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Fusion gene ID: 8148 |
FusionGeneSummary for COTL1_G6PC3 |
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Fusion gene information | Fusion gene name: COTL1_G6PC3 | Fusion gene ID: 8148 | Hgene | Tgene | Gene symbol | COTL1 | G6PC3 | Gene ID | 23406 | 92579 |
Gene name | coactosin like F-actin binding protein 1 | glucose-6-phosphatase catalytic subunit 3 | |
Synonyms | CLP | SCN4|UGRP | |
Cytomap | 16q24.1 | 17q21.31 | |
Type of gene | protein-coding | protein-coding | |
Description | coactosin-like proteincoactosin-like 1 | glucose-6-phosphatase 3G-6-Pase 3G6Pase 3G6Pase-betaglucose 6 phosphatase, catalytic, 3ubiquitous glucose-6-phosphatase catalytic subunit-related proteinubiquitously expressed G6Pase catalytic subunit-related protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q14019 | Q9BUM1 | |
Ensembl transtripts involved in fusion gene | ENST00000262428, ENST00000567278, ENST00000564057, | ENST00000269097, | |
Fusion gene scores | * DoF score | 5 X 5 X 2=50 | 2 X 2 X 2=8 |
# samples | 5 | 2 | |
** MAII score | log2(5/50*10)=0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: COTL1 [Title/Abstract] AND G6PC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BP430643 | COTL1 | chr16 | 84599590 | - | G6PC3 | chr17 | 42153420 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3UTR | ENST00000262428 | ENST00000269097 | COTL1 | chr16 | 84599590 | - | G6PC3 | chr17 | 42153420 | + |
intron-3UTR | ENST00000567278 | ENST00000269097 | COTL1 | chr16 | 84599590 | - | G6PC3 | chr17 | 42153420 | + |
intron-3UTR | ENST00000564057 | ENST00000269097 | COTL1 | chr16 | 84599590 | - | G6PC3 | chr17 | 42153420 | + |
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FusionProtFeatures for COTL1_G6PC3 |
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Hgene | Tgene |
COTL1 | G6PC3 |
Binds to F-actin in a calcium-independent manner. Has nodirect effect on actin depolymerization. Acts as a chaperone forALOX5 (5LO), influencing both its stability and activity inleukotrienes synthesis. {ECO:0000269|PubMed:11583571,ECO:0000269|PubMed:19807693}. | Hydrolyzes glucose-6-phosphate to glucose in theendoplasmic reticulum. May form with the glucose-6-phosphatetransporter (SLC37A4/G6PT) a ubiquitously expressed complexresponsible for glucose production through glycogenolysis andgluconeogenesis. Probably required for normal neutrophil function.{ECO:0000269|PubMed:12370122, ECO:0000269|PubMed:12965222,ECO:0000269|PubMed:13129915}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for COTL1_G6PC3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for COTL1_G6PC3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COTL1_G6PC3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COTL1_G6PC3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | COTL1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | COTL1 | C1458155 | Mammary Neoplasms | 1 | CTD_human |
Tgene | G6PC3 | C2675526 | Neutropenia, Severe Congenital, Autosomal Recessive 4 | 5 | CTD_human;ORPHANET;UNIPROT |