![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 8160 |
FusionGeneSummary for COX18_INPP4B |
![]() |
Fusion gene information | Fusion gene name: COX18_INPP4B | Fusion gene ID: 8160 | Hgene | Tgene | Gene symbol | COX18 | INPP4B | Gene ID | 285521 | 8821 |
Gene name | COX18, cytochrome c oxidase assembly factor | inositol polyphosphate-4-phosphatase type II B | |
Synonyms | COX18HS | - | |
Cytomap | 4q13.3 | 4q31.21 | |
Type of gene | protein-coding | protein-coding | |
Description | cytochrome c oxidase assembly protein COX18, mitochondrialcytochrome c oxidase assembly homolog 18cytochrome c oxidase assembly protein 18mitochondrial inner membrane protein COX18 | type II inositol 3,4-bisphosphate 4-phosphataseinositol polyphosphate 4-phosphatase II; 4-phosphatase IIinositol polyphosphate-4-phosphatase, type II, 105kDa | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q8N8Q8 | O15327 | |
Ensembl transtripts involved in fusion gene | ENST00000295890, ENST00000507544, ENST00000421792, | ENST00000513000, ENST00000509777, ENST00000262992, ENST00000308502, ENST00000508116, ENST00000507861, ENST00000506217, ENST00000508084, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 9 X 7 X 6=378 |
# samples | 2 | 9 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: COX18 [Title/Abstract] AND INPP4B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | COX18 | GO:0032979 | protein insertion into mitochondrial membrane from inner side | 28330871 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-C8-A1HN-01A | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000295890 | ENST00000513000 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-5UTR | ENST00000295890 | ENST00000509777 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-5UTR | ENST00000295890 | ENST00000262992 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-intron | ENST00000295890 | ENST00000308502 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-5UTR | ENST00000295890 | ENST00000508116 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-5UTR | ENST00000295890 | ENST00000507861 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-intron | ENST00000295890 | ENST00000506217 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-intron | ENST00000295890 | ENST00000508084 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-5UTR | ENST00000507544 | ENST00000513000 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-5UTR | ENST00000507544 | ENST00000509777 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-5UTR | ENST00000507544 | ENST00000262992 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-intron | ENST00000507544 | ENST00000308502 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-5UTR | ENST00000507544 | ENST00000508116 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-5UTR | ENST00000507544 | ENST00000507861 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-intron | ENST00000507544 | ENST00000506217 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
5CDS-intron | ENST00000507544 | ENST00000508084 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
intron-5UTR | ENST00000421792 | ENST00000513000 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
intron-5UTR | ENST00000421792 | ENST00000509777 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
intron-5UTR | ENST00000421792 | ENST00000262992 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
intron-intron | ENST00000421792 | ENST00000308502 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
intron-5UTR | ENST00000421792 | ENST00000508116 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
intron-5UTR | ENST00000421792 | ENST00000507861 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
intron-intron | ENST00000421792 | ENST00000506217 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
intron-intron | ENST00000421792 | ENST00000508084 | COX18 | chr4 | 73930967 | - | INPP4B | chr4 | 143383879 | - |
Top |
FusionProtFeatures for COX18_INPP4B |
![]() |
Hgene | Tgene |
COX18 | INPP4B |
Mitochondrial membrane insertase required for thetranslocation of the C-terminus of cytochrome c oxidase subunit II(MT-CO2/COX2) across the mitochondrial inner membrane. Plays arole in MT-CO2/COX2 maturation following the COX20-mediatedstabilization of newly synthesized MT-CO2/COX2 protein and beforethe action of the metallochaperones SCO1/2. Essential for theassembly and stability of the mitochondrial respiratory chaincomplex IV (also known as cytochrome c oxidase).{ECO:0000269|PubMed:16911509, ECO:0000269|PubMed:28330871}. | Catalyzes the hydrolysis of the 4-position phosphate ofphosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for COX18_INPP4B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for COX18_INPP4B |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
COX18 | VNN2 | INPP4B | ELAVL1, PYCARD, ZNF131 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for COX18_INPP4B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for COX18_INPP4B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |