|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 8167 |
FusionGeneSummary for COX4I1_TOMM22 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COX4I1_TOMM22 | Fusion gene ID: 8167 | Hgene | Tgene | Gene symbol | COX4I1 | TOMM22 | Gene ID | 1327 | 56993 |
| Gene name | cytochrome c oxidase subunit 4I1 | translocase of outer mitochondrial membrane 22 | |
| Synonyms | COX IV-1|COX4|COX4-1|COXIV|COXIV-1 | 1C9-2|MST065|MSTP065|TOM22 | |
| Cytomap | 16q24.1 | 22q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | cytochrome c oxidase subunit 4 isoform 1, mitochondrialcytochrome c oxidase polypeptide IVcytochrome c oxidase subunit IV | mitochondrial import receptor subunit TOM22 homologmitochondrial import receptor Tom22translocase of outer membrane 22 kDa subunit homologtranslocase of outer mitochondrial membrane 22 homolog | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P13073 | Q9NS69 | |
| Ensembl transtripts involved in fusion gene | ENST00000570123, ENST00000568794, ENST00000253452, ENST00000562336, ENST00000561569, ENST00000564903, | ENST00000216034, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 2=8 |
| # samples | 2 | 2 | |
| ** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: COX4I1 [Title/Abstract] AND TOMM22 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TOMM22 | GO:0045040 | protein import into mitochondrial outer membrane | 15644312 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA740171 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000570123 | ENST00000216034 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
| 3UTR-3CDS | ENST00000568794 | ENST00000216034 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
| Frame-shit | ENST00000253452 | ENST00000216034 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
| Frame-shit | ENST00000562336 | ENST00000216034 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
| Frame-shit | ENST00000561569 | ENST00000216034 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
| 3UTR-3CDS | ENST00000564903 | ENST00000216034 | COX4I1 | chr16 | 85840356 | - | TOMM22 | chr22 | 39078421 | - |
Top |
FusionProtFeatures for COX4I1_TOMM22 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COX4I1 | TOMM22 |
| This protein is one of the nuclear-coded polypeptidechains of cytochrome c oxidase, the terminal oxidase inmitochondrial electron transport. | Central receptor component of the translocase of theouter membrane of mitochondria (TOM complex) responsible for therecognition and translocation of cytosolically synthesizedmitochondrial preproteins. Together with the peripheral receptorTOM20 functions as the transit peptide receptor and facilitatesthe movement of preproteins into the translocation pore.{ECO:0000269|PubMed:10982837}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for COX4I1_TOMM22 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for COX4I1_TOMM22 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for COX4I1_TOMM22 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | COX4I1 | P13073 | DB02659 | Cholic Acid | Cytochrome c oxidase subunit 4 isoform 1, mitochondrial | small molecule | approved |
Top |
RelatedDiseases for COX4I1_TOMM22 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|