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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 810

FusionGeneSummary for ADCY1_JUN

check button Fusion gene summary
Fusion gene informationFusion gene name: ADCY1_JUN
Fusion gene ID: 810
HgeneTgene
Gene symbol

ADCY1

JUN

Gene ID

107

3725

Gene nameadenylate cyclase 1Jun proto-oncogene, AP-1 transcription factor subunit
SynonymsAC1|DFNB44AP-1|AP1|c-Jun|p39
Cytomap

7p12.3

1p32.1

Type of geneprotein-codingprotein-coding
Descriptionadenylate cyclase type 13',5'-cyclic AMP synthetaseATP pyrophosphate-lyase 1Ca(2+)/calmodulin-activated adenylyl cyclaseadenyl cyclaseadenylate cyclase 1 (brain)adenylate cyclase type Iadenylyl cyclase 1transcription factor AP-1Jun activation domain binding proteinactivator protein 1enhancer-binding protein AP1jun oncogeneproto-oncogene c-Junv-jun avian sarcoma virus 17 oncogene homologv-jun sarcoma virus 17 oncogene homolog
Modification date2018052320180527
UniProtAcc

Q08828

P05412

Ensembl transtripts involved in fusion geneENST00000297323, ENST00000432715, 
ENST00000371222, 
Fusion gene scores* DoF score5 X 5 X 3=754 X 4 X 1=16
# samples 56
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/16*10)=1.90689059560852
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ADCY1 [Title/Abstract] AND JUN [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneJUN

GO:0007179

transforming growth factor beta receptor signaling pathway

9732876

TgeneJUN

GO:0007265

Ras protein signal transduction

24623306

TgeneJUN

GO:0043392

negative regulation of DNA binding

14645924

TgeneJUN

GO:0043922

negative regulation by host of viral transcription

2833704

TgeneJUN

GO:0043923

positive regulation by host of viral transcription

2833704

TgeneJUN

GO:0045892

negative regulation of transcription, DNA-templated

2833704

TgeneJUN

GO:0045893

positive regulation of transcription, DNA-templated

2833704|9732876

TgeneJUN

GO:0045944

positive regulation of transcription by RNA polymerase II

2833704|10508860|12490281

TgeneJUN

GO:0060395

SMAD protein signal transduction

9732876

TgeneJUN

GO:2000144

positive regulation of DNA-templated transcription, initiation

23027619


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BG315024ADCY1chr7

45761756

+JUNchr1

59248643

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000297323ENST00000371222ADCY1chr7

45761756

+JUNchr1

59248643

+
intron-3CDSENST00000432715ENST00000371222ADCY1chr7

45761756

+JUNchr1

59248643

+

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FusionProtFeatures for ADCY1_JUN


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADCY1

Q08828

JUN

P05412

Catalyzes the formation of the signaling molecule cAMPin response to G-protein signaling. Mediates responses toincreased cellular Ca(2+)/calmodulin levels (By similarity). Maybe involved in regulatory processes in the central nervous system.May play a role in memory and learning. Plays a role in theregulation of the circadian rhythm of daytime contrast sensitivityprobably by modulating the rhythmic synthesis of cyclic AMP in theretina (By similarity). {ECO:0000250|UniProtKB:O88444,ECO:0000250|UniProtKB:P19754}. Transcription factor that recognizes and binds to theenhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity ofNR5A1 when phosphorylated by HIPK3 leading to increasedsteroidogenic gene expression upon cAMP signaling pathwaystimulation. Involved in activated KRAS-mediated transcriptionalactivation of USP28 in colorectal cancer (CRC) cells(PubMed:24623306). Binds to the USP28 promoter in colorectalcancer (CRC) cells (PubMed:24623306).{ECO:0000269|PubMed:10995748, ECO:0000269|PubMed:17210646,ECO:0000269|PubMed:24623306}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADCY1_JUN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADCY1_JUN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADCY1_JUN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneADCY1Q08828DB09121AurothioglucoseAdenylate cyclase type 1small moleculeapproved|withdrawn
TgeneJUNP05412DB00570VinblastineTranscription factor AP-1small moleculeapproved
TgeneJUNP05412DB01029IrbesartanTranscription factor AP-1small moleculeapproved|investigational
TgeneJUNP05412DB01169Arsenic trioxideTranscription factor AP-1small moleculeapproved|investigational

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RelatedDiseases for ADCY1_JUN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADCY1C0038587Substance Withdrawal Syndrome1CTD_human
HgeneADCY1C0149925Small cell carcinoma of lung1CTD_human
HgeneADCY1C0424295Hyperactive behavior1CTD_human
TgeneJUNC0009375Colonic Neoplasms2CTD_human
TgeneJUNC0023903Liver neoplasms2CTD_human
TgeneJUNC0036341Schizophrenia2PSYGENET
TgeneJUNC0007621Neoplastic Cell Transformation1CTD_human
TgeneJUNC0007786Brain Ischemia1CTD_human
TgeneJUNC0018843Heat Stroke1CTD_human
TgeneJUNC0018923Hemangiosarcoma1CTD_human
TgeneJUNC0020538Hypertensive disease1CTD_human
TgeneJUNC0021846Intestinal Polyps1CTD_human
TgeneJUNC0024121Lung Neoplasms1CTD_human
TgeneJUNC0029463Osteosarcoma1CTD_human
TgeneJUNC0031117Peripheral Neuropathy1CTD_human
TgeneJUNC0035126Reperfusion Injury1CTD_human
TgeneJUNC0038220Status Epilepticus1CTD_human
TgeneJUNC0038356Stomach Neoplasms1CTD_human
TgeneJUNC0546127Mercury Poisoning, Nervous System1CTD_human
TgeneJUNC1458155Mammary Neoplasms1CTD_human
TgeneJUNC2239176Liver carcinoma1CTD_human
TgeneJUNC3495559Juvenile arthritis1CTD_human