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Fusion gene ID: 8033 |
FusionGeneSummary for COMMD10_DGKI |
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Fusion gene information | Fusion gene name: COMMD10_DGKI | Fusion gene ID: 8033 | Hgene | Tgene | Gene symbol | COMMD10 | DGKI | Gene ID | 51397 | 9162 |
Gene name | COMM domain containing 10 | diacylglycerol kinase iota | |
Synonyms | PTD002 | DGK-IOTA | |
Cytomap | 5q23.1 | 7q33 | |
Type of gene | protein-coding | protein-coding | |
Description | COMM domain-containing protein 10 | diacylglycerol kinase iotaDAG kinase iotadiglyceride kinase iota | |
Modification date | 20180519 | 20180519 | |
UniProtAcc | Q9Y6G5 | O75912 | |
Ensembl transtripts involved in fusion gene | ENST00000274458, ENST00000515539, ENST00000503424, | ENST00000453654, ENST00000288490, ENST00000424189, ENST00000446122, ENST00000494390, | |
Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 4 X 4 X 3=48 |
# samples | 6 | 4 | |
** MAII score | log2(6/32*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: COMMD10 [Title/Abstract] AND DGKI [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | DGKI | GO:0046834 | lipid phosphorylation | 9830018 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | BRCA | TCGA-B6-A0IO-01A | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000274458 | ENST00000453654 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
Frame-shift | ENST00000274458 | ENST00000288490 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
Frame-shift | ENST00000274458 | ENST00000424189 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
Frame-shift | ENST00000274458 | ENST00000446122 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
5CDS-5UTR | ENST00000274458 | ENST00000494390 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
Frame-shift | ENST00000515539 | ENST00000453654 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
Frame-shift | ENST00000515539 | ENST00000288490 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
Frame-shift | ENST00000515539 | ENST00000424189 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
Frame-shift | ENST00000515539 | ENST00000446122 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
5CDS-5UTR | ENST00000515539 | ENST00000494390 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
intron-3CDS | ENST00000503424 | ENST00000453654 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
intron-3CDS | ENST00000503424 | ENST00000288490 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
intron-3CDS | ENST00000503424 | ENST00000424189 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
intron-3CDS | ENST00000503424 | ENST00000446122 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
intron-5UTR | ENST00000503424 | ENST00000494390 | COMMD10 | chr5 | 115469875 | + | DGKI | chr7 | 137076082 | - |
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FusionProtFeatures for COMMD10_DGKI |
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Hgene | Tgene |
COMMD10 | DGKI |
May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). May down-regulate activation ofNF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966,ECO:0000305|PubMed:21778237}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for COMMD10_DGKI |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for COMMD10_DGKI |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
COMMD10 | COMMD1, RELA, RELB, NFKB1, COMMD7, COMMD8, CCDC22, COMMD6, COMMD3, COMMD4, CCDC93, COMMD2, COMMD5, FAM45A, VPS29, C16orf62, TRIM13, COMMD9, FKBP15, TCTEX1D2, DSCR3, TRAF7, C11orf73, TP53RK, TPRKB, ACOT9 | DGKI | VHL, RASGRP3, RAP1A, AP2M1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COMMD10_DGKI |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COMMD10_DGKI |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |