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Fusion gene ID: 8125 |
FusionGeneSummary for CORIN_HECW2 |
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Fusion gene information | Fusion gene name: CORIN_HECW2 | Fusion gene ID: 8125 | Hgene | Tgene | Gene symbol | CORIN | HECW2 | Gene ID | 10699 | 57520 |
Gene name | corin, serine peptidase | HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 | |
Synonyms | ATC2|CRN|Lrp4|PEE5|TMPRSS10 | NDHSAL|NEDL2 | |
Cytomap | 4p12 | 2q32.3 | |
Type of gene | protein-coding | protein-coding | |
Description | atrial natriuretic peptide-converting enzymeheart-specific serine proteinase ATC2pro-ANP-convertasepro-ANP-converting enzymetransmembrane protease serine 10 | E3 ubiquitin-protein ligase HECW2HECT-type E3 ubiquitin transferase HECW2NEDD4-like E3 ubiquitin-protein ligase 2NEDD4-related E3 ubiquitin ligase NEDL2 | |
Modification date | 20180506 | 20180526 | |
UniProtAcc | Q9Y5Q5 | Q9P2P5 | |
Ensembl transtripts involved in fusion gene | ENST00000273857, ENST00000508498, ENST00000502252, ENST00000505909, ENST00000504584, ENST00000515827, | ENST00000260983, ENST00000409111, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 5 X 4 X 4=80 |
# samples | 1 | 5 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CORIN [Title/Abstract] AND HECW2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | CORIN | GO:0016486 | peptide hormone processing | 10880574 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BG429734 | CORIN | chr4 | 47774289 | - | HECW2 | chr2 | 197069604 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000273857 | ENST00000260983 | CORIN | chr4 | 47774289 | - | HECW2 | chr2 | 197069604 | - |
intron-intron | ENST00000273857 | ENST00000409111 | CORIN | chr4 | 47774289 | - | HECW2 | chr2 | 197069604 | - |
intron-intron | ENST00000508498 | ENST00000260983 | CORIN | chr4 | 47774289 | - | HECW2 | chr2 | 197069604 | - |
intron-intron | ENST00000508498 | ENST00000409111 | CORIN | chr4 | 47774289 | - | HECW2 | chr2 | 197069604 | - |
intron-intron | ENST00000502252 | ENST00000260983 | CORIN | chr4 | 47774289 | - | HECW2 | chr2 | 197069604 | - |
intron-intron | ENST00000502252 | ENST00000409111 | CORIN | chr4 | 47774289 | - | HECW2 | chr2 | 197069604 | - |
intron-intron | ENST00000505909 | ENST00000260983 | CORIN | chr4 | 47774289 | - | HECW2 | chr2 | 197069604 | - |
intron-intron | ENST00000505909 | ENST00000409111 | CORIN | chr4 | 47774289 | - | HECW2 | chr2 | 197069604 | - |
intron-intron | ENST00000504584 | ENST00000260983 | CORIN | chr4 | 47774289 | - | HECW2 | chr2 | 197069604 | - |
intron-intron | ENST00000504584 | ENST00000409111 | CORIN | chr4 | 47774289 | - | HECW2 | chr2 | 197069604 | - |
intron-intron | ENST00000515827 | ENST00000260983 | CORIN | chr4 | 47774289 | - | HECW2 | chr2 | 197069604 | - |
intron-intron | ENST00000515827 | ENST00000409111 | CORIN | chr4 | 47774289 | - | HECW2 | chr2 | 197069604 | - |
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FusionProtFeatures for CORIN_HECW2 |
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Hgene | Tgene |
CORIN | HECW2 |
Serine-type endopeptidase involved in atrial natriureticpeptide hormone (NPPA) processing. Converts through proteolyticcleavage the non-functional propeptide NPPA into the activehormone, thereby regulating blood pressure in heart and promotingnatriuresis, diuresis and vasodilation. Proteolytic cleavage ofpro-NPPA also plays a role in female pregnancy by promotingtrophoblast invasion and spiral artery remodeling in uterus. Alsoacts as a regulator of sodium reabsorption in kidney. May alsoprocess pro-NPPB the B-type natriuretic peptide. Isoform 2: has weaker endopeptidase activity compared toisoform 1. | E3 ubiquitin-protein ligase that mediates ubiquitinationof TP73. Acts to stabilize TP73 and enhance activation oftranscription by TP73 (PubMed:12890487). Involved in theregulation of mitotic metaphase/anaphase transition(PubMed:24163370). {ECO:0000269|PubMed:12890487,ECO:0000269|PubMed:24163370}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CORIN_HECW2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CORIN_HECW2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CORIN_HECW2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CORIN_HECW2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | CORIN | C3281288 | PREECLAMPSIA/ECLAMPSIA 5 | 1 | UNIPROT |