAGAGGAAACAATCCCTCCAACTGCCAACACAACAAACACAAGCTTTTCA GCCTCAAATAATCAGGTGGCGATTCTGCGTGCGCAGAATTTATTTTTCCTCCCGTACTTTATCTACAGCTGCATTCTGGGACTGATATCC TGTTCCGTGTTCCTGCGGGTAAACTATGAGCTGAAGATGTTGATCATGATGGTGGCCTTGGTGGGCTACAACACCATCCTACTCCACACC CACGCCCACGTCCTGGGCGACTACAGCCAGGTCTTATTTGAGAGATCTAAAGCATGTATTCCTTATTTGAAAAAGAGCAAAGTTGCTCAT ATCCTCAATATCAGTCCACCACTGAACCTAAATCCAGTTTGGTTCAAACAGCACTGTGCTTATACCATTGCTAAGTATGGTATGTCTATG TATGTGCTTGGAATGGCAGAAGAATTTAAAGGTGAAATTGCAGTCAATGCATTATGGCCTAAAACAGCCATACACACTGCTGCTATGGAT ATGCTGGGAGGACCTGGTATCGAAAGCCAGTGTAGAAAAGTTGATATCATTGCAGATGCAGCATATTCCATTTTCCAAAAGCCAAAAAGT TTTACTGGCAACTTTGTCATTGATGAAAATATCTTAAAAGAAGAAGGAATAGAAAATTTTGACGTTTATGCAATTAAACCAGGTCATCCT TTGCAACCAGATTTCTTCTTAGATGAATACCCAGAAGCAGTTAGCAAGAAAGTGGAATCAACTGGTGCTGTTCCAGAATTCAAAGAAGAG AAACTGCAGCTGCAACCAAAACCACGTTCTGGAGCTGTGGAAGAAACATTTAGAATTGTTAAGGACTCTCTCAGTGATGATGTTGTTAAA GCCACTCAAGCAATCTATCTGTTTGAACTCTCCGGTGAAGATGGTGGCACGTGGTTTCTTGATCTGAAAAGCAAGGGTGGGAATGTCGGA TATGGAGAGCCTTCTGATCAGGCAGATGTGGTGATGAGTATGACTACTGATGACTTTGTAAAAATGTTTTCAGGGAAACTAAAACCAACA ATGGCATTCATGTCAGGGAAATTGAAGATTAAAGGTAACATGGCCCTAGCAATCAAATTGGAGAAGCTAATGAATCAGATGAATGCCAGA >In-frame_ADCY2_ENST00000537121_chr5_7773214_+_HSDL2_ENST00000398805_chr9_115179121_+_2706nt ATGGACCTGCGCTGGGCCAGAGATCTGCATTTGAGAGAAGCCAGCAGATCAGTAGCATTTACCACCCTGAGGCTGGGCGCAGTCACCACG GGACTCCTGACATTCAGAGAGCCAGGAGATAAAGAGAAGTCAGGAAAGGGCCTTGGGAAGAGATGGCGCATCCAGCGAGAGGAAAGCCAG GAGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGC CAGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACC CGGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAA TGCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAA ATGGGGCTGGACATGTGTGAAGCCATAAAGAAAGTGAGGGATGCTACTGGAGTTGATATCAACATGCGCGTGGGCGTGCATTCTGGGAAT GTCCTGTGTGGCGTGATTGGTCTGCAGAAGTGGCAATATGATGTGTGGTCACATGATGTGACCTTGGCCAACCACATGGAAGCTGGAGGG GTCCCTGGACGTGTTCACATTTCTTCTGTCACCCTGGAGCACTTGAATGGCGCTTATAAAGTGGAGGAGGGAGATGGTGACATTAGGGAC CCATATTTAAAACAGCACCTGGTGAAAACCTACTTTGTGATCAACCCCAAGGGAGAACGACGGAGCCCCCAGCATCTCTTCAGACCTCGC CACACCCTTGATGGAGCCAAAATGAGGGCCTCGGTCCGCATGACCCGGTACTTGGAGTCCTGGGGGGCAGCCAAGCCCTTTGCACACCTA CATCACAGGGACAGCATGACCACAGAGAACGGCAAGATCAGCACCACGGATGTACCCATGGGTCAGCATAATTTTCAAAATCGCACCTTA AGAACCAAGTCACAAAAGAAGAGATTTGAAGAAGAATTGAATGAAAGGATGATTCAAGCAATTGATGGGATTAATGCACAGAAGCAATGG CTCAAGTCTGAAGACATTCAGAGAATCTCACTGCTTTTCTATAACAAAGTACTAGAAAAAGAGTACCGGGCCACGGCACTGCCAGCGTTC AAGTATTATGTGACTTGTGCCTGTCTCATATTCTTCTGCATCTTCATTGTGCAGATTCTCGTGCTGCCAAAAACGTCCGTCCTGGGCATC TCCTTTGGGGCTGCGTTTCTCTTGCTGGCCTTCATCCTCTTCGTCTGCTTTGCTGGACAGCTTCTGCAATGCAGCAAAAAAGCCTCTCCC CTGCTCATGTGGCTTTTGAAGTCCTCGGGCATCATTGCCAACCGCCCCTGGCCACGGATCTCTCTCACGATCATCACCACAGCCATCATA TTAATGATGGCCGTGTTCAACATGTTTTTCCTGAGTGACTCAGAGGAAACAATCCCTCCAACTGCCAACACAACAAACACAAGCTTTTCA GCCTCAAATAATCAGGTGGCGATTCTGCGTGCGCAGAATTTATTTTTCCTCCCGTACTTTATCTACAGCTGCATTCTGGGACTGATATCC TGTTCCGTGTTCCTGCGGGTAAACTATGAGCTGAAGATGTTGATCATGATGGTGGCCTTGGTGGGCTACAACACCATCCTACTCCACACC CACGCCCACGTCCTGGGCGACTACAGCCAGGTCTTATTTGAGAGATCTAAAGCATGTATTCCTTATTTGAAAAAGAGCAAAGTTGCTCAT ATCCTCAATATCAGTCCACCACTGAACCTAAATCCAGTTTGGTTCAAACAGCACTGTGCTTATACCATTGCTAAGTATGGTATGTCTATG TATGTGCTTGGAATGGCAGAAGAATTTAAAGGTGAAATTGCAGTCAATGCATTATGGCCTAAAACAGCCATACACACTGCTGCTATGGAT ATGCTGGGAGGACCTGGTATCGAAAGCCAGTGTAGAAAAGTTGATATCATTGCAGATGCAGCATATTCCATTTTCCAAAAGCCAAAAAGT TTTACTGGCAACTTTGTCATTGATGAAAATATCTTAAAAGAAGAAGGAATAGAAAATTTTGACGTTTATGCAATTAAACCAGGTCATCCT TTGCAACCAGATTTCTTCTTAGATGAATACCCAGAAGCAGTTAGCAAGAAAGTGGAATCAACTGGTGCTGTTCCAGAATTCAAAGAAGAG AAACTGCAGCTGCAACCAAAACCACGTTCTGGAGCTGTGGAAGAAACATTTAGAATTGTTAAGGACTCTCTCAGTGATGATGTTGTTAAA GCCACTCAAGCAATCTATCTGTTTGAACTCTCCGGTGAAGATGGTGGCACGTGGTTTCTTGATCTGAAAAGCAAGGGTGGGAATGTCGGA TATGGAGAGCCTTCTGATCAGGCAGATGTGGTGATGAGTATGACTACTGATGACTTTGTAAAAATGTTTTCAGGGAAACTAAAACCAACA ATGGCATTCATGTCAGGGAAATTGAAGATTAAAGGTAACATGGCCCTAGCAATCAAATTGGAGAAGCTAATGAATCAGATGAATGCCAGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ADCY2_ENST00000338316_chr5_7773214_+_HSDL2_ENST00000398805_chr9_115179121_+_5201nt AGGCGGCGCGGGGGTGGGACGCGGGCGGCCGCGGCGAGCGGCGCTGCCCGGGCCGGGCGCGCACGGCGGGCGCCCTGTGAGCGGCCCCGA TGTGGCAGGAGGCGATGCGGCGCCGCCGCTACCTGCGGGACCGCTCCGAGGAGGCGGCGGGCGGCGGAGACGGGCTGCCGCGGTCCCGGG ACTGGCTCTACGAGTCCTACTACTGCATGAGCCAGCAGCACCCGCTCATCGTCTTCCTGCTGCTCATCGTCATGGGCTCCTGCCTCGCCC TGCTCGCCGTCTTCTTCGCGCTCGGGCTGGAAGTTGAAGACCATGTGGCGTTTCTAATAACAGTTCCAACTGCCCTGGCGATTTTCTTTG CGATATTTATCCTGGTCTGCATCGAGTCTGTGTTTAAGAAGCTGCTGCGCCTCTTCTCGTTGGTGATATGGATATGCCTTGTTGCCATGG GATACCTGTTCATGTGTTTTGGAGGCACCGTCTCTCCCTGGGACCAGGTATCGTTCTTCCTCTTCATCATCTTCGTGGTGTACACCATGC TGCCCTTCAACATGCGAGACGCCATCATTGCCAGCGTCCTCACCTCCTCCTCCCACACCATCGTGCTTAGCGTCTGCCTGTCTGCAACAC CGGGAGGCAAGGAGCACCTGGTCTGGCAGATCCTGGCCAATGTGATCATTTTCATCTGTGGGAACCTGGCGGGAGCCTACCATAAGCACC TCATGGAACTCGCTCTTCAGCAAACATATCAGGACACCTGTAATTGCATCAAGTCGCGGATCAAGTTGGAATTTGAAAAACGTCAACAGG AGCGGCTTCTGCTCTCCCTGCTGCCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCC AGATGGAGAACACAAATAACTTCCACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCC GGCTGGCAAGTGACTGCTCCCCGGGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAAT GCATGAGAATTAAAATTTTAGGAGACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAA TGGGGCTGGACATGTGTGAAGCCATAAAGAAAGTGAGGGATGCTACTGGAGTTGATATCAACATGCGCGTGGGCGTGCATTCTGGGAATG TCCTGTGTGGCGTGATTGGTCTGCAGAAGTGGCAATATGATGTGTGGTCACATGATGTGACCTTGGCCAACCACATGGAAGCTGGAGGGG TCCCTGGACGTGTTCACATTTCTTCTGTCACCCTGGAGCACTTGAATGGCGCTTATAAAGTGGAGGAGGGAGATGGTGACATTAGGGACC CATATTTAAAACAGCACCTGGTGAAAACCTACTTTGTGATCAACCCCAAGGGAGAACGACGGAGCCCCCAGCATCTCTTCAGACCTCGCC ACACCCTTGATGGAGCCAAAATGAGGGCCTCGGTCCGCATGACCCGGTACTTGGAGTCCTGGGGGGCAGCCAAGCCCTTTGCACACCTAC ATCACAGGGACAGCATGACCACAGAGAACGGCAAGATCAGCACCACGGATGTACCCATGGGTCAGCATAATTTTCAAAATCGCACCTTAA GAACCAAGTCACAAAAGAAGAGATTTGAAGAAGAATTGAATGAAAGGATGATTCAAGCAATTGATGGGATTAATGCACAGAAGCAATGGC TCAAGTCTGAAGACATTCAGAGAATCTCACTGCTTTTCTATAACAAAGTACTAGAAAAAGAGTACCGGGCCACGGCACTGCCAGCGTTCA AGTATTATGTGACTTGTGCCTGTCTCATATTCTTCTGCATCTTCATTGTGCAGATTCTCGTGCTGCCAAAAACGTCCGTCCTGGGCATCT CCTTTGGGGCTGCGTTTCTCTTGCTGGCCTTCATCCTCTTCGTCTGCTTTGCTGGACAGCTTCTGCAATGCAGCAAAAAAGCCTCTCCCC TGCTCATGTGGCTTTTGAAGTCCTCGGGCATCATTGCCAACCGCCCCTGGCCACGGATCTCTCTCACGATCATCACCACAGCCATCATAT TAATGATGGCCGTGTTCAACATGTTTTTCCTGAGTGACTCAGAGGAAACAATCCCTCCAACTGCCAACACAACAAACACAAGCTTTTCAG CCTCAAATAATCAGGTGGCGATTCTGCGTGCGCAGAATTTATTTTTCCTCCCGTACTTTATCTACAGCTGCATTCTGGGACTGATATCCT GTTCCGTGTTCCTGCGGGTAAACTATGAGCTGAAGATGTTGATCATGATGGTGGCCTTGGTGGGCTACAACACCATCCTACTCCACACCC ACGCCCACGTCCTGGGCGACTACAGCCAGGTCTTATTTGAGAGATCTAAAGCATGTATTCCTTATTTGAAAAAGAGCAAAGTTGCTCATA TCCTCAATATCAGTCCACCACTGAACCTAAATCCAGTTTGGTTCAAACAGCACTGTGCTTATACCATTGCTAAGTATGGTATGTCTATGT ATGTGCTTGGAATGGCAGAAGAATTTAAAGGTGAAATTGCAGTCAATGCATTATGGCCTAAAACAGCCATACACACTGCTGCTATGGATA TGCTGGGAGGACCTGGTATCGAAAGCCAGTGTAGAAAAGTTGATATCATTGCAGATGCAGCATATTCCATTTTCCAAAAGCCAAAAAGTT TTACTGGCAACTTTGTCATTGATGAAAATATCTTAAAAGAAGAAGGAATAGAAAATTTTGACGTTTATGCAATTAAACCAGGTCATCCTT TGCAACCAGATTTCTTCTTAGATGAATACCCAGAAGCAGTTAGCAAGAAAGTGGAATCAACTGGTGCTGTTCCAGAATTCAAAGAAGAGA AACTGCAGCTGCAACCAAAACCACGTTCTGGAGCTGTGGAAGAAACATTTAGAATTGTTAAGGACTCTCTCAGTGATGATGTTGTTAAAG CCACTCAAGCAATCTATCTGTTTGAACTCTCCGGTGAAGATGGTGGCACGTGGTTTCTTGATCTGAAAAGCAAGGGTGGGAATGTCGGAT ATGGAGAGCCTTCTGATCAGGCAGATGTGGTGATGAGTATGACTACTGATGACTTTGTAAAAATGTTTTCAGGGAAACTAAAACCAACAA TGGCATTCATGTCAGGGAAATTGAAGATTAAAGGTAACATGGCCCTAGCAATCAAATTGGAGAAGCTAATGAATCAGATGAATGCCAGAC TGTGAAGGAAAATATAAAAAAAAAGTCGACTGCTATGCTCAAAAAGTAAAAAAAGCTCAACAGTTAAAATCTAATGTTTGTTTTCTTTCC TGTTATATTATAAGGATATGCACGTTTGTTCTGGAAAAGATAGAATTTGTCTCTAAAAGACTTGAAATTGTAATTAAAATGGCAAGCTAA TCAAACATAAGCTTCATTAAGTGGGATTCTAAGACAGTCTGTGTTTTTATATTTCAAGGGTTTAACCCTTTGAGCCTTACATCTCATTCA CTGTCTTTCTCCAAGAAAAGTATTTTGGGCGGACAGTCAGATCAAGCAGTAAAATTAGCTCTTTCAAATCTTCTTGTCATGTAAAATGAA GCTAGTCTGTTTTAAAATTTTTAGTTTTGGATTGTATACTAATGAAAATCTTAATGATGTTTTTGATTTTTATATACTTATTTTAAAGAA AATCTTATATAGTACATTTTACAAAAATTATAAAAAATGAATTAGTACTGGCGAGGACTAAATGAAACAATAATTTTTCATTTTGATAAC TAGCTTTCCAGGTGGACTTAGCCATAGGAAAATATTACTAATGTAATTTAACAAATTGCTGCATGTATTCCATTTAAAAATATGTTTAAA TTGTCCTAAAACAAAATAATTTTCTCCCTAGGAGTATGCATTTGGCTACAGTGTTTTGAAACAGAAACCTTAGAATAGGTCATTGGTATG GGCTGAACTGTGTATCCCCCAATTCATTTGTTGAGGTCCTAACTCCCATTTCTTTTGAATGTGACTGTTCGGAGATGAGGCCTTTAAAGA GGTGACTTAAGTTCAAAGGAGGCTGTTAGTCTAATCCAACATGGTGTCCTTTGGACATAAGAGATACCAGCAATGTGTGCACAGAACAAA GACCAGGAGAGGACACAGTGAGAAGGCAGTTATCTGCAAGCAAAGAGAGAGGCTTCAGAAGAAACAAAATCACCAGCACCTTGATCTTTG ACTTCTAATCTCCAGAATAGTGAGAAATAAATTTCTGTTGTTAAGCCGTCCACTGTGGGAGGCCGACGCAGGAGGATTGCTTGAGGCCAG GAGTTCAAGGCCAGCCTGGACAACATAGTAAGACCCTATCTCTACCCCCCTAATAAATTAATTTAAAAAGCCCCCCAATCTGTGGTATTT TATTATGGCAGCCCTAGCAAGCTAATACAGTGGTTTGAGAGGCTGGGAGGGTTGAGGGGAAGATAAACTTTTAAAAAGCTCTTATCTTTC ATTTCAATCAGTTAAAAATACTTGCTCAGTGTAACAATTTTGCTTCTCAGCTTCCACTCTAATATTGTTGTGCCATTAAGCAATTTAGCT AATCCTGACATTTCTTAGATTCATAATGTTAGGAGCATTTAATCTGTATTTTACAAGTTAGGAAGCAGAGGATCAGAGATGGGAAAGGAC TAGCCCAAGGCCAACATTAACAAGCCCTCTAACAAAAACTTTACAATACATTTATGTTGAATGGAACTCCAAGATCTCACCTCTCCATCC AGGAATGGAGTCCATGTAATCAAAGTGAACTTAAAAATAGGACAGTTTCAACAAGTCAGGAGATTCACAGCAACTGATCAAAGGGAGTCC AGTCAACGTGAGCAAGCGTGATTATGATGAGGAAGCCCCCTCTGCTTTAATCCACACAAGGAACGTAACCTGAAGTAACCTGATGTTAAC CAATCTGCTGTGTCTACTATGCTGTTTCCTTGTTCCTGCTAGTGCTGCTTTACAAATGCAGACCATTCTATCATACCTGGCGGGGCTTCT >In-frame_ADCY2_ENST00000537121_chr5_7773214_+_HSDL2_ENST00000398805_chr9_115179121_+_4638nt GAGGAGTTTGGTAGAAATCCCAGAAGAGCTGTTGAGAAGACCAGTGGAGCCACACGTCTAGAGGTCATGGACCTGCGCTGGGCCAGAGAT CTGCATTTGAGAGAAGCCAGCAGATCAGTAGCATTTACCACCCTGAGGCTGGGCGCAGTCACCACGGGACTCCTGACATTCAGAGAGCCA GGAGATAAAGAGAAGTCAGGAAAGGGCCTTGGGAAGAGATGGCGCATCCAGCGAGAGGAAAGCCAGGAGCGGCTTCTGCTCTCCCTGCTG CCGGCCCACATCGCCATGGAGATGAAAGCGGAGATCATCCAGAGGCTGCAGGGCCCCAAGGCGGGCCAGATGGAGAACACAAATAACTTC CACAACCTGTATGTGAAGCGGCATACAAACGTGAGCATCTTATACGCTGACATCGTTGGCTTTACCCGGCTGGCAAGTGACTGCTCCCCG GGAGAACTAGTCCACATGCTGAATGAGCTCTTTGGAAAGTTTGATCAAATTGCAAAGGAGAATGAATGCATGAGAATTAAAATTTTAGGA GACTGCTACTACTGTGTATCTGGACTCCCTATATCTCTCCCTAACCATGCCAAGAACTGTGTGAAAATGGGGCTGGACATGTGTGAAGCC ATAAAGAAAGTGAGGGATGCTACTGGAGTTGATATCAACATGCGCGTGGGCGTGCATTCTGGGAATGTCCTGTGTGGCGTGATTGGTCTG CAGAAGTGGCAATATGATGTGTGGTCACATGATGTGACCTTGGCCAACCACATGGAAGCTGGAGGGGTCCCTGGACGTGTTCACATTTCT TCTGTCACCCTGGAGCACTTGAATGGCGCTTATAAAGTGGAGGAGGGAGATGGTGACATTAGGGACCCATATTTAAAACAGCACCTGGTG AAAACCTACTTTGTGATCAACCCCAAGGGAGAACGACGGAGCCCCCAGCATCTCTTCAGACCTCGCCACACCCTTGATGGAGCCAAAATG AGGGCCTCGGTCCGCATGACCCGGTACTTGGAGTCCTGGGGGGCAGCCAAGCCCTTTGCACACCTACATCACAGGGACAGCATGACCACA GAGAACGGCAAGATCAGCACCACGGATGTACCCATGGGTCAGCATAATTTTCAAAATCGCACCTTAAGAACCAAGTCACAAAAGAAGAGA TTTGAAGAAGAATTGAATGAAAGGATGATTCAAGCAATTGATGGGATTAATGCACAGAAGCAATGGCTCAAGTCTGAAGACATTCAGAGA ATCTCACTGCTTTTCTATAACAAAGTACTAGAAAAAGAGTACCGGGCCACGGCACTGCCAGCGTTCAAGTATTATGTGACTTGTGCCTGT CTCATATTCTTCTGCATCTTCATTGTGCAGATTCTCGTGCTGCCAAAAACGTCCGTCCTGGGCATCTCCTTTGGGGCTGCGTTTCTCTTG CTGGCCTTCATCCTCTTCGTCTGCTTTGCTGGACAGCTTCTGCAATGCAGCAAAAAAGCCTCTCCCCTGCTCATGTGGCTTTTGAAGTCC TCGGGCATCATTGCCAACCGCCCCTGGCCACGGATCTCTCTCACGATCATCACCACAGCCATCATATTAATGATGGCCGTGTTCAACATG TTTTTCCTGAGTGACTCAGAGGAAACAATCCCTCCAACTGCCAACACAACAAACACAAGCTTTTCAGCCTCAAATAATCAGGTGGCGATT CTGCGTGCGCAGAATTTATTTTTCCTCCCGTACTTTATCTACAGCTGCATTCTGGGACTGATATCCTGTTCCGTGTTCCTGCGGGTAAAC TATGAGCTGAAGATGTTGATCATGATGGTGGCCTTGGTGGGCTACAACACCATCCTACTCCACACCCACGCCCACGTCCTGGGCGACTAC AGCCAGGTCTTATTTGAGAGATCTAAAGCATGTATTCCTTATTTGAAAAAGAGCAAAGTTGCTCATATCCTCAATATCAGTCCACCACTG AACCTAAATCCAGTTTGGTTCAAACAGCACTGTGCTTATACCATTGCTAAGTATGGTATGTCTATGTATGTGCTTGGAATGGCAGAAGAA TTTAAAGGTGAAATTGCAGTCAATGCATTATGGCCTAAAACAGCCATACACACTGCTGCTATGGATATGCTGGGAGGACCTGGTATCGAA AGCCAGTGTAGAAAAGTTGATATCATTGCAGATGCAGCATATTCCATTTTCCAAAAGCCAAAAAGTTTTACTGGCAACTTTGTCATTGAT GAAAATATCTTAAAAGAAGAAGGAATAGAAAATTTTGACGTTTATGCAATTAAACCAGGTCATCCTTTGCAACCAGATTTCTTCTTAGAT GAATACCCAGAAGCAGTTAGCAAGAAAGTGGAATCAACTGGTGCTGTTCCAGAATTCAAAGAAGAGAAACTGCAGCTGCAACCAAAACCA CGTTCTGGAGCTGTGGAAGAAACATTTAGAATTGTTAAGGACTCTCTCAGTGATGATGTTGTTAAAGCCACTCAAGCAATCTATCTGTTT GAACTCTCCGGTGAAGATGGTGGCACGTGGTTTCTTGATCTGAAAAGCAAGGGTGGGAATGTCGGATATGGAGAGCCTTCTGATCAGGCA GATGTGGTGATGAGTATGACTACTGATGACTTTGTAAAAATGTTTTCAGGGAAACTAAAACCAACAATGGCATTCATGTCAGGGAAATTG AAGATTAAAGGTAACATGGCCCTAGCAATCAAATTGGAGAAGCTAATGAATCAGATGAATGCCAGACTGTGAAGGAAAATATAAAAAAAA AGTCGACTGCTATGCTCAAAAAGTAAAAAAAGCTCAACAGTTAAAATCTAATGTTTGTTTTCTTTCCTGTTATATTATAAGGATATGCAC GTTTGTTCTGGAAAAGATAGAATTTGTCTCTAAAAGACTTGAAATTGTAATTAAAATGGCAAGCTAATCAAACATAAGCTTCATTAAGTG GGATTCTAAGACAGTCTGTGTTTTTATATTTCAAGGGTTTAACCCTTTGAGCCTTACATCTCATTCACTGTCTTTCTCCAAGAAAAGTAT TTTGGGCGGACAGTCAGATCAAGCAGTAAAATTAGCTCTTTCAAATCTTCTTGTCATGTAAAATGAAGCTAGTCTGTTTTAAAATTTTTA GTTTTGGATTGTATACTAATGAAAATCTTAATGATGTTTTTGATTTTTATATACTTATTTTAAAGAAAATCTTATATAGTACATTTTACA AAAATTATAAAAAATGAATTAGTACTGGCGAGGACTAAATGAAACAATAATTTTTCATTTTGATAACTAGCTTTCCAGGTGGACTTAGCC ATAGGAAAATATTACTAATGTAATTTAACAAATTGCTGCATGTATTCCATTTAAAAATATGTTTAAATTGTCCTAAAACAAAATAATTTT CTCCCTAGGAGTATGCATTTGGCTACAGTGTTTTGAAACAGAAACCTTAGAATAGGTCATTGGTATGGGCTGAACTGTGTATCCCCCAAT TCATTTGTTGAGGTCCTAACTCCCATTTCTTTTGAATGTGACTGTTCGGAGATGAGGCCTTTAAAGAGGTGACTTAAGTTCAAAGGAGGC TGTTAGTCTAATCCAACATGGTGTCCTTTGGACATAAGAGATACCAGCAATGTGTGCACAGAACAAAGACCAGGAGAGGACACAGTGAGA AGGCAGTTATCTGCAAGCAAAGAGAGAGGCTTCAGAAGAAACAAAATCACCAGCACCTTGATCTTTGACTTCTAATCTCCAGAATAGTGA GAAATAAATTTCTGTTGTTAAGCCGTCCACTGTGGGAGGCCGACGCAGGAGGATTGCTTGAGGCCAGGAGTTCAAGGCCAGCCTGGACAA CATAGTAAGACCCTATCTCTACCCCCCTAATAAATTAATTTAAAAAGCCCCCCAATCTGTGGTATTTTATTATGGCAGCCCTAGCAAGCT AATACAGTGGTTTGAGAGGCTGGGAGGGTTGAGGGGAAGATAAACTTTTAAAAAGCTCTTATCTTTCATTTCAATCAGTTAAAAATACTT GCTCAGTGTAACAATTTTGCTTCTCAGCTTCCACTCTAATATTGTTGTGCCATTAAGCAATTTAGCTAATCCTGACATTTCTTAGATTCA TAATGTTAGGAGCATTTAATCTGTATTTTACAAGTTAGGAAGCAGAGGATCAGAGATGGGAAAGGACTAGCCCAAGGCCAACATTAACAA GCCCTCTAACAAAAACTTTACAATACATTTATGTTGAATGGAACTCCAAGATCTCACCTCTCCATCCAGGAATGGAGTCCATGTAATCAA AGTGAACTTAAAAATAGGACAGTTTCAACAAGTCAGGAGATTCACAGCAACTGATCAAAGGGAGTCCAGTCAACGTGAGCAAGCGTGATT ATGATGAGGAAGCCCCCTCTGCTTTAATCCACACAAGGAACGTAACCTGAAGTAACCTGATGTTAACCAATCTGCTGTGTCTACTATGCT GTTTCCTTGTTCCTGCTAGTGCTGCTTTACAAATGCAGACCATTCTATCATACCTGGCGGGGCTTCTGTTTTATTTTGTAGGCTGGATGC |
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FusionGenePPI for ADCY2_HSDL2 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ADCY2 | ADCY5, GNAS | HSDL2 | PEX5, ADRB2, FBXO6, PARK2, DLD, NDUFA8, SF1, TAGLN2, TRAP1, KRAS, TCTN3, CNTRL, NPHP1, RPGRIP1L, HDAC1, COQ9, PPM1A, MIPEP, HERC2, F2RL1, NEURL4, NIPSNAP3A, DNAJC9, XRCC4, DNPEP, KIF3A, DLST, PDHA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 905_922 | 794 | 1092 | GNAS |
| Hgene | ADCY2 | chr5:7773214 | chr9:115179121 | ENST00000338316 | + | 18 | 25 | 990_993 | 794 | 1092 | GNAS |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADCY2_HSDL2 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ADCY2 | Q08462 | DB09121 | Aurothioglucose | Adenylate cyclase type 2 | small molecule | approved|withdrawn |
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RelatedDiseases for ADCY2_HSDL2 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ADCY2 | C0004096 | Asthma | 1 | CTD_human |
| Hgene | ADCY2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
| Tgene | HSDL2 | C0023903 | Liver neoplasms | 1 | CTD_human |
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