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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 8033

FusionGeneSummary for COMMD10_DGKI

check button Fusion gene summary
Fusion gene informationFusion gene name: COMMD10_DGKI
Fusion gene ID: 8033
HgeneTgene
Gene symbol

COMMD10

DGKI

Gene ID

51397

9162

Gene nameCOMM domain containing 10diacylglycerol kinase iota
SynonymsPTD002DGK-IOTA
Cytomap

5q23.1

7q33

Type of geneprotein-codingprotein-coding
DescriptionCOMM domain-containing protein 10diacylglycerol kinase iotaDAG kinase iotadiglyceride kinase iota
Modification date2018051920180519
UniProtAcc

Q9Y6G5

O75912

Ensembl transtripts involved in fusion geneENST00000274458, ENST00000515539, 
ENST00000503424, 
ENST00000453654, 
ENST00000288490, ENST00000424189, 
ENST00000446122, ENST00000494390, 
Fusion gene scores* DoF score4 X 2 X 4=324 X 4 X 3=48
# samples 64
** MAII scorelog2(6/32*10)=0.906890595608518
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COMMD10 [Title/Abstract] AND DGKI [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDGKI

GO:0046834

lipid phosphorylation

9830018


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-B6-A0IO-01ACOMMD10chr5

115469875

+DGKIchr7

137076082

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000274458ENST00000453654COMMD10chr5

115469875

+DGKIchr7

137076082

-
Frame-shiftENST00000274458ENST00000288490COMMD10chr5

115469875

+DGKIchr7

137076082

-
Frame-shiftENST00000274458ENST00000424189COMMD10chr5

115469875

+DGKIchr7

137076082

-
Frame-shiftENST00000274458ENST00000446122COMMD10chr5

115469875

+DGKIchr7

137076082

-
5CDS-5UTRENST00000274458ENST00000494390COMMD10chr5

115469875

+DGKIchr7

137076082

-
Frame-shiftENST00000515539ENST00000453654COMMD10chr5

115469875

+DGKIchr7

137076082

-
Frame-shiftENST00000515539ENST00000288490COMMD10chr5

115469875

+DGKIchr7

137076082

-
Frame-shiftENST00000515539ENST00000424189COMMD10chr5

115469875

+DGKIchr7

137076082

-
Frame-shiftENST00000515539ENST00000446122COMMD10chr5

115469875

+DGKIchr7

137076082

-
5CDS-5UTRENST00000515539ENST00000494390COMMD10chr5

115469875

+DGKIchr7

137076082

-
intron-3CDSENST00000503424ENST00000453654COMMD10chr5

115469875

+DGKIchr7

137076082

-
intron-3CDSENST00000503424ENST00000288490COMMD10chr5

115469875

+DGKIchr7

137076082

-
intron-3CDSENST00000503424ENST00000424189COMMD10chr5

115469875

+DGKIchr7

137076082

-
intron-3CDSENST00000503424ENST00000446122COMMD10chr5

115469875

+DGKIchr7

137076082

-
intron-5UTRENST00000503424ENST00000494390COMMD10chr5

115469875

+DGKIchr7

137076082

-

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FusionProtFeatures for COMMD10_DGKI


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COMMD10

Q9Y6G5

DGKI

O75912

May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). May down-regulate activation ofNF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966,ECO:0000305|PubMed:21778237}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COMMD10_DGKI


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COMMD10_DGKI


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COMMD10COMMD1, RELA, RELB, NFKB1, COMMD7, COMMD8, CCDC22, COMMD6, COMMD3, COMMD4, CCDC93, COMMD2, COMMD5, FAM45A, VPS29, C16orf62, TRIM13, COMMD9, FKBP15, TCTEX1D2, DSCR3, TRAF7, C11orf73, TP53RK, TPRKB, ACOT9DGKIVHL, RASGRP3, RAP1A, AP2M1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COMMD10_DGKI


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COMMD10_DGKI


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource