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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8103

FusionGeneSummary for COPS7B_PTMA

check button Fusion gene summary
Fusion gene informationFusion gene name: COPS7B_PTMA
Fusion gene ID: 8103
HgeneTgene
Gene symbol

COPS7B

PTMA

Gene ID

64708

5757

Gene nameCOP9 signalosome subunit 7Bprothymosin alpha
SynonymsCSN7B|SGN7bTMSA
Cytomap

2q37.1

2q37.1

Type of geneprotein-codingprotein-coding
DescriptionCOP9 signalosome complex subunit 7bCOP9 constitutive photomorphogenic homolog subunit 7BJAB1-containing signalosome subunit 7bsignalosome subunit 7bprothymosin alphagene sequence 28prothymosin alpha proteinprothymosin-I+/-
Modification date2018052320180522
UniProtAcc

Q9H9Q2

P06454

Ensembl transtripts involved in fusion geneENST00000410024, ENST00000409295, 
ENST00000409091, ENST00000350033, 
ENST00000410017, ENST00000373608, 
ENST00000466801, ENST00000409321, 
ENST00000409115, ENST00000341369, 
ENST00000409683, ENST00000410064, 
Fusion gene scores* DoF score4 X 5 X 2=4017 X 17 X 2=578
# samples 718
** MAII scorelog2(7/40*10)=0.807354922057604
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(18/578*10)=-1.683072586171
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COPS7B [Title/Abstract] AND PTMA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOPS7B

GO:0000338

protein deneddylation

19141280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDPAADTCGA-FB-AAPZ-01ACOPS7Bchr2

232646593

+PTMAchr2

232576058

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3UTRENST00000410024ENST00000466801COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5UTR-3UTRENST00000410024ENST00000409321COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5UTR-3UTRENST00000410024ENST00000409115COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5UTR-3UTRENST00000410024ENST00000341369COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5UTR-3UTRENST00000410024ENST00000409683COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5UTR-3UTRENST00000410024ENST00000410064COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5CDS-3UTRENST00000409295ENST00000466801COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5CDS-3UTRENST00000409295ENST00000409321COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5CDS-3UTRENST00000409295ENST00000409115COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5CDS-3UTRENST00000409295ENST00000341369COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5CDS-3UTRENST00000409295ENST00000409683COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5CDS-3UTRENST00000409295ENST00000410064COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5UTR-3UTRENST00000409091ENST00000466801COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5UTR-3UTRENST00000409091ENST00000409321COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5UTR-3UTRENST00000409091ENST00000409115COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5UTR-3UTRENST00000409091ENST00000341369COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5UTR-3UTRENST00000409091ENST00000409683COPS7Bchr2

232646593

+PTMAchr2

232576058

+
5UTR-3UTRENST00000409091ENST00000410064COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000350033ENST00000466801COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000350033ENST00000409321COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000350033ENST00000409115COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000350033ENST00000341369COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000350033ENST00000409683COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000350033ENST00000410064COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000410017ENST00000466801COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000410017ENST00000409321COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000410017ENST00000409115COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000410017ENST00000341369COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000410017ENST00000409683COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000410017ENST00000410064COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000373608ENST00000466801COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000373608ENST00000409321COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000373608ENST00000409115COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000373608ENST00000341369COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000373608ENST00000409683COPS7Bchr2

232646593

+PTMAchr2

232576058

+
intron-3UTRENST00000373608ENST00000410064COPS7Bchr2

232646593

+PTMAchr2

232576058

+

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FusionProtFeatures for COPS7B_PTMA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COPS7B

Q9H9Q2

PTMA

P06454

Component of the COP9 signalosome complex (CSN), acomplex involved in various cellular and developmental processes.The CSN complex is an essential regulator of the ubiquitin (Ubl)conjugation pathway by mediating the deneddylation of the cullinsubunits of SCF-type E3 ligase complexes, leading to decrease theUbl ligase activity of SCF-type complexes such as SCF, CSA orDDB2. The complex is also involved in phosphorylation of p53/TP53,JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly viaits association with CK2 and PKD kinases. CSN-dependentphosphorylation of TP53 and JUN promotes and protects degradationby the Ubl system, respectively. {ECO:0000269|PubMed:11285227,ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923,ECO:0000269|PubMed:12732143}. Prothymosin alpha may mediate immune function byconferring resistance to certain opportunistic infections.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COPS7B_PTMA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COPS7B_PTMA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COPS7BCOPS8, COPS5, COPS6, DDB1, CUL4A, COPS3, GPS1, ELAVL1, VPRBP, CUL3, CUL4B, CUL5, CUL2, CUL1, DCUN1D1, NEDD8, LRR1, DDA1, RFWD2, COPS4, APP, COPS2, IRF5, FBXW4, FBXO6, COPS7A, PRMT1, HEXIM1, USP24, NMI, FBXO17, DDB2, EWSR1, KRAS, PPIA, YWHAZ, CDK2AP1, ERP44, MYH7B, BTRC, USP15, SUN2, BTBD1, SPAG5, DST, APPBP2, FBXO7, APBB3, KLHL10, DET1, UBE3A, FEM1B, UBB, KNSTRN, DCAF4, DCAF11, HECTD3, UBE2M, SYCE3, ZZEF1, ASPM, PCMT1, JUNB, DENR, FAM98A, DLD, DCAF4L2PTMAPHB2, ESR1, HDAC1, HDAC2, NCOR1, SIN3A, CREBBP, EP300, SET, ELAVL1, TERF1, TERF2IP, TERF2, DSTN, PSME2, NUBP2, PSMA1, PTMS, PSRC1, SRSF2, PPIA, IL7R, PAN2, KPNA2, RAN, RCC1, KPNB1, PCNA, CDK2, CDK4, CDK1, CCNB1, CDK17, ASNS, ATIC, CAPNS1, CAPZA2, ISOC1, MCTS1, MSN, NSFL1C, PDIA4, PROSC, CAPN2, CTH, FH, GMDS, STK26, OGFOD1, PAPSS1, RAP1GDS1, TATDN1, TBCB, YWHAE, YWHAH, KEAP1, HIST1H1A, NUPR1, ZDHHC17, C11orf58, EIF5B, GTF2A1, NCL, RPGRIP1L, SYNCRIP, BAG6, DLD, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COPS7B_PTMA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COPS7B_PTMA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTMAC0001430Adenoma1CTD_human
TgenePTMAC0015695Fatty Liver1CTD_human
TgenePTMAC0024121Lung Neoplasms1CTD_human
TgenePTMAC0035412Rhabdomyosarcoma1CTD_human