![]() |
||||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Fusion gene ID: 8122 |
FusionGeneSummary for COQ7_OSBPL2 |
![]() |
Fusion gene information | Fusion gene name: COQ7_OSBPL2 | Fusion gene ID: 8122 | Hgene | Tgene | Gene symbol | COQ7 | OSBPL2 | Gene ID | 10229 | 9885 |
Gene name | coenzyme Q7, hydroxylase | oxysterol binding protein like 2 | |
Synonyms | CAT5|CLK-1|CLK1|COQ10D8 | DFNA67|DNFA67|ORP-2|ORP2 | |
Cytomap | 16p12.3 | 20q13.33 | |
Type of gene | protein-coding | protein-coding | |
Description | 5-demethoxyubiquinone hydroxylase, mitochondrialCOQ7 coenzyme Q, 7 homolog ubiquinoneDMQ hydroxylasecoenzyme Q biosynthesis protein 7 homologcoenzyme Q7 homolog, ubiquinoneplacental protein KG-20timing protein clk-1 homologubiquinone biosynthesis m | oxysterol-binding protein-related protein 2OSBP-related protein 2 | |
Modification date | 20180526 | 20180523 | |
UniProtAcc | Q99807 | Q9H1P3 | |
Ensembl transtripts involved in fusion gene | ENST00000321998, ENST00000568985, ENST00000544894, ENST00000569127, ENST00000567314, | ENST00000439951, ENST00000313733, ENST00000358053, ENST00000471817, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 6 X 5 X 5=150 |
# samples | 1 | 7 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(7/150*10)=-1.09953567355091 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: COQ7 [Title/Abstract] AND OSBPL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-AR-A0TX-01A | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-5UTR | ENST00000321998 | ENST00000439951 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-5UTR | ENST00000321998 | ENST00000313733 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-5UTR | ENST00000321998 | ENST00000358053 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-intron | ENST00000321998 | ENST00000471817 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-5UTR | ENST00000568985 | ENST00000439951 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-5UTR | ENST00000568985 | ENST00000313733 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-5UTR | ENST00000568985 | ENST00000358053 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-intron | ENST00000568985 | ENST00000471817 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-5UTR | ENST00000544894 | ENST00000439951 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-5UTR | ENST00000544894 | ENST00000313733 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-5UTR | ENST00000544894 | ENST00000358053 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-intron | ENST00000544894 | ENST00000471817 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-5UTR | ENST00000569127 | ENST00000439951 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-5UTR | ENST00000569127 | ENST00000313733 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-5UTR | ENST00000569127 | ENST00000358053 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
5CDS-intron | ENST00000569127 | ENST00000471817 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
intron-5UTR | ENST00000567314 | ENST00000439951 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
intron-5UTR | ENST00000567314 | ENST00000313733 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
intron-5UTR | ENST00000567314 | ENST00000358053 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
intron-intron | ENST00000567314 | ENST00000471817 | COQ7 | chr16 | 19087182 | + | OSBPL2 | chr20 | 60831113 | + |
Top |
FusionProtFeatures for COQ7_OSBPL2 |
![]() |
Hgene | Tgene |
COQ7 | OSBPL2 |
Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis.Has also a structural role in the COQ enzyme complex, stabilizingother COQ polypeptides. Involved in lifespan determination in aubiquinone-independent manner. {ECO:0000255|HAMAP-Rule:MF_03194}. | Binds phospholipids; exhibits strong binding tophosphatidic acid and weak binding to phosphatidylinositol 3-phosphate (PubMed:11279184). Binds 25-hydroxycholesterol(PubMed:17428193). {ECO:0000269|PubMed:11279184,ECO:0000269|PubMed:17428193}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for COQ7_OSBPL2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for COQ7_OSBPL2 |
![]() |
![]() |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
COQ7 | COQ9, COQ4, COQ7, BOLA3, COQ5, ADCK3, NRD1, CHCHD2, ADCK4, ECH1, CYCS, GLRX5, PITRM1, IDE, POLDIP2, PTPMT1, C1QBP, COQ3, PMPCA, ATP5C1, ATP5E, PMPCB | OSBPL2 | ELAVL1, VAPB, APBB2, HNRNPD, SGTB, BAG6, VAPA, ZFPL1, BIRC6 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for COQ7_OSBPL2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for COQ7_OSBPL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | COQ7 | C4225226 | COENZYME Q10 DEFICIENCY, PRIMARY, 8 | 1 | UNIPROT |