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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 8090

FusionGeneSummary for COPS4_NFXL1

check button Fusion gene summary
Fusion gene informationFusion gene name: COPS4_NFXL1
Fusion gene ID: 8090
HgeneTgene
Gene symbol

COPS4

NFXL1

Gene ID

51138

152518

Gene nameCOP9 signalosome subunit 4nuclear transcription factor, X-box binding like 1
SynonymsCSN4|SGN4CDZFP|HOZFP|OZFP|URCC5
Cytomap

4q21.22

4p12

Type of geneprotein-codingprotein-coding
DescriptionCOP9 signalosome complex subunit 4COP9 constitutive photomorphogenic homolog subunit 4COP9 constitutive photomorphogenic-like protein subunit 4JAB1-containing signalosome subunit 4signalosome subunit 4testis tissue sperm-binding protein Li 42aNF-X1-type zinc finger protein NFXL1cytoplasm-distribution zinc finger proteinovarian zinc finger proteinup-regulated in colon cancer 5
Modification date2018052320180523
UniProtAcc

Q9BT78

Q6ZNB6

Ensembl transtripts involved in fusion geneENST00000509093, ENST00000264389, 
ENST00000503682, ENST00000511653, 
ENST00000511708, 
ENST00000381538, 
ENST00000507489, ENST00000329043, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: COPS4 [Title/Abstract] AND NFXL1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOPS4

GO:0000338

protein deneddylation

19141280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-AZ-6601-01ACOPS4chr4

83966858

+NFXL1chr4

47888016

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000509093ENST00000381538COPS4chr4

83966858

+NFXL1chr4

47888016

-
In-frameENST00000509093ENST00000507489COPS4chr4

83966858

+NFXL1chr4

47888016

-
In-frameENST00000509093ENST00000329043COPS4chr4

83966858

+NFXL1chr4

47888016

-
In-frameENST00000264389ENST00000381538COPS4chr4

83966858

+NFXL1chr4

47888016

-
In-frameENST00000264389ENST00000507489COPS4chr4

83966858

+NFXL1chr4

47888016

-
In-frameENST00000264389ENST00000329043COPS4chr4

83966858

+NFXL1chr4

47888016

-
In-frameENST00000503682ENST00000381538COPS4chr4

83966858

+NFXL1chr4

47888016

-
In-frameENST00000503682ENST00000507489COPS4chr4

83966858

+NFXL1chr4

47888016

-
In-frameENST00000503682ENST00000329043COPS4chr4

83966858

+NFXL1chr4

47888016

-
In-frameENST00000511653ENST00000381538COPS4chr4

83966858

+NFXL1chr4

47888016

-
In-frameENST00000511653ENST00000507489COPS4chr4

83966858

+NFXL1chr4

47888016

-
In-frameENST00000511653ENST00000329043COPS4chr4

83966858

+NFXL1chr4

47888016

-
3UTR-3CDSENST00000511708ENST00000381538COPS4chr4

83966858

+NFXL1chr4

47888016

-
3UTR-3CDSENST00000511708ENST00000507489COPS4chr4

83966858

+NFXL1chr4

47888016

-
3UTR-3CDSENST00000511708ENST00000329043COPS4chr4

83966858

+NFXL1chr4

47888016

-

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FusionProtFeatures for COPS4_NFXL1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COPS4

Q9BT78

NFXL1

Q6ZNB6

Component of the COP9 signalosome complex (CSN), acomplex involved in various cellular and developmental processes.The CSN complex is an essential regulator of the ubiquitin (Ubl)conjugation pathway by mediating the deneddylation of the cullinsubunits of SCF-type E3 ligase complexes, leading to decrease theUbl ligase activity of SCF-type complexes such as SCF, CSA orDDB2. Also involved in the deneddylation of non-cullin subunitssuch as STON2. The complex is also involved in phosphorylation ofp53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1, IRF8/ICSBP andSNAPIN, possibly via its association with CK2 and PKD kinases.CSN-dependent phosphorylation of TP53 and JUN promotes andprotects degradation by the Ubl system, respectively.{ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588,ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143,ECO:0000269|PubMed:21102408, ECO:0000269|PubMed:9535219}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNFXL1chr4:83966858chr4:47888016ENST00000329043-1118822_873514734Coiled coilOntology_term=ECO:0000255
TgeneNFXL1chr4:83966858chr4:47888016ENST00000381538-1123822_873514912Coiled coilOntology_term=ECO:0000255
TgeneNFXL1chr4:83966858chr4:47888016ENST00000507489-1123822_873514912Coiled coilOntology_term=ECO:0000255
TgeneNFXL1chr4:83966858chr4:47888016ENST00000329043-1118889_906514734TransmembraneHelical
TgeneNFXL1chr4:83966858chr4:47888016ENST00000381538-1123889_906514912TransmembraneHelical
TgeneNFXL1chr4:83966858chr4:47888016ENST00000507489-1123889_906514912TransmembraneHelical
TgeneNFXL1chr4:83966858chr4:47888016ENST00000329043-1118674_702514734Zinc fingerNote=NF-X1-type 8
TgeneNFXL1chr4:83966858chr4:47888016ENST00000329043-1118715_733514734Zinc fingerNote=NF-X1-type 9
TgeneNFXL1chr4:83966858chr4:47888016ENST00000329043-1118777_796514734Zinc fingerNote=NF-X1-type 10
TgeneNFXL1chr4:83966858chr4:47888016ENST00000381538-1123674_702514912Zinc fingerNote=NF-X1-type 8
TgeneNFXL1chr4:83966858chr4:47888016ENST00000381538-1123715_733514912Zinc fingerNote=NF-X1-type 9
TgeneNFXL1chr4:83966858chr4:47888016ENST00000381538-1123777_796514912Zinc fingerNote=NF-X1-type 10
TgeneNFXL1chr4:83966858chr4:47888016ENST00000507489-1123674_702514912Zinc fingerNote=NF-X1-type 8
TgeneNFXL1chr4:83966858chr4:47888016ENST00000507489-1123715_733514912Zinc fingerNote=NF-X1-type 9
TgeneNFXL1chr4:83966858chr4:47888016ENST00000507489-1123777_796514912Zinc fingerNote=NF-X1-type 10

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOPS4chr4:83966858chr4:47888016ENST00000264389+210197_36651407DomainPCI
HgeneCOPS4chr4:83966858chr4:47888016ENST00000509093+29197_36651353DomainPCI
TgeneNFXL1chr4:83966858chr4:47888016ENST00000329043-1118160_220514734Zinc fingerRING-type%3B atypical
TgeneNFXL1chr4:83966858chr4:47888016ENST00000329043-1118269_287514734Zinc fingerNote=NF-X1-type 1
TgeneNFXL1chr4:83966858chr4:47888016ENST00000329043-1118322_341514734Zinc fingerNote=NF-X1-type 2
TgeneNFXL1chr4:83966858chr4:47888016ENST00000329043-1118375_394514734Zinc fingerNote=NF-X1-type 3
TgeneNFXL1chr4:83966858chr4:47888016ENST00000329043-1118428_447514734Zinc fingerNote=NF-X1-type 4
TgeneNFXL1chr4:83966858chr4:47888016ENST00000329043-1118455_476514734Zinc fingerNote=NF-X1-type 5
TgeneNFXL1chr4:83966858chr4:47888016ENST00000329043-1118480_499514734Zinc fingerNote=NF-X1-type 6
TgeneNFXL1chr4:83966858chr4:47888016ENST00000329043-1118507_526514734Zinc fingerNote=NF-X1-type 7
TgeneNFXL1chr4:83966858chr4:47888016ENST00000381538-1123160_220514912Zinc fingerRING-type%3B atypical
TgeneNFXL1chr4:83966858chr4:47888016ENST00000381538-1123269_287514912Zinc fingerNote=NF-X1-type 1
TgeneNFXL1chr4:83966858chr4:47888016ENST00000381538-1123322_341514912Zinc fingerNote=NF-X1-type 2
TgeneNFXL1chr4:83966858chr4:47888016ENST00000381538-1123375_394514912Zinc fingerNote=NF-X1-type 3
TgeneNFXL1chr4:83966858chr4:47888016ENST00000381538-1123428_447514912Zinc fingerNote=NF-X1-type 4
TgeneNFXL1chr4:83966858chr4:47888016ENST00000381538-1123455_476514912Zinc fingerNote=NF-X1-type 5
TgeneNFXL1chr4:83966858chr4:47888016ENST00000381538-1123480_499514912Zinc fingerNote=NF-X1-type 6
TgeneNFXL1chr4:83966858chr4:47888016ENST00000381538-1123507_526514912Zinc fingerNote=NF-X1-type 7
TgeneNFXL1chr4:83966858chr4:47888016ENST00000507489-1123160_220514912Zinc fingerRING-type%3B atypical
TgeneNFXL1chr4:83966858chr4:47888016ENST00000507489-1123269_287514912Zinc fingerNote=NF-X1-type 1
TgeneNFXL1chr4:83966858chr4:47888016ENST00000507489-1123322_341514912Zinc fingerNote=NF-X1-type 2
TgeneNFXL1chr4:83966858chr4:47888016ENST00000507489-1123375_394514912Zinc fingerNote=NF-X1-type 3
TgeneNFXL1chr4:83966858chr4:47888016ENST00000507489-1123428_447514912Zinc fingerNote=NF-X1-type 4
TgeneNFXL1chr4:83966858chr4:47888016ENST00000507489-1123455_476514912Zinc fingerNote=NF-X1-type 5
TgeneNFXL1chr4:83966858chr4:47888016ENST00000507489-1123480_499514912Zinc fingerNote=NF-X1-type 6
TgeneNFXL1chr4:83966858chr4:47888016ENST00000507489-1123507_526514912Zinc fingerNote=NF-X1-type 7


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FusionGeneSequence for COPS4_NFXL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_COPS4_ENST00000509093_chr4_83966858_+_NFXL1_ENST00000381538_chr4_47888016_-_449aa
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEASSCYPCPETVDVKCNCGNTKVTVPCGRERTTRPPKCKEQ
CSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLG
KHEVSPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKAGPECLHCEEGCSKSRPLGCLHPCILRCHPGECPPCVQML
RIKCHCKITSLYVECRKITTADVNEKNLLSCCKNQCPKELPCGHRCKEMCHPGECPFNCNQKVKLRCPCKRIKKELQCNKVRENQVSIEC

>In-frame_COPS4_ENST00000509093_chr4_83966858_+_NFXL1_ENST00000507489_chr4_47888016_-_449aa
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEASSCYPCPETVDVKCNCGNTKVTVPCGRERTTRPPKCKEQ
CSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLG
KHEVSPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKAGPECLHCEEGCSKSRPLGCLHPCILRCHPGECPPCVQML
RIKCHCKITSLYVECRKITTADVNEKNLLSCCKNQCPKELPCGHRCKEMCHPGECPFNCNQKVKLRCPCKRIKKELQCNKVRENQVSIEC

>In-frame_COPS4_ENST00000509093_chr4_83966858_+_NFXL1_ENST00000329043_chr4_47888016_-_271aa
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEASSCYPCPETVDVKCNCGNTKVTVPCGRERTTRPPKCKEQ
CSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLG
KHEVSPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKIGKLKLCDLSMILQQESSKSESTVPDLLTPSPMCSSTHVI

>In-frame_COPS4_ENST00000264389_chr4_83966858_+_NFXL1_ENST00000381538_chr4_47888016_-_449aa
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEASSCYPCPETVDVKCNCGNTKVTVPCGRERTTRPPKCKEQ
CSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLG
KHEVSPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKAGPECLHCEEGCSKSRPLGCLHPCILRCHPGECPPCVQML
RIKCHCKITSLYVECRKITTADVNEKNLLSCCKNQCPKELPCGHRCKEMCHPGECPFNCNQKVKLRCPCKRIKKELQCNKVRENQVSIEC

>In-frame_COPS4_ENST00000264389_chr4_83966858_+_NFXL1_ENST00000507489_chr4_47888016_-_449aa
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEASSCYPCPETVDVKCNCGNTKVTVPCGRERTTRPPKCKEQ
CSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLG
KHEVSPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKAGPECLHCEEGCSKSRPLGCLHPCILRCHPGECPPCVQML
RIKCHCKITSLYVECRKITTADVNEKNLLSCCKNQCPKELPCGHRCKEMCHPGECPFNCNQKVKLRCPCKRIKKELQCNKVRENQVSIEC

>In-frame_COPS4_ENST00000264389_chr4_83966858_+_NFXL1_ENST00000329043_chr4_47888016_-_271aa
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEASSCYPCPETVDVKCNCGNTKVTVPCGRERTTRPPKCKEQ
CSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLG
KHEVSPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKIGKLKLCDLSMILQQESSKSESTVPDLLTPSPMCSSTHVI

>In-frame_COPS4_ENST00000503682_chr4_83966858_+_NFXL1_ENST00000381538_chr4_47888016_-_449aa
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEASSCYPCPETVDVKCNCGNTKVTVPCGRERTTRPPKCKEQ
CSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLG
KHEVSPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKAGPECLHCEEGCSKSRPLGCLHPCILRCHPGECPPCVQML
RIKCHCKITSLYVECRKITTADVNEKNLLSCCKNQCPKELPCGHRCKEMCHPGECPFNCNQKVKLRCPCKRIKKELQCNKVRENQVSIEC

>In-frame_COPS4_ENST00000503682_chr4_83966858_+_NFXL1_ENST00000507489_chr4_47888016_-_449aa
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEASSCYPCPETVDVKCNCGNTKVTVPCGRERTTRPPKCKEQ
CSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLG
KHEVSPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKAGPECLHCEEGCSKSRPLGCLHPCILRCHPGECPPCVQML
RIKCHCKITSLYVECRKITTADVNEKNLLSCCKNQCPKELPCGHRCKEMCHPGECPFNCNQKVKLRCPCKRIKKELQCNKVRENQVSIEC

>In-frame_COPS4_ENST00000503682_chr4_83966858_+_NFXL1_ENST00000329043_chr4_47888016_-_271aa
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEASSCYPCPETVDVKCNCGNTKVTVPCGRERTTRPPKCKEQ
CSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLG
KHEVSPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKIGKLKLCDLSMILQQESSKSESTVPDLLTPSPMCSSTHVI

>In-frame_COPS4_ENST00000511653_chr4_83966858_+_NFXL1_ENST00000381538_chr4_47888016_-_449aa
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEASSCYPCPETVDVKCNCGNTKVTVPCGRERTTRPPKCKEQ
CSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLG
KHEVSPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKAGPECLHCEEGCSKSRPLGCLHPCILRCHPGECPPCVQML
RIKCHCKITSLYVECRKITTADVNEKNLLSCCKNQCPKELPCGHRCKEMCHPGECPFNCNQKVKLRCPCKRIKKELQCNKVRENQVSIEC

>In-frame_COPS4_ENST00000511653_chr4_83966858_+_NFXL1_ENST00000507489_chr4_47888016_-_449aa
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEASSCYPCPETVDVKCNCGNTKVTVPCGRERTTRPPKCKEQ
CSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLG
KHEVSPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKAGPECLHCEEGCSKSRPLGCLHPCILRCHPGECPPCVQML
RIKCHCKITSLYVECRKITTADVNEKNLLSCCKNQCPKELPCGHRCKEMCHPGECPFNCNQKVKLRCPCKRIKKELQCNKVRENQVSIEC

>In-frame_COPS4_ENST00000511653_chr4_83966858_+_NFXL1_ENST00000329043_chr4_47888016_-_271aa
MAAAVRQDLAQLMNSSGSHKDLAGKYRQILEKAIQLSGAEQLEALKAFVEASSCYPCPETVDVKCNCGNTKVTVPCGRERTTRPPKCKEQ
CSRPPTCHHTSQEKHRCHFGSCPPCHQPCQKVLEKCGHLCPAPCHDQALIKQTGRHQPTGPWEQPSEPAFIQTALPCPPCQVPIPMECLG
KHEVSPLPCHAVGPYSCKRVCGRILDCQNHTCMKECHKVTKTDGCTGKNKIGKLKLCDLSMILQQESSKSESTVPDLLTPSPMCSSTHVI


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_COPS4_ENST00000509093_chr4_83966858_+_NFXL1_ENST00000381538_chr4_47888016_-_1347nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAA
GGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTT
AGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGT
TGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAAC
CAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGT
GACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAA
CAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTA

>In-frame_COPS4_ENST00000509093_chr4_83966858_+_NFXL1_ENST00000507489_chr4_47888016_-_1347nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAA
GGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTT
AGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGT
TGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAAC
CAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGT
GACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAA
CAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTA

>In-frame_COPS4_ENST00000509093_chr4_83966858_+_NFXL1_ENST00000329043_chr4_47888016_-_813nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGATAGGGAAACTGAAGCTCTGTGATTTGTCC
ATGATTCTGCAACAGGAGAGTAGCAAATCAGAAAGTACTGTGCCTGATCTTTTAACTCCCAGCCCAATGTGCTCTTCTACTCATGTTATT

>In-frame_COPS4_ENST00000264389_chr4_83966858_+_NFXL1_ENST00000381538_chr4_47888016_-_1347nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAA
GGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTT
AGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGT
TGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAAC
CAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGT
GACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAA
CAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTA

>In-frame_COPS4_ENST00000264389_chr4_83966858_+_NFXL1_ENST00000507489_chr4_47888016_-_1347nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAA
GGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTT
AGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGT
TGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAAC
CAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGT
GACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAA
CAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTA

>In-frame_COPS4_ENST00000264389_chr4_83966858_+_NFXL1_ENST00000329043_chr4_47888016_-_813nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGATAGGGAAACTGAAGCTCTGTGATTTGTCC
ATGATTCTGCAACAGGAGAGTAGCAAATCAGAAAGTACTGTGCCTGATCTTTTAACTCCCAGCCCAATGTGCTCTTCTACTCATGTTATT

>In-frame_COPS4_ENST00000503682_chr4_83966858_+_NFXL1_ENST00000381538_chr4_47888016_-_1347nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAA
GGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTT
AGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGT
TGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAAC
CAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGT
GACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAA
CAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTA

>In-frame_COPS4_ENST00000503682_chr4_83966858_+_NFXL1_ENST00000507489_chr4_47888016_-_1347nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAA
GGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTT
AGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGT
TGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAAC
CAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGT
GACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAA
CAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTA

>In-frame_COPS4_ENST00000503682_chr4_83966858_+_NFXL1_ENST00000329043_chr4_47888016_-_813nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGATAGGGAAACTGAAGCTCTGTGATTTGTCC
ATGATTCTGCAACAGGAGAGTAGCAAATCAGAAAGTACTGTGCCTGATCTTTTAACTCCCAGCCCAATGTGCTCTTCTACTCATGTTATT

>In-frame_COPS4_ENST00000511653_chr4_83966858_+_NFXL1_ENST00000381538_chr4_47888016_-_1347nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAA
GGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTT
AGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGT
TGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAAC
CAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGT
GACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAA
CAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTA

>In-frame_COPS4_ENST00000511653_chr4_83966858_+_NFXL1_ENST00000507489_chr4_47888016_-_1347nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAA
GGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTT
AGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGT
TGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAAC
CAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGT
GACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAA
CAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTA

>In-frame_COPS4_ENST00000511653_chr4_83966858_+_NFXL1_ENST00000329043_chr4_47888016_-_813nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGATAGGGAAACTGAAGCTCTGTGATTTGTCC
ATGATTCTGCAACAGGAGAGTAGCAAATCAGAAAGTACTGTGCCTGATCTTTTAACTCCCAGCCCAATGTGCTCTTCTACTCATGTTATT


* Fusion transcript sequences (Full-length transcript).
>In-frame_COPS4_ENST00000509093_chr4_83966858_+_NFXL1_ENST00000381538_chr4_47888016_-_3048nt
ATTCTCCTGCCTCAGCCTCCCGAGTTGCTGGGACTACAGGGGTGCACCACCTACGCCCGGCTAATTTTTTTGTATTTTTAGTAGAGAACG
GGGTTTCACCGTGTTAGCCAGGATGGCCTCGATCTCTTGACCTCGTGATCCGCCCGCCTCGGCTGCCCAAAGTGCTGGGATTACAGGCGT
GAGCCACCGCGCCCGGCCGAAAGGGGGGATATTAATCATTACTCCAGGACGACAGAGGGAAAATCGCTTTGTACTGGACAAACTGGAATG
TCTGACCAACCATTATAAAGTGCACGGAGTGGGAGGAGGAATAGGGACATTTTAATTGTATTTCTAAAAAGTATCTTCTGTGGTGAATCG
GAAACAAAACTCATTCTTTACCACAGGCAGTTTAAGCGCTGCCTGAAAGATCGAAGGACGGTAAACCACAGACGTGAGAAACGGAACTTT
GCGAAAACGCAGTCGTTTTATGTACCGGCTACTCATTGGAGTTACACCAGAGACTCACTACTGGAGTTCATCAGCCAATCCAAAGTCCAA
GCGTGAGAGCCAGAGCCTGTAGGAGAGACCTGGGCAGGCCTCAGACCTGAGGAGTGGAGCTCCGCATCACTCAACCCTGGGGGCGGAGCT
AGCCCAGGCTCCCACACCCGACGCTCTGGCCCACACAGACGCTACTCTGTAGCATCTCAGGTTCCCTCTGGCTGCACTCTGGAGGACCAC
ACTCGTTTTCTTTTTGGCTGCCAGAGGCCCCCGCATCCACCGCTGAGCTGGGAGAAAGATGGCGGCAGCCGTGCGACAGGATTTGGCCCA
GCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTGGAAAAAGCCATTCAGTTATCTGGAGCAGAACA
ACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACCGTAGATGTGAAGTGTAATTGTGGCAATACAAA
GGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAATGCAGTCGACCACCAACTTGTCATCATACAAG
TCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAAAAAGTTTTGGAGAAATGTGGTCACTTGTGTCC
TGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGCCCTTGGGAACAGCCTTCTGAGCCAGCATTTAT
TCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGGAAACATGAGGTGAGTCCACTACCATGCCATGC
TGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCACACATGTATGAAAGAATGCCACAAAGTAACCAA
AACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAAGGGTGCTCCAAGTCACGGCCACTAGGTTGTCT
TCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTTAGAATAAAATGTCACTGTAAGATCACAAGCCT
GTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGTTGTTGCAAAAATCAGTGCCCTAAAGAGCTTCC
TTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAACCAGAAGGTAAAACTTAGATGTCCTTGTAAAAG
AATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGTGACACAACGTGCAAGGAAATGAAGCGGAAAGC
ATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAACAGGCTGAACTAGAAGCTTTTGAAAACAGACT
GAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTATGGCAAAAACATAAATATTATCTCATTTCAGT
GTGTGGAGTTGTGGTTGTAGTGTTTGCCTGGTACATCACCCATGATGTCAATTAAAAAAAGTTTTGATCTTTTAATGTAACTCAGATTGG
ATTTAGATAAGTTGTTAAATTTGAAATATTAGAAAATGTATATTATAGAACATGATATATATTTACATTCATCTCTGTATTCTCTCAGCT
GTTGTTAGAAGGACAGAATGTTAAACTTTATCTTAATTAGTATACTAGAAAGGGCAGTATAATACTGTTTTAAAGTGAAGGCATGACTGA
AACTAAAATATTTCATAAGGCTTAGCTAGAGGCAGAGTAACGTGTTTTTGTTCATTGGGCTTCCTTGTACTTAGTTTTTTCATTTAATAA
TTCAAACCAACACTTTTAAAAAAATAATTCAGATGAGACTGAGCCATATCTGCAGTAAGAGAAATATTTCTTAATGTTTTGGTTACTTAT
GATAGAGTACTTTTCTTGATACTGTTAACTTTGTGCTTTTTAAAAAAAGTGATTCTCTAACAGACCTCTTAAATTGTGACATGAAGGTAT
GTAATTAGATTTCAGAAATTGGTTTATTAGTGAGGAATTTTTATCAATAAATGTCATGGGGCGTGTTCTTCAGAATATATAGTTATTTTC
AACAAATGCCAGGCTAGATTCCTCACATGTGGCTATTTCTTATGTAAGAAGCTTTTAACTGAAGTTGGCATGTTTCGTAAAACTTGCGTG
TCTTTTAAAAATAATAAAAGGAAGATGAGTATTTATGAAGAATATGTGCTGACAACAGGGCTTATGAGGTCTATGTACCTTAATCTCGTT
TCTCCTTACCACAATCTTAAATAGATTTCAGCTGAAAATAATCAGTTCTTATGAAAACAAATAGAGAAATATCAGTAAGTCAAATCTGTT

>In-frame_COPS4_ENST00000509093_chr4_83966858_+_NFXL1_ENST00000507489_chr4_47888016_-_3045nt
ATTCTCCTGCCTCAGCCTCCCGAGTTGCTGGGACTACAGGGGTGCACCACCTACGCCCGGCTAATTTTTTTGTATTTTTAGTAGAGAACG
GGGTTTCACCGTGTTAGCCAGGATGGCCTCGATCTCTTGACCTCGTGATCCGCCCGCCTCGGCTGCCCAAAGTGCTGGGATTACAGGCGT
GAGCCACCGCGCCCGGCCGAAAGGGGGGATATTAATCATTACTCCAGGACGACAGAGGGAAAATCGCTTTGTACTGGACAAACTGGAATG
TCTGACCAACCATTATAAAGTGCACGGAGTGGGAGGAGGAATAGGGACATTTTAATTGTATTTCTAAAAAGTATCTTCTGTGGTGAATCG
GAAACAAAACTCATTCTTTACCACAGGCAGTTTAAGCGCTGCCTGAAAGATCGAAGGACGGTAAACCACAGACGTGAGAAACGGAACTTT
GCGAAAACGCAGTCGTTTTATGTACCGGCTACTCATTGGAGTTACACCAGAGACTCACTACTGGAGTTCATCAGCCAATCCAAAGTCCAA
GCGTGAGAGCCAGAGCCTGTAGGAGAGACCTGGGCAGGCCTCAGACCTGAGGAGTGGAGCTCCGCATCACTCAACCCTGGGGGCGGAGCT
AGCCCAGGCTCCCACACCCGACGCTCTGGCCCACACAGACGCTACTCTGTAGCATCTCAGGTTCCCTCTGGCTGCACTCTGGAGGACCAC
ACTCGTTTTCTTTTTGGCTGCCAGAGGCCCCCGCATCCACCGCTGAGCTGGGAGAAAGATGGCGGCAGCCGTGCGACAGGATTTGGCCCA
GCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTGGAAAAAGCCATTCAGTTATCTGGAGCAGAACA
ACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACCGTAGATGTGAAGTGTAATTGTGGCAATACAAA
GGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAATGCAGTCGACCACCAACTTGTCATCATACAAG
TCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAAAAAGTTTTGGAGAAATGTGGTCACTTGTGTCC
TGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGCCCTTGGGAACAGCCTTCTGAGCCAGCATTTAT
TCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGGAAACATGAGGTGAGTCCACTACCATGCCATGC
TGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCACACATGTATGAAAGAATGCCACAAAGTAACCAA
AACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAAGGGTGCTCCAAGTCACGGCCACTAGGTTGTCT
TCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTTAGAATAAAATGTCACTGTAAGATCACAAGCCT
GTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGTTGTTGCAAAAATCAGTGCCCTAAAGAGCTTCC
TTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAACCAGAAGGTAAAACTTAGATGTCCTTGTAAAAG
AATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGTGACACAACGTGCAAGGAAATGAAGCGGAAAGC
ATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAACAGGCTGAACTAGAAGCTTTTGAAAACAGACT
GAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTATGGCAAAAACATAAATATTATCTCATTTCAGT
GTGTGGAGTTGTGGTTGTAGTGTTTGCCTGGTACATCACCCATGATGTCAATTAAAAAAAGTTTTGATCTTTTAATGTAACTCAGATTGG
ATTTAGATAAGTTGTTAAATTTGAAATATTAGAAAATGTATATTATAGAACATGATATATATTTACATTCATCTCTGTATTCTCTCAGCT
GTTGTTAGAAGGACAGAATGTTAAACTTTATCTTAATTAGTATACTAGAAAGGGCAGTATAATACTGTTTTAAAGTGAAGGCATGACTGA
AACTAAAATATTTCATAAGGCTTAGCTAGAGGCAGAGTAACGTGTTTTTGTTCATTGGGCTTCCTTGTACTTAGTTTTTTCATTTAATAA
TTCAAACCAACACTTTTAAAAAAATAATTCAGATGAGACTGAGCCATATCTGCAGTAAGAGAAATATTTCTTAATGTTTTGGTTACTTAT
GATAGAGTACTTTTCTTGATACTGTTAACTTTGTGCTTTTTAAAAAAAGTGATTCTCTAACAGACCTCTTAAATTGTGACATGAAGGTAT
GTAATTAGATTTCAGAAATTGGTTTATTAGTGAGGAATTTTTATCAATAAATGTCATGGGGCGTGTTCTTCAGAATATATAGTTATTTTC
AACAAATGCCAGGCTAGATTCCTCACATGTGGCTATTTCTTATGTAAGAAGCTTTTAACTGAAGTTGGCATGTTTCGTAAAACTTGCGTG
TCTTTTAAAAATAATAAAAGGAAGATGAGTATTTATGAAGAATATGTGCTGACAACAGGGCTTATGAGGTCTATGTACCTTAATCTCGTT
TCTCCTTACCACAATCTTAAATAGATTTCAGCTGAAAATAATCAGTTCTTATGAAAACAAATAGAGAAATATCAGTAAGTCAAATCTGTT

>In-frame_COPS4_ENST00000509093_chr4_83966858_+_NFXL1_ENST00000329043_chr4_47888016_-_1591nt
ATTCTCCTGCCTCAGCCTCCCGAGTTGCTGGGACTACAGGGGTGCACCACCTACGCCCGGCTAATTTTTTTGTATTTTTAGTAGAGAACG
GGGTTTCACCGTGTTAGCCAGGATGGCCTCGATCTCTTGACCTCGTGATCCGCCCGCCTCGGCTGCCCAAAGTGCTGGGATTACAGGCGT
GAGCCACCGCGCCCGGCCGAAAGGGGGGATATTAATCATTACTCCAGGACGACAGAGGGAAAATCGCTTTGTACTGGACAAACTGGAATG
TCTGACCAACCATTATAAAGTGCACGGAGTGGGAGGAGGAATAGGGACATTTTAATTGTATTTCTAAAAAGTATCTTCTGTGGTGAATCG
GAAACAAAACTCATTCTTTACCACAGGCAGTTTAAGCGCTGCCTGAAAGATCGAAGGACGGTAAACCACAGACGTGAGAAACGGAACTTT
GCGAAAACGCAGTCGTTTTATGTACCGGCTACTCATTGGAGTTACACCAGAGACTCACTACTGGAGTTCATCAGCCAATCCAAAGTCCAA
GCGTGAGAGCCAGAGCCTGTAGGAGAGACCTGGGCAGGCCTCAGACCTGAGGAGTGGAGCTCCGCATCACTCAACCCTGGGGGCGGAGCT
AGCCCAGGCTCCCACACCCGACGCTCTGGCCCACACAGACGCTACTCTGTAGCATCTCAGGTTCCCTCTGGCTGCACTCTGGAGGACCAC
ACTCGTTTTCTTTTTGGCTGCCAGAGGCCCCCGCATCCACCGCTGAGCTGGGAGAAAGATGGCGGCAGCCGTGCGACAGGATTTGGCCCA
GCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTGGAAAAAGCCATTCAGTTATCTGGAGCAGAACA
ACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACCGTAGATGTGAAGTGTAATTGTGGCAATACAAA
GGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAATGCAGTCGACCACCAACTTGTCATCATACAAG
TCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAAAAAGTTTTGGAGAAATGTGGTCACTTGTGTCC
TGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGCCCTTGGGAACAGCCTTCTGAGCCAGCATTTAT
TCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGGAAACATGAGGTGAGTCCACTACCATGCCATGC
TGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCACACATGTATGAAAGAATGCCACAAAGTAACCAA
AACTGATGGCTGCACTGGAAAAAACAAGATAGGGAAACTGAAGCTCTGTGATTTGTCCATGATTCTGCAACAGGAGAGTAGCAAATCAGA

>In-frame_COPS4_ENST00000264389_chr4_83966858_+_NFXL1_ENST00000381538_chr4_47888016_-_2405nt
ACACCCGACGCTCTGGCCCACACAGACGCTACTCTGTAGCATCTCAGGTTCCCTCTGGCTGCACTCTGGAGGACCACACTCGTTTTCTTT
TTGGCTGCCAGAGGCCCCCGCATCCACCGCTGAGCTGGGAGAAAGATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCG
AGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTGGAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTG
AAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACCGTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCC
TGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAATGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACAT
CGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAAAAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCAT
GATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGCCCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTA
CCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGGAAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTAC
TCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCACACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGC
ACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAAGGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATT
TTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTTAGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGT
AGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGTTGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGA
TGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAACCAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAA
TTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGTGACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAA
GAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAACAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGG
AAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTATGGCAAAAACATAAATATTATCTCATTTCAGTGTGTGGAGTTGTG
GTTGTAGTGTTTGCCTGGTACATCACCCATGATGTCAATTAAAAAAAGTTTTGATCTTTTAATGTAACTCAGATTGGATTTAGATAAGTT
GTTAAATTTGAAATATTAGAAAATGTATATTATAGAACATGATATATATTTACATTCATCTCTGTATTCTCTCAGCTGTTGTTAGAAGGA
CAGAATGTTAAACTTTATCTTAATTAGTATACTAGAAAGGGCAGTATAATACTGTTTTAAAGTGAAGGCATGACTGAAACTAAAATATTT
CATAAGGCTTAGCTAGAGGCAGAGTAACGTGTTTTTGTTCATTGGGCTTCCTTGTACTTAGTTTTTTCATTTAATAATTCAAACCAACAC
TTTTAAAAAAATAATTCAGATGAGACTGAGCCATATCTGCAGTAAGAGAAATATTTCTTAATGTTTTGGTTACTTATGATAGAGTACTTT
TCTTGATACTGTTAACTTTGTGCTTTTTAAAAAAAGTGATTCTCTAACAGACCTCTTAAATTGTGACATGAAGGTATGTAATTAGATTTC
AGAAATTGGTTTATTAGTGAGGAATTTTTATCAATAAATGTCATGGGGCGTGTTCTTCAGAATATATAGTTATTTTCAACAAATGCCAGG
CTAGATTCCTCACATGTGGCTATTTCTTATGTAAGAAGCTTTTAACTGAAGTTGGCATGTTTCGTAAAACTTGCGTGTCTTTTAAAAATA
ATAAAAGGAAGATGAGTATTTATGAAGAATATGTGCTGACAACAGGGCTTATGAGGTCTATGTACCTTAATCTCGTTTCTCCTTACCACA
ATCTTAAATAGATTTCAGCTGAAAATAATCAGTTCTTATGAAAACAAATAGAGAAATATCAGTAAGTCAAATCTGTTTGAATTATAATTC

>In-frame_COPS4_ENST00000264389_chr4_83966858_+_NFXL1_ENST00000507489_chr4_47888016_-_2402nt
ACACCCGACGCTCTGGCCCACACAGACGCTACTCTGTAGCATCTCAGGTTCCCTCTGGCTGCACTCTGGAGGACCACACTCGTTTTCTTT
TTGGCTGCCAGAGGCCCCCGCATCCACCGCTGAGCTGGGAGAAAGATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCG
AGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTGGAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTG
AAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACCGTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCC
TGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAATGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACAT
CGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAAAAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCAT
GATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGCCCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTA
CCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGGAAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTAC
TCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCACACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGC
ACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAAGGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATT
TTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTTAGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGT
AGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGTTGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGA
TGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAACCAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAA
TTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGTGACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAA
GAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAACAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGG
AAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTATGGCAAAAACATAAATATTATCTCATTTCAGTGTGTGGAGTTGTG
GTTGTAGTGTTTGCCTGGTACATCACCCATGATGTCAATTAAAAAAAGTTTTGATCTTTTAATGTAACTCAGATTGGATTTAGATAAGTT
GTTAAATTTGAAATATTAGAAAATGTATATTATAGAACATGATATATATTTACATTCATCTCTGTATTCTCTCAGCTGTTGTTAGAAGGA
CAGAATGTTAAACTTTATCTTAATTAGTATACTAGAAAGGGCAGTATAATACTGTTTTAAAGTGAAGGCATGACTGAAACTAAAATATTT
CATAAGGCTTAGCTAGAGGCAGAGTAACGTGTTTTTGTTCATTGGGCTTCCTTGTACTTAGTTTTTTCATTTAATAATTCAAACCAACAC
TTTTAAAAAAATAATTCAGATGAGACTGAGCCATATCTGCAGTAAGAGAAATATTTCTTAATGTTTTGGTTACTTATGATAGAGTACTTT
TCTTGATACTGTTAACTTTGTGCTTTTTAAAAAAAGTGATTCTCTAACAGACCTCTTAAATTGTGACATGAAGGTATGTAATTAGATTTC
AGAAATTGGTTTATTAGTGAGGAATTTTTATCAATAAATGTCATGGGGCGTGTTCTTCAGAATATATAGTTATTTTCAACAAATGCCAGG
CTAGATTCCTCACATGTGGCTATTTCTTATGTAAGAAGCTTTTAACTGAAGTTGGCATGTTTCGTAAAACTTGCGTGTCTTTTAAAAATA
ATAAAAGGAAGATGAGTATTTATGAAGAATATGTGCTGACAACAGGGCTTATGAGGTCTATGTACCTTAATCTCGTTTCTCCTTACCACA
ATCTTAAATAGATTTCAGCTGAAAATAATCAGTTCTTATGAAAACAAATAGAGAAATATCAGTAAGTCAAATCTGTTTGAATTATAATTC

>In-frame_COPS4_ENST00000264389_chr4_83966858_+_NFXL1_ENST00000329043_chr4_47888016_-_948nt
ACACCCGACGCTCTGGCCCACACAGACGCTACTCTGTAGCATCTCAGGTTCCCTCTGGCTGCACTCTGGAGGACCACACTCGTTTTCTTT
TTGGCTGCCAGAGGCCCCCGCATCCACCGCTGAGCTGGGAGAAAGATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCG
AGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTGGAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTG
AAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACCGTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCC
TGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAATGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACAT
CGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAAAAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCAT
GATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGCCCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTA
CCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGGAAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTAC
TCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCACACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGC
ACTGGAAAAAACAAGATAGGGAAACTGAAGCTCTGTGATTTGTCCATGATTCTGCAACAGGAGAGTAGCAAATCAGAAAGTACTGTGCCT

>In-frame_COPS4_ENST00000503682_chr4_83966858_+_NFXL1_ENST00000381538_chr4_47888016_-_2288nt
CGCTGAGCTGGGAGAAAGATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGC
AAGTATCGTCAGATCCTGGAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGC
TATCCCTGCCCAGAAACCGTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCA
CCCAAGTGCAAGGAGCAATGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCA
TGTCATCAACCTTGCCAAAAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGC
AGGCACCAGCCTACAGGCCCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATT
CCTATGGAATGTCTTGGGAAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATC
TTGGATTGTCAGAATCACACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAA
TGCCTTCATTGTGAGGAAGGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCA
CCTTGTGTTCAGATGCTTAGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAAT
GAAAAGAACCTCCTCAGTTGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAA
TGTCCCTTTAACTGCAACCAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAAT
CAGGTTTCAATAGAATGTGACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAA
GAAGAAAAACGAAGACAACAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTG
GCAGTTGAGCTATCACTATGGCAAAAACATAAATATTATCTCATTTCAGTGTGTGGAGTTGTGGTTGTAGTGTTTGCCTGGTACATCACC
CATGATGTCAATTAAAAAAAGTTTTGATCTTTTAATGTAACTCAGATTGGATTTAGATAAGTTGTTAAATTTGAAATATTAGAAAATGTA
TATTATAGAACATGATATATATTTACATTCATCTCTGTATTCTCTCAGCTGTTGTTAGAAGGACAGAATGTTAAACTTTATCTTAATTAG
TATACTAGAAAGGGCAGTATAATACTGTTTTAAAGTGAAGGCATGACTGAAACTAAAATATTTCATAAGGCTTAGCTAGAGGCAGAGTAA
CGTGTTTTTGTTCATTGGGCTTCCTTGTACTTAGTTTTTTCATTTAATAATTCAAACCAACACTTTTAAAAAAATAATTCAGATGAGACT
GAGCCATATCTGCAGTAAGAGAAATATTTCTTAATGTTTTGGTTACTTATGATAGAGTACTTTTCTTGATACTGTTAACTTTGTGCTTTT
TAAAAAAAGTGATTCTCTAACAGACCTCTTAAATTGTGACATGAAGGTATGTAATTAGATTTCAGAAATTGGTTTATTAGTGAGGAATTT
TTATCAATAAATGTCATGGGGCGTGTTCTTCAGAATATATAGTTATTTTCAACAAATGCCAGGCTAGATTCCTCACATGTGGCTATTTCT
TATGTAAGAAGCTTTTAACTGAAGTTGGCATGTTTCGTAAAACTTGCGTGTCTTTTAAAAATAATAAAAGGAAGATGAGTATTTATGAAG
AATATGTGCTGACAACAGGGCTTATGAGGTCTATGTACCTTAATCTCGTTTCTCCTTACCACAATCTTAAATAGATTTCAGCTGAAAATA
ATCAGTTCTTATGAAAACAAATAGAGAAATATCAGTAAGTCAAATCTGTTTGAATTATAATTCCTTTCAAATAGTTTTGCTATTTAATTT

>In-frame_COPS4_ENST00000503682_chr4_83966858_+_NFXL1_ENST00000507489_chr4_47888016_-_2285nt
CGCTGAGCTGGGAGAAAGATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGC
AAGTATCGTCAGATCCTGGAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGC
TATCCCTGCCCAGAAACCGTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCA
CCCAAGTGCAAGGAGCAATGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCA
TGTCATCAACCTTGCCAAAAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGC
AGGCACCAGCCTACAGGCCCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATT
CCTATGGAATGTCTTGGGAAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATC
TTGGATTGTCAGAATCACACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAA
TGCCTTCATTGTGAGGAAGGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCA
CCTTGTGTTCAGATGCTTAGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAAT
GAAAAGAACCTCCTCAGTTGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAA
TGTCCCTTTAACTGCAACCAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAAT
CAGGTTTCAATAGAATGTGACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAA
GAAGAAAAACGAAGACAACAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTG
GCAGTTGAGCTATCACTATGGCAAAAACATAAATATTATCTCATTTCAGTGTGTGGAGTTGTGGTTGTAGTGTTTGCCTGGTACATCACC
CATGATGTCAATTAAAAAAAGTTTTGATCTTTTAATGTAACTCAGATTGGATTTAGATAAGTTGTTAAATTTGAAATATTAGAAAATGTA
TATTATAGAACATGATATATATTTACATTCATCTCTGTATTCTCTCAGCTGTTGTTAGAAGGACAGAATGTTAAACTTTATCTTAATTAG
TATACTAGAAAGGGCAGTATAATACTGTTTTAAAGTGAAGGCATGACTGAAACTAAAATATTTCATAAGGCTTAGCTAGAGGCAGAGTAA
CGTGTTTTTGTTCATTGGGCTTCCTTGTACTTAGTTTTTTCATTTAATAATTCAAACCAACACTTTTAAAAAAATAATTCAGATGAGACT
GAGCCATATCTGCAGTAAGAGAAATATTTCTTAATGTTTTGGTTACTTATGATAGAGTACTTTTCTTGATACTGTTAACTTTGTGCTTTT
TAAAAAAAGTGATTCTCTAACAGACCTCTTAAATTGTGACATGAAGGTATGTAATTAGATTTCAGAAATTGGTTTATTAGTGAGGAATTT
TTATCAATAAATGTCATGGGGCGTGTTCTTCAGAATATATAGTTATTTTCAACAAATGCCAGGCTAGATTCCTCACATGTGGCTATTTCT
TATGTAAGAAGCTTTTAACTGAAGTTGGCATGTTTCGTAAAACTTGCGTGTCTTTTAAAAATAATAAAAGGAAGATGAGTATTTATGAAG
AATATGTGCTGACAACAGGGCTTATGAGGTCTATGTACCTTAATCTCGTTTCTCCTTACCACAATCTTAAATAGATTTCAGCTGAAAATA
ATCAGTTCTTATGAAAACAAATAGAGAAATATCAGTAAGTCAAATCTGTTTGAATTATAATTCCTTTCAAATAGTTTTGCTATTTAATTT

>In-frame_COPS4_ENST00000503682_chr4_83966858_+_NFXL1_ENST00000329043_chr4_47888016_-_831nt
CGCTGAGCTGGGAGAAAGATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGC
AAGTATCGTCAGATCCTGGAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGC
TATCCCTGCCCAGAAACCGTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCA
CCCAAGTGCAAGGAGCAATGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCA
TGTCATCAACCTTGCCAAAAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGC
AGGCACCAGCCTACAGGCCCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATT
CCTATGGAATGTCTTGGGAAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATC
TTGGATTGTCAGAATCACACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGATAGGGAAACTG
AAGCTCTGTGATTTGTCCATGATTCTGCAACAGGAGAGTAGCAAATCAGAAAGTACTGTGCCTGATCTTTTAACTCCCAGCCCAATGTGC

>In-frame_COPS4_ENST00000511653_chr4_83966858_+_NFXL1_ENST00000381538_chr4_47888016_-_2270nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAA
GGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTT
AGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGT
TGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAAC
CAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGT
GACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAA
CAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTA
TGGCAAAAACATAAATATTATCTCATTTCAGTGTGTGGAGTTGTGGTTGTAGTGTTTGCCTGGTACATCACCCATGATGTCAATTAAAAA
AAGTTTTGATCTTTTAATGTAACTCAGATTGGATTTAGATAAGTTGTTAAATTTGAAATATTAGAAAATGTATATTATAGAACATGATAT
ATATTTACATTCATCTCTGTATTCTCTCAGCTGTTGTTAGAAGGACAGAATGTTAAACTTTATCTTAATTAGTATACTAGAAAGGGCAGT
ATAATACTGTTTTAAAGTGAAGGCATGACTGAAACTAAAATATTTCATAAGGCTTAGCTAGAGGCAGAGTAACGTGTTTTTGTTCATTGG
GCTTCCTTGTACTTAGTTTTTTCATTTAATAATTCAAACCAACACTTTTAAAAAAATAATTCAGATGAGACTGAGCCATATCTGCAGTAA
GAGAAATATTTCTTAATGTTTTGGTTACTTATGATAGAGTACTTTTCTTGATACTGTTAACTTTGTGCTTTTTAAAAAAAGTGATTCTCT
AACAGACCTCTTAAATTGTGACATGAAGGTATGTAATTAGATTTCAGAAATTGGTTTATTAGTGAGGAATTTTTATCAATAAATGTCATG
GGGCGTGTTCTTCAGAATATATAGTTATTTTCAACAAATGCCAGGCTAGATTCCTCACATGTGGCTATTTCTTATGTAAGAAGCTTTTAA
CTGAAGTTGGCATGTTTCGTAAAACTTGCGTGTCTTTTAAAAATAATAAAAGGAAGATGAGTATTTATGAAGAATATGTGCTGACAACAG
GGCTTATGAGGTCTATGTACCTTAATCTCGTTTCTCCTTACCACAATCTTAAATAGATTTCAGCTGAAAATAATCAGTTCTTATGAAAAC
AAATAGAGAAATATCAGTAAGTCAAATCTGTTTGAATTATAATTCCTTTCAAATAGTTTTGCTATTTAATTTATATGATTAATGTTTTCA

>In-frame_COPS4_ENST00000511653_chr4_83966858_+_NFXL1_ENST00000507489_chr4_47888016_-_2267nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGGCTGGCCCAGAATGCCTTCATTGTGAGGAA
GGGTGCTCCAAGTCACGGCCACTAGGTTGTCTTCACCCATGTATTTTGCGATGTCACCCTGGAGAATGTCCACCTTGTGTTCAGATGCTT
AGAATAAAATGTCACTGTAAGATCACAAGCCTGTATGTGGAATGTAGAAAAATAACCACAGCTGATGTAAATGAAAAGAACCTCCTCAGT
TGTTGCAAAAATCAGTGCCCTAAAGAGCTTCCTTGTGGTCATAGATGCAAAGAGATGTGTCATCCTGGTGAATGTCCCTTTAACTGCAAC
CAGAAGGTAAAACTTAGATGTCCTTGTAAAAGAATAAAAAAGGAATTGCAGTGCAACAAAGTACGTGAAAATCAGGTTTCAATAGAATGT
GACACAACGTGCAAGGAAATGAAGCGGAAAGCATCTGAGATAAAAGAAGCAGAAGCCAAAGCTGCTCTTGAAGAAGAAAAACGAAGACAA
CAGGCTGAACTAGAAGCTTTTGAAAACAGACTGAAGGGTCGTCGGAAGAAGAACAGGAAAAGAGATGAAGTGGCAGTTGAGCTATCACTA
TGGCAAAAACATAAATATTATCTCATTTCAGTGTGTGGAGTTGTGGTTGTAGTGTTTGCCTGGTACATCACCCATGATGTCAATTAAAAA
AAGTTTTGATCTTTTAATGTAACTCAGATTGGATTTAGATAAGTTGTTAAATTTGAAATATTAGAAAATGTATATTATAGAACATGATAT
ATATTTACATTCATCTCTGTATTCTCTCAGCTGTTGTTAGAAGGACAGAATGTTAAACTTTATCTTAATTAGTATACTAGAAAGGGCAGT
ATAATACTGTTTTAAAGTGAAGGCATGACTGAAACTAAAATATTTCATAAGGCTTAGCTAGAGGCAGAGTAACGTGTTTTTGTTCATTGG
GCTTCCTTGTACTTAGTTTTTTCATTTAATAATTCAAACCAACACTTTTAAAAAAATAATTCAGATGAGACTGAGCCATATCTGCAGTAA
GAGAAATATTTCTTAATGTTTTGGTTACTTATGATAGAGTACTTTTCTTGATACTGTTAACTTTGTGCTTTTTAAAAAAAGTGATTCTCT
AACAGACCTCTTAAATTGTGACATGAAGGTATGTAATTAGATTTCAGAAATTGGTTTATTAGTGAGGAATTTTTATCAATAAATGTCATG
GGGCGTGTTCTTCAGAATATATAGTTATTTTCAACAAATGCCAGGCTAGATTCCTCACATGTGGCTATTTCTTATGTAAGAAGCTTTTAA
CTGAAGTTGGCATGTTTCGTAAAACTTGCGTGTCTTTTAAAAATAATAAAAGGAAGATGAGTATTTATGAAGAATATGTGCTGACAACAG
GGCTTATGAGGTCTATGTACCTTAATCTCGTTTCTCCTTACCACAATCTTAAATAGATTTCAGCTGAAAATAATCAGTTCTTATGAAAAC
AAATAGAGAAATATCAGTAAGTCAAATCTGTTTGAATTATAATTCCTTTCAAATAGTTTTGCTATTTAATTTATATGATTAATGTTTTCA

>In-frame_COPS4_ENST00000511653_chr4_83966858_+_NFXL1_ENST00000329043_chr4_47888016_-_813nt
ATGGCGGCAGCCGTGCGACAGGATTTGGCCCAGCTCATGAATTCGAGCGGCTCTCATAAAGATCTGGCTGGCAAGTATCGTCAGATCCTG
GAAAAAGCCATTCAGTTATCTGGAGCAGAACAACTAGAAGCTTTGAAAGCTTTTGTGGAAGCAAGCAGTTGCTATCCCTGCCCAGAAACC
GTAGATGTGAAGTGTAATTGTGGCAATACAAAGGTGACAGTGCCCTGTGGCCGAGAACGTACCACAAGACCACCCAAGTGCAAGGAGCAA
TGCAGTCGACCACCAACTTGTCATCATACAAGTCAAGAAAAACATCGCTGTCACTTTGGTTCTTGTCCACCATGTCATCAACCTTGCCAA
AAAGTTTTGGAGAAATGTGGTCACTTGTGTCCTGCTCCGTGTCATGATCAAGCATTAATAAAGCAGACTGGCAGGCACCAGCCTACAGGC
CCTTGGGAACAGCCTTCTGAGCCAGCATTTATTCAGACTGCATTACCGTGTCCTCCATGTCAAGTTCCTATTCCTATGGAATGTCTTGGG
AAACATGAGGTGAGTCCACTACCATGCCATGCTGTAGGACCCTACTCTTGTAAAAGAGTTTGTGGAAGAATCTTGGATTGTCAGAATCAC
ACATGTATGAAAGAATGCCACAAAGTAACCAAAACTGATGGCTGCACTGGAAAAAACAAGATAGGGAAACTGAAGCTCTGTGATTTGTCC
ATGATTCTGCAACAGGAGAGTAGCAAATCAGAAAGTACTGTGCCTGATCTTTTAACTCCCAGCCCAATGTGCTCTTCTACTCATGTTATT


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FusionGenePPI for COPS4_NFXL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COPS4RCBTB2, CCDC85B, USHBP1, C19orf57, MBIP, WRAP73, COPS8, COPS5, COPS6, BTRC, KLHL13, DDB1, CUL4A, COPS3, CUL1, UBC, IKBKB, IRF8, GPS1, COPS2, NEDD8, COPS7A, DDB2, ERCC8, VPRBP, CUL3, CUL4B, CUL5, CUL2, DCUN1D1, PTPN14, TOR1A, SNAPIN, STON2, ERCC6, GRK5, LRR1, DDA1, RFWD2, COPS7B, RBX1, SKP1, FBXO17, TCEB2, TCEB1, FEM1B, LRRC14, BTBD1, BTBD2, KLHL42, KLHL18, DCAF11, DTL, CRBN, TOR1AIP2, IRF5, FBXW4, BAG3, FOS, YWHAQ, FBXO6, CAST, DCAF8, ENAH, EPB41L1, EPB41L2, HSP90AB1, KPNA2, PRMT5, WDR77, STIP1, MOV10, NXF1, STK11, GUCY1A3, TP53, CSNK2A1, EIF3M, NTRK1, KRAS, IBTK, FGFR1OP, HEMGN, APBB3, DET1, UBE2M, FBXO7, KLHL10, DCAF4, DENR, DLD, DCAF4L2, SIRT7NFXL1SARM1, ILF3, CLINT1, RNF2, WDFY2, FOXL1, AURKA


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COPS4_NFXL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COPS4_NFXL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNFXL1C0008370Cholestasis1CTD_human
TgeneNFXL1C4277682Chemical and Drug Induced Liver Injury1CTD_human