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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7963

FusionGeneSummary for COL4A2_STK24

check button Fusion gene summary
Fusion gene informationFusion gene name: COL4A2_STK24
Fusion gene ID: 7963
HgeneTgene
Gene symbol

COL4A2

STK24

Gene ID

1284

8428

Gene namecollagen type IV alpha 2 chainserine/threonine kinase 24
SynonymsICH|POREN2HEL-S-95|MST3|MST3B|STE20|STK3
Cytomap

13q34

13q32.2

Type of geneprotein-codingprotein-coding
Descriptioncollagen alpha-2(IV) chaincanstatinserine/threonine-protein kinase 24STE20-like kinase 3STE20-like kinase MST3epididymis secretory protein Li 95mammalian STE20-like protein kinase 3serine/threonine kinase 24 (STE20 homolog, yeast)sterile 20-like kinase 3
Modification date2018052320180523
UniProtAcc

P08572

Q9Y6E0

Ensembl transtripts involved in fusion geneENST00000360467, ENST00000462309, 
ENST00000397517, ENST00000539966, 
ENST00000481288, ENST00000376547, 
Fusion gene scores* DoF score8 X 5 X 7=2804 X 3 X 3=36
# samples 95
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: COL4A2 [Title/Abstract] AND STK24 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOL4A2

GO:0016525

negative regulation of angiogenesis

10625665

TgeneSTK24

GO:0006468

protein phosphorylation

19604147

TgeneSTK24

GO:0042542

response to hydrogen peroxide

22291017

TgeneSTK24

GO:0046777

protein autophosphorylation

17046825|17657516


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1DA820540COL4A2chr13

110960470

+STK24chr13

99171728

-
ChiTaRS3.1AK300060COL4A2chr13

110960470

+STK24chr13

99171728

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000360467ENST00000397517COL4A2chr13

110960470

+STK24chr13

99171728

-
In-frameENST00000360467ENST00000539966COL4A2chr13

110960470

+STK24chr13

99171728

-
5CDS-5UTRENST00000360467ENST00000481288COL4A2chr13

110960470

+STK24chr13

99171728

-
5CDS-5UTRENST00000360467ENST00000376547COL4A2chr13

110960470

+STK24chr13

99171728

-
intron-3CDSENST00000462309ENST00000397517COL4A2chr13

110960470

+STK24chr13

99171728

-
intron-3CDSENST00000462309ENST00000539966COL4A2chr13

110960470

+STK24chr13

99171728

-
intron-5UTRENST00000462309ENST00000481288COL4A2chr13

110960470

+STK24chr13

99171728

-
intron-5UTRENST00000462309ENST00000376547COL4A2chr13

110960470

+STK24chr13

99171728

-

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FusionProtFeatures for COL4A2_STK24


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COL4A2

P08572

STK24

Q9Y6E0

Type IV collagen is the major structural component ofglomerular basement membranes (GBM), forming a 'chicken-wire'meshwork together with laminins, proteoglycans andentactin/nidogen. Canstatin, a cleavage product corresponding to thecollagen alpha 2(IV) NC1 domain, possesses both anti-angiogenicand anti-tumor cell activity. It inhibits proliferation andmigration of endothelial cells, reduces mitochondrial membranepotential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity.Ligand for alphavbeta3 and alphavbeta5 integrins. Serine/threonine-protein kinase that acts on both serineand threonine residues and promotes apoptosis in response tostress stimuli and caspase activation. Mediates oxidative-stress-induced cell death by modulating phosphorylation of JNK1-JNK2(MAPK8 and MAPK9), p38 (MAPK11, MAPK12, MAPK13 and MAPK14) duringoxidative stress. Plays a role in a staurosporine-induced caspase-independent apoptotic pathway by regulating the nucleartranslocation of AIFM1 and ENDOG and the DNase activity associatedwith ENDOG. Phosphorylates STK38L on 'Thr-442' and stimulates itskinase activity. In association with STK26 negatively regulatesGolgi reorientation in polarized cell migration upon RHOactivation (PubMed:27807006). Regulates also cellular migrationwith alteration of PTPN12 activity and PXN phosphorylation:phosphorylates PTPN12 and inhibits its activity and may regulatePXN phosphorylation through PTPN12. May act as a key regulator ofaxon regeneration in the optic nerve and radial nerve.{ECO:0000269|PubMed:16314523, ECO:0000269|PubMed:17046825,ECO:0000269|PubMed:19604147, ECO:0000269|PubMed:19782762,ECO:0000269|PubMed:19855390, ECO:0000269|PubMed:27807006}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneSTK24chr13:110960470chr13:99171728ENST00000376547-01136_28626444DomainProtein kinase
TgeneSTK24chr13:110960470chr13:99171728ENST00000397517-01136_28614432DomainProtein kinase
TgeneSTK24chr13:110960470chr13:99171728ENST00000376547-011278_29226444MotifNote=Bipartite nuclear localization signal
TgeneSTK24chr13:110960470chr13:99171728ENST00000376547-011335_38626444MotifNote=Nuclear export signal (NES)
TgeneSTK24chr13:110960470chr13:99171728ENST00000397517-011278_29214432MotifNote=Bipartite nuclear localization signal
TgeneSTK24chr13:110960470chr13:99171728ENST00000397517-011335_38614432MotifNote=Nuclear export signal (NES)
TgeneSTK24chr13:110960470chr13:99171728ENST00000376547-011112_11426444Nucleotide bindingNote=ATP
TgeneSTK24chr13:110960470chr13:99171728ENST00000376547-01142_5026444Nucleotide bindingNote=ATP
TgeneSTK24chr13:110960470chr13:99171728ENST00000397517-011112_11414432Nucleotide bindingNote=ATP
TgeneSTK24chr13:110960470chr13:99171728ENST00000397517-01142_5014432Nucleotide bindingNote=ATP

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOL4A2chr13:110960470chr13:99171728ENST00000360467+3481489_1712331713DomainCollagen IV NC1
HgeneCOL4A2chr13:110960470chr13:99171728ENST00000360467+348184_1484331713RegionNote=Triple-helical region


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FusionGeneSequence for COL4A2_STK24


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).
>In-frame_COL4A2_ENST00000360467_chr13_110960470_+_STK24_ENST00000397517_chr13_99171728_-_4631nt
GGGAGCGCGCGGCCCGGGAGTGTGGCTGCAGTGCGCCGGGACACCAGGGCTCCGCGCTCCGCACTCAAGAGGCTCCCGCGTCCCAACCCC
TCGCGCCCGCGCGTTCGCGGATCCAGGCCGAGGACCGAAAGGGGCCGCCCGAGCCCCCGGGGCCGGCGCCCAGAGAGCCCAGCAAGGCCG
GCCGCCCTGCCGGTGTGCCGCCGGCGGGTGCTTCTGGAAGGGCCAATGCGTTCGGGCAGCAGCCCCTGAAGCCGAGCCCGAGGCTAAGTG
GGACTGACCGGGGCCCAGAGTGGACGAACCGCCAGCATGGGGAGAGACCAGCGCGCGGTGGCCGGCCCTGCCCTACGGCGGTGGCTGCTG
CTGGGGACAGTGACCGTGGGGTTCCTCGCCCAGAGCGTCTTGGCGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAGAGAAA
ATTGGGAAGGGCTCCTTTGGAGAGGTGTTCAAAGGCATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGGAAGAA
GCTGAAGATGAGATAGAGGACATTCAACAAGAAATCACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGATCCTAT
CTGAAGGATACAAAATTATGGATAATAATGGAATATCTTGGTGGAGGCTCCGCACTAGATCTATTAGAACCTGGCCCATTAGATGAAACC
CAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGATTATCTCCATTCGGAGAAGAAAATCCACAGAGACATTAAAGCGGCCAAC
GTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTGGCCAGCTGACAGACACCCAGATCAAAAGGAACACCTTC
GTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAGTCGGCCTATGACTCGAAGGCAGACATCTGGTCCCTGGGCATAACAGCT
ATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTG
GAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTG
AAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGC
CATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATC
CGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCT
TTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATT
GAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAG
AGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCT
CCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCA
GGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTT
TATTTTATTACTTTTGTTTTTAATTTTAACCATAGTGCACATATTCCAGGAAAGTGTCTTTAAAAACAAAAACAAACCCTGAAATGTATA
TTTGGGATTATGATAAGGCAACTAAAGACATGAAACCTCAGGTATCCTGCTTTAAGTTGATAACTCCCTCTGGGAGCTGGAGAATCGCTC
TGGTGGATGGGTGTACAGATTTGTATATAATGTCATTTTTACGGAAACCCTTTCGGCGTGCATAAGGAATCACTGTGTACAAACTGGCCA
AGTGCTTCTGTAGATAACGTCAGTGGAGTAAATATTCGACAGGCCATAACTTGAGTCTATTGCCTTGCCTTTATTACATGTACATTTTGA
ATTCTGTGACCAGTGATTTGGGTTTTATTTTGTATTTGCAGGGTTTGTCATTAATAATTAATGCCCCTCTCTTACAGAACACTCCTATTT
GTACCTCAACAAATGCAAATTTTCCCCGTTTGCCCTACGCCCCTTTTGGTACACCTAGAGGTTGATTTCCTTTTTCATCGATGGTACTAT
TTCTTAGTGTTTTAAATTGGAACATATCTTGCCTCATGAAGCTTTAAATTATAATTTTCAGTTTCTCCCCATGAAGCGCTCTCGTCTGAC
ATTTGTTTGGAATCGTGCCACTGCTGGTCTGCGCCAGATGTACCGTCCTTTCCAATACGATTTTCTGTTGCACCTTGTAGTGGATTCTGC
ATATCATCTTTCCCACCTAAAAATGTCTGAATGCTTACACAAATAAATTTTATAACACGCTTATTTTGCATACTCCTTGAAATGTGACTC
TTCAGAGGACAGGGCACCTGCTGTGTATGTGTGGCCGTGCGTGTGTACTCGTGGCTGTGTGTGTGTGATGAGACACTTTGGAAGACTCCA
GGGAGAAGTCCCCAGGCCTGGAGCTGCCGAGTGCCCAGGTCAGCGCCCTGGACTGCTTGCGCACTTGCTCACCGAGATGATGCAGTTGGA
GGTTGCTGATCTGTGCGATTGCTGTAGCGGTTGCCGGGGACCTTAAGAGTTATTTTGCTTCTCTGGAAGGGGCCTATGCTTGCTAGGCAG
GCAGCCAGTGTGTCTGTTTTTCTTGGTTTGCTGTGGGACCTTGCTTGGCGAGGGGGAAAATCTCTGGGTTTCTGGAGTGGGAGGGTTCGT
GCAGCAGCTGTTGACTGGTACATGAAGCATTCTTTTATGTTTGTTGAAGCTGATGATTGACATCTCCCGTGGGTGTGCCAGTTCTTGTGG
AGTTAAGACAGGATTTTTGGAAGCAAGGAAGTTAGTGGGTGAGCTTGGGGATGTAGCTCAGCTATCTGCTGGTCTAGTGGCCTCTAAGCT
ATAGGGAGGGGACAGAGCCCTGAGCTACAGATGCTTGAGTGGGTTATTGTGTCGGTTTGCTAGTGCAGTCTGGTTTTTAAGCTCTAAAAT
TGAGGTATTTTATTAGAAGTGGATTTGGGTTGAACTCTTAATTTGTATAAGGGATATATTTTGGTTGGGGAAATAGAACTGAGTTGCTAA
TTCTTATTGTACTCATTACTCCATACAAGAATGTTATGTTGAATAATAAAATTGGAGAAGATTTCATTTTGTGTTTCCAGGGAGTATTCT
GTGTGGGGAACTGTTTCCTTACGTGAGGCCGGCGGCATAAGTCAAAGATGAGTTTTGTCCTTGCGAATCACACAGATTGAGTCTGTGTTC
CCCAGGGTGTGCCGTTACCTGATTTTTAAGTGAGCCAGGGCGGACAGCAGCTTTTCTGATTTACAGAGTTCTTCAGATTTACAAATGGAC
AATGACATCACAGTTTTTAGCACTGAAGCCAGTCTCATGCTAGTAACAGTGGGTGAGCCGCTCGAGGGACTGGGTTCTAATGAATACTGG
TATGAACGGGGAGTCTCTGCAGTCGCCAGACAAATCATACTCAGCCCCTTCCCCCGTAGAGCAACAAGTGGTTCTTTTAGAGTTGACTGG
CAGCATTTCCTGTCGGGGGAGGTGGGGTTTGATGGAGTTAGAAAGCTCGCCTCTGTGTACATTCTCTCCTGGGCTGTTACTTTCTGTAGA
CGCACAAAATCAGCCCCAATGTTTTTAAGGGCATCTTAGCCAAGGAAGCTGGCTTTTGTGTCGCCACTTCCAGGCCTGCATTAAGAGAGA
GCCCAGGCACCAGGGCTACCACTGGAACCTGCCTCAGCGTCAACTGCTGCTGGTCTGTAGCCAGGCCCAGCCTTTGAGACGGGTTTACTG
TCACCAGTAGCCTCTCAGTGCCAGCCCTGAGCTGCTCCTGGCTCAGCTGCCCAGAGCCTGCAGCCTGGGGAGGTACTCAGCCTCTGGGAG
ACGAGGGCCGTGGACTGGGTGGCTGGTAGCTCCTGCGTTTTTGAGCTGTGTCCTGGCTGGCTGCTGCCAATGAGGTGGACACCAGTGTGG
TTTGGGGTGCACTGGCCACTTCTTGCTGGGTTCTGATTTTCTTGGAAGTGCATCTGCCTTCCTTATCCAATAGTTTTATCCCTGCATTGC
TCTTGTGAAGTGGCTGGTTTGGTTCTGTATGTAGCATTTTGTACCTTTCCTCTGGCAAAACACTGTCAGTTTATAAACATTTTTTATATT
TCCCTCCTTTAAAAACAGCTTGTGTATTTCTGCTATAAAATGTGTCAGCAAAGGCAGAGTGACCTAATAGGGCATGTTCTTAAGCACAGG

>In-frame_COL4A2_ENST00000360467_chr13_110960470_+_STK24_ENST00000539966_chr13_99171728_-_1860nt
GGGAGCGCGCGGCCCGGGAGTGTGGCTGCAGTGCGCCGGGACACCAGGGCTCCGCGCTCCGCACTCAAGAGGCTCCCGCGTCCCAACCCC
TCGCGCCCGCGCGTTCGCGGATCCAGGCCGAGGACCGAAAGGGGCCGCCCGAGCCCCCGGGGCCGGCGCCCAGAGAGCCCAGCAAGGCCG
GCCGCCCTGCCGGTGTGCCGCCGGCGGGTGCTTCTGGAAGGGCCAATGCGTTCGGGCAGCAGCCCCTGAAGCCGAGCCCGAGGCTAAGTG
GGACTGACCGGGGCCCAGAGTGGACGAACCGCCAGCATGGGGAGAGACCAGCGCGCGGTGGCCGGCCCTGCCCTACGGCGGTGGCTGCTG
CTGGGGACAGTGACCGTGGGGTTCCTCGCCCAGAGCGTCTTGGCGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAGAGAAA
ATTGGGAAGGGCTCCTTTGGAGAGGTGTTCAAAGGCATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGGAAGAA
GCTGAAGATGAGATAGAGGACATTCAACAAGAAATCACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGATCCTAT
CTGAAGTTAGAACCTGGCCCATTAGATGAAACCCAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGATTATCTCCATTCGGAG
AAGAAAATCCACAGAGACATTAAAGCGGCCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTGGCCAG
CTGACAGACACCCAGATCAAAAGGAACACCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAGTCGGCCTATGACTCG
AAGGCAGACATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTA
TTCCTCATTCCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAG
CCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATC
GACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGG
GGCAGTGATTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGAC
AGAAATAAGATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAG
AGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGAC
ACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGG
GGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCA
CTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGG

>In-frame_COL4A2_ENST00000360467_chr13_110960470_+_STK24_ENST00000397517_chr13_99171728_-_4631nt
GGGAGCGCGCGGCCCGGGAGTGTGGCTGCAGTGCGCCGGGACACCAGGGCTCCGCGCTCCGCACTCAAGAGGCTCCCGCGTCCCAACCCC
TCGCGCCCGCGCGTTCGCGGATCCAGGCCGAGGACCGAAAGGGGCCGCCCGAGCCCCCGGGGCCGGCGCCCAGAGAGCCCAGCAAGGCCG
GCCGCCCTGCCGGTGTGCCGCCGGCGGGTGCTTCTGGAAGGGCCAATGCGTTCGGGCAGCAGCCCCTGAAGCCGAGCCCGAGGCTAAGTG
GGACTGACCGGGGCCCAGAGTGGACGAACCGCCAGCATGGGGAGAGACCAGCGCGCGGTGGCCGGCCCTGCCCTACGGCGGTGGCTGCTG
CTGGGGACAGTGACCGTGGGGTTCCTCGCCCAGAGCGTCTTGGCGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAGAGAAA
ATTGGGAAGGGCTCCTTTGGAGAGGTGTTCAAAGGCATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGGAAGAA
GCTGAAGATGAGATAGAGGACATTCAACAAGAAATCACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGATCCTAT
CTGAAGGATACAAAATTATGGATAATAATGGAATATCTTGGTGGAGGCTCCGCACTAGATCTATTAGAACCTGGCCCATTAGATGAAACC
CAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGATTATCTCCATTCGGAGAAGAAAATCCACAGAGACATTAAAGCGGCCAAC
GTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTGGCCAGCTGACAGACACCCAGATCAAAAGGAACACCTTC
GTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAGTCGGCCTATGACTCGAAGGCAGACATCTGGTCCCTGGGCATAACAGCT
ATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTATTCCTCATTCCAAAGAACAACCCACCGACGTTG
GAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAGCCGAGCTTTAGACCCACTGCTAAGGAGTTATTG
AAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATCGACAGGTACAAGAGATGGAAGGCCGAGCAGAGC
CATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGGGGCAGTGATTCTGGGGACTGGATCTTCACAATC
CGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGACAGAAATAAGATGAAAGACATCCCGAAGAGGCCT
TTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAGAGCCAGGCGTGCGGAGGGAACTTGGGGTCCATT
GAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGACACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAG
AGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGGGGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCT
CCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCACTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCA
GGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGGGAGGGTCAGCTCCTTCCAGCGATCATTTTATTT
TATTTTATTACTTTTGTTTTTAATTTTAACCATAGTGCACATATTCCAGGAAAGTGTCTTTAAAAACAAAAACAAACCCTGAAATGTATA
TTTGGGATTATGATAAGGCAACTAAAGACATGAAACCTCAGGTATCCTGCTTTAAGTTGATAACTCCCTCTGGGAGCTGGAGAATCGCTC
TGGTGGATGGGTGTACAGATTTGTATATAATGTCATTTTTACGGAAACCCTTTCGGCGTGCATAAGGAATCACTGTGTACAAACTGGCCA
AGTGCTTCTGTAGATAACGTCAGTGGAGTAAATATTCGACAGGCCATAACTTGAGTCTATTGCCTTGCCTTTATTACATGTACATTTTGA
ATTCTGTGACCAGTGATTTGGGTTTTATTTTGTATTTGCAGGGTTTGTCATTAATAATTAATGCCCCTCTCTTACAGAACACTCCTATTT
GTACCTCAACAAATGCAAATTTTCCCCGTTTGCCCTACGCCCCTTTTGGTACACCTAGAGGTTGATTTCCTTTTTCATCGATGGTACTAT
TTCTTAGTGTTTTAAATTGGAACATATCTTGCCTCATGAAGCTTTAAATTATAATTTTCAGTTTCTCCCCATGAAGCGCTCTCGTCTGAC
ATTTGTTTGGAATCGTGCCACTGCTGGTCTGCGCCAGATGTACCGTCCTTTCCAATACGATTTTCTGTTGCACCTTGTAGTGGATTCTGC
ATATCATCTTTCCCACCTAAAAATGTCTGAATGCTTACACAAATAAATTTTATAACACGCTTATTTTGCATACTCCTTGAAATGTGACTC
TTCAGAGGACAGGGCACCTGCTGTGTATGTGTGGCCGTGCGTGTGTACTCGTGGCTGTGTGTGTGTGATGAGACACTTTGGAAGACTCCA
GGGAGAAGTCCCCAGGCCTGGAGCTGCCGAGTGCCCAGGTCAGCGCCCTGGACTGCTTGCGCACTTGCTCACCGAGATGATGCAGTTGGA
GGTTGCTGATCTGTGCGATTGCTGTAGCGGTTGCCGGGGACCTTAAGAGTTATTTTGCTTCTCTGGAAGGGGCCTATGCTTGCTAGGCAG
GCAGCCAGTGTGTCTGTTTTTCTTGGTTTGCTGTGGGACCTTGCTTGGCGAGGGGGAAAATCTCTGGGTTTCTGGAGTGGGAGGGTTCGT
GCAGCAGCTGTTGACTGGTACATGAAGCATTCTTTTATGTTTGTTGAAGCTGATGATTGACATCTCCCGTGGGTGTGCCAGTTCTTGTGG
AGTTAAGACAGGATTTTTGGAAGCAAGGAAGTTAGTGGGTGAGCTTGGGGATGTAGCTCAGCTATCTGCTGGTCTAGTGGCCTCTAAGCT
ATAGGGAGGGGACAGAGCCCTGAGCTACAGATGCTTGAGTGGGTTATTGTGTCGGTTTGCTAGTGCAGTCTGGTTTTTAAGCTCTAAAAT
TGAGGTATTTTATTAGAAGTGGATTTGGGTTGAACTCTTAATTTGTATAAGGGATATATTTTGGTTGGGGAAATAGAACTGAGTTGCTAA
TTCTTATTGTACTCATTACTCCATACAAGAATGTTATGTTGAATAATAAAATTGGAGAAGATTTCATTTTGTGTTTCCAGGGAGTATTCT
GTGTGGGGAACTGTTTCCTTACGTGAGGCCGGCGGCATAAGTCAAAGATGAGTTTTGTCCTTGCGAATCACACAGATTGAGTCTGTGTTC
CCCAGGGTGTGCCGTTACCTGATTTTTAAGTGAGCCAGGGCGGACAGCAGCTTTTCTGATTTACAGAGTTCTTCAGATTTACAAATGGAC
AATGACATCACAGTTTTTAGCACTGAAGCCAGTCTCATGCTAGTAACAGTGGGTGAGCCGCTCGAGGGACTGGGTTCTAATGAATACTGG
TATGAACGGGGAGTCTCTGCAGTCGCCAGACAAATCATACTCAGCCCCTTCCCCCGTAGAGCAACAAGTGGTTCTTTTAGAGTTGACTGG
CAGCATTTCCTGTCGGGGGAGGTGGGGTTTGATGGAGTTAGAAAGCTCGCCTCTGTGTACATTCTCTCCTGGGCTGTTACTTTCTGTAGA
CGCACAAAATCAGCCCCAATGTTTTTAAGGGCATCTTAGCCAAGGAAGCTGGCTTTTGTGTCGCCACTTCCAGGCCTGCATTAAGAGAGA
GCCCAGGCACCAGGGCTACCACTGGAACCTGCCTCAGCGTCAACTGCTGCTGGTCTGTAGCCAGGCCCAGCCTTTGAGACGGGTTTACTG
TCACCAGTAGCCTCTCAGTGCCAGCCCTGAGCTGCTCCTGGCTCAGCTGCCCAGAGCCTGCAGCCTGGGGAGGTACTCAGCCTCTGGGAG
ACGAGGGCCGTGGACTGGGTGGCTGGTAGCTCCTGCGTTTTTGAGCTGTGTCCTGGCTGGCTGCTGCCAATGAGGTGGACACCAGTGTGG
TTTGGGGTGCACTGGCCACTTCTTGCTGGGTTCTGATTTTCTTGGAAGTGCATCTGCCTTCCTTATCCAATAGTTTTATCCCTGCATTGC
TCTTGTGAAGTGGCTGGTTTGGTTCTGTATGTAGCATTTTGTACCTTTCCTCTGGCAAAACACTGTCAGTTTATAAACATTTTTTATATT
TCCCTCCTTTAAAAACAGCTTGTGTATTTCTGCTATAAAATGTGTCAGCAAAGGCAGAGTGACCTAATAGGGCATGTTCTTAAGCACAGG

>In-frame_COL4A2_ENST00000360467_chr13_110960470_+_STK24_ENST00000539966_chr13_99171728_-_1860nt
GGGAGCGCGCGGCCCGGGAGTGTGGCTGCAGTGCGCCGGGACACCAGGGCTCCGCGCTCCGCACTCAAGAGGCTCCCGCGTCCCAACCCC
TCGCGCCCGCGCGTTCGCGGATCCAGGCCGAGGACCGAAAGGGGCCGCCCGAGCCCCCGGGGCCGGCGCCCAGAGAGCCCAGCAAGGCCG
GCCGCCCTGCCGGTGTGCCGCCGGCGGGTGCTTCTGGAAGGGCCAATGCGTTCGGGCAGCAGCCCCTGAAGCCGAGCCCGAGGCTAAGTG
GGACTGACCGGGGCCCAGAGTGGACGAACCGCCAGCATGGGGAGAGACCAGCGCGCGGTGGCCGGCCCTGCCCTACGGCGGTGGCTGCTG
CTGGGGACAGTGACCGTGGGGTTCCTCGCCCAGAGCGTCTTGGCGAACCTAAAGGCAGACCCAGAAGAGCTTTTTACAAAACTAGAGAAA
ATTGGGAAGGGCTCCTTTGGAGAGGTGTTCAAAGGCATTGACAATCGGACTCAGAAAGTGGTTGCCATAAAGATCATTGATCTGGAAGAA
GCTGAAGATGAGATAGAGGACATTCAACAAGAAATCACAGTGCTGAGTCAGTGTGACAGTCCATATGTAACCAAATATTATGGATCCTAT
CTGAAGTTAGAACCTGGCCCATTAGATGAAACCCAGATCGCTACTATATTAAGAGAAATACTGAAAGGACTCGATTATCTCCATTCGGAG
AAGAAAATCCACAGAGACATTAAAGCGGCCAACGTCCTGCTGTCTGAGCATGGCGAGGTGAAGCTGGCGGACTTTGGCGTGGCTGGCCAG
CTGACAGACACCCAGATCAAAAGGAACACCTTCGTGGGCACCCCATTCTGGATGGCACCCGAGGTCATCAAACAGTCGGCCTATGACTCG
AAGGCAGACATCTGGTCCCTGGGCATAACAGCTATTGAACTTGCAAGAGGGGAACCACCTCATTCCGAGCTGCACCCCATGAAAGTTTTA
TTCCTCATTCCAAAGAACAACCCACCGACGTTGGAAGGAAACTACAGTAAACCCCTCAAGGAGTTTGTGGAGGCCTGTTTGAATAAGGAG
CCGAGCTTTAGACCCACTGCTAAGGAGTTATTGAAGCACAAGTTTATACTACGCAATGCAAAGAAAACTTCCTACTTGACCGAGCTCATC
GACAGGTACAAGAGATGGAAGGCCGAGCAGAGCCATGACGACTCGAGCTCCGAGGATTCCGACGCGGAAACAGATGGCCAAGCCTCGGGG
GGCAGTGATTCTGGGGACTGGATCTTCACAATCCGAGAAAAAGATCCCAAGAATCTCGAGAATGGAGCTCTTCAGCCATCGGACTTGGAC
AGAAATAAGATGAAAGACATCCCGAAGAGGCCTTTCTCTCAGTGTTTATCTACAATTATTTCTCCTCTGTTTGCAGAGTTGAAGGAGAAG
AGCCAGGCGTGCGGAGGGAACTTGGGGTCCATTGAAGAGCTGCGAGGGGCCATCTACCTAGCGGAGGAGGCGTGCCCTGGCATCTCCGAC
ACCATGGTGGCCCAGCTCGTGCAGCGGCTCCAGAGATACTCTCTAAGTGGTGGAGGAACTTCATCCCACTGAAATTCCTTTGGCATTTGG
GGTTTTGTTTTTCCTTTTTTCCTTCTTCATCCTCCTCCTTTTTTAAAAGTCAACGAGAGCCTTCGCTGACTCCACCGAAGAGGTGCGCCA
CTGGGAGCCACCCCAGCGCCAGGCGCCCGTCCAGGGACACACACAGTCTTCACTGTGCTGCAGCCAGATGAAGTCTCTCAGATGGGTGGG


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FusionGenePPI for COL4A2_STK24


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COL4A2COL4A2, COL4A1, CSNK2B, DAZAP2, TK1, SMN1, ANXA7, VHL, SKIL, FAM46A, FBXO6, C1QB, C1QTNF2, CELA2B, FGL1, ITLN2, COL9A1, C1QTNF9, STBD1, SERPINA6, TMEM25, SEMG1, PTPRK, COL8A2, CLPSL1, TNPO3, PLOD1, COLGALT2, MMP9, MMP2, FKBP9, LYG2, COL10A1, COLQ, CRP, MSR1, IFNA21STK24PDCD10, STRN, MCC, STRN3, PPP2R1A, STRN4, MOB4, STK25, STRIP1, PPP2CB, SLMAP, APOD, DDX5, G3BP2, HNRNPH3, PDCD6IP, ZBTB24, JPH3, SYNCRIP, HNRNPA3, FABP5, DSP, CTTNBP2NL, SIKE1, PPP2CA, PPP2R1B, STRIP2, CCT2, CCT8, CTTNBP2, CCT3, TCP1, CCT5, FGFR1OP2, CCT6A, CCT7, CCT4, TRAF3IP3, NEDD4, VAV2, ELAVL1, LRRK2, CEP135, RPL12, ALDH7A1, ASNS, EIF5, ISOC1, MAT2B, MSN, PDIA4, PPP1CA, SCPEP1, PRCP, TBCB, VCL, TUBB, XPO1, DYNLL1, PROSER2, STK26, STK24, C4orf19, MAGIX, ATP6V1C2, COG5, MAD1L1, TRMT6, TLK2, ERBB2, STK11, CEP19, LRPPRC, WRAP53, CDC5L, CDH1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COL4A2_STK24


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COL4A2_STK24


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOL4A2C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCOL4A2C0027726Nephrotic Syndrome1CTD_human
HgeneCOL4A2C0149925Small cell carcinoma of lung1CTD_human
HgeneCOL4A2C3280970PORENCEPHALY 21UNIPROT