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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8125

FusionGeneSummary for CORIN_HECW2

check button Fusion gene summary
Fusion gene informationFusion gene name: CORIN_HECW2
Fusion gene ID: 8125
HgeneTgene
Gene symbol

CORIN

HECW2

Gene ID

10699

57520

Gene namecorin, serine peptidaseHECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
SynonymsATC2|CRN|Lrp4|PEE5|TMPRSS10NDHSAL|NEDL2
Cytomap

4p12

2q32.3

Type of geneprotein-codingprotein-coding
Descriptionatrial natriuretic peptide-converting enzymeheart-specific serine proteinase ATC2pro-ANP-convertasepro-ANP-converting enzymetransmembrane protease serine 10E3 ubiquitin-protein ligase HECW2HECT-type E3 ubiquitin transferase HECW2NEDD4-like E3 ubiquitin-protein ligase 2NEDD4-related E3 ubiquitin ligase NEDL2
Modification date2018050620180526
UniProtAcc

Q9Y5Q5

Q9P2P5

Ensembl transtripts involved in fusion geneENST00000273857, ENST00000508498, 
ENST00000502252, ENST00000505909, 
ENST00000504584, ENST00000515827, 
ENST00000260983, ENST00000409111, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 4 X 4=80
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CORIN [Title/Abstract] AND HECW2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCORIN

GO:0016486

peptide hormone processing

10880574


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG429734CORINchr4

47774289

-HECW2chr2

197069604

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000273857ENST00000260983CORINchr4

47774289

-HECW2chr2

197069604

-
intron-intronENST00000273857ENST00000409111CORINchr4

47774289

-HECW2chr2

197069604

-
intron-intronENST00000508498ENST00000260983CORINchr4

47774289

-HECW2chr2

197069604

-
intron-intronENST00000508498ENST00000409111CORINchr4

47774289

-HECW2chr2

197069604

-
intron-intronENST00000502252ENST00000260983CORINchr4

47774289

-HECW2chr2

197069604

-
intron-intronENST00000502252ENST00000409111CORINchr4

47774289

-HECW2chr2

197069604

-
intron-intronENST00000505909ENST00000260983CORINchr4

47774289

-HECW2chr2

197069604

-
intron-intronENST00000505909ENST00000409111CORINchr4

47774289

-HECW2chr2

197069604

-
intron-intronENST00000504584ENST00000260983CORINchr4

47774289

-HECW2chr2

197069604

-
intron-intronENST00000504584ENST00000409111CORINchr4

47774289

-HECW2chr2

197069604

-
intron-intronENST00000515827ENST00000260983CORINchr4

47774289

-HECW2chr2

197069604

-
intron-intronENST00000515827ENST00000409111CORINchr4

47774289

-HECW2chr2

197069604

-

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FusionProtFeatures for CORIN_HECW2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CORIN

Q9Y5Q5

HECW2

Q9P2P5

Serine-type endopeptidase involved in atrial natriureticpeptide hormone (NPPA) processing. Converts through proteolyticcleavage the non-functional propeptide NPPA into the activehormone, thereby regulating blood pressure in heart and promotingnatriuresis, diuresis and vasodilation. Proteolytic cleavage ofpro-NPPA also plays a role in female pregnancy by promotingtrophoblast invasion and spiral artery remodeling in uterus. Alsoacts as a regulator of sodium reabsorption in kidney. May alsoprocess pro-NPPB the B-type natriuretic peptide. Isoform 2: has weaker endopeptidase activity compared toisoform 1. E3 ubiquitin-protein ligase that mediates ubiquitinationof TP73. Acts to stabilize TP73 and enhance activation oftranscription by TP73 (PubMed:12890487). Involved in theregulation of mitotic metaphase/anaphase transition(PubMed:24163370). {ECO:0000269|PubMed:12890487,ECO:0000269|PubMed:24163370}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CORIN_HECW2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CORIN_HECW2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CORIN_HECW2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CORIN_HECW2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCORINC3281288PREECLAMPSIA/ECLAMPSIA 51UNIPROT