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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8088

FusionGeneSummary for COPS2_DPH6

check button Fusion gene summary
Fusion gene informationFusion gene name: COPS2_DPH6
Fusion gene ID: 8088
HgeneTgene
Gene symbol

COPS2

DPH6

Gene ID

9318

89978

Gene nameCOP9 signalosome subunit 2diphthamine biosynthesis 6
SynonymsALIEN|CSN2|SGN2|TRIP15ATPBD4
Cytomap

15q21.1

15q14

Type of geneprotein-codingprotein-coding
DescriptionCOP9 signalosome complex subunit 2COP9 constitutive photomorphogenic homolog subunit 2JAB1-containing signalosome subunit 2TR-interacting protein 15TRIP-15alien homologsignalosome subunit 2thyroid receptor-interacting protein 15diphthine--ammonia ligaseATP binding domain 4ATP-binding domain-containing protein 4DPH6 homologdiphthamide synthasediphthamide synthetaseprotein DPH6 homolog
Modification date2018052320180523
UniProtAcc

P61201

Q7L8W6

Ensembl transtripts involved in fusion geneENST00000388901, ENST00000299259, 
ENST00000542928, 
ENST00000560386, 
ENST00000256538, ENST00000440392, 
Fusion gene scores* DoF score4 X 3 X 3=365 X 4 X 3=60
# samples 45
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COPS2 [Title/Abstract] AND DPH6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOPS2

GO:0000338

protein deneddylation

19141280


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-EW-A1PD-01ACOPS2chr15

49447722

-DPH6chr15

35747021

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000388901ENST00000560386COPS2chr15

49447722

-DPH6chr15

35747021

-
5CDS-intronENST00000388901ENST00000256538COPS2chr15

49447722

-DPH6chr15

35747021

-
5CDS-intronENST00000388901ENST00000440392COPS2chr15

49447722

-DPH6chr15

35747021

-
5CDS-intronENST00000299259ENST00000560386COPS2chr15

49447722

-DPH6chr15

35747021

-
5CDS-intronENST00000299259ENST00000256538COPS2chr15

49447722

-DPH6chr15

35747021

-
5CDS-intronENST00000299259ENST00000440392COPS2chr15

49447722

-DPH6chr15

35747021

-
5CDS-intronENST00000542928ENST00000560386COPS2chr15

49447722

-DPH6chr15

35747021

-
5CDS-intronENST00000542928ENST00000256538COPS2chr15

49447722

-DPH6chr15

35747021

-
5CDS-intronENST00000542928ENST00000440392COPS2chr15

49447722

-DPH6chr15

35747021

-

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FusionProtFeatures for COPS2_DPH6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COPS2

P61201

DPH6

Q7L8W6

Essential component of the COP9 signalosome complex(CSN), a complex involved in various cellular and developmentalprocesses. The CSN complex is an essential regulator of theubiquitin (Ubl) conjugation pathway by mediating the deneddylationof the cullin subunits of SCF-type E3 ligase complexes, leading todecrease the Ubl ligase activity of SCF-type complexes such asSCF, CSA or DDB2. The complex is also involved in phosphorylationof p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP,possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protectsdegradation by the Ubl system, respectively. Involved in earlystage of neuronal differentiation via its interaction with NIF3L1.{ECO:0000269|PubMed:11285227, ECO:0000269|PubMed:11337588,ECO:0000269|PubMed:12628923, ECO:0000269|PubMed:12732143,ECO:0000269|PubMed:9535219}. Amidase that catalyzes the last step of diphthamidebiosynthesis using ammonium and ATP. Diphthamide biosynthesisconsists in the conversion of an L-histidine residue in thetranslation elongation factor (EEF2) to diphthamide (Bysimilarity). {ECO:0000250, ECO:0000269|PubMed:23169644}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COPS2_DPH6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COPS2_DPH6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COPS2WRAP73, COPS8, NR0B1, IRF8, NIF3L1, THRA, THRB, NR2F1, SIN3A, CPSF1, COPS5, COPS6, KLHL13, UIMC1, DDB1, CUL4A, COPS3, CUL1, RFWD2, VDR, NCOR1, SIN3B, CUL2, ING1, ING2, ABCA1, NFKBIA, GPS1, COPS4, TP53, JUN, CUL3, CSNK2A1, EIF3E, NEDD8, AR, PRKD1, COPS7A, ANAPC1, CDC16, ANAPC4, PSMC5, PSMC3, PSMD5, PSMC1, PSMA6, DDB2, ERCC8, CUL4B, CUL5, DCUN1D1, MAP3K10, GFER, NAP1L1, HIST1H3A, HIST1H4A, NPM1, ERCC3, GTF2H2, TRIP11, MED4, MED23, GRK5, LRR1, DDA1, DCAF8, DCAF11, FBXO6, COPS7B, SEPT2, SLAIN2, SEPHS1, PFKFB2, EHBP1L1, GAPVD1, PMPCA, IRS2, IRF5, SENP8, FBXW4, EPB41L1, EP300, CREBBP, IP6K1, FBXO17, KLHDC3, DCAF4, APPBP2, FEM1B, DCAF6, FBXO7, BTBD1, BTBD2, DCAF4L2, PRAME, KDM1A, NUCKS1, KRAS, IBTK, RAB5C, CEP170P1, MYEOV2, APBB3, KLHL10, DET1, UBE2M, SYCE3, FBXL5, DENR, FBXL14, SKP2, TRIM25DPH6ATP2B2, KIAA1919, SLC18A1, ADAMTS4, S100A8, GRPR, PTGIR, TMCO3, C5AR2, SMARCB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COPS2_DPH6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COPS2_DPH6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOPS2C0014175Endometriosis1CTD_human