FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 7969

FusionGeneSummary for COL4A6_ZNF589

check button Fusion gene summary
Fusion gene informationFusion gene name: COL4A6_ZNF589
Fusion gene ID: 7969
HgeneTgene
Gene symbol

COL4A6

ZNF589

Gene ID

1288

51385

Gene namecollagen type IV alpha 6 chainzinc finger protein 589
SynonymsCXDELq22.3|DELXq22.3|DFNX6SZF1
Cytomap

Xq22.3

3p21.31

Type of geneprotein-codingprotein-coding
Descriptioncollagen alpha-6(IV) chaincollagen IV, alpha-6 polypeptidecollagen of basement membrane, alpha-6collagen, type IV, alpha 6dJ889N15.4 (Collagen Alpha 6(IV))zinc finger protein 589KRAB-zinc finger protein SZF1-1stem cell zinc finger protein 1
Modification date2018052320180523
UniProtAcc

Q14031

Q86UQ0

Ensembl transtripts involved in fusion geneENST00000334504, ENST00000372216, 
ENST00000394872, ENST00000538570, 
ENST00000545689, ENST00000461897, 
ENST00000418180, 
ENST00000354698, 
ENST00000427617, ENST00000412564, 
ENST00000440261, ENST00000454212, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 2 X 3=18
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: COL4A6 [Title/Abstract] AND ZNF589 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneZNF589

GO:0000122

negative regulation of transcription by RNA polymerase II

12097288


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE835987COL4A6chrX

107654044

-ZNF589chr3

48309898

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000334504ENST00000354698COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000334504ENST00000427617COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000334504ENST00000412564COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000334504ENST00000440261COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000334504ENST00000454212COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-3CDSENST00000372216ENST00000354698COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000372216ENST00000427617COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000372216ENST00000412564COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000372216ENST00000440261COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000372216ENST00000454212COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-3CDSENST00000394872ENST00000354698COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000394872ENST00000427617COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000394872ENST00000412564COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000394872ENST00000440261COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000394872ENST00000454212COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-3CDSENST00000538570ENST00000354698COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000538570ENST00000427617COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000538570ENST00000412564COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000538570ENST00000440261COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000538570ENST00000454212COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-3CDSENST00000545689ENST00000354698COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000545689ENST00000427617COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000545689ENST00000412564COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000545689ENST00000440261COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000545689ENST00000454212COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-3CDSENST00000461897ENST00000354698COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000461897ENST00000427617COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000461897ENST00000412564COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000461897ENST00000440261COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000461897ENST00000454212COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-3CDSENST00000418180ENST00000354698COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000418180ENST00000427617COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000418180ENST00000412564COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000418180ENST00000440261COL4A6chrX

107654044

-ZNF589chr3

48309898

+
intron-intronENST00000418180ENST00000454212COL4A6chrX

107654044

-ZNF589chr3

48309898

+

Top

FusionProtFeatures for COL4A6_ZNF589


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COL4A6

Q14031

ZNF589

Q86UQ0

May play a role in hematopoietic stem/progenitor celldifferentiation. May play a role as a DNA binding-dependenttranscriptional repressor. {ECO:0000269|PubMed:10029171,ECO:0000269|PubMed:12097288}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for COL4A6_ZNF589


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for COL4A6_ZNF589


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for COL4A6_ZNF589


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for COL4A6_ZNF589


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOL4A6C0000786Spontaneous abortion1CTD_human
HgeneCOL4A6C0086533Leiomyoma, Epithelioid1CTD_human
HgeneCOL4A6C3806737DEAFNESS, X-LINKED 61UNIPROT