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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8047

FusionGeneSummary for COMMD9_CDKL2

check button Fusion gene summary
Fusion gene informationFusion gene name: COMMD9_CDKL2
Fusion gene ID: 8047
HgeneTgene
Gene symbol

COMMD9

CDKL2

Gene ID

29099

8999

Gene nameCOMM domain containing 9cyclin dependent kinase like 2
SynonymsC11orf55|HSPC166|LINC00610KKIAMRE|P56
Cytomap

11p13

4q21.1

Type of geneprotein-codingprotein-coding
DescriptionCOMM domain-containing protein 9cyclin-dependent kinase-like 2CDC2-related kinasep56 KKIAMRE protein kinaseprotein kinase p56 KKIAMREserine/threonine protein kinase KKIAMREtesticular tissue protein Li 35
Modification date2018051920180523
UniProtAcc

Q9P000

Q92772

Ensembl transtripts involved in fusion geneENST00000263401, ENST00000452374, 
ENST00000532705, ENST00000533308, 
ENST00000429927, ENST00000307465, 
Fusion gene scores* DoF score6 X 3 X 4=722 X 2 X 2=8
# samples 43
** MAII scorelog2(4/72*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/8*10)=1.90689059560852
Context

PubMed: COMMD9 [Title/Abstract] AND CDKL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-BC-A10Z-01ACOMMD9chr11

36310912

-CDKL2chr4

76507108

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000263401ENST00000429927COMMD9chr11

36310912

-CDKL2chr4

76507108

-
Frame-shiftENST00000263401ENST00000307465COMMD9chr11

36310912

-CDKL2chr4

76507108

-
Frame-shiftENST00000452374ENST00000429927COMMD9chr11

36310912

-CDKL2chr4

76507108

-
Frame-shiftENST00000452374ENST00000307465COMMD9chr11

36310912

-CDKL2chr4

76507108

-
Frame-shiftENST00000532705ENST00000429927COMMD9chr11

36310912

-CDKL2chr4

76507108

-
Frame-shiftENST00000532705ENST00000307465COMMD9chr11

36310912

-CDKL2chr4

76507108

-
intron-3CDSENST00000533308ENST00000429927COMMD9chr11

36310912

-CDKL2chr4

76507108

-
intron-3CDSENST00000533308ENST00000307465COMMD9chr11

36310912

-CDKL2chr4

76507108

-

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FusionProtFeatures for COMMD9_CDKL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COMMD9

Q9P000

CDKL2

Q92772

May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). May down-regulate activation ofNF-kappa-B (PubMed:15799966). Modulates Na(+) transport inepithelial cells by regulation of apical cell surface expressionof amiloride-sensitive sodium channel (ENaC) subunits(PubMed:23637203). {ECO:0000269|PubMed:15799966,ECO:0000269|PubMed:23637203, ECO:0000305|PubMed:21778237}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COMMD9_CDKL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COMMD9_CDKL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COMMD9RELB, NFKB1, COMMD7, CCDC22, MOV10, NXF1, AKR7A3, LYPD3, COMMD3, COMMD4, COMMD6, XPO7, CCDC93, COMMD8, COMMD10, COMMD1, FAM45A, COMMD2, VPS29CDKL2APP, FRY, HSP90AA1, HSP90AA5P, HSP90AA4P, CDC37, CDK14


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COMMD9_CDKL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COMMD9_CDKL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCDKL2C0007621Neoplastic Cell Transformation1CTD_human
TgeneCDKL2C0024668Mammary Neoplasms, Experimental1CTD_human
TgeneCDKL2C0027627Neoplasm Metastasis1CTD_human