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Fusion gene ID: 813 |
FusionGeneSummary for ADCY2_CASC3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ADCY2_CASC3 | Fusion gene ID: 813 | Hgene | Tgene | Gene symbol | ADCY2 | CASC3 | Gene ID | 108 | 22794 |
| Gene name | adenylate cyclase 2 | CASC3, exon junction complex subunit | |
| Synonyms | AC2|HBAC2 | BTZ|MLN51 | |
| Cytomap | 5p15.31 | 17q21.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | adenylate cyclase type 23',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 2adenylate cyclase 2 (brain)adenylate cyclase IIadenylate cyclase type IIadenylyl cyclase 2type II adenylate cyclase | protein CASC3MLN 51barentszcancer susceptibility 3cancer susceptibility candidate 3cancer susceptibility candidate gene 3 proteinmetastatic lymph node 51metastatic lymph node gene 51 proteinprotein barentsz | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q08462 | O15234 | |
| Ensembl transtripts involved in fusion gene | ENST00000338316, ENST00000537121, ENST00000513693, | ENST00000264645, | |
| Fusion gene scores | * DoF score | 20 X 19 X 5=1900 | 8 X 4 X 4=128 |
| # samples | 21 | 8 | |
| ** MAII score | log2(21/1900*10)=-3.17753818555219 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/128*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ADCY2 [Title/Abstract] AND CASC3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | CESC | TCGA-MA-AA43-01A | ADCY2 | chr5 | 7414883 | + | CASC3 | chr17 | 38318006 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000338316 | ENST00000264645 | ADCY2 | chr5 | 7414883 | + | CASC3 | chr17 | 38318006 | + |
| intron-3CDS | ENST00000537121 | ENST00000264645 | ADCY2 | chr5 | 7414883 | + | CASC3 | chr17 | 38318006 | + |
| intron-3CDS | ENST00000513693 | ENST00000264645 | ADCY2 | chr5 | 7414883 | + | CASC3 | chr17 | 38318006 | + |
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FusionProtFeatures for ADCY2_CASC3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ADCY2 | CASC3 |
| Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling (PubMed:15385642). Down-streamsignaling cascades mediate changes in gene expression patterns andlead to increased IL6 production. Functions in signaling cascadesdownstream of the muscarinic acetylcholine receptors (Bysimilarity). {ECO:0000250|UniProtKB:P26769,ECO:0000269|PubMed:15385642}. | Core component of the splicing-dependent multiproteinexon junction complex (EJC) deposited at splice junctions onmRNAs. The EJC is a dynamic structure consisting of core proteinsand several peripheral nuclear and cytoplasmic associated factorsthat join the complex only transiently either during EJC assemblyor during subsequent mRNA metabolism. The EJC marks the positionof the exon-exon junction in the mature mRNA for the geneexpression machinery and the core components remain bound tospliced mRNAs throughout all stages of mRNA metabolism therebyinfluencing downstream processes including nuclear mRNA export,subcellular mRNA localization, translation efficiency andnonsense-mediated mRNA decay (NMD). Stimulates the ATPase and RNA-helicase activities of EIF4A3. Plays a role in the stress responseby participating in cytoplasmic stress granules assembly and byfavoring cell recovery following stress. Component of thedendritic ribonucleoprotein particles (RNPs) in hippocampalneurons. May play a role in mRNA transport. Binds spliced mRNA insequence-independent manner, 20-24 nucleotides upstream of mRNAexon-exon junctions. Binds poly(G) and poly(U) RNA homopolymer.{ECO:0000269|PubMed:17375189, ECO:0000269|PubMed:17652158}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 1_45 | 136 | 1092 | Topological domain | Cytoplasmic |
| Hgene | ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 108_128 | 136 | 1092 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 46_66 | 136 | 1092 | Transmembrane | Helical |
| Hgene | ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 76_96 | 136 | 1092 | Transmembrane | Helical |
| Tgene | >CASC3 | chr5:7414883 | chr17:38318006 | ENST00000264645 | + | 2 | 14 | 392_395 | 99 | 1130 | Compositional bias | Note=Poly-Pro |
| Tgene | >CASC3 | chr5:7414883 | chr17:38318006 | ENST00000264645 | + | 2 | 14 | 425_428 | 99 | 1130 | Compositional bias | Note=Poly-Pro |
| Tgene | >CASC3 | chr5:7414883 | chr17:38318006 | ENST00000264645 | + | 2 | 14 | 643_648 | 99 | 1130 | Compositional bias | Note=Poly-Pro |
| Tgene | >CASC3 | chr5:7414883 | chr17:38318006 | ENST00000264645 | + | 2 | 14 | 692_695 | 99 | 1130 | Compositional bias | Note=Poly-Pro |
| Tgene | >CASC3 | chr5:7414883 | chr17:38318006 | ENST00000264645 | + | 2 | 14 | 204_210 | 99 | 1130 | Motif | Nuclear localization signal 1 |
| Tgene | >CASC3 | chr5:7414883 | chr17:38318006 | ENST00000264645 | + | 2 | 14 | 254_262 | 99 | 1130 | Motif | Nuclear localization signal 2 |
| Tgene | >CASC3 | chr5:7414883 | chr17:38318006 | ENST00000264645 | + | 2 | 14 | 462_466 | 99 | 1130 | Motif | Note=Nuclear export signal |
| Tgene | >CASC3 | chr5:7414883 | chr17:38318006 | ENST00000264645 | + | 2 | 14 | 137_283 | 99 | 1130 | Region | Note=Sufficient to form the EJC |
| Tgene | >CASC3 | chr5:7414883 | chr17:38318006 | ENST00000264645 | + | 2 | 14 | 377_703 | 99 | 1130 | Region | Note=Necessary for localization in cytoplasmic stress granules |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 1019_1021 | 136 | 1092 | Nucleotide binding | ATP |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 1026_1030 | 136 | 1092 | Nucleotide binding | ATP |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 295_300 | 136 | 1092 | Nucleotide binding | ATP |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 337_339 | 136 | 1092 | Nucleotide binding | ATP |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 208_601 | 136 | 1092 | Topological domain | Cytoplasmic |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 822_1091 | 136 | 1092 | Topological domain | Cytoplasmic |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 133_153 | 136 | 1092 | Transmembrane | Helical |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 159_179 | 136 | 1092 | Transmembrane | Helical |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 187_207 | 136 | 1092 | Transmembrane | Helical |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 602_622 | 136 | 1092 | Transmembrane | Helical |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 628_652 | 136 | 1092 | Transmembrane | Helical |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 680_701 | 136 | 1092 | Transmembrane | Helical |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 734_755 | 136 | 1092 | Transmembrane | Helical |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 763_780 | 136 | 1092 | Transmembrane | Helical |
| Hgene | >ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 801_821 | 136 | 1092 | Transmembrane | Helical |
| Tgene | CASC3 | chr5:7414883 | chr17:38318006 | ENST00000264645 | + | 2 | 14 | 95_131 | 99 | 1130 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CASC3 | chr5:7414883 | chr17:38318006 | ENST00000264645 | + | 2 | 14 | 41_46 | 99 | 1130 | Compositional bias | Note=Poly-Gly |
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FusionGeneSequence for ADCY2_CASC3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ADCY2_ENST00000338316_chr5_7414883_+_CASC3_ENST00000264645_chr17_38318006_+_741aa MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFF AIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQGEEGEYSEEENSKVELKSEANDAVNSSTKEEKGEEKPDTKSTVT GERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSR QELIALYGYDIRSAHNPDDIKPRRIRKPRYGSPPQRDPNWNGERLNKSHRHQGLGGTLPPRTFINRNAAGTGRMSAPRNYSRSGGFKEGR AGFRPVEAGGQHGGRSGETVKHEISYRSRRLEQTSVRDPSPEADAPVLGSPEKEEAASEPPAAAPDAAPPPPDRPIEKKSYSRARRTRTK VGDAVKLAEEVPPPPEGLIPAPPVPETTPTPPTKTGTWEAPVDSSTSGLEQDVAQLNIAEQNWSPGQPSFLQPRELRGMPNHIHMGAGPP PQFNRMEEMGVQGGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMLVQPGMNLPHPGLHPHQTPAP LPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPSYPYAPGALPPPPPPHLYPNTQAPSQVYGGVTYYNPAQQQVQPKPSPPRR |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ADCY2_ENST00000338316_chr5_7414883_+_CASC3_ENST00000264645_chr17_38318006_+_2223nt ATGTGGCAGGAGGCGATGCGGCGCCGCCGCTACCTGCGGGACCGCTCCGAGGAGGCGGCGGGCGGCGGAGACGGGCTGCCGCGGTCCCGG GACTGGCTCTACGAGTCCTACTACTGCATGAGCCAGCAGCACCCGCTCATCGTCTTCCTGCTGCTCATCGTCATGGGCTCCTGCCTCGCC CTGCTCGCCGTCTTCTTCGCGCTCGGGCTGGAAGTTGAAGACCATGTGGCGTTTCTAATAACAGTTCCAACTGCCCTGGCGATTTTCTTT GCGATATTTATCCTGGTCTGCATCGAGTCTGTGTTTAAGAAGCTGCTGCGCCTCTTCTCGTTGGTGATATGGATATGCCTTGTTGCCATG GGATACCTGTTCATGTGTTTTGGAGGCACCGTCTCTCCCTGGGACCAGGGTGAAGAAGGTGAATACAGTGAAGAGGAAAACTCCAAAGTG GAGCTGAAATCAGAAGCTAATGATGCTGTTAATTCTTCAACAAAAGAAGAGAAGGGAGAAGAAAAGCCTGACACCAAAAGCACTGTGACT GGAGAGAGGCAAAGTGGGGACGGACAGGAGAGCACAGAGCCTGTGGAGAACAAAGTGGGTAAAAAGGGCCCTAAGCATTTGGATGATGAT GAAGATCGGAAGAATCCAGCATACATACCTCGGAAAGGGCTCTTCTTTGAGCATGATCTTCGAGGGCAAACTCAGGAGGAGGAAGTCAGA CCCAAGGGGCGTCAGCGAAAGCTATGGAAGGATGAGGGTCGCTGGGAGCATGACAAGTTCCGGGAAGATGAGCAGGCCCCAAAGTCCCGA CAGGAGCTCATTGCTCTTTATGGTTATGACATTCGCTCAGCTCATAATCCTGATGACATCAAACCTCGAAGAATCCGGAAACCCCGATAT GGGAGTCCTCCACAAAGAGATCCAAACTGGAACGGTGAGCGGCTAAACAAGTCTCATCGCCACCAGGGTCTTGGGGGCACCCTACCACCA AGGACATTTATTAACAGGAATGCTGCAGGTACCGGCCGTATGTCTGCACCCAGGAATTATTCTCGATCTGGGGGCTTCAAGGAAGGTCGT GCTGGTTTTAGGCCTGTGGAAGCTGGTGGGCAGCATGGTGGCCGGTCTGGTGAGACTGTTAAGCATGAGATTAGTTACCGGTCACGGCGC CTAGAGCAGACTTCTGTGAGGGATCCATCTCCAGAAGCAGATGCTCCAGTGCTTGGCAGTCCTGAGAAGGAAGAGGCAGCCTCAGAGCCA CCAGCTGCTGCTCCTGATGCTGCACCACCACCCCCTGATAGGCCCATTGAGAAGAAATCCTATTCCCGGGCAAGAAGAACTCGAACCAAA GTTGGAGATGCAGTCAAGCTTGCAGAGGAGGTGCCCCCTCCTCCTGAAGGACTGATTCCAGCACCTCCAGTCCCAGAAACCACCCCAACT CCACCTACTAAGACTGGGACCTGGGAAGCTCCGGTGGATTCTAGTACAAGTGGACTTGAGCAAGATGTGGCACAACTAAATATAGCAGAA CAGAATTGGAGTCCGGGGCAGCCTTCTTTCCTGCAACCACGGGAACTTCGAGGTATGCCCAACCATATACACATGGGAGCAGGACCTCCA CCTCAGTTTAACCGGATGGAAGAAATGGGTGTCCAGGGTGGTCGAGCCAAACGCTATTCATCCCAGCGGCAAAGACCTGTGCCAGAGCCC CCCGCCCCTCCAGTGCATATCAGTATCATGGAGGGACATTACTATGATCCACTGCAGTTCCAGGGACCAATCTATACCCATGGTGACAGC CCTGCCCCGCTGCCTCCACAGGGCATGCTTGTGCAGCCAGGAATGAACCTTCCCCACCCAGGTTTACATCCCCACCAGACACCAGCTCCT CTGCCCAATCCAGGCCTCTATCCCCCACCAGTGTCCATGTCTCCAGGACAGCCACCACCTCAGCAGTTGCTTGCTCCTACTTACTTTTCT GCTCCAGGCGTCATGAACTTTGGTAATCCCAGTTACCCTTATGCTCCAGGGGCACTGCCTCCCCCACCACCGCCTCATCTGTATCCTAAT ACACAGGCCCCATCACAGGTATATGGAGGAGTGACCTACTATAACCCCGCCCAGCAGCAGGTGCAGCCAAAGCCCTCCCCACCCCGGAGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ADCY2_ENST00000338316_chr5_7414883_+_CASC3_ENST00000264645_chr17_38318006_+_4090nt AGGCGGCGCGGGGGTGGGACGCGGGCGGCCGCGGCGAGCGGCGCTGCCCGGGCCGGGCGCGCACGGCGGGCGCCCTGTGAGCGGCCCCGA TGTGGCAGGAGGCGATGCGGCGCCGCCGCTACCTGCGGGACCGCTCCGAGGAGGCGGCGGGCGGCGGAGACGGGCTGCCGCGGTCCCGGG ACTGGCTCTACGAGTCCTACTACTGCATGAGCCAGCAGCACCCGCTCATCGTCTTCCTGCTGCTCATCGTCATGGGCTCCTGCCTCGCCC TGCTCGCCGTCTTCTTCGCGCTCGGGCTGGAAGTTGAAGACCATGTGGCGTTTCTAATAACAGTTCCAACTGCCCTGGCGATTTTCTTTG CGATATTTATCCTGGTCTGCATCGAGTCTGTGTTTAAGAAGCTGCTGCGCCTCTTCTCGTTGGTGATATGGATATGCCTTGTTGCCATGG GATACCTGTTCATGTGTTTTGGAGGCACCGTCTCTCCCTGGGACCAGGGTGAAGAAGGTGAATACAGTGAAGAGGAAAACTCCAAAGTGG AGCTGAAATCAGAAGCTAATGATGCTGTTAATTCTTCAACAAAAGAAGAGAAGGGAGAAGAAAAGCCTGACACCAAAAGCACTGTGACTG GAGAGAGGCAAAGTGGGGACGGACAGGAGAGCACAGAGCCTGTGGAGAACAAAGTGGGTAAAAAGGGCCCTAAGCATTTGGATGATGATG AAGATCGGAAGAATCCAGCATACATACCTCGGAAAGGGCTCTTCTTTGAGCATGATCTTCGAGGGCAAACTCAGGAGGAGGAAGTCAGAC CCAAGGGGCGTCAGCGAAAGCTATGGAAGGATGAGGGTCGCTGGGAGCATGACAAGTTCCGGGAAGATGAGCAGGCCCCAAAGTCCCGAC AGGAGCTCATTGCTCTTTATGGTTATGACATTCGCTCAGCTCATAATCCTGATGACATCAAACCTCGAAGAATCCGGAAACCCCGATATG GGAGTCCTCCACAAAGAGATCCAAACTGGAACGGTGAGCGGCTAAACAAGTCTCATCGCCACCAGGGTCTTGGGGGCACCCTACCACCAA GGACATTTATTAACAGGAATGCTGCAGGTACCGGCCGTATGTCTGCACCCAGGAATTATTCTCGATCTGGGGGCTTCAAGGAAGGTCGTG CTGGTTTTAGGCCTGTGGAAGCTGGTGGGCAGCATGGTGGCCGGTCTGGTGAGACTGTTAAGCATGAGATTAGTTACCGGTCACGGCGCC TAGAGCAGACTTCTGTGAGGGATCCATCTCCAGAAGCAGATGCTCCAGTGCTTGGCAGTCCTGAGAAGGAAGAGGCAGCCTCAGAGCCAC CAGCTGCTGCTCCTGATGCTGCACCACCACCCCCTGATAGGCCCATTGAGAAGAAATCCTATTCCCGGGCAAGAAGAACTCGAACCAAAG TTGGAGATGCAGTCAAGCTTGCAGAGGAGGTGCCCCCTCCTCCTGAAGGACTGATTCCAGCACCTCCAGTCCCAGAAACCACCCCAACTC CACCTACTAAGACTGGGACCTGGGAAGCTCCGGTGGATTCTAGTACAAGTGGACTTGAGCAAGATGTGGCACAACTAAATATAGCAGAAC AGAATTGGAGTCCGGGGCAGCCTTCTTTCCTGCAACCACGGGAACTTCGAGGTATGCCCAACCATATACACATGGGAGCAGGACCTCCAC CTCAGTTTAACCGGATGGAAGAAATGGGTGTCCAGGGTGGTCGAGCCAAACGCTATTCATCCCAGCGGCAAAGACCTGTGCCAGAGCCCC CCGCCCCTCCAGTGCATATCAGTATCATGGAGGGACATTACTATGATCCACTGCAGTTCCAGGGACCAATCTATACCCATGGTGACAGCC CTGCCCCGCTGCCTCCACAGGGCATGCTTGTGCAGCCAGGAATGAACCTTCCCCACCCAGGTTTACATCCCCACCAGACACCAGCTCCTC TGCCCAATCCAGGCCTCTATCCCCCACCAGTGTCCATGTCTCCAGGACAGCCACCACCTCAGCAGTTGCTTGCTCCTACTTACTTTTCTG CTCCAGGCGTCATGAACTTTGGTAATCCCAGTTACCCTTATGCTCCAGGGGCACTGCCTCCCCCACCACCGCCTCATCTGTATCCTAATA CACAGGCCCCATCACAGGTATATGGAGGAGTGACCTACTATAACCCCGCCCAGCAGCAGGTGCAGCCAAAGCCCTCCCCACCCCGGAGGA CTCCCCAGCCAGTCACCATCAAGCCCCCTCCACCTGAGGTTGTAAGCAGGGGTTCCAGTTAATACAAGTTTCTGAATATTTTAAATCTTA ACATCATATAAAAAGCAGCAGAGGTGAGAACTCAGAAGAGAAATACAGCTGGCTATCTACTACCAGAAGGGCTTCAAAGATATAGGGTGT GGCTCCTACCAGCAAACAGCTGAAAGAGGAGGACCCCTGCCTTCCTCTGAGGACAGGCTCTAGAGAGAGGGAGAAACAAGTGGACCTCGT CCCATCTTCACTCTTCACTTGAGTTGGCTGTGTTCGGGGGAGCAGAGAGAGCCAGACAGCCCCAAGCTTCTGAGTCTAGATACAGAAGCC CATGTCTTCTGCTGTTCTTCACTTCTGGGAAATTGAAGTGTCTTCTGTTCCCAAGGAAGCTCCTTCCTGTTTGTTTTGTTTTCTAAGATG TTCATTTTTAAAGCCTGGCTTCTTATCCTTAATATTATTTTAATTTTTTCTCTTTGTTTCTGTTTCTTGCTCTCTCTCCCTGCCTTTAAA TGAAACAAGTCTAGTCTTCTGGTTTTCTAGCCCCTCTGGATTCCCTTTTGACTCTTCCGTGCATCCCAGATAATGGAGAATGTATCAGCC AGCCTTCCCCACCAAGTCTAAAAAGACCTGGCCTTTCACTTTTAGTTGGCATTTGTTATCCTCTTGTATACTTGTATTCCCTTAACTCTA ACCCTGTGGAAGCATGGCTGTCTGCACAGAGGGTCCCATTGTGCAGAAAAGCTCAGAGTAGGTGGGTAGGAGCCCTTCTCTTTGACTTAG GTTTTTAGGAGTCTGAGCATCCATCAATACCTGTACTATGATGGGCTTCTGTTCTCTGCTGAGGGCCAATACCCTACTGTGGGGAGAGAT GGCACACCAGATGCTTTTGTGAGAAAGGGATGGTGGAGTGAGAGCCTTTGCCTTTAGGGGTGTGTATTCACATAGTCCTCAGGGCTCAGT CTTTTGAGGTAAGTGGAATTAGAGGGCCTTGCTTCTCTTCTTTCCATTCTTCTTGCTACACCCCTTTTCCAGTTGCTGTGGACCAATGCA TCTCTTTAAAGGCAAATATTATCCAGCAAGCAGTCTACCCTGTCCTTTGCAATTGCTCTTCTCCACGTCTTTCCTGCTACAAGTGTTTTA GATGTTACTACCTTATTTTCCCCGAATTCTATTTTTGTCCTTGCAGACAGAATATAAAAACTCCTGGGCTTAAGGCCTAAGGAAGCCAGT CACCTTCTGGGCAAGGGCTCCTATCTTTCCTCCCTATCCATGGCACTAAACCACTTCTCTGCTGCCTCTGTGGAAGAGATTCCTATTACT GCAGTACATACGTCTGCCAGGGGTAACCTGGCCACTGTCCCTGTCCTTCTACAGAACCTGAGGGCAAAGATGGTGGCTGTGTCTCTCCCC GGTAATGTCACTGTTTTTATTCCTTCCATCTAGCAGCTGGCCTAATCACTCTGAGTCACAGGTGTGGGATGGAGAGTGGGGAGAGGCACT TAATCTGTAACCCCCAAGGAGGAAATAACTAAGAGATTCTTCTAGGGGTAGCTGGTGGTTGTGCCTTTTGTAGGCTGTTCCCTTTGCCTT AAACCTGAAGATGTCTCCTCAAGCCTGTGGGCAGCATGCCCAGATTCCCAGACCTTAAGACACTGTGAGAGTTGTCTCTGTTGGTCCACT GTGTTTAGTTGCAAGGATTTTTCCATGTGTGGTGGTGTTTTTTGTTACTGTTTTAAAGGGTGCCCATTTGTGATCAGCATTGTGACTTGG |
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FusionGenePPI for ADCY2_CASC3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ADCY2 | ADCY5, GNAS | CASC3 | ELAVL1, CAND1, EIF4A3, MAGOH, CDK6, GRB2, NXF1, BMI1, VTI1B, TRA2A, PRR11, LUC7L, LUC7L2, SNIP1, UPF3B, AKT1, APC, CASP8, CDKN2A, ESR2, FGFR4, NBN, PHB, PTPN1, PTPRJ, EWSR1, XPO1, LLGL2, RBM8A, MED12, CHST15, KDM1B, UPF3A, WIBG, PNN, ELAVL2, GSPT2, U2AF2, CDX1, APOBEC3D, C11orf57, CLK2, PRDM5, CELF5, RBM3 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 905_922 | 136 | 1092 | GNAS |
| Hgene | ADCY2 | chr5:7414883 | chr17:38318006 | ENST00000338316 | + | 2 | 25 | 990_993 | 136 | 1092 | GNAS |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADCY2_CASC3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | ADCY2 | Q08462 | DB09121 | Aurothioglucose | Adenylate cyclase type 2 | small molecule | approved|withdrawn |
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RelatedDiseases for ADCY2_CASC3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ADCY2 | C0004096 | Asthma | 1 | CTD_human |
| Hgene | ADCY2 | C0005586 | Bipolar Disorder | 1 | PSYGENET |
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