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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8153

FusionGeneSummary for COX10_PCGF3

check button Fusion gene summary
Fusion gene informationFusion gene name: COX10_PCGF3
Fusion gene ID: 8153
HgeneTgene
Gene symbol

COX10

PCGF3

Gene ID

1352

10336

Gene nameCOX10, heme A:farnesyltransferase cytochrome c oxidase assembly factorpolycomb group ring finger 3
Synonyms-DONG1|RNF3|RNF3A
Cytomap

17p12

4p16.3

Type of geneprotein-codingprotein-coding
Descriptionprotoheme IX farnesyltransferase, mitochondrialCOX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferasecytochrome c oxidase assembly homolog 10cytochrome c oxidase assembly proteincytochrome c oxidase subunit Xheme A: farnesypolycomb group RING finger protein 3RING finger protein 3Aring finger protein 3
Modification date2018052320180523
UniProtAcc

Q12887

Q3KNV8

Ensembl transtripts involved in fusion geneENST00000261643, ENST00000536205, 
ENST00000537334, ENST00000429152, 
ENST00000362003, ENST00000400151, 
ENST00000482726, ENST00000470161, 
ENST00000521023, ENST00000505655, 
Fusion gene scores* DoF score2 X 2 X 2=84 X 4 X 3=48
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COX10 [Title/Abstract] AND PCGF3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DB233923COX10chr17

13982667

+PCGF3chr4

760119

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000261643ENST00000362003COX10chr17

13982667

+PCGF3chr4

760119

+
intron-intronENST00000261643ENST00000400151COX10chr17

13982667

+PCGF3chr4

760119

+
intron-intronENST00000261643ENST00000482726COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000261643ENST00000470161COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000261643ENST00000521023COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000261643ENST00000505655COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000536205ENST00000362003COX10chr17

13982667

+PCGF3chr4

760119

+
intron-intronENST00000536205ENST00000400151COX10chr17

13982667

+PCGF3chr4

760119

+
intron-intronENST00000536205ENST00000482726COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000536205ENST00000470161COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000536205ENST00000521023COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000536205ENST00000505655COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000537334ENST00000362003COX10chr17

13982667

+PCGF3chr4

760119

+
intron-intronENST00000537334ENST00000400151COX10chr17

13982667

+PCGF3chr4

760119

+
intron-intronENST00000537334ENST00000482726COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000537334ENST00000470161COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000537334ENST00000521023COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000537334ENST00000505655COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000429152ENST00000362003COX10chr17

13982667

+PCGF3chr4

760119

+
intron-intronENST00000429152ENST00000400151COX10chr17

13982667

+PCGF3chr4

760119

+
intron-intronENST00000429152ENST00000482726COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000429152ENST00000470161COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000429152ENST00000521023COX10chr17

13982667

+PCGF3chr4

760119

+
intron-3UTRENST00000429152ENST00000505655COX10chr17

13982667

+PCGF3chr4

760119

+

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FusionProtFeatures for COX10_PCGF3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COX10

Q12887

PCGF3

Q3KNV8

Converts protoheme IX and farnesyl diphosphate to hemeO. {ECO:0000250}. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain thetranscriptionally repressive state of many genes, including Hoxgenes, throughout development. PcG PRC1 complex acts via chromatinremodeling and modification of histones; it mediatesmonoubiquitination of histone H2A 'Lys-119', rendering chromatinheritably changed in its expressibility. Within the PRC1-likecomplex, regulates RNF2 ubiquitin ligase activity(PubMed:26151332). Plays a redundant role with PCGF5 as part of aPRC1-like complex that mediates monoubiquitination of histone H2A'Lys-119' on the X chromosome and is required for normal silencingof one copy of the X chromosome in XX females (By similarity).{ECO:0000250|UniProtKB:Q8BTQ0, ECO:0000269|PubMed:26151332}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COX10_PCGF3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COX10_PCGF3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COX10_PCGF3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COX10_PCGF3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOX10C0268237Cytochrome-c Oxidase Deficiency3ORPHANET;UNIPROT