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Fusion gene ID: 8081 |
FusionGeneSummary for COPG2_CEP41 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COPG2_CEP41 | Fusion gene ID: 8081 | Hgene | Tgene | Gene symbol | COPG2 | CEP41 | Gene ID | 26958 | 95681 |
| Gene name | coatomer protein complex subunit gamma 2 | centrosomal protein 41 | |
| Synonyms | 2-COP|gamma-2-COP | JBTS15|TSGA14 | |
| Cytomap | 7q32.2 | 7q32.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | coatomer subunit gamma-2coat protein, nonclathrin, gamma-2-copgamma-2-coat proteintesticular secretory protein Li 12 | centrosomal protein of 41 kDacentrosomal protein 41 kDacentrosomal protein 41kDatestis specific protein A14testis specific, 14testis-specific gene A14 protein | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9UBF2 | Q9BYV8 | |
| Ensembl transtripts involved in fusion gene | ENST00000445977, | ENST00000223208, ENST00000541543, ENST00000343969, ENST00000489512, ENST00000495702, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 4 X 4 X 4=64 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: COPG2 [Title/Abstract] AND CEP41 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | COPG2 | GO:0006891 | intra-Golgi vesicle-mediated transport | 11056392 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-B0-4691-01A | COPG2 | chr7 | 130337709 | - | CEP41 | chr7 | 130042640 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000445977 | ENST00000223208 | COPG2 | chr7 | 130337709 | - | CEP41 | chr7 | 130042640 | - |
| In-frame | ENST00000445977 | ENST00000541543 | COPG2 | chr7 | 130337709 | - | CEP41 | chr7 | 130042640 | - |
| In-frame | ENST00000445977 | ENST00000343969 | COPG2 | chr7 | 130337709 | - | CEP41 | chr7 | 130042640 | - |
| 5CDS-intron | ENST00000445977 | ENST00000489512 | COPG2 | chr7 | 130337709 | - | CEP41 | chr7 | 130042640 | - |
| 5CDS-intron | ENST00000445977 | ENST00000495702 | COPG2 | chr7 | 130337709 | - | CEP41 | chr7 | 130042640 | - |
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FusionProtFeatures for COPG2_CEP41 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COPG2 | CEP41 |
| The coatomer is a cytosolic protein complex that bindsto dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosyntheticprotein transport from the ER, via the Golgi up to the trans Golginetwork. Coatomer complex is required for budding from Golgimembranes, and is essential for the retrograde Golgi-to-ERtransport of dilysine-tagged proteins. In mammals, the coatomercan only be recruited by membranes associated to ADP-ribosylationfactors (ARFs), which are small GTP-binding proteins; the complexalso influences the Golgi structural integrity, as well as theprocessing, activity, and endocytic recycling of LDL receptors (Bysimilarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CEP41 | chr7:130337709 | chr7:130042640 | ENST00000223208 | - | 5 | 11 | 169_266 | 140 | 374 | Domain | Rhodanese |
| Tgene | >CEP41 | chr7:130337709 | chr7:130042640 | ENST00000343969 | - | 5 | 10 | 169_266 | 140 | 302 | Domain | Rhodanese |
| Tgene | >CEP41 | chr7:130337709 | chr7:130042640 | ENST00000489512 | - | 0 | 3 | 169_266 | -30 | 55 | Domain | Rhodanese |
| Tgene | >CEP41 | chr7:130337709 | chr7:130042640 | ENST00000541543 | - | 4 | 9 | 169_266 | 124 | 286 | Domain | Rhodanese |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for COPG2_CEP41 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_COPG2_ENST00000445977_chr7_130337709_-_CEP41_ENST00000223208_chr7_130042640_-_341aa MIKKFDKKDEESGSGSNPFQHLEKSAVLQEARIFNETPINPRRCLHILTKILYLLNQGEHFGTTEATEAFFAMTRLFQSNDQTLRRMCYL TIKEMATISEDVIIVTSSVISGVGELDLDKGPVKKAEPHTKDKPYPDCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILE YKNAHGKIIILYDDDERLASQAATTMCERGFENLFMLSGGLKVLAQKFPEGLITGSLPASCQQALPPGSARKRSSPKGPPLPAENKWRFT >In-frame_COPG2_ENST00000445977_chr7_130337709_-_CEP41_ENST00000541543_chr7_130042640_-_269aa MIKKFDKKDEESGSGSNPFQHLEKSAVLQEARIFNETPINPRRCLHILTKILYLLNQGEHFGTTEATEAFFAMTRLFQSNDQTLRRMCYL TIKEMATISEDVIIVTSSVISGVGELDLDKGPVKKAEPHTKDKPYPDCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILE >In-frame_COPG2_ENST00000445977_chr7_130337709_-_CEP41_ENST00000343969_chr7_130042640_-_269aa MIKKFDKKDEESGSGSNPFQHLEKSAVLQEARIFNETPINPRRCLHILTKILYLLNQGEHFGTTEATEAFFAMTRLFQSNDQTLRRMCYL TIKEMATISEDVIIVTSSVISGVGELDLDKGPVKKAEPHTKDKPYPDCPFLLLDVRDRDSYQQCHIVGAYSYPIATLSRTMNPYSNDILE |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_COPG2_ENST00000445977_chr7_130337709_-_CEP41_ENST00000223208_chr7_130042640_-_1023nt ATGATTAAAAAATTCGACAAGAAGGACGAGGAGTCTGGTAGTGGCTCCAATCCTTTCCAGCATCTGGAGAAGAGTGCTGTTTTACAGGAG GCTCGTATATTCAATGAAACTCCAATCAATCCAAGAAGATGTTTGCATATTCTTACAAAGATTCTTTACTTACTGAACCAGGGTGAACAC TTTGGAACAACGGAAGCTACAGAAGCCTTCTTTGCAATGACGCGATTGTTTCAATCTAATGATCAAACATTGAGGAGAATGTGCTACCTT ACCATCAAAGAAATGGCTACCATCTCTGAGGATGTGATAATTGTCACAAGCAGTGTCATCAGTGGTGTTGGGGAACTGGATCTAGACAAA GGGCCAGTGAAGAAAGCAGAGCCCCATACCAAAGACAAACCTTATCCTGACTGCCCCTTCCTGCTGCTAGATGTGCGTGATAGAGATTCT TACCAGCAGTGCCACATTGTTGGAGCTTACAGTTACCCAATTGCAACTCTGTCTAGAACAATGAACCCTTATTCAAATGATATTCTTGAA TATAAAAATGCCCATGGCAAGATCATCATTCTGTATGACGATGATGAAAGGCTGGCCAGTCAGGCGGCCACCACCATGTGCGAGCGTGGA TTTGAAAACCTCTTCATGCTTTCCGGAGGTCTAAAAGTCTTAGCTCAGAAATTCCCGGAAGGACTGATTACTGGTTCCCTGCCAGCATCT TGCCAGCAGGCCCTTCCTCCTGGGTCTGCCCGGAAACGATCCAGCCCCAAAGGGCCACCCCTACCAGCTGAGAATAAATGGAGATTTACC CCAGAAGACTTAAAAAAGATAGAATATTATCTGGAAGAGGAGCAAGGGCCTGCAGATCATCCTAGCCGACTGAACCAAGCTAACTCCTCC GGAAGAGAGTCCAAGGTGCCTGGTGCCCGAAGCGCTCAGAATCTGCCAGGTGGCGGCCCCGCCAGCCACTCAAACCCCCGCTCCCTCAGC >In-frame_COPG2_ENST00000445977_chr7_130337709_-_CEP41_ENST00000541543_chr7_130042640_-_807nt ATGATTAAAAAATTCGACAAGAAGGACGAGGAGTCTGGTAGTGGCTCCAATCCTTTCCAGCATCTGGAGAAGAGTGCTGTTTTACAGGAG GCTCGTATATTCAATGAAACTCCAATCAATCCAAGAAGATGTTTGCATATTCTTACAAAGATTCTTTACTTACTGAACCAGGGTGAACAC TTTGGAACAACGGAAGCTACAGAAGCCTTCTTTGCAATGACGCGATTGTTTCAATCTAATGATCAAACATTGAGGAGAATGTGCTACCTT ACCATCAAAGAAATGGCTACCATCTCTGAGGATGTGATAATTGTCACAAGCAGTGTCATCAGTGGTGTTGGGGAACTGGATCTAGACAAA GGGCCAGTGAAGAAAGCAGAGCCCCATACCAAAGACAAACCTTATCCTGACTGCCCCTTCCTGCTGCTAGATGTGCGTGATAGAGATTCT TACCAGCAGTGCCACATTGTTGGAGCTTACAGTTACCCAATTGCAACTCTGTCTAGAACAATGAACCCTTATTCAAATGATATTCTTGAA TATAAAAATGCCCATGGCAAGATCATCATTCTGTATGACGATGATGAAAGGCTGGCCAGTCAGGCGGCCACCACCATGTGCGAGCGTGGA TTTGAAAACCTCTTCATGCTTTCCGGAGGCCGACTGAACCAAGCTAACTCCTCCGGAAGAGAGTCCAAGGTGCCTGGTGCCCGAAGCGCT >In-frame_COPG2_ENST00000445977_chr7_130337709_-_CEP41_ENST00000343969_chr7_130042640_-_807nt ATGATTAAAAAATTCGACAAGAAGGACGAGGAGTCTGGTAGTGGCTCCAATCCTTTCCAGCATCTGGAGAAGAGTGCTGTTTTACAGGAG GCTCGTATATTCAATGAAACTCCAATCAATCCAAGAAGATGTTTGCATATTCTTACAAAGATTCTTTACTTACTGAACCAGGGTGAACAC TTTGGAACAACGGAAGCTACAGAAGCCTTCTTTGCAATGACGCGATTGTTTCAATCTAATGATCAAACATTGAGGAGAATGTGCTACCTT ACCATCAAAGAAATGGCTACCATCTCTGAGGATGTGATAATTGTCACAAGCAGTGTCATCAGTGGTGTTGGGGAACTGGATCTAGACAAA GGGCCAGTGAAGAAAGCAGAGCCCCATACCAAAGACAAACCTTATCCTGACTGCCCCTTCCTGCTGCTAGATGTGCGTGATAGAGATTCT TACCAGCAGTGCCACATTGTTGGAGCTTACAGTTACCCAATTGCAACTCTGTCTAGAACAATGAACCCTTATTCAAATGATATTCTTGAA TATAAAAATGCCCATGGCAAGATCATCATTCTGTATGACGATGATGAAAGGCTGGCCAGTCAGGCGGCCACCACCATGTGCGAGCGTGGA TTTGAAAACCTCTTCATGCTTTCCGGAGGCCGACTGAACCAAGCTAACTCCTCCGGAAGAGAGTCCAAGGTGCCTGGTGCCCGAAGCGCT |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_COPG2_ENST00000445977_chr7_130337709_-_CEP41_ENST00000223208_chr7_130042640_-_6233nt CGGGGCCGGCCTTCCTGCAGCCTCTTCCGCTCGCCGGCTGCGGCGCCTGGGACGGTTGCGGTGGGTCTGGGCGCTGGGAAGTCGTCCAAG ATGATTAAAAAATTCGACAAGAAGGACGAGGAGTCTGGTAGTGGCTCCAATCCTTTCCAGCATCTGGAGAAGAGTGCTGTTTTACAGGAG GCTCGTATATTCAATGAAACTCCAATCAATCCAAGAAGATGTTTGCATATTCTTACAAAGATTCTTTACTTACTGAACCAGGGTGAACAC TTTGGAACAACGGAAGCTACAGAAGCCTTCTTTGCAATGACGCGATTGTTTCAATCTAATGATCAAACATTGAGGAGAATGTGCTACCTT ACCATCAAAGAAATGGCTACCATCTCTGAGGATGTGATAATTGTCACAAGCAGTGTCATCAGTGGTGTTGGGGAACTGGATCTAGACAAA GGGCCAGTGAAGAAAGCAGAGCCCCATACCAAAGACAAACCTTATCCTGACTGCCCCTTCCTGCTGCTAGATGTGCGTGATAGAGATTCT TACCAGCAGTGCCACATTGTTGGAGCTTACAGTTACCCAATTGCAACTCTGTCTAGAACAATGAACCCTTATTCAAATGATATTCTTGAA TATAAAAATGCCCATGGCAAGATCATCATTCTGTATGACGATGATGAAAGGCTGGCCAGTCAGGCGGCCACCACCATGTGCGAGCGTGGA TTTGAAAACCTCTTCATGCTTTCCGGAGGTCTAAAAGTCTTAGCTCAGAAATTCCCGGAAGGACTGATTACTGGTTCCCTGCCAGCATCT TGCCAGCAGGCCCTTCCTCCTGGGTCTGCCCGGAAACGATCCAGCCCCAAAGGGCCACCCCTACCAGCTGAGAATAAATGGAGATTTACC CCAGAAGACTTAAAAAAGATAGAATATTATCTGGAAGAGGAGCAAGGGCCTGCAGATCATCCTAGCCGACTGAACCAAGCTAACTCCTCC GGAAGAGAGTCCAAGGTGCCTGGTGCCCGAAGCGCTCAGAATCTGCCAGGTGGCGGCCCCGCCAGCCACTCAAACCCCCGCTCCCTCAGC AGTGGTCACCTGCAAGGCAAACCCTGGAAGTAAAGACTTTGTCTCACTTAGGCAAATAAATGTTCTTCCTCTTTTCAGAACCCCTGAGCA TTTCCCAAGTTGGGTCATTTCCAGAAACTTCTGCAGAGGAAAGACCATGACATATGTATGGGATAGGCCTCTTCCCTGTCCCTGTCTCCA GTTCCTCTCCCCTCAGGAGGCCACCTCAGGAAGGATTTTGACAGGTGACCATAAAAACCAGAGGTGTGACAGGCTCTAGTCTCCTCCCTG TTGTTTACAGCATATTTAAGTCTTGTGAAACTGTATAGGAAAAAAGTATCTACGTTTTTAGTTTTTTTGTTTTGTTTTTTTTTAATAAGG TCCAGCTTGTTGGGTCTCTCTGTGTTGTTTTGTAAATACTTCAGTCACATCTGCCCGTGTGCCTGTCCCTGCCACCTTTTCATTCACTGT TCTTGACTTCATGAAGGCTTCTCCGGGCAGTCTTGGTGTGAGAAGCTGTTTCCAAGGGTGCAGATGAGCCTTAGGTTCCAGCCGCCTGCA GACCCCACCCCAGCAGGCTCACTCAGCAAGGAGCTCTCTGCCCAGCATATTGCAGGCCCTGTTTTGAGTATGGAAGCCAGTGCCTGTGTA CTCACTGAAATTGAAGATGAGGAAAGTAGCTGTACACTCACTGAATGCTCCCCCTTACTAGATATTTCCTGGAGCCAGAAAGGTATGCAT GTGGGTGTCTTCACACCGGGGAGGAGGGCCTCTCATGGGAAAGCCCTGGCCACCACACCGGCCTGTGCCCCTTGAAGCCCACCAAAGCGG CCCTCACTTGTGGTCAGTATATCAGTTATGACGCCCATTGCCCAGCTTCAGTCCATCCATGTTAGATGGACAGAAATTATGGCCAGTTGA AAATACCAGCTTTGGTTGGACAACTGTGGACACACAAGGTGAAGAGGACTCCGAAGTCCTTTGTCAGGGCTGACAACCTCGTAAGCCCTT GCTTAGAAATACAGTATTAGTCTAATTGAGTAATTAGTGCAATTTCCTGCTTACTTTTCATTCTCATGACTGAACTGTGATTAGGAAGTT GTGATTATAGATTCTGGTTTTGGCCGGAATTTTGAATCAGCATTAATTGAATTGCTAAATGACTGACATTCATTCCATTTAATTGGGGGA ACAAAAGGCCTCAGGTAAGGATGAGGAACTCTGAAATCAGATGGAAAAGAGCGGTGTTAATTTTTATGGTCTGTGATCGTAGCTGTGATA AGGGACTGAGGAATAAATTGTGCTCTTTGTCATGGCAACCAGCTTCTGAAAAGCCCACTGAAAATTGCCTGTCCTGCTGGTAACTGCTAC GGGGTAAGATTTGCCTTAACAGTACTATTTTCTCGCCACCAAAAAAAAAAAAAAAAAAAAAAAAAAATGCACCACAGTATTTCTAGCATG GGGGCTGTGTTTGTATGAGAAATAAACGTAATAAATATCTCATAGAGACATATGGAAAAATAACTTTCAGATTCAGCCCAGTTCTGTTTT AGAGTGTGTTTATTCTTCTCTACTTGATTTCCAAAGTGCAACATTTTCCGATGCTTTAGAAATCAAACAAACCAGGGACATTGTTCAGAT GTCAAGCCATGCCCAATTTTCCACAAGATTCAAGAATCTTGTATAAAATTCAGCCAACGTACACATAGCTTTAATGAGGAGCCTGTCATG TTTCCCCATAAATTTATTGCCTGAGAACTTAGTTCAGCCTTTGCTAATGCCAAAATGCTCTGGCTTTGTATTTTCTTTACAGCATAGATA GAAAAATGCACATTTTTCCACACTCAGCTTTCCCCTAGCATGGACAAGATTTTCAGCCATTTTTGCCACATATACATTTTTAAGGAAAAA AGATTTTTCTCTGTAAGAAAGTTCTGGTTATGCTGTTTTAAAGGTGACTTGTCAGGAGTTGAGACTTCCCTGCCGGATTCTATTTTGAAA GTAAATGGTCTTCCCTCCTTGTTCCGATTCTGCGTTCCCATCGTCAGACAACTTTGGAGTATTAGAAACCACTGTATATATGTGGAAAGC CAGGTCAGCCAGACCTGTTAGAATTGGTGTGCACTCACCTGAGAGATCTGGCAGGTTGGATATATTTATGTGTATTTCTCCACAGTGCTT GCTTTGCCCTGTTGGTAAGGATTTTAAATAACCATGCTCAAAAGAGCTGTTCTAATCTGCGTTTTGCATGTTAAGTGTTAATATCAAACA TTCTTTACGTGCTCGAGGTATTGCTTTTAACATTCTACTTTGCCAGTTTCTTCATTAGATTAATTGACATGTATTATTTAAATGACCAGT GATGCTTTGTGCAATTATGAATGTTGAAGATTAAAGTACATAGTTACTAATTTGTCGTTTGCTATTAATATGCTGAAAACTGCCAACTTC TCTCTTCTTTTCTGTCGAGATGATTTGGGGGAGCCACAGGAGACTGGTGTGATTTTTGCTGCATCTCCTAGGAAAGCATTTTTTAAAAAA AATAAATGAATCAGGAAATCAGTCCAATTAGGGCAGGGGGCCTCAGCTCTCCAGTCAGAAAGCCTGGATTTCTTTTCCTGCTCAGGCTGG GACTGAAGCCACCTTCAACAACTGGATCATGGCTTCCTACCAGCGTCTCAGGGGTTGACTAGCTGCCCTTGTCTGGGGCTTGTGAACCCT GAGACAGAAGGTGCTTCATCGATGTACAACTACAGCACCCTGAACAGCAGTGATGGCCAAAGTTTAAATAATACCTTAAATGCTTTAAAG GGGTTTGTGTTTAAGGAAGGGAGAAAAGAAAAAAAGAAAGGAAGGGAGAAAGAAGCAAGGAAATGGGAAGAAGGGAGGGCAGAGAGAAGA AAAGAAGCAGAAAGCGAGAGAGAAAGGAGAAAGCTACATTACTTATTTGAAAACAAAAGGAACACCCTGGGCTGTAATAATGTCAGGCTC AATCTCTTGAAAAAGTATGGAATGATTTAAATGGCCTGCATTCATTTTATCTTTTATCTTTTTTTTTTTTTTTAACCTTTAGTGGTTAGC CAGGACCAGCACGATCATATTGGGCTTGGTATAAATCCGAATGAAAAGAGACCAAATAACATTCATTAGTTGCTCAGGGATTTTTCCTGT GGTGCTATTTAAATTATACAAAAATTCTTAAGACTTTAGGCTACTCGACCAAGAAAACAGAACAAAACAAAAAATCGTGTTTTCTCTAAT TCCCTTGTGGAATGTAAGTGAAATCAGAGTCCTAGGCTAGGAAGAAATACGTAGGTAATTTTTCTTGTGTTGGTTTTGGTTTCTGTCATG TTGTTTATTGGCTATAGATTCTGTCTTTTATGTTATCTGACTTTTTTAGAGCGAATAATTAGTTTCTGTCCACCTGGATTTAAATCCATG ACCACCTTCTTGCTCTACTCTGAAGATAATCAGTAAGAACCTTTCTTTCTCCAGTTCTAAAACGTTCTCAGTGTCTTTAATGTGTGTTTA TTTTCTTCCCAATTCTTTCAAAGATTTAACTCCCACGATACTTTTTTTTCCCCAGGAAACACCGCAAATGTGTGGAATATAATTCACCAG TTTAATTATGTGAGCATGTTGAGTACTTACATGCAGGTCCATTAATTTTTCACTAACAATTATTTTTTCATGCAAAAGCAATAAATAACA TTGTGCTTCCAAAATGTTCAGAATACATTTGGGTAGTAATACTTTCCTAGATTTACAATAATTATTGAAATTATTATTATGACATCTTTA AATGGATACACAGGTCAGTTACAACATAAAAAATGTAATGGTGGAAATTTGTCAGCCTTGAATTCAGGCAGAACAGGATTCGGTGCATGA TTTTATGTGTTTTCGAAACGGTGTCTGTCACATTGTGATCCCCTGATGGCTCCCCTCTCTGTTGCTGATCCTCTTTGTTCTGTACAGAAG CAAATTCTCACCTGTGTAACATCCTGAAGCACCTGGTAAAATGTGAGGCAAAGAGAGGCCACTTCTCAAATGCTGTGGACGGATGGGCTG CATCTTTTAAAGGATATCAATATGTCTTCCTGTTGCAATTATTTTGACTATAAGCTCCCAGAGAGTGAAAATCACCAACCCTGTGACAGT GGCCCTTAATAAGTGTTCATGAATAAATGAATTGAACCTGTCAAGATTGAAGTTTGGATGTGATGCCCACTGTGGTGGCCACTCAGTGCT AGTCTGTCATTCTGGAGACCCAGAAAGCTCGTTATCTTCTGTCCCCCTTGTGTATCCTGCCTTTGTGGGCGAGGCATTCAAAACCCTGAG GTTTTTAGATCTCCCTCTACAGGAAGTACCCAGAGAGCTGCTGGGGGTGTTATTACCCTGTCTCTGCCAGGCTTAAAGTATCCTCCCAAA TTCAGCACGCAAAGGTCACACACCACCCCCATCTTAAGAGTAGGTTTTCTCTTTTGTTTCAAATCTTGAAGATTTCCAGAAAATAATAAT ACTAGCCAATGTTTGTGGAGAGCTTACTTTGCTCCTAGATTCTTCATTATATGTTTTGACCCATTTAATTTCCACAACAGTCTGATGAGG CAGGCACCCCCATTTTCAGATGAGGAGACTGAGGTTCGGGTAGAAATTAAGTGACTCAGGTTTGCCTTCAGTCTCTGACCAAGGGTTTGA AAAGCCAGGAGCCAGCCTGAGAACTGTGGCTCCAGAGGGTGTTCTTTCAGCCACTCCGCTCTATGCTTCTCACTCTGGGTGGGCACAACC ATGTTCTCCTTTGGTGATGCCTCTAACTTACCGTGAAAATGTACCTTTCCCTTCGCTATTGGCTTCCCTTCCCTCCTAGTCAGCCGAGAT TCTTTTGAAAACTTTCCTCCGCTTGCCTGCACAAAAGGCGATGGAAATTCAGGAACTGAAACATCTGCTCTGGGGAATGCGTATTTCCAC ATTTCCACCGCCTGTGTCTGCTGTCTTATCTTGAAGACAGGTGCTCCAGGGCTTCCGAGGTTATTTTGTCTGTTAATGGACACCTTGCAA AGTACCACTTAAGGAATGAGAATTACAAACTTTTAATTATATTGTAGGGGGAAAAAAGTAGGCTGTTTTCCTGATAGGTCTAGCCATTCA >In-frame_COPG2_ENST00000445977_chr7_130337709_-_CEP41_ENST00000541543_chr7_130042640_-_1257nt CGGGGCCGGCCTTCCTGCAGCCTCTTCCGCTCGCCGGCTGCGGCGCCTGGGACGGTTGCGGTGGGTCTGGGCGCTGGGAAGTCGTCCAAG ATGATTAAAAAATTCGACAAGAAGGACGAGGAGTCTGGTAGTGGCTCCAATCCTTTCCAGCATCTGGAGAAGAGTGCTGTTTTACAGGAG GCTCGTATATTCAATGAAACTCCAATCAATCCAAGAAGATGTTTGCATATTCTTACAAAGATTCTTTACTTACTGAACCAGGGTGAACAC TTTGGAACAACGGAAGCTACAGAAGCCTTCTTTGCAATGACGCGATTGTTTCAATCTAATGATCAAACATTGAGGAGAATGTGCTACCTT ACCATCAAAGAAATGGCTACCATCTCTGAGGATGTGATAATTGTCACAAGCAGTGTCATCAGTGGTGTTGGGGAACTGGATCTAGACAAA GGGCCAGTGAAGAAAGCAGAGCCCCATACCAAAGACAAACCTTATCCTGACTGCCCCTTCCTGCTGCTAGATGTGCGTGATAGAGATTCT TACCAGCAGTGCCACATTGTTGGAGCTTACAGTTACCCAATTGCAACTCTGTCTAGAACAATGAACCCTTATTCAAATGATATTCTTGAA TATAAAAATGCCCATGGCAAGATCATCATTCTGTATGACGATGATGAAAGGCTGGCCAGTCAGGCGGCCACCACCATGTGCGAGCGTGGA TTTGAAAACCTCTTCATGCTTTCCGGAGGCCGACTGAACCAAGCTAACTCCTCCGGAAGAGAGTCCAAGGTGCCTGGTGCCCGAAGCGCT CAGAATCTGCCAGGTGGCGGCCCCGCCAGCCACTCAAACCCCCGCTCCCTCAGCAGTGGTCACCTGCAAGGCAAACCCTGGAAGTAAAGA CTTTGTCTCACTTAGGCAAATAAATGTTCTTCCTCTTTTCAGAACCCCTGAGCATTTCCCAAGTTGGGTCATTTCCAGAAACTTCTGCAG AGGAAAGACCATGACATATGTATGGGATAGGCCTCTTCCCTGTCCCTGTCTCCAGTTCCTCTCCCCTCAGGAGGCCACCTCAGGAAGGAT TTTGACAGGTGACCATAAAAACCAGAGGTGTGACAGGCTCTAGTCTCCTCCCTGTTGTTTACAGCATATTTAAGTCTTGTGAAACTGTAT >In-frame_COPG2_ENST00000445977_chr7_130337709_-_CEP41_ENST00000343969_chr7_130042640_-_1049nt CGGGGCCGGCCTTCCTGCAGCCTCTTCCGCTCGCCGGCTGCGGCGCCTGGGACGGTTGCGGTGGGTCTGGGCGCTGGGAAGTCGTCCAAG ATGATTAAAAAATTCGACAAGAAGGACGAGGAGTCTGGTAGTGGCTCCAATCCTTTCCAGCATCTGGAGAAGAGTGCTGTTTTACAGGAG GCTCGTATATTCAATGAAACTCCAATCAATCCAAGAAGATGTTTGCATATTCTTACAAAGATTCTTTACTTACTGAACCAGGGTGAACAC TTTGGAACAACGGAAGCTACAGAAGCCTTCTTTGCAATGACGCGATTGTTTCAATCTAATGATCAAACATTGAGGAGAATGTGCTACCTT ACCATCAAAGAAATGGCTACCATCTCTGAGGATGTGATAATTGTCACAAGCAGTGTCATCAGTGGTGTTGGGGAACTGGATCTAGACAAA GGGCCAGTGAAGAAAGCAGAGCCCCATACCAAAGACAAACCTTATCCTGACTGCCCCTTCCTGCTGCTAGATGTGCGTGATAGAGATTCT TACCAGCAGTGCCACATTGTTGGAGCTTACAGTTACCCAATTGCAACTCTGTCTAGAACAATGAACCCTTATTCAAATGATATTCTTGAA TATAAAAATGCCCATGGCAAGATCATCATTCTGTATGACGATGATGAAAGGCTGGCCAGTCAGGCGGCCACCACCATGTGCGAGCGTGGA TTTGAAAACCTCTTCATGCTTTCCGGAGGCCGACTGAACCAAGCTAACTCCTCCGGAAGAGAGTCCAAGGTGCCTGGTGCCCGAAGCGCT CAGAATCTGCCAGGTGGCGGCCCCGCCAGCCACTCAAACCCCCGCTCCCTCAGCAGTGGTCACCTGCAAGGCAAACCCTGGAAGTAAAGA CTTTGTCTCACTTAGGCAAATAAATGTTCTTCCTCTTTTCAGAACCCCTGAGCATTTCCCAAGTTGGGTCATTTCCAGAAACTTCTGCAG 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FusionGenePPI for COPG2_CEP41 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| COPG2 | COPB1, COPG1, MAGED1, DRD1, PMS2, MYC, ELAVL1, SIRT7, COPB2, COPA, COPG2, ARCN1, COPE, COPZ1, NDUFB8, ECT2, HES4, FBXO6, NUDCD1, STAU1, SHMT2, CD74, ATP1B2, HTR6, NTRK1, TMED10, HERC2, XPO1, MCM2, SNW1, CDC5L, SENP3, CDH1, PTPRD, TES | CEP41 | HIP1R, MVB12A, WARS, DCTN1, XPO1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COPG2_CEP41 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COPG2_CEP41 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | COPG2 | C0043094 | Weight Gain | 1 | CTD_human |
| Tgene | CEP41 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |
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