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Fusion gene ID: 7957 |
FusionGeneSummary for COL4A2_CDC16 |
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Fusion gene information | Fusion gene name: COL4A2_CDC16 | Fusion gene ID: 7957 | Hgene | Tgene | Gene symbol | COL4A2 | CDC16 | Gene ID | 1284 | 8881 |
Gene name | collagen type IV alpha 2 chain | cell division cycle 16 | |
Synonyms | ICH|POREN2 | ANAPC6|APC6|CDC16Hs|CUT9 | |
Cytomap | 13q34 | 13q34 | |
Type of gene | protein-coding | protein-coding | |
Description | collagen alpha-2(IV) chaincanstatin | cell division cycle protein 16 homologanaphase-promoting complex, subunit 6cell division cycle 16 homologcyclosome subunit 6 | |
Modification date | 20180523 | 20180522 | |
UniProtAcc | P08572 | Q13042 | |
Ensembl transtripts involved in fusion gene | ENST00000360467, ENST00000462309, | ENST00000375312, ENST00000360383, ENST00000356221, ENST00000375310, ENST00000375308, ENST00000252457, ENST00000252458, ENST00000461716, | |
Fusion gene scores | * DoF score | 8 X 5 X 7=280 | 4 X 6 X 6=144 |
# samples | 9 | 9 | |
** MAII score | log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/144*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: COL4A2 [Title/Abstract] AND CDC16 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | COL4A2 | GO:0016525 | negative regulation of angiogenesis | 10625665 |
Tgene | CDC16 | GO:0070979 | protein K11-linked ubiquitination | 18485873 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LUSC | TCGA-56-7823-01B | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000360467 | ENST00000375312 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
Frame-shift | ENST00000360467 | ENST00000360383 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
Frame-shift | ENST00000360467 | ENST00000356221 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
Frame-shift | ENST00000360467 | ENST00000375310 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
Frame-shift | ENST00000360467 | ENST00000375308 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
Frame-shift | ENST00000360467 | ENST00000252457 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
Frame-shift | ENST00000360467 | ENST00000252458 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
5CDS-intron | ENST00000360467 | ENST00000461716 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
intron-3CDS | ENST00000462309 | ENST00000375312 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
intron-3CDS | ENST00000462309 | ENST00000360383 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
intron-3CDS | ENST00000462309 | ENST00000356221 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
intron-3CDS | ENST00000462309 | ENST00000375310 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
intron-3CDS | ENST00000462309 | ENST00000375308 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
intron-3CDS | ENST00000462309 | ENST00000252457 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
intron-3CDS | ENST00000462309 | ENST00000252458 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
intron-intron | ENST00000462309 | ENST00000461716 | COL4A2 | chr13 | 111009899 | + | CDC16 | chr13 | 115028354 | + |
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FusionProtFeatures for COL4A2_CDC16 |
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Hgene | Tgene |
COL4A2 | CDC16 |
Type IV collagen is the major structural component ofglomerular basement membranes (GBM), forming a 'chicken-wire'meshwork together with laminins, proteoglycans andentactin/nidogen. Canstatin, a cleavage product corresponding to thecollagen alpha 2(IV) NC1 domain, possesses both anti-angiogenicand anti-tumor cell activity. It inhibits proliferation andmigration of endothelial cells, reduces mitochondrial membranepotential, and induces apoptosis. Specifically induces Fas-dependent apoptosis and activates procaspase-8 and -9 activity.Ligand for alphavbeta3 and alphavbeta5 integrins. | Component of the anaphase promoting complex/cyclosome(APC/C), a cell cycle-regulated E3 ubiquitin ligase that controlsprogression through mitosis and the G1 phase of the cell cycle.The APC/C complex acts by mediating ubiquitination and subsequentdegradation of target proteins: it mainly mediates the formationof 'Lys-11'-linked polyubiquitin chains and, to a lower extent,the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitinchains. {ECO:0000269|PubMed:18485873}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for COL4A2_CDC16 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for COL4A2_CDC16 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
COL4A2 | COL4A2, COL4A1, CSNK2B, DAZAP2, TK1, SMN1, ANXA7, VHL, SKIL, FAM46A, FBXO6, C1QB, C1QTNF2, CELA2B, FGL1, ITLN2, COL9A1, C1QTNF9, STBD1, SERPINA6, TMEM25, SEMG1, PTPRK, COL8A2, CLPSL1, TNPO3, PLOD1, COLGALT2, MMP9, MMP2, FKBP9, LYG2, COL10A1, COLQ, CRP, MSR1, IFNA21 | CDC16 | CDC27, SMAD3, SMAD2, CDC20, ANAPC1, BUB1B, TTK, EP300, CREBBP, MDC1, MAD2L1, ANAPC4, ANAPC7, SMARCAD1, SH3KBP1, RB1, CCNB1, COPS2, ANAPC10, FBXO5, CDC23, ANAPC2, ANAPC5, ANAPC13, PAXIP1, TP53BP1, ANAPC15, TRIM33, CDC26, DNAJA1, FTH1, DAB2, HINT1, XRCC5, C11orf49, PHF8, ANAPC11, HECW2, UBE2S, MOV10, NXF1, BRCA1, FZR1, MAGIX, TTLL1, TAF4, TAF5, NAP1L4, TAF3, KRAS, ATP5J, NEK2, PYCR1, CFAP97, B4GALT7, PYCR2, NSUN5, ANAPC16, SMCR8, USP37, CDC5L, C16orf87, KIAA0586, CEP295, STIL, KRBA1, CEP350, EIF4ENIF1, ZNF318, USP54, IZUMO1, CEP164, ANO6, YY1AP1, ANKHD1-EIF4EBP3, SALL2, TTC8, KIF2B, RECQL4, MYO5C, ALMS1, ZBTB5, HAUS8, TRPS1, DUS3L, C14orf80, TROAP, ZNF644, SMG8, IQCB1, BUB1, SMG7, C15orf39, GPR156, RSBN1, PLCH1, LONP2, RICTOR, PIK3C2A, CCP110, NCOR1, HAUS6, ERF, PHLDB3, MYO9A, BCOR, DISC1, HAUS3, SNX18, HOOK3, CSRP2BP, RAVER1, TRIM37, ZNF687, ASPM, ZNF408, CEP97, IQGAP3, EIF4E2, HAUS7, FAM208A, ALOX5, JMJD4, FAM83H, MGA, HAUS5, TRIM24, ZNF281, HOOK1, MKS1, GTSE1, MAP7D3, DHX35, ZNHIT6, YDJC, SAMD1, ESPL1, TUBB8, MED12, DDX11L8, MLF1, GATAD2B, ALG13, MTNR1B, UHRF2 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COL4A2_CDC16 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COL4A2_CDC16 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | COL4A2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
Hgene | COL4A2 | C0027726 | Nephrotic Syndrome | 1 | CTD_human |
Hgene | COL4A2 | C0149925 | Small cell carcinoma of lung | 1 | CTD_human |
Hgene | COL4A2 | C3280970 | PORENCEPHALY 2 | 1 | UNIPROT |