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Fusion gene ID: 8057 |
FusionGeneSummary for COMT_THBS3 |
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Fusion gene information | Fusion gene name: COMT_THBS3 | Fusion gene ID: 8057 | Hgene | Tgene | Gene symbol | COMT | THBS3 | Gene ID | 1312 | 7059 |
Gene name | catechol-O-methyltransferase | thrombospondin 3 | |
Synonyms | HEL-S-98n | TSP3 | |
Cytomap | 22q11.21 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | catechol O-methyltransferasecatechol-O-methyltransferase isoformepididymis secretory sperm binding protein Li 98ntesticular tissue protein Li 42 | thrombospondin-3 | |
Modification date | 20180527 | 20180519 | |
UniProtAcc | P21964 | P49746 | |
Ensembl transtripts involved in fusion gene | ENST00000361682, ENST00000403184, ENST00000403710, ENST00000407537, ENST00000406520, ENST00000449653, ENST00000493893, | ENST00000368378, ENST00000541576, ENST00000457183, ENST00000541990, ENST00000486260, | |
Fusion gene scores | * DoF score | 9 X 8 X 4=288 | 6 X 6 X 2=72 |
# samples | 10 | 7 | |
** MAII score | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: COMT [Title/Abstract] AND THBS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | COMT | GO:0042424 | catecholamine catabolic process | 15645182|21846718 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AW340773 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-3CDS | ENST00000361682 | ENST00000368378 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
3UTR-intron | ENST00000361682 | ENST00000541576 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
3UTR-intron | ENST00000361682 | ENST00000457183 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
3UTR-5UTR | ENST00000361682 | ENST00000541990 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
3UTR-intron | ENST00000361682 | ENST00000486260 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-3CDS | ENST00000403184 | ENST00000368378 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000403184 | ENST00000541576 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000403184 | ENST00000457183 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-5UTR | ENST00000403184 | ENST00000541990 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000403184 | ENST00000486260 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-3CDS | ENST00000403710 | ENST00000368378 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000403710 | ENST00000541576 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000403710 | ENST00000457183 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-5UTR | ENST00000403710 | ENST00000541990 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000403710 | ENST00000486260 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-3CDS | ENST00000407537 | ENST00000368378 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000407537 | ENST00000541576 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000407537 | ENST00000457183 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-5UTR | ENST00000407537 | ENST00000541990 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000407537 | ENST00000486260 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-3CDS | ENST00000406520 | ENST00000368378 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000406520 | ENST00000541576 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000406520 | ENST00000457183 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-5UTR | ENST00000406520 | ENST00000541990 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000406520 | ENST00000486260 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
3UTR-3CDS | ENST00000449653 | ENST00000368378 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
3UTR-intron | ENST00000449653 | ENST00000541576 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
3UTR-intron | ENST00000449653 | ENST00000457183 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
3UTR-5UTR | ENST00000449653 | ENST00000541990 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
3UTR-intron | ENST00000449653 | ENST00000486260 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-3CDS | ENST00000493893 | ENST00000368378 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000493893 | ENST00000541576 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000493893 | ENST00000457183 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-5UTR | ENST00000493893 | ENST00000541990 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
intron-intron | ENST00000493893 | ENST00000486260 | COMT | chr22 | 19957168 | - | THBS3 | chr1 | 155177604 | + |
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FusionProtFeatures for COMT_THBS3 |
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Hgene | Tgene |
COMT | THBS3 |
Catalyzes the O-methylation, and thereby theinactivation, of catecholamine neurotransmitters and catecholhormones. Also shortens the biological half-lives of certainneuroactive drugs, like L-DOPA, alpha-methyl DOPA andisoproterenol. {ECO:0000269|PubMed:21846718}. | Adhesive glycoprotein that mediates cell-to-cell andcell-to-matrix interactions. Can bind to fibrinogen, fibronectin,laminin and type V collagen. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for COMT_THBS3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for COMT_THBS3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COMT_THBS3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Hgene | COMT | P21964 | DB00494 | Entacapone | Catechol O-methyltransferase | small molecule | approved|investigational |
Hgene | COMT | P21964 | DB00118 | Ademetionine | Catechol O-methyltransferase | small molecule | approved|investigational|nutraceutical |
Hgene | COMT | P21964 | DB00323 | Tolcapone | Catechol O-methyltransferase | small molecule | approved|withdrawn |
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RelatedDiseases for COMT_THBS3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | COMT | C0005586 | Bipolar Disorder | 6 | CTD_human;PSYGENET |
Hgene | COMT | C0001723 | Affective Disorders, Psychotic | 5 | PSYGENET |
Hgene | COMT | C0011570 | Mental Depression | 5 | PSYGENET |
Hgene | COMT | C0011581 | Depressive disorder | 5 | PSYGENET |
Hgene | COMT | C0041696 | Unipolar Depression | 5 | PSYGENET |
Hgene | COMT | C0525045 | Mood Disorders | 5 | PSYGENET |
Hgene | COMT | C1269683 | Major Depressive Disorder | 5 | PSYGENET |
Hgene | COMT | C0036341 | Schizophrenia | 4 | CTD_human |
Hgene | COMT | C0024809 | Marijuana Abuse | 3 | PSYGENET |
Hgene | COMT | C0600427 | Cocaine Dependence | 3 | PSYGENET |
Hgene | COMT | C1458155 | Mammary Neoplasms | 3 | CTD_human |
Hgene | COMT | C0005587 | Depression, Bipolar | 2 | PSYGENET |
Hgene | COMT | C0233477 | Dysphoric mood | 2 | PSYGENET |
Hgene | COMT | C3160814 | Cannabis use | 2 | PSYGENET |
Hgene | COMT | C0001973 | Alcoholic Intoxication, Chronic | 1 | CTD_human |
Hgene | COMT | C0004352 | Autistic Disorder | 1 | CTD_human |
Hgene | COMT | C0004936 | Mental disorders | 1 | CTD_human |
Hgene | COMT | C0009241 | Cognition Disorders | 1 | CTD_human |
Hgene | COMT | C0012236 | DiGeorge Syndrome | 1 | CTD_human;ORPHANET |
Hgene | COMT | C0015934 | Fetal Growth Retardation | 1 | CTD_human |
Hgene | COMT | C0024667 | Animal Mammary Neoplasms | 1 | CTD_human |
Hgene | COMT | C0026858 | Musculoskeletal Pain | 1 | CTD_human |
Hgene | COMT | C0030193 | Pain | 1 | CTD_human |
Hgene | COMT | C0031511 | Pheochromocytoma | 1 | CTD_human |
Hgene | COMT | C0033578 | Prostatic Neoplasms | 1 | CTD_human |
Hgene | COMT | C0039494 | Temporomandibular Joint Disorders | 1 | CTD_human |
Hgene | COMT | C0086133 | Depressive Syndrome | 1 | PSYGENET |
Hgene | COMT | C0178417 | Anhedonia | 1 | PSYGENET |
Hgene | COMT | C0236733 | Amphetamine-Related Disorders | 1 | CTD_human |
Hgene | COMT | C0236736 | Cocaine-Related Disorders | 1 | CTD_human |
Hgene | COMT | C1263846 | Attention deficit hyperactivity disorder | 1 | CTD_human;HPO |
Hgene | COMT | C1306067 | Drug-induced paranoid state | 1 | PSYGENET |
Hgene | COMT | C2239176 | Liver carcinoma | 1 | CTD_human |
Hgene | COMT | C2750088 | HEARING LOSS, CISPLATIN-INDUCED, SUSCEPTIBILITY TO | 1 | CTD_human |