![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 8131 |
FusionGeneSummary for CORO1C_PACRG |
![]() |
Fusion gene information | Fusion gene name: CORO1C_PACRG | Fusion gene ID: 8131 | Hgene | Tgene | Gene symbol | CORO1C | PACRG | Gene ID | 23603 | 135138 |
Gene name | coronin 1C | parkin coregulated | |
Synonyms | HCRNN4 | GLUP|HAK005771|PARK2CRG | |
Cytomap | 12q24.11 | 6q26 | |
Type of gene | protein-coding | protein-coding | |
Description | coronin-1Ccoronin, actin binding protein, 1Ccoronin-3 | parkin coregulated gene proteinPARK2 co-regulatedPARK2 coregulatedmolecular chaperone/chaperonin-binding proteinparkin co-regulated gene protein | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9ULV4 | Q96M98 | |
Ensembl transtripts involved in fusion gene | ENST00000261401, ENST00000541050, ENST00000549384, ENST00000421578, ENST00000420959, ENST00000549772, | ENST00000337019, ENST00000366889, ENST00000366888, ENST00000542669, | |
Fusion gene scores | * DoF score | 6 X 3 X 5=90 | 8 X 6 X 11=528 |
# samples | 6 | 12 | |
** MAII score | log2(6/90*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/528*10)=-2.13750352374993 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CORO1C [Title/Abstract] AND PACRG [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-XR-A8TG-01A | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000261401 | ENST00000337019 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
5UTR-3CDS | ENST00000261401 | ENST00000366889 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
5UTR-3CDS | ENST00000261401 | ENST00000366888 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
5UTR-intron | ENST00000261401 | ENST00000542669 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-3CDS | ENST00000541050 | ENST00000337019 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-3CDS | ENST00000541050 | ENST00000366889 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-3CDS | ENST00000541050 | ENST00000366888 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-intron | ENST00000541050 | ENST00000542669 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
5UTR-3CDS | ENST00000549384 | ENST00000337019 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
5UTR-3CDS | ENST00000549384 | ENST00000366889 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
5UTR-3CDS | ENST00000549384 | ENST00000366888 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
5UTR-intron | ENST00000549384 | ENST00000542669 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-3CDS | ENST00000421578 | ENST00000337019 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-3CDS | ENST00000421578 | ENST00000366889 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-3CDS | ENST00000421578 | ENST00000366888 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-intron | ENST00000421578 | ENST00000542669 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-3CDS | ENST00000420959 | ENST00000337019 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-3CDS | ENST00000420959 | ENST00000366889 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-3CDS | ENST00000420959 | ENST00000366888 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-intron | ENST00000420959 | ENST00000542669 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-3CDS | ENST00000549772 | ENST00000337019 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-3CDS | ENST00000549772 | ENST00000366889 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-3CDS | ENST00000549772 | ENST00000366888 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
intron-intron | ENST00000549772 | ENST00000542669 | CORO1C | chr12 | 109125205 | - | PACRG | chr6 | 163735859 | + |
Top |
FusionProtFeatures for CORO1C_PACRG |
![]() |
Hgene | Tgene |
CORO1C | PACRG |
May be involved in cytokinesis, motility, and signaltransduction. {ECO:0000250}. Isoform 3: Involved in myogenic differentiation. | Suppresses cell death induced by accumulation ofunfolded Pael receptor (Pael-R, a substrate of Parkin).Facilitates the formation of inclusions consisting of Pael-R,molecular chaperones, protein degradation molecules and itselfwhen proteasome is inhibited. May play an important role in theformation of Lewy bodies and protection of dopaminergic neuronsagainst Parkinson disease. {ECO:0000269|PubMed:14532270}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for CORO1C_PACRG |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for CORO1C_PACRG |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CORO1C | USP45, ELAVL1, CBL, UBASH3B, PIK3R2, SHC1, CRK, AP2M1, MRPS5, ACTB, STT3B, GNAI2, RAB7A, CYB5B, MMGT1, ACTR2, RHOB, TPM4, PREB, FMNL1, BTK, FN1, VCAM1, UBL4A, PAN2, LMO2, LRCH3, CORO1B, DNAJB11, VPS26A, VPS35, ETF1, FAM129B, GARS, H3F3A, NUDC, PAPOLA, SMOC1, TARS, TP53, ALK, CUL7, OBSL1, DAPK1, ABCE1, ACTG1, ACTR3, AIMP1, ATP6V1F, ALG9, FAP, MCTS1, MDH2, NFYC, NHP2L1, PHKB, RAD23B, SEPT10, SFTPA2, MRPL1, MYCBP, PDIA3, RPA1, SKP1, TIPRL, MED4, MED20, MED23, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, PPP1CC, IQGAP1, SYNPO, LIMA1, ANLN, MYO19, MYO18A, RCC2, RAC1, ESR1, PDP1, CORO6, CORO1A, GTPBP1, SSH1, DLST, PDHA1, TES | PACRG | HSP90AA1, CCT3, CCT4, CCT5, TCP1, CCT6A, CCT7, CCT2, TUBA1A, TUBB, HSPA4, PARK2, STUB1, DNAJA1, VCP, GPR37, APP, KLHL36, TP53, STIP1, CCDC40 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for CORO1C_PACRG |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for CORO1C_PACRG |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CORO1C | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
Hgene | CORO1C | C0017661 | IGA Glomerulonephritis | 1 | CTD_human |