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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8089

FusionGeneSummary for COPS3_TEKT3

check button Fusion gene summary
Fusion gene informationFusion gene name: COPS3_TEKT3
Fusion gene ID: 8089
HgeneTgene
Gene symbol

COPS3

TEKT3

Gene ID

8533

64518

Gene nameCOP9 signalosome subunit 3tektin 3
SynonymsCSN3|SGN3-
Cytomap

17p11.2

17p12

Type of geneprotein-codingprotein-coding
DescriptionCOP9 signalosome complex subunit 3COP9 complex subunit 3COP9 constitutive photomorphogenic homolog subunit 3JAB1-containing signalosome subunit 3signalosome subunit 3tektin-3testicular microtubules-related protein
Modification date2018052320180523
UniProtAcc

Q9UNS2

Q9BXF9

Ensembl transtripts involved in fusion geneENST00000539941, ENST00000268717, 
ENST00000439936, 
ENST00000462175, 
ENST00000395930, ENST00000338696, 
Fusion gene scores* DoF score1 X 1 X 1=14 X 3 X 3=36
# samples 14
** MAII scorelog2(1/1*10)=3.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: COPS3 [Title/Abstract] AND TEKT3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOPS3

GO:0000338

protein deneddylation

19141280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-AR-A5QN-01ACOPS3chr17

17163615

-TEKT3chr17

15217547

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000539941ENST00000462175COPS3chr17

17163615

-TEKT3chr17

15217547

-
5CDS-intronENST00000539941ENST00000395930COPS3chr17

17163615

-TEKT3chr17

15217547

-
5CDS-intronENST00000539941ENST00000338696COPS3chr17

17163615

-TEKT3chr17

15217547

-
5CDS-intronENST00000268717ENST00000462175COPS3chr17

17163615

-TEKT3chr17

15217547

-
5CDS-intronENST00000268717ENST00000395930COPS3chr17

17163615

-TEKT3chr17

15217547

-
5CDS-intronENST00000268717ENST00000338696COPS3chr17

17163615

-TEKT3chr17

15217547

-
intron-intronENST00000439936ENST00000462175COPS3chr17

17163615

-TEKT3chr17

15217547

-
intron-intronENST00000439936ENST00000395930COPS3chr17

17163615

-TEKT3chr17

15217547

-
intron-intronENST00000439936ENST00000338696COPS3chr17

17163615

-TEKT3chr17

15217547

-

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FusionProtFeatures for COPS3_TEKT3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COPS3

Q9UNS2

TEKT3

Q9BXF9

Component of the COP9 signalosome complex (CSN), acomplex involved in various cellular and developmental processes.The CSN complex is an essential regulator of the ubiquitin (Ubl)conjugation pathway by mediating the deneddylation of the cullinsubunits of SCF-type E3 ligase complexes, leading to decrease theUbl ligase activity of SCF-type complexes such as SCF, CSA orDDB2. The complex is also involved in phosphorylation of p53/TP53,c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly viaits association with CK2 and PKD kinases. CSN-dependentphosphorylation of TP53 and JUN promotes and protects degradationby the Ubl system, respectively. {ECO:0000269|PubMed:11285227,ECO:0000269|PubMed:11337588, ECO:0000269|PubMed:12628923,ECO:0000269|PubMed:12732143, ECO:0000269|PubMed:9535219}. Structural component of ciliary and flagellarmicrotubules. Forms filamentous polymers in the walls of ciliaryand flagellar microtubules. Required for progressive spermmobility (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COPS3_TEKT3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COPS3_TEKT3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COPS3ARAF, WRAP73, PHYH, COPS8, IKBKG, COPS5, COPS6, PTGS2, DDB1, CUL4A, CUL1, CUL2, CUL3, CUL4B, HSP90AA1, GPS1, COPS2, COPS4, COPS7A, COPS7B, IKBKB, CTNNB1, NEDD8, DDA1, CSNK2A1, CSNK2B, DDB2, ERCC8, VPRBP, MLF1, CUL5, DCUN1D1, CEBPE, ERCC6, LRR1, LRRC14, RFWD2, RBX1, SKP1, FBXO17, TCEB2, TCEB1, BTBD1, BTBD2, KLHL42, KLHL18, DCAF11, DTL, CRBN, TOR1AIP2, DCAF8, DDIT3, IRF5, VCP, SOX2, CHUK, FBXW4, NFKBIA, FBXO6, EPB41L1, STK11, MYEOV2, DCAF4, APPBP2, FEM1B, KLHL15, SRP14, HBB, UNK, DR1, PBRM1, PSMD11, SF3A3, SMARCA5, NTRK1, EWSR1, IBTK, LCA5, CENPJ, SNW1, FBXW7, APBB3, KLHL10, FBXO7, FBXL5, DET1, FBXL14, MCPH1, DCAF4L2TEKT3TRAF2, CALCOCO2, GORASP2, CLUH, LIMD1, ZNF703, TYSND1, PITRM1, PRRC2A


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COPS3_TEKT3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COPS3_TEKT3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource