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Fusion gene ID: 8032 |
FusionGeneSummary for COMMD10_CHSY3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COMMD10_CHSY3 | Fusion gene ID: 8032 | Hgene | Tgene | Gene symbol | COMMD10 | CHSY3 | Gene ID | 51397 | 337876 |
| Gene name | COMM domain containing 10 | chondroitin sulfate synthase 3 | |
| Synonyms | PTD002 | CHSY2|CSS3 | |
| Cytomap | 5q23.1 | 5q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | COMM domain-containing protein 10 | chondroitin sulfate synthase 3N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase 3N-acetylgalactosaminyltransferase 3carbohydrate synthase 2chSy-2chondroitin glucuronyltransferase 3chondroitin synthase-2glucuronosyl-N-acetylgalactos | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9Y6G5 | Q70JA7 | |
| Ensembl transtripts involved in fusion gene | ENST00000274458, ENST00000515539, ENST00000503424, | ENST00000305031, ENST00000507545, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 2 X 2 X 1=4 |
| # samples | 6 | 2 | |
| ** MAII score | log2(6/32*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: COMMD10 [Title/Abstract] AND CHSY3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-XX-A899-01A | COMMD10 | chr5 | 115469875 | + | CHSY3 | chr5 | 129519922 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000274458 | ENST00000305031 | COMMD10 | chr5 | 115469875 | + | CHSY3 | chr5 | 129519922 | + |
| 5CDS-3UTR | ENST00000274458 | ENST00000507545 | COMMD10 | chr5 | 115469875 | + | CHSY3 | chr5 | 129519922 | + |
| In-frame | ENST00000515539 | ENST00000305031 | COMMD10 | chr5 | 115469875 | + | CHSY3 | chr5 | 129519922 | + |
| 5CDS-3UTR | ENST00000515539 | ENST00000507545 | COMMD10 | chr5 | 115469875 | + | CHSY3 | chr5 | 129519922 | + |
| intron-3CDS | ENST00000503424 | ENST00000305031 | COMMD10 | chr5 | 115469875 | + | CHSY3 | chr5 | 129519922 | + |
| intron-3UTR | ENST00000503424 | ENST00000507545 | COMMD10 | chr5 | 115469875 | + | CHSY3 | chr5 | 129519922 | + |
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FusionProtFeatures for COMMD10_CHSY3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COMMD10 | CHSY3 |
| May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). May down-regulate activation ofNF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966,ECO:0000305|PubMed:21778237}. | Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronicacid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc)from UDP-GalNAc to the non-reducing end of the elongatingchondroitin polymer. Specific activity is much reduced compared toCHSY1. {ECO:0000269|PubMed:12907687}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CHSY3 | chr5:115469875 | chr5:129519922 | ENST00000305031 | + | 1 | 3 | 539_544 | 362 | 883 | Compositional bias | Note=Poly-Leu |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >COMMD10 | chr5:115469875 | chr5:129519922 | ENST00000274458 | + | 5 | 7 | 133_202 | 170 | 203 | Domain | COMM |
| Tgene | CHSY3 | chr5:115469875 | chr5:129519922 | ENST00000305031 | + | 1 | 3 | 211_235 | 362 | 883 | Compositional bias | Note=Pro-rich |
| Tgene | CHSY3 | chr5:115469875 | chr5:129519922 | ENST00000305031 | + | 1 | 3 | 1_7 | 362 | 883 | Topological domain | Cytoplasmic |
| Tgene | CHSY3 | chr5:115469875 | chr5:129519922 | ENST00000305031 | + | 1 | 3 | 29_882 | 362 | 883 | Topological domain | Lumenal |
| Tgene | CHSY3 | chr5:115469875 | chr5:129519922 | ENST00000305031 | + | 1 | 3 | 8_28 | 362 | 883 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
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FusionGeneSequence for COMMD10_CHSY3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_COMMD10_ENST00000274458_chr5_115469875_+_CHSY3_ENST00000305031_chr5_129519922_+_691aa MAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPA ALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKMQQLFHENYE HNRKGYIQDLHNSKIHAAITLHPNKRPAYQYRLHNYMLSRKISELRYRTIQLHRESALMSKLSNTEVSKEDQQLGVIPSFNHFQPRERNE VIEWEFLTGKLLYSAAENQPPRQSLSSILRTALDDTVLQVMEMINENAKSRGRLIDFKEIQYGYRRVNPMHGVEYILDLLLLYKRHKGRK LTVPVRRHAYLQQLFSKPFFRETEELDVNSLVESINSETQSFSFISNSLKILSSFQGAKEMGGHNEKKVHILVPLIGRYDIFLRFMENFE NMCLIPKQNVKLVIILFSRDSGQDSSKHIELIKGYQNKYPKAEMTLIPMKGEFSRGLGLEMASAQFDNDTLLLFCDVDLIFREDFLQRCR DNTIQGQQVYYPIIFSQYDPKVTNGGNPPTDDYFIFSKKTGFWRDYGYGITCIYKSDLLGAGGFDTSIQGWGLEDVDLYNKVILSGLRPF >In-frame_COMMD10_ENST00000515539_chr5_115469875_+_CHSY3_ENST00000305031_chr5_129519922_+_677aa MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQD KAEAFVNTWSSMGQETVEKFRQRILAPCKLETVGWQLNLQMAHSAQAKLKSPQAVLQLGVNNEDSKMQQLFHENYEHNRKGYIQDLHNSK IHAAITLHPNKRPAYQYRLHNYMLSRKISELRYRTIQLHRESALMSKLSNTEVSKEDQQLGVIPSFNHFQPRERNEVIEWEFLTGKLLYS AAENQPPRQSLSSILRTALDDTVLQVMEMINENAKSRGRLIDFKEIQYGYRRVNPMHGVEYILDLLLLYKRHKGRKLTVPVRRHAYLQQL FSKPFFRETEELDVNSLVESINSETQSFSFISNSLKILSSFQGAKEMGGHNEKKVHILVPLIGRYDIFLRFMENFENMCLIPKQNVKLVI ILFSRDSGQDSSKHIELIKGYQNKYPKAEMTLIPMKGEFSRGLGLEMASAQFDNDTLLLFCDVDLIFREDFLQRCRDNTIQGQQVYYPII FSQYDPKVTNGGNPPTDDYFIFSKKTGFWRDYGYGITCIYKSDLLGAGGFDTSIQGWGLEDVDLYNKVILSGLRPFRSQEVGVVHIFHPV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_COMMD10_ENST00000274458_chr5_115469875_+_CHSY3_ENST00000305031_chr5_129519922_+_2073nt ATGGCGGTCCCCGCGGCGCTGATCCTACGGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTT CCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCA TTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCA GCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACA GTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAA GCAAAACTAAAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGATGCAACAACTGTTCCATGAAAATTATGAA CACAATCGGAAGGGTTACATCCAAGACCTTCACAATAGCAAAATCCATGCAGCCATAACACTTCATCCCAACAAAAGGCCTGCATACCAA TACAGGCTGCATAATTACATGCTCAGCCGCAAAATTTCTGAACTTCGCTACCGCACCATCCAGCTCCACAGGGAAAGTGCCCTGATGAGC AAGCTCAGTAACACAGAAGTGAGCAAAGAGGACCAGCAGCTGGGAGTGATACCTTCTTTCAACCACTTCCAGCCTCGGGAGAGAAATGAA GTGATAGAATGGGAGTTCCTGACAGGGAAGCTTCTATACTCAGCAGCTGAGAACCAGCCCCCTCGACAGAGCCTCAGTAGCATTTTAAGA ACAGCACTGGATGATACCGTCCTACAGGTGATGGAGATGATCAATGAGAATGCCAAGAGCAGAGGACGGCTCATTGACTTCAAGGAAATT CAGTATGGCTACCGCAGAGTTAACCCCATGCACGGGGTGGAGTACATTTTGGATTTACTCCTTTTATACAAAAGACACAAGGGAAGGAAA CTGACTGTGCCAGTGAGACGTCATGCCTATCTTCAGCAGTTGTTCAGCAAGCCTTTCTTCAGAGAGACCGAAGAGCTAGATGTCAACAGT CTTGTGGAGAGTATTAACAGTGAAACTCAGTCATTCTCCTTTATATCTAATTCTTTAAAGATATTATCTTCTTTTCAAGGTGCCAAAGAA ATGGGAGGGCACAATGAAAAGAAAGTACACATTCTCGTTCCTCTCATCGGAAGGTATGACATTTTCTTGAGATTCATGGAGAACTTTGAA AACATGTGTCTTATCCCAAAGCAGAATGTAAAGTTGGTCATTATCCTTTTCAGTAGGGATTCTGGCCAAGACTCCAGCAAGCATATTGAG CTGATAAAAGGGTACCAGAACAAGTACCCCAAAGCAGAAATGACCCTGATCCCAATGAAGGGAGAGTTTTCCAGAGGTCTTGGTCTTGAA ATGGCTTCTGCCCAGTTTGACAATGACACTTTGCTGCTATTTTGTGATGTTGACTTGATCTTCAGAGAAGATTTTCTCCAACGATGTAGA GACAATACAATTCAGGGACAACAGGTGTACTATCCCATCATCTTTAGCCAGTATGACCCAAAGGTAACAAACGGGGGAAATCCTCCCACT GATGATTACTTCATATTCTCAAAAAAGACTGGATTTTGGAGAGACTATGGATATGGCATCACCTGTATTTACAAAAGTGATCTTCTAGGT GCAGGTGGATTTGATACCTCAATACAAGGCTGGGGACTAGAAGATGTAGATCTCTACAATAAAGTCATTCTATCTGGCTTAAGGCCATTC AGAAGCCAAGAAGTAGGAGTGGTGCATATTTTCCATCCAGTTCATTGTGATCCTAACTTGGACCCTAAGCAGTATAAGATGTGCTTAGGA TCCAAGGCAAGTACTTTCGCCTCAACCATGCAACTGGCTGAACTCTGGCTTGAAAAACATTTAGGTGTCAGGTACAATCGAACTCTCTCC >In-frame_COMMD10_ENST00000515539_chr5_115469875_+_CHSY3_ENST00000305031_chr5_129519922_+_2031nt ATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAG GCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACA ATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGAC AAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGCTA GAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAACTCGGAGTG AACAATGAAGATTCAAAGATGCAACAACTGTTCCATGAAAATTATGAACACAATCGGAAGGGTTACATCCAAGACCTTCACAATAGCAAA ATCCATGCAGCCATAACACTTCATCCCAACAAAAGGCCTGCATACCAATACAGGCTGCATAATTACATGCTCAGCCGCAAAATTTCTGAA CTTCGCTACCGCACCATCCAGCTCCACAGGGAAAGTGCCCTGATGAGCAAGCTCAGTAACACAGAAGTGAGCAAAGAGGACCAGCAGCTG GGAGTGATACCTTCTTTCAACCACTTCCAGCCTCGGGAGAGAAATGAAGTGATAGAATGGGAGTTCCTGACAGGGAAGCTTCTATACTCA GCAGCTGAGAACCAGCCCCCTCGACAGAGCCTCAGTAGCATTTTAAGAACAGCACTGGATGATACCGTCCTACAGGTGATGGAGATGATC AATGAGAATGCCAAGAGCAGAGGACGGCTCATTGACTTCAAGGAAATTCAGTATGGCTACCGCAGAGTTAACCCCATGCACGGGGTGGAG TACATTTTGGATTTACTCCTTTTATACAAAAGACACAAGGGAAGGAAACTGACTGTGCCAGTGAGACGTCATGCCTATCTTCAGCAGTTG TTCAGCAAGCCTTTCTTCAGAGAGACCGAAGAGCTAGATGTCAACAGTCTTGTGGAGAGTATTAACAGTGAAACTCAGTCATTCTCCTTT ATATCTAATTCTTTAAAGATATTATCTTCTTTTCAAGGTGCCAAAGAAATGGGAGGGCACAATGAAAAGAAAGTACACATTCTCGTTCCT CTCATCGGAAGGTATGACATTTTCTTGAGATTCATGGAGAACTTTGAAAACATGTGTCTTATCCCAAAGCAGAATGTAAAGTTGGTCATT ATCCTTTTCAGTAGGGATTCTGGCCAAGACTCCAGCAAGCATATTGAGCTGATAAAAGGGTACCAGAACAAGTACCCCAAAGCAGAAATG ACCCTGATCCCAATGAAGGGAGAGTTTTCCAGAGGTCTTGGTCTTGAAATGGCTTCTGCCCAGTTTGACAATGACACTTTGCTGCTATTT TGTGATGTTGACTTGATCTTCAGAGAAGATTTTCTCCAACGATGTAGAGACAATACAATTCAGGGACAACAGGTGTACTATCCCATCATC TTTAGCCAGTATGACCCAAAGGTAACAAACGGGGGAAATCCTCCCACTGATGATTACTTCATATTCTCAAAAAAGACTGGATTTTGGAGA GACTATGGATATGGCATCACCTGTATTTACAAAAGTGATCTTCTAGGTGCAGGTGGATTTGATACCTCAATACAAGGCTGGGGACTAGAA GATGTAGATCTCTACAATAAAGTCATTCTATCTGGCTTAAGGCCATTCAGAAGCCAAGAAGTAGGAGTGGTGCATATTTTCCATCCAGTT CATTGTGATCCTAACTTGGACCCTAAGCAGTATAAGATGTGCTTAGGATCCAAGGCAAGTACTTTCGCCTCAACCATGCAACTGGCTGAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_COMMD10_ENST00000274458_chr5_115469875_+_CHSY3_ENST00000305031_chr5_129519922_+_2978nt GCGGCCGCCATTGGCTGGGTTCGGCGCAGCTAACAGACGGCGGCAGTGCGAGAAAGCCGAAGATGGCGGTCCCCGCGGCGCTGATCCTAC GGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAA AACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACC TAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTC ATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGG CTCCCTGTAAGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTCAAGCAAAACTAAAATCTCCTCAAGCTGTGT TACAACTCGGAGTGAACAATGAAGATTCAAAGATGCAACAACTGTTCCATGAAAATTATGAACACAATCGGAAGGGTTACATCCAAGACC TTCACAATAGCAAAATCCATGCAGCCATAACACTTCATCCCAACAAAAGGCCTGCATACCAATACAGGCTGCATAATTACATGCTCAGCC GCAAAATTTCTGAACTTCGCTACCGCACCATCCAGCTCCACAGGGAAAGTGCCCTGATGAGCAAGCTCAGTAACACAGAAGTGAGCAAAG AGGACCAGCAGCTGGGAGTGATACCTTCTTTCAACCACTTCCAGCCTCGGGAGAGAAATGAAGTGATAGAATGGGAGTTCCTGACAGGGA AGCTTCTATACTCAGCAGCTGAGAACCAGCCCCCTCGACAGAGCCTCAGTAGCATTTTAAGAACAGCACTGGATGATACCGTCCTACAGG TGATGGAGATGATCAATGAGAATGCCAAGAGCAGAGGACGGCTCATTGACTTCAAGGAAATTCAGTATGGCTACCGCAGAGTTAACCCCA TGCACGGGGTGGAGTACATTTTGGATTTACTCCTTTTATACAAAAGACACAAGGGAAGGAAACTGACTGTGCCAGTGAGACGTCATGCCT ATCTTCAGCAGTTGTTCAGCAAGCCTTTCTTCAGAGAGACCGAAGAGCTAGATGTCAACAGTCTTGTGGAGAGTATTAACAGTGAAACTC AGTCATTCTCCTTTATATCTAATTCTTTAAAGATATTATCTTCTTTTCAAGGTGCCAAAGAAATGGGAGGGCACAATGAAAAGAAAGTAC ACATTCTCGTTCCTCTCATCGGAAGGTATGACATTTTCTTGAGATTCATGGAGAACTTTGAAAACATGTGTCTTATCCCAAAGCAGAATG TAAAGTTGGTCATTATCCTTTTCAGTAGGGATTCTGGCCAAGACTCCAGCAAGCATATTGAGCTGATAAAAGGGTACCAGAACAAGTACC CCAAAGCAGAAATGACCCTGATCCCAATGAAGGGAGAGTTTTCCAGAGGTCTTGGTCTTGAAATGGCTTCTGCCCAGTTTGACAATGACA CTTTGCTGCTATTTTGTGATGTTGACTTGATCTTCAGAGAAGATTTTCTCCAACGATGTAGAGACAATACAATTCAGGGACAACAGGTGT ACTATCCCATCATCTTTAGCCAGTATGACCCAAAGGTAACAAACGGGGGAAATCCTCCCACTGATGATTACTTCATATTCTCAAAAAAGA CTGGATTTTGGAGAGACTATGGATATGGCATCACCTGTATTTACAAAAGTGATCTTCTAGGTGCAGGTGGATTTGATACCTCAATACAAG GCTGGGGACTAGAAGATGTAGATCTCTACAATAAAGTCATTCTATCTGGCTTAAGGCCATTCAGAAGCCAAGAAGTAGGAGTGGTGCATA TTTTCCATCCAGTTCATTGTGATCCTAACTTGGACCCTAAGCAGTATAAGATGTGCTTAGGATCCAAGGCAAGTACTTTCGCCTCAACCA TGCAACTGGCTGAACTCTGGCTTGAAAAACATTTAGGTGTCAGGTACAATCGAACTCTCTCCTGACAGTCCAGGCAACACATTTTGCCTT TTTTAAGGGGAGTTTACCTCATTGTTGGTTGTTGTTATTTTTATTGTATTATTGTTATTTTATTATTATTATTGTTATAATTTTATTTTG TTGTCCTGGTCTTAAACTACTCTTGGTTGTCTTCCTAAGGGTGTTTGTTGACCTCAAGCAAGAAGAGTCTGCAGTTCACTGATGTTTCAG ATTTCTACTGAAGTCAATATGTTATTACTTTTATATAACTTTATTTGAGATTGAGTTAAATCATAGCAATCAAATGACTTTTGAAACGCA TTCATCACAAGAGACAGCTTAGAAGAATGTTCTCTTGGGGCTTAAAGATGCAATATCGACTTTTATTTGGTTTCTCAAATTCAATGTGAT ACAAATATTTACTGGTGAAAGGTACCACAAAAGTGCTTTATGCTTCCTATGGGGAAGGGACTCTGTAACATAAACTTGAGTTTTGTAATT TATACAAGGACTTAAATATATAAACAATAATTTTCTTCATCTTTAGAATTTTTAAAGTAAATGAATACCTATGATTGTATGTTTATTTTT TAAAAAAAGTTTTAAAAATTGAGGAGTTTTGTTCCACAAGCAACCGGTACTGGCTACCCTGGTCTTATGACAATTATGAGCTCCTCACAA CTGTCTGCTATAAATGCGAATGAACTTTATTTTCTCAAGGAAATATGATTTAATTAAATATTCATGTACATTTTAGAAGCTTTATGAAAC AATGTCCTTCATTTGCTGGCAAGAAGATAAAATATGACAGAACCTGTTTATTTAAAATAAAACACAGGTATAGCAGTATTCTTTTTCAAA >In-frame_COMMD10_ENST00000515539_chr5_115469875_+_CHSY3_ENST00000305031_chr5_129519922_+_3008nt GACACTCTGGTGGGAAAGGCTCACGCTGCTGCTGGAGGGTCTTTAATAGCCAACATGTGTTAATACCCCTTTTAAATCAGTATCGAATAG GGGACCGAATTTTTGGTTGGTAGAAGAATCTAGCCTGGCTTTGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGAT TTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGG CATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAG CAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAA CAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGCTAGAGACCGTTGGATGGCAGCTTAACCTTCAGATGGCTCACTCTGCTC AAGCAAAACTAAAATCTCCTCAAGCTGTGTTACAACTCGGAGTGAACAATGAAGATTCAAAGATGCAACAACTGTTCCATGAAAATTATG AACACAATCGGAAGGGTTACATCCAAGACCTTCACAATAGCAAAATCCATGCAGCCATAACACTTCATCCCAACAAAAGGCCTGCATACC AATACAGGCTGCATAATTACATGCTCAGCCGCAAAATTTCTGAACTTCGCTACCGCACCATCCAGCTCCACAGGGAAAGTGCCCTGATGA GCAAGCTCAGTAACACAGAAGTGAGCAAAGAGGACCAGCAGCTGGGAGTGATACCTTCTTTCAACCACTTCCAGCCTCGGGAGAGAAATG AAGTGATAGAATGGGAGTTCCTGACAGGGAAGCTTCTATACTCAGCAGCTGAGAACCAGCCCCCTCGACAGAGCCTCAGTAGCATTTTAA GAACAGCACTGGATGATACCGTCCTACAGGTGATGGAGATGATCAATGAGAATGCCAAGAGCAGAGGACGGCTCATTGACTTCAAGGAAA TTCAGTATGGCTACCGCAGAGTTAACCCCATGCACGGGGTGGAGTACATTTTGGATTTACTCCTTTTATACAAAAGACACAAGGGAAGGA AACTGACTGTGCCAGTGAGACGTCATGCCTATCTTCAGCAGTTGTTCAGCAAGCCTTTCTTCAGAGAGACCGAAGAGCTAGATGTCAACA GTCTTGTGGAGAGTATTAACAGTGAAACTCAGTCATTCTCCTTTATATCTAATTCTTTAAAGATATTATCTTCTTTTCAAGGTGCCAAAG AAATGGGAGGGCACAATGAAAAGAAAGTACACATTCTCGTTCCTCTCATCGGAAGGTATGACATTTTCTTGAGATTCATGGAGAACTTTG AAAACATGTGTCTTATCCCAAAGCAGAATGTAAAGTTGGTCATTATCCTTTTCAGTAGGGATTCTGGCCAAGACTCCAGCAAGCATATTG AGCTGATAAAAGGGTACCAGAACAAGTACCCCAAAGCAGAAATGACCCTGATCCCAATGAAGGGAGAGTTTTCCAGAGGTCTTGGTCTTG AAATGGCTTCTGCCCAGTTTGACAATGACACTTTGCTGCTATTTTGTGATGTTGACTTGATCTTCAGAGAAGATTTTCTCCAACGATGTA GAGACAATACAATTCAGGGACAACAGGTGTACTATCCCATCATCTTTAGCCAGTATGACCCAAAGGTAACAAACGGGGGAAATCCTCCCA CTGATGATTACTTCATATTCTCAAAAAAGACTGGATTTTGGAGAGACTATGGATATGGCATCACCTGTATTTACAAAAGTGATCTTCTAG GTGCAGGTGGATTTGATACCTCAATACAAGGCTGGGGACTAGAAGATGTAGATCTCTACAATAAAGTCATTCTATCTGGCTTAAGGCCAT TCAGAAGCCAAGAAGTAGGAGTGGTGCATATTTTCCATCCAGTTCATTGTGATCCTAACTTGGACCCTAAGCAGTATAAGATGTGCTTAG GATCCAAGGCAAGTACTTTCGCCTCAACCATGCAACTGGCTGAACTCTGGCTTGAAAAACATTTAGGTGTCAGGTACAATCGAACTCTCT CCTGACAGTCCAGGCAACACATTTTGCCTTTTTTAAGGGGAGTTTACCTCATTGTTGGTTGTTGTTATTTTTATTGTATTATTGTTATTT TATTATTATTATTGTTATAATTTTATTTTGTTGTCCTGGTCTTAAACTACTCTTGGTTGTCTTCCTAAGGGTGTTTGTTGACCTCAAGCA AGAAGAGTCTGCAGTTCACTGATGTTTCAGATTTCTACTGAAGTCAATATGTTATTACTTTTATATAACTTTATTTGAGATTGAGTTAAA TCATAGCAATCAAATGACTTTTGAAACGCATTCATCACAAGAGACAGCTTAGAAGAATGTTCTCTTGGGGCTTAAAGATGCAATATCGAC TTTTATTTGGTTTCTCAAATTCAATGTGATACAAATATTTACTGGTGAAAGGTACCACAAAAGTGCTTTATGCTTCCTATGGGGAAGGGA CTCTGTAACATAAACTTGAGTTTTGTAATTTATACAAGGACTTAAATATATAAACAATAATTTTCTTCATCTTTAGAATTTTTAAAGTAA ATGAATACCTATGATTGTATGTTTATTTTTTAAAAAAAGTTTTAAAAATTGAGGAGTTTTGTTCCACAAGCAACCGGTACTGGCTACCCT GGTCTTATGACAATTATGAGCTCCTCACAACTGTCTGCTATAAATGCGAATGAACTTTATTTTCTCAAGGAAATATGATTTAATTAAATA TTCATGTACATTTTAGAAGCTTTATGAAACAATGTCCTTCATTTGCTGGCAAGAAGATAAAATATGACAGAACCTGTTTATTTAAAATAA |
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FusionGenePPI for COMMD10_CHSY3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| COMMD10 | COMMD1, RELA, RELB, NFKB1, COMMD7, COMMD8, CCDC22, COMMD6, COMMD3, COMMD4, CCDC93, COMMD2, COMMD5, FAM45A, VPS29, C16orf62, TRIM13, COMMD9, FKBP15, TCTEX1D2, DSCR3, TRAF7, C11orf73, TP53RK, TPRKB, ACOT9 | CHSY3 | PLAUR, SIAE, ISLR, FOXN3, CHSY1, SCGB2A2, LRFN4, GOLPH3, GDPD5, ADAM21, RMND1, CCPG1, P3H4, MGAT4C, STK17B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COMMD10_CHSY3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COMMD10_CHSY3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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