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Fusion gene ID: 8047 |
FusionGeneSummary for COMMD9_CDKL2 |
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Fusion gene information | Fusion gene name: COMMD9_CDKL2 | Fusion gene ID: 8047 | Hgene | Tgene | Gene symbol | COMMD9 | CDKL2 | Gene ID | 29099 | 8999 |
Gene name | COMM domain containing 9 | cyclin dependent kinase like 2 | |
Synonyms | C11orf55|HSPC166|LINC00610 | KKIAMRE|P56 | |
Cytomap | 11p13 | 4q21.1 | |
Type of gene | protein-coding | protein-coding | |
Description | COMM domain-containing protein 9 | cyclin-dependent kinase-like 2CDC2-related kinasep56 KKIAMRE protein kinaseprotein kinase p56 KKIAMREserine/threonine protein kinase KKIAMREtesticular tissue protein Li 35 | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q9P000 | Q92772 | |
Ensembl transtripts involved in fusion gene | ENST00000263401, ENST00000452374, ENST00000532705, ENST00000533308, | ENST00000429927, ENST00000307465, | |
Fusion gene scores | * DoF score | 6 X 3 X 4=72 | 2 X 2 X 2=8 |
# samples | 4 | 3 | |
** MAII score | log2(4/72*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/8*10)=1.90689059560852 | |
Context | PubMed: COMMD9 [Title/Abstract] AND CDKL2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LIHC | TCGA-BC-A10Z-01A | COMMD9 | chr11 | 36310912 | - | CDKL2 | chr4 | 76507108 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000263401 | ENST00000429927 | COMMD9 | chr11 | 36310912 | - | CDKL2 | chr4 | 76507108 | - |
Frame-shift | ENST00000263401 | ENST00000307465 | COMMD9 | chr11 | 36310912 | - | CDKL2 | chr4 | 76507108 | - |
Frame-shift | ENST00000452374 | ENST00000429927 | COMMD9 | chr11 | 36310912 | - | CDKL2 | chr4 | 76507108 | - |
Frame-shift | ENST00000452374 | ENST00000307465 | COMMD9 | chr11 | 36310912 | - | CDKL2 | chr4 | 76507108 | - |
Frame-shift | ENST00000532705 | ENST00000429927 | COMMD9 | chr11 | 36310912 | - | CDKL2 | chr4 | 76507108 | - |
Frame-shift | ENST00000532705 | ENST00000307465 | COMMD9 | chr11 | 36310912 | - | CDKL2 | chr4 | 76507108 | - |
intron-3CDS | ENST00000533308 | ENST00000429927 | COMMD9 | chr11 | 36310912 | - | CDKL2 | chr4 | 76507108 | - |
intron-3CDS | ENST00000533308 | ENST00000307465 | COMMD9 | chr11 | 36310912 | - | CDKL2 | chr4 | 76507108 | - |
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FusionProtFeatures for COMMD9_CDKL2 |
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Hgene | Tgene |
COMMD9 | CDKL2 |
May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). May down-regulate activation ofNF-kappa-B (PubMed:15799966). Modulates Na(+) transport inepithelial cells by regulation of apical cell surface expressionof amiloride-sensitive sodium channel (ENaC) subunits(PubMed:23637203). {ECO:0000269|PubMed:15799966,ECO:0000269|PubMed:23637203, ECO:0000305|PubMed:21778237}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for COMMD9_CDKL2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for COMMD9_CDKL2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
COMMD9 | RELB, NFKB1, COMMD7, CCDC22, MOV10, NXF1, AKR7A3, LYPD3, COMMD3, COMMD4, COMMD6, XPO7, CCDC93, COMMD8, COMMD10, COMMD1, FAM45A, COMMD2, VPS29 | CDKL2 | APP, FRY, HSP90AA1, HSP90AA5P, HSP90AA4P, CDC37, CDK14 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COMMD9_CDKL2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COMMD9_CDKL2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CDKL2 | C0007621 | Neoplastic Cell Transformation | 1 | CTD_human |
Tgene | CDKL2 | C0024668 | Mammary Neoplasms, Experimental | 1 | CTD_human |
Tgene | CDKL2 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |