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Fusion gene ID: 8031 |
FusionGeneSummary for COMMD10_AP3S1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COMMD10_AP3S1 | Fusion gene ID: 8031 | Hgene | Tgene | Gene symbol | COMMD10 | AP3S1 | Gene ID | 51397 | 1176 |
| Gene name | COMM domain containing 10 | adaptor related protein complex 3 subunit sigma 1 | |
| Synonyms | PTD002 | CLAPS3|Sigma3A | |
| Cytomap | 5q23.1 | 5q22.3-q23.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | COMM domain-containing protein 10 | AP-3 complex subunit sigma-1adapter-related protein complex 3 subunit sigma-1adaptor related protein complex 3 sigma 1 subunitclathrin adaptor complex AP3, sigma-3A subunitclathrin-associated/assembly/adapter protein, small 3clathrin-associated/assem | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9Y6G5 | Q92572 | |
| Ensembl transtripts involved in fusion gene | ENST00000274458, ENST00000515539, ENST00000503424, | ENST00000316788, ENST00000505423, | |
| Fusion gene scores | * DoF score | 4 X 2 X 4=32 | 2 X 2 X 3=12 |
| # samples | 6 | 4 | |
| ** MAII score | log2(6/32*10)=0.906890595608518 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/12*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: COMMD10 [Title/Abstract] AND AP3S1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-2F-A9KT-01A | COMMD10 | chr5 | 115428397 | + | AP3S1 | chr5 | 115230784 | + |
| TCGA | RV | LGG | TCGA-DH-A7US-01A | COMMD10 | chr5 | 115428397 | + | AP3S1 | chr5 | 115230784 | + |
| TCGA | RV | LGG | TCGA-DB-5273-01A | COMMD10 | chr5 | 115428397 | + | AP3S1 | chr5 | 115230784 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000274458 | ENST00000316788 | COMMD10 | chr5 | 115428397 | + | AP3S1 | chr5 | 115230784 | + |
| In-frame | ENST00000274458 | ENST00000505423 | COMMD10 | chr5 | 115428397 | + | AP3S1 | chr5 | 115230784 | + |
| In-frame | ENST00000515539 | ENST00000316788 | COMMD10 | chr5 | 115428397 | + | AP3S1 | chr5 | 115230784 | + |
| In-frame | ENST00000515539 | ENST00000505423 | COMMD10 | chr5 | 115428397 | + | AP3S1 | chr5 | 115230784 | + |
| intron-3CDS | ENST00000503424 | ENST00000316788 | COMMD10 | chr5 | 115428397 | + | AP3S1 | chr5 | 115230784 | + |
| intron-3CDS | ENST00000503424 | ENST00000505423 | COMMD10 | chr5 | 115428397 | + | AP3S1 | chr5 | 115230784 | + |
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FusionProtFeatures for COMMD10_AP3S1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COMMD10 | AP3S1 |
| May modulate activity of cullin-RING E3 ubiquitin ligase(CRL) complexes (PubMed:21778237). May down-regulate activation ofNF-kappa-B (PubMed:15799966). {ECO:0000269|PubMed:15799966,ECO:0000305|PubMed:21778237}. | Part of the AP-3 complex, an adaptor-related complexwhich is not clathrin-associated. The complex is associated withthe Golgi region as well as more peripheral structures. Itfacilitates the budding of vesicles from the Golgi membrane andmay be directly involved in trafficking to lysosomes. In concertwith the BLOC-1 complex, AP-3 is required to target cargos intovesicles assembled at cell bodies for delivery into neurites andnerve terminals. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >COMMD10 | chr5:115428397 | chr5:115230784 | ENST00000274458 | + | 4 | 7 | 133_202 | 133 | 203 | Domain | COMM |
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FusionGeneSequence for COMMD10_AP3S1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_COMMD10_ENST00000274458_chr5_115428397_+_AP3S1_ENST00000316788_chr5_115230784_+_236aa MAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPA ALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIV >In-frame_COMMD10_ENST00000274458_chr5_115428397_+_AP3S1_ENST00000505423_chr5_115230784_+_169aa MAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPA >In-frame_COMMD10_ENST00000515539_chr5_115428397_+_AP3S1_ENST00000316788_chr5_115230784_+_222aa MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQD KAEAFVNTWSSMGQETVEKFRQRILAPCKVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEA >In-frame_COMMD10_ENST00000515539_chr5_115428397_+_AP3S1_ENST00000505423_chr5_115230784_+_155aa MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQD >In-frame_COMMD10_ENST00000274458_chr5_115428397_+_AP3S1_ENST00000316788_chr5_115230784_+_236aa MAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPA ALQQQLENIHLRQDKAEAFVNTWSSMGQETVEKFRQRILAPCKVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIV >In-frame_COMMD10_ENST00000274458_chr5_115428397_+_AP3S1_ENST00000505423_chr5_115230784_+_169aa MAVPAALILRESPSMKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPA >In-frame_COMMD10_ENST00000515539_chr5_115428397_+_AP3S1_ENST00000316788_chr5_115230784_+_222aa MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQD KAEAFVNTWSSMGQETVEKFRQRILAPCKVFVETLDKCFENVCELDLIFHVDKVHNILAEMVMGGMVLETNMNEIVTQIDAQNKLEKSEA >In-frame_COMMD10_ENST00000515539_chr5_115428397_+_AP3S1_ENST00000505423_chr5_115230784_+_155aa MKKAVSLINAIDTGRFPRLLTRILQKLHLKAESSFSEEEEEKLQAAFSLEKQDLHLVLETISFILEQAVYHNVKPAALQQQLENIHLRQD |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_COMMD10_ENST00000274458_chr5_115428397_+_AP3S1_ENST00000316788_chr5_115230784_+_708nt ATGGCGGTCCCCGCGGCGCTGATCCTACGGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTT CCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCA TTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCA GCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACA GTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGAT TTGATTTTCCATGTAGACAAGGTTCACAATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTGTT ACACAAATTGATGCACAAAATAAGCTGGAAAAATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATG >In-frame_COMMD10_ENST00000274458_chr5_115428397_+_AP3S1_ENST00000505423_chr5_115230784_+_507nt ATGGCGGTCCCCGCGGCGCTGATCCTACGGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTT CCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCA TTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCA GCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACA GTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTTCACAATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACA >In-frame_COMMD10_ENST00000515539_chr5_115428397_+_AP3S1_ENST00000316788_chr5_115230784_+_666nt ATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAG GCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACA ATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGAC AAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTA TTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGATTTGATTTTCCATGTAGACAAGGTTCACAATATTCTTGCAGAA ATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTGTTACACAAATTGATGCACAAAATAAGCTGGAAAAATCTGAGGCT GGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATC >In-frame_COMMD10_ENST00000515539_chr5_115428397_+_AP3S1_ENST00000505423_chr5_115230784_+_465nt ATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAG GCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACA ATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGAC AAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTT CACAATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTGTTACACAAATTGATGCACAAAATAAG >In-frame_COMMD10_ENST00000274458_chr5_115428397_+_AP3S1_ENST00000316788_chr5_115230784_+_708nt ATGGCGGTCCCCGCGGCGCTGATCCTACGGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTT CCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCA TTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCA GCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACA GTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGAT TTGATTTTCCATGTAGACAAGGTTCACAATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTGTT ACACAAATTGATGCACAAAATAAGCTGGAAAAATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATG >In-frame_COMMD10_ENST00000274458_chr5_115428397_+_AP3S1_ENST00000505423_chr5_115230784_+_507nt ATGGCGGTCCCCGCGGCGCTGATCCTACGGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTT CCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCA TTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCA GCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACA GTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTTCACAATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACA >In-frame_COMMD10_ENST00000515539_chr5_115428397_+_AP3S1_ENST00000316788_chr5_115230784_+_666nt ATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAG GCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACA ATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGAC AAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTA TTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGATTTGATTTTCCATGTAGACAAGGTTCACAATATTCTTGCAGAA ATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTGTTACACAAATTGATGCACAAAATAAGCTGGAAAAATCTGAGGCT GGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATC >In-frame_COMMD10_ENST00000515539_chr5_115428397_+_AP3S1_ENST00000505423_chr5_115230784_+_465nt ATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAG GCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACA ATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGAC AAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTT CACAATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTGTTACACAAATTGATGCACAAAATAAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_COMMD10_ENST00000274458_chr5_115428397_+_AP3S1_ENST00000316788_chr5_115230784_+_1361nt GCGGCCGCCATTGGCTGGGTTCGGCGCAGCTAACAGACGGCGGCAGTGCGAGAAAGCCGAAGATGGCGGTCCCCGCGGCGCTGATCCTAC GGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAA AACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACC TAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTC ATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGG CTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGATTTGATTTTCCATGTAGACAAGGTTCACA ATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTGTTACACAAATTGATGCACAAAATAAGCTGG AAAAATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTA ACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAAATCCAGGGGGAA GAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGTCAAGGTACTGTA TAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCCTATGTGATTTTT TTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAAGTGTTTCAGATA TTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCATTCCTTAATTCCTTCTGCTATATGTCACACA GTTGTTATTTGGAGAACCAAGTATGTATTGCATGAAAACATTATGACTTTTTTCTCTTAGTTTAAATAAACTCCAAGGTAACTGGACTTC TAAAGCACCTTTCTGTTTGCCTGATATCTACTTTAGCAATAATTTTTTTTACAACCCTCTGACTCAACAAAGTAAATAAAAGTATATTTT >In-frame_COMMD10_ENST00000274458_chr5_115428397_+_AP3S1_ENST00000505423_chr5_115230784_+_1072nt GCGGCCGCCATTGGCTGGGTTCGGCGCAGCTAACAGACGGCGGCAGTGCGAGAAAGCCGAAGATGGCGGTCCCCGCGGCGCTGATCCTAC GGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAA AACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACC TAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTC ATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGG CTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGATTTGATTTTCCATGTAGACAAGGCTGGCT TAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATCAGTA TAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAAATCCAGGGGGAAGAGTCATCTAAGTTTACC ATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGTCAAGGTACTGTATAGAAGTTGTGTAAAATC AGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCCTATGTGATTTTTTTTTTTCTTTTCTAAACT GCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAAGTGTTTCAGATATTTCTCTAATTATGTACA >In-frame_COMMD10_ENST00000515539_chr5_115428397_+_AP3S1_ENST00000316788_chr5_115230784_+_1391nt GACACTCTGGTGGGAAAGGCTCACGCTGCTGCTGGAGGGTCTTTAATAGCCAACATGTGTTAATACCCCTTTTAAATCAGTATCGAATAG GGGACCGAATTTTTGGTTGGTAGAAGAATCTAGCCTGGCTTTGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGAT TTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGG CATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAG CAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAA CAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGG ATTTGATTTTCCATGTAGACAAGGTTCACAATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTG TTACACAAATTGATGCACAAAATAAGCTGGAAAAATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATA TGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAA AGGCCACTCCCAGGTAAAATCCAGGGGGAAGAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTT TTGCTCTTGGATTTAAGTCAAGGTACTGTATAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTA AAGAAATTGAGTAGTTCCTATGTGATTTTTTTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCT ACTACAGTGTTTTAAAAAGTGTTTCAGATATTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCAT TCCTTAATTCCTTCTGCTATATGTCACACAGTTGTTATTTGGAGAACCAAGTATGTATTGCATGAAAACATTATGACTTTTTTCTCTTAG TTTAAATAAACTCCAAGGTAACTGGACTTCTAAAGCACCTTTCTGTTTGCCTGATATCTACTTTAGCAATAATTTTTTTTACAACCCTCT >In-frame_COMMD10_ENST00000515539_chr5_115428397_+_AP3S1_ENST00000505423_chr5_115230784_+_1102nt GACACTCTGGTGGGAAAGGCTCACGCTGCTGCTGGAGGGTCTTTAATAGCCAACATGTGTTAATACCCCTTTTAAATCAGTATCGAATAG GGGACCGAATTTTTGGTTGGTAGAAGAATCTAGCCTGGCTTTGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGAT TTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGG CATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAG CAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAA CAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGG ATTTGATTTTCCATGTAGACAAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCC CAAGAAATATTAACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAA ATCCAGGGGGAAGAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGT CAAGGTACTGTATAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCC TATGTGATTTTTTTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAA GTGTTTCAGATATTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCATTCCTTAATTCCTTCTGCT >In-frame_COMMD10_ENST00000274458_chr5_115428397_+_AP3S1_ENST00000316788_chr5_115230784_+_1361nt GCGGCCGCCATTGGCTGGGTTCGGCGCAGCTAACAGACGGCGGCAGTGCGAGAAAGCCGAAGATGGCGGTCCCCGCGGCGCTGATCCTAC GGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAA AACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACC TAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTC ATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGG CTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGATTTGATTTTCCATGTAGACAAGGTTCACA ATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTGTTACACAAATTGATGCACAAAATAAGCTGG AAAAATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTA ACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAAATCCAGGGGGAA GAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGTCAAGGTACTGTA TAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCCTATGTGATTTTT TTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAAGTGTTTCAGATA TTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCATTCCTTAATTCCTTCTGCTATATGTCACACA GTTGTTATTTGGAGAACCAAGTATGTATTGCATGAAAACATTATGACTTTTTTCTCTTAGTTTAAATAAACTCCAAGGTAACTGGACTTC TAAAGCACCTTTCTGTTTGCCTGATATCTACTTTAGCAATAATTTTTTTTACAACCCTCTGACTCAACAAAGTAAATAAAAGTATATTTT >In-frame_COMMD10_ENST00000274458_chr5_115428397_+_AP3S1_ENST00000505423_chr5_115230784_+_1072nt GCGGCCGCCATTGGCTGGGTTCGGCGCAGCTAACAGACGGCGGCAGTGCGAGAAAGCCGAAGATGGCGGTCCCCGCGGCGCTGATCCTAC GGGAGAGCCCCAGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGATTTCCACGGTTGCTCACTCGGATTCTTCAAA AACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGGCATTTTCTCTAGAGAAACAAGATCTTCACC TAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAGCAGCTTTGCAGCAGCAATTAGAGAACATTC ATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAACAGTTGAAAAGTTCCGGCAGAGAATTCTGG CTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGGATTTGATTTTCCATGTAGACAAGGCTGGCT TAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATCAGTA TAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAAATCCAGGGGGAAGAGTCATCTAAGTTTACC ATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGTCAAGGTACTGTATAGAAGTTGTGTAAAATC AGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCCTATGTGATTTTTTTTTTTCTTTTCTAAACT GCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAAGTGTTTCAGATATTTCTCTAATTATGTACA >In-frame_COMMD10_ENST00000515539_chr5_115428397_+_AP3S1_ENST00000316788_chr5_115230784_+_1391nt GACACTCTGGTGGGAAAGGCTCACGCTGCTGCTGGAGGGTCTTTAATAGCCAACATGTGTTAATACCCCTTTTAAATCAGTATCGAATAG GGGACCGAATTTTTGGTTGGTAGAAGAATCTAGCCTGGCTTTGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGAT TTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGG CATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAG CAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAA CAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGG ATTTGATTTTCCATGTAGACAAGGTTCACAATATTCTTGCAGAAATGGTGATGGGGGGAATGGTATTGGAGACAAATATGAATGAGATTG TTACACAAATTGATGCACAAAATAAGCTGGAAAAATCTGAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATA TGAATCTTCCTGAGATCCCAAGAAATATTAACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAA AGGCCACTCCCAGGTAAAATCCAGGGGGAAGAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTT TTGCTCTTGGATTTAAGTCAAGGTACTGTATAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTA AAGAAATTGAGTAGTTCCTATGTGATTTTTTTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCT ACTACAGTGTTTTAAAAAGTGTTTCAGATATTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCAT TCCTTAATTCCTTCTGCTATATGTCACACAGTTGTTATTTGGAGAACCAAGTATGTATTGCATGAAAACATTATGACTTTTTTCTCTTAG TTTAAATAAACTCCAAGGTAACTGGACTTCTAAAGCACCTTTCTGTTTGCCTGATATCTACTTTAGCAATAATTTTTTTTACAACCCTCT >In-frame_COMMD10_ENST00000515539_chr5_115428397_+_AP3S1_ENST00000505423_chr5_115230784_+_1102nt GACACTCTGGTGGGAAAGGCTCACGCTGCTGCTGGAGGGTCTTTAATAGCCAACATGTGTTAATACCCCTTTTAAATCAGTATCGAATAG GGGACCGAATTTTTGGTTGGTAGAAGAATCTAGCCTGGCTTTGCATGAAGAAAGCAGTGTCACTGATAAATGCAATAGATACAGGAAGAT TTCCACGGTTGCTCACTCGGATTCTTCAAAAACTTCACCTGAAGGCTGAGAGCAGTTTCAGTGAAGAAGAGGAAGAAAAACTTCAAGCGG CATTTTCTCTAGAGAAACAAGATCTTCACCTAGTTCTTGAAACAATATCATTTATTTTAGAACAGGCAGTGTATCACAATGTGAAGCCAG CAGCTTTGCAGCAGCAATTAGAGAACATTCATCTTAGACAAGACAAAGCTGAAGCATTTGTCAATACGTGGTCTTCTATGGGTCAAGAAA CAGTTGAAAAGTTCCGGCAGAGAATTCTGGCTCCCTGTAAGGTATTTGTGGAAACATTAGACAAATGTTTTGAAAATGTCTGTGAGCTGG ATTTGATTTTCCATGTAGACAAGGCTGGCTTAGCAGGAGCTCCAGCCCGTGCTGTATCAGCTGTAAAGAATATGAATCTTCCTGAGATCC CAAGAAATATTAACATTGGTGACATCAGTATAAAAGTGCCAAACCTGCCCTCTTTTAAATAAAAATGTAAAAAGGCCACTCCCAGGTAAA ATCCAGGGGGAAGAGTCATCTAAGTTTACCATGCAGTTGTTTACCAAAAATAGAGGAGGAGAGTCTTAACTTTTGCTCTTGGATTTAAGT CAAGGTACTGTATAGAAGTTGTGTAAAATCAGTATGAAAGTTCAATGTTGCTGTTCTTGCTCAGTGATTTTAAAGAAATTGAGTAGTTCC TATGTGATTTTTTTTTTTCTTTTCTAAACTGCATTCCTGTGCCCACCTACGGCATGCCTCTATGTATTGGCTACTACAGTGTTTTAAAAA GTGTTTCAGATATTTCTCTAATTATGTACAACCTAAAATGTTGGTGTTTTGTATGGATCACAAGTGCAGCATTCCTTAATTCCTTCTGCT |
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FusionGenePPI for COMMD10_AP3S1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| COMMD10 | COMMD1, RELA, RELB, NFKB1, COMMD7, COMMD8, CCDC22, COMMD6, COMMD3, COMMD4, CCDC93, COMMD2, COMMD5, FAM45A, VPS29, C16orf62, TRIM13, COMMD9, FKBP15, TCTEX1D2, DSCR3, TRAF7, C11orf73, TP53RK, TPRKB, ACOT9 | AP3S1 | IRS1, ELAVL1, AP3B1, ECT2, AP3D1, AP3M1, FLNC, KRT7, RABL6, SMC4, SSSCA1, EGFR, STAU1, RUFY1, KLK11, SRPRB, KLK5, AGO3, DTNBP1, RNF13, VSIG4, EPB41L3, CDC73, XPO1, CD14, EMC2, ZWINT, KIAA1107, PCDHB15, DUSP1, DUSP19, DUSP2, DUSP23, DUSP4, DUSP5, DUSP6, AP3M2, AP3B2, RNF167, TMEM63A, DHRS2, FBXO11, ZYG11B, MUC20, AGK, PMEL, TPCN2, IRGC, IGSF6, VSIG1, ICAM1, SPG7, FNDC3A, DLD |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COMMD10_AP3S1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COMMD10_AP3S1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | AP3S1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
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