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Fusion gene ID: 8041 |
FusionGeneSummary for COMMD6_PCDH9 |
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Fusion gene information | Fusion gene name: COMMD6_PCDH9 | Fusion gene ID: 8041 | Hgene | Tgene | Gene symbol | COMMD6 | PCDH9 | Gene ID | 170622 | 5101 |
Gene name | COMM domain containing 6 | protocadherin 9 | |
Synonyms | Acrg | - | |
Cytomap | 13q22.2 | 13q21.32 | |
Type of gene | protein-coding | protein-coding | |
Description | COMM domain-containing protein 6Acrg embryonic lethality minimal region ortholog | protocadherin-9cadherin superfamily protein VR4-11 | |
Modification date | 20180519 | 20180527 | |
UniProtAcc | Q7Z4G1 | Q9HC56 | |
Ensembl transtripts involved in fusion gene | ENST00000406936, ENST00000377615, ENST00000377619, ENST00000355801, ENST00000460675, | ENST00000544246, ENST00000377865, ENST00000456367, ENST00000328454, ENST00000377861, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 7 X 5 X 4=140 |
# samples | 2 | 7 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: COMMD6 [Title/Abstract] AND PCDH9 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | COMMD6 | GO:0032088 | negative regulation of NF-kappaB transcription factor activity | 16573520 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LGG | TCGA-TQ-A7RW-01A | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000406936 | ENST00000544246 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000406936 | ENST00000377865 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000406936 | ENST00000456367 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000406936 | ENST00000328454 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-intron | ENST00000406936 | ENST00000377861 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000377615 | ENST00000544246 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000377615 | ENST00000377865 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000377615 | ENST00000456367 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000377615 | ENST00000328454 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-intron | ENST00000377615 | ENST00000377861 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000377619 | ENST00000544246 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000377619 | ENST00000377865 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000377619 | ENST00000456367 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000377619 | ENST00000328454 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-intron | ENST00000377619 | ENST00000377861 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000355801 | ENST00000544246 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000355801 | ENST00000377865 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000355801 | ENST00000456367 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-3CDS | ENST00000355801 | ENST00000328454 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
intron-intron | ENST00000355801 | ENST00000377861 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
5UTR-3CDS | ENST00000460675 | ENST00000544246 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
5UTR-3CDS | ENST00000460675 | ENST00000377865 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
5UTR-3CDS | ENST00000460675 | ENST00000456367 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
5UTR-3CDS | ENST00000460675 | ENST00000328454 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
5UTR-intron | ENST00000460675 | ENST00000377861 | COMMD6 | chr13 | 76123459 | - | PCDH9 | chr13 | 67205543 | - |
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FusionProtFeatures for COMMD6_PCDH9 |
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Hgene | Tgene |
COMMD6 | PCDH9 |
May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). Down-regulates activation ofNF-kappa-B. Inhibits TNF-induced NFKB1 activation.{ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520,ECO:0000305|PubMed:21778237}. | Potential calcium-dependent cell-adhesion protein. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for COMMD6_PCDH9 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for COMMD6_PCDH9 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
COMMD6 | COMMD1, RELA, NFKB1, COMMD6, COMMD4, VCP, CCDC22, COMMD10, ZFP36, CCDC93, E2F6, COMMD3, UNK, COMMD9, SCLT1, COMMD7, FAM45A, COMMD2, COMMD8, C16orf62, COMMD5, DSCR3, VPS29, TFDP1, VPS33B, MFAP3, KIF2B, EMB, TM2D3 | PCDH9 | RYK, BCL6, ELAVL1, MEOX2, HLA-DPA1, NXPH2, CEACAM21, LGALS9, VSIG4, LPPR2, EVA1C, PCDHGB1, TPCN2, IKBIP |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COMMD6_PCDH9 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COMMD6_PCDH9 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | PCDH9 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |