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Fusion gene ID: 8167 |
FusionGeneSummary for COX4I1_TOMM22 |
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Fusion gene information | Fusion gene name: COX4I1_TOMM22 | Fusion gene ID: 8167 | Hgene | Tgene | Gene symbol | COX4I1 | TOMM22 | Gene ID | 1327 | 56993 |
Gene name | cytochrome c oxidase subunit 4I1 | translocase of outer mitochondrial membrane 22 | |
Synonyms | COX IV-1|COX4|COX4-1|COXIV|COXIV-1 | 1C9-2|MST065|MSTP065|TOM22 | |
Cytomap | 16q24.1 | 22q13.1 | |
Type of gene | protein-coding | protein-coding | |
Description | cytochrome c oxidase subunit 4 isoform 1, mitochondrialcytochrome c oxidase polypeptide IVcytochrome c oxidase subunit IV | mitochondrial import receptor subunit TOM22 homologmitochondrial import receptor Tom22translocase of outer membrane 22 kDa subunit homologtranslocase of outer mitochondrial membrane 22 homolog | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P13073 | Q9NS69 | |
Ensembl transtripts involved in fusion gene | ENST00000570123, ENST00000568794, ENST00000253452, ENST00000562336, ENST00000561569, ENST00000564903, | ENST00000216034, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 2=8 |
# samples | 2 | 2 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: COX4I1 [Title/Abstract] AND TOMM22 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | TOMM22 | GO:0045040 | protein import into mitochondrial outer membrane | 15644312 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA740171 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000570123 | ENST00000216034 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
3UTR-3CDS | ENST00000568794 | ENST00000216034 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
Frame-shift | ENST00000253452 | ENST00000216034 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
Frame-shift | ENST00000562336 | ENST00000216034 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
Frame-shift | ENST00000561569 | ENST00000216034 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
3UTR-3CDS | ENST00000564903 | ENST00000216034 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
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FusionProtFeatures for COX4I1_TOMM22 |
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Hgene | Tgene |
COX4I1 | TOMM22 |
This protein is one of the nuclear-coded polypeptidechains of cytochrome c oxidase, the terminal oxidase inmitochondrial electron transport. | Central receptor component of the translocase of theouter membrane of mitochondria (TOM complex) responsible for therecognition and translocation of cytosolically synthesizedmitochondrial preproteins. Together with the peripheral receptorTOM20 functions as the transit peptide receptor and facilitatesthe movement of preproteins into the translocation pore.{ECO:0000269|PubMed:10982837}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for COX4I1_TOMM22 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for COX4I1_TOMM22 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COX4I1_TOMM22 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | COX4I1 | P13073 | DB02659 | Cholic Acid | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | small molecule | approved |
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RelatedDiseases for COX4I1_TOMM22 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |