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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8131

FusionGeneSummary for CORO1C_PACRG

check button Fusion gene summary
Fusion gene informationFusion gene name: CORO1C_PACRG
Fusion gene ID: 8131
HgeneTgene
Gene symbol

CORO1C

PACRG

Gene ID

23603

135138

Gene namecoronin 1Cparkin coregulated
SynonymsHCRNN4GLUP|HAK005771|PARK2CRG
Cytomap

12q24.11

6q26

Type of geneprotein-codingprotein-coding
Descriptioncoronin-1Ccoronin, actin binding protein, 1Ccoronin-3parkin coregulated gene proteinPARK2 co-regulatedPARK2 coregulatedmolecular chaperone/chaperonin-binding proteinparkin co-regulated gene protein
Modification date2018051920180523
UniProtAcc

Q9ULV4

Q96M98

Ensembl transtripts involved in fusion geneENST00000261401, ENST00000541050, 
ENST00000549384, ENST00000421578, 
ENST00000420959, ENST00000549772, 
ENST00000337019, ENST00000366889, 
ENST00000366888, ENST00000542669, 
Fusion gene scores* DoF score6 X 3 X 5=908 X 6 X 11=528
# samples 612
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(12/528*10)=-2.13750352374993
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CORO1C [Title/Abstract] AND PACRG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-XR-A8TG-01ACORO1Cchr12

109125205

-PACRGchr6

163735859

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000261401ENST00000337019CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-3CDSENST00000261401ENST00000366889CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-3CDSENST00000261401ENST00000366888CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-intronENST00000261401ENST00000542669CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000541050ENST00000337019CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000541050ENST00000366889CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000541050ENST00000366888CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-intronENST00000541050ENST00000542669CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-3CDSENST00000549384ENST00000337019CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-3CDSENST00000549384ENST00000366889CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-3CDSENST00000549384ENST00000366888CORO1Cchr12

109125205

-PACRGchr6

163735859

+
5UTR-intronENST00000549384ENST00000542669CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000421578ENST00000337019CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000421578ENST00000366889CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000421578ENST00000366888CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-intronENST00000421578ENST00000542669CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000420959ENST00000337019CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000420959ENST00000366889CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000420959ENST00000366888CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-intronENST00000420959ENST00000542669CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000549772ENST00000337019CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000549772ENST00000366889CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-3CDSENST00000549772ENST00000366888CORO1Cchr12

109125205

-PACRGchr6

163735859

+
intron-intronENST00000549772ENST00000542669CORO1Cchr12

109125205

-PACRGchr6

163735859

+

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FusionProtFeatures for CORO1C_PACRG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CORO1C

Q9ULV4

PACRG

Q96M98

May be involved in cytokinesis, motility, and signaltransduction. {ECO:0000250}. Isoform 3: Involved in myogenic differentiation. Suppresses cell death induced by accumulation ofunfolded Pael receptor (Pael-R, a substrate of Parkin).Facilitates the formation of inclusions consisting of Pael-R,molecular chaperones, protein degradation molecules and itselfwhen proteasome is inhibited. May play an important role in theformation of Lewy bodies and protection of dopaminergic neuronsagainst Parkinson disease. {ECO:0000269|PubMed:14532270}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CORO1C_PACRG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CORO1C_PACRG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CORO1CUSP45, ELAVL1, CBL, UBASH3B, PIK3R2, SHC1, CRK, AP2M1, MRPS5, ACTB, STT3B, GNAI2, RAB7A, CYB5B, MMGT1, ACTR2, RHOB, TPM4, PREB, FMNL1, BTK, FN1, VCAM1, UBL4A, PAN2, LMO2, LRCH3, CORO1B, DNAJB11, VPS26A, VPS35, ETF1, FAM129B, GARS, H3F3A, NUDC, PAPOLA, SMOC1, TARS, TP53, ALK, CUL7, OBSL1, DAPK1, ABCE1, ACTG1, ACTR3, AIMP1, ATP6V1F, ALG9, FAP, MCTS1, MDH2, NFYC, NHP2L1, PHKB, RAD23B, SEPT10, SFTPA2, MRPL1, MYCBP, PDIA3, RPA1, SKP1, TIPRL, MED4, MED20, MED23, CAPZA2, CDK2, DBN1, FLNA, MYH9, MYO1C, PPP1CB, PPP1CC, IQGAP1, SYNPO, LIMA1, ANLN, MYO19, MYO18A, RCC2, RAC1, ESR1, PDP1, CORO6, CORO1A, GTPBP1, SSH1, DLST, PDHA1, TESPACRGHSP90AA1, CCT3, CCT4, CCT5, TCP1, CCT6A, CCT7, CCT2, TUBA1A, TUBB, HSPA4, PARK2, STUB1, DNAJA1, VCP, GPR37, APP, KLHL36, TP53, STIP1, CCDC40


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CORO1C_PACRG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CORO1C_PACRG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCORO1CC0007131Non-Small Cell Lung Carcinoma1CTD_human
HgeneCORO1CC0017661IGA Glomerulonephritis1CTD_human