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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8040

FusionGeneSummary for COMMD6_COMMD6

check button Fusion gene summary
Fusion gene informationFusion gene name: COMMD6_COMMD6
Fusion gene ID: 8040
HgeneTgene
Gene symbol

COMMD6

COMMD6

Gene ID

170622

170622

Gene nameCOMM domain containing 6COMM domain containing 6
SynonymsAcrgAcrg
Cytomap

13q22.2

13q22.2

Type of geneprotein-codingprotein-coding
DescriptionCOMM domain-containing protein 6Acrg embryonic lethality minimal region orthologCOMM domain-containing protein 6Acrg embryonic lethality minimal region ortholog
Modification date2018051920180519
UniProtAcc

Q7Z4G1

Q7Z4G1

Ensembl transtripts involved in fusion geneENST00000406936, ENST00000377615, 
ENST00000377619, ENST00000355801, 
ENST00000460675, 		ENST00000406936, 
ENST00000377615, ENST00000377619, 
ENST00000355801, ENST00000460675, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 4 X 3=36
# samples 24
** MAII scorelog2(2/8*10)=1.32192809488736log2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: COMMD6 [Title/Abstract] AND COMMD6 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOMMD6

GO:0032088

negative regulation of NF-kappaB transcription factor activity

16573520

TgeneCOMMD6

GO:0032088

negative regulation of NF-kappaB transcription factor activity

16573520


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB242821COMMD6chr13

76100716

+COMMD6chr13

76104289

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000406936ENST00000406936COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000406936ENST00000377615COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000406936ENST00000377619COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000406936ENST00000355801COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-5UTRENST00000406936ENST00000460675COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000377615ENST00000406936COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000377615ENST00000377615COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000377615ENST00000377619COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000377615ENST00000355801COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-5UTRENST00000377615ENST00000460675COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000377619ENST00000406936COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000377619ENST00000377615COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000377619ENST00000377619COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000377619ENST00000355801COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-5UTRENST00000377619ENST00000460675COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000355801ENST00000406936COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000355801ENST00000377615COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000355801ENST00000377619COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000355801ENST00000355801COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-5UTRENST00000355801ENST00000460675COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000460675ENST00000406936COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000460675ENST00000377615COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000460675ENST00000377619COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-3CDSENST00000460675ENST00000355801COMMD6chr13

76100716

+COMMD6chr13

76104289

-
intron-5UTRENST00000460675ENST00000460675COMMD6chr13

76100716

+COMMD6chr13

76104289

-

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FusionProtFeatures for COMMD6_COMMD6


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COMMD6

Q7Z4G1

COMMD6

Q7Z4G1

May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). Down-regulates activation ofNF-kappa-B. Inhibits TNF-induced NFKB1 activation.{ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520,ECO:0000305|PubMed:21778237}. May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). Down-regulates activation ofNF-kappa-B. Inhibits TNF-induced NFKB1 activation.{ECO:0000269|PubMed:15799966, ECO:0000269|PubMed:16573520,ECO:0000305|PubMed:21778237}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COMMD6_COMMD6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COMMD6_COMMD6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COMMD6_COMMD6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COMMD6_COMMD6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource