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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDiseases

Fusion gene ID: 7955

FusionGeneSummary for COL4A1_ZNF827

check button Fusion gene summary
Fusion gene informationFusion gene name: COL4A1_ZNF827
Fusion gene ID: 7955
HgeneTgene
Gene symbol

COL4A1

ZNF827

Gene ID

1282

152485

Gene namecollagen type IV alpha 1 chainzinc finger protein 827
SynonymsBSVD|RATOR-
Cytomap

13q34

4q31.21-q31.22

Type of geneprotein-codingprotein-coding
Descriptioncollagen alpha-1(IV) chainCOL4A1 NC1 domainarrestencollagen IV, alpha-1 polypeptidecollagen of basement membrane, alpha-1 chainzinc finger protein 827
Modification date2018052720180523
UniProtAcc

P02462

Q17R98

Ensembl transtripts involved in fusion geneENST00000375820, ENST00000543140, 
ENST00000467182, 		ENST00000508784, 
ENST00000513320, ENST00000379448, 
ENST00000511534, 
Fusion gene scores* DoF score7 X 9 X 5=31510 X 4 X 7=280
# samples 910
** MAII scorelog2(9/315*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/280*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: COL4A1 [Title/Abstract] AND ZNF827 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-BP-4986-01ACOL4A1chr13

110801311

-ZNF827chr4

146859787

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000375820ENST00000508784COL4A1chr13

110801311

-ZNF827chr4

146859787

-
5CDS-intronENST00000375820ENST00000513320COL4A1chr13

110801311

-ZNF827chr4

146859787

-
5CDS-intronENST00000375820ENST00000379448COL4A1chr13

110801311

-ZNF827chr4

146859787

-
5CDS-intronENST00000375820ENST00000511534COL4A1chr13

110801311

-ZNF827chr4

146859787

-
intron-3CDSENST00000543140ENST00000508784COL4A1chr13

110801311

-ZNF827chr4

146859787

-
intron-intronENST00000543140ENST00000513320COL4A1chr13

110801311

-ZNF827chr4

146859787

-
intron-intronENST00000543140ENST00000379448COL4A1chr13

110801311

-ZNF827chr4

146859787

-
intron-intronENST00000543140ENST00000511534COL4A1chr13

110801311

-ZNF827chr4

146859787

-
intron-3CDSENST00000467182ENST00000508784COL4A1chr13

110801311

-ZNF827chr4

146859787

-
intron-intronENST00000467182ENST00000513320COL4A1chr13

110801311

-ZNF827chr4

146859787

-
intron-intronENST00000467182ENST00000379448COL4A1chr13

110801311

-ZNF827chr4

146859787

-
intron-intronENST00000467182ENST00000511534COL4A1chr13

110801311

-ZNF827chr4

146859787

-

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FusionProtFeatures for COL4A1_ZNF827


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COL4A1

P02462

ZNF827

Q17R98

May be involved in transcriptional regulation.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCOL4A1chr13:110801311chr4:146859787ENST00000375820-52521445_166921341670DomainCollagen IV NC1
HgeneCOL4A1chr13:110801311chr4:146859787ENST00000375820-5252173_144021341670RegionNote=Triple-helical region
TgeneZNF827chr13:110801311chr4:146859787ENST00000379448-015311_354-22995Compositional biasNote=Pro-rich
TgeneZNF827chr13:110801311chr4:146859787ENST00000379448-015961_972-22995Compositional biasNote=Poly-Ser
TgeneZNF827chr13:110801311chr4:146859787ENST00000508784--115311_354141976Compositional biasNote=Pro-rich
TgeneZNF827chr13:110801311chr4:146859787ENST00000508784--115961_972141976Compositional biasNote=Poly-Ser
TgeneZNF827chr13:110801311chr4:146859787ENST00000379448-0151019_1041-22995Zinc fingerC2H2-type 8
TgeneZNF827chr13:110801311chr4:146859787ENST00000379448-0151047_1069-22995Zinc fingerC2H2-type 9
TgeneZNF827chr13:110801311chr4:146859787ENST00000379448-015374_396-22995Zinc fingerC2H2-type 1
TgeneZNF827chr13:110801311chr4:146859787ENST00000379448-015402_424-22995Zinc fingerC2H2-type 2
TgeneZNF827chr13:110801311chr4:146859787ENST00000379448-015433_455-22995Zinc fingerC2H2-type 3
TgeneZNF827chr13:110801311chr4:146859787ENST00000379448-015817_839-22995Zinc fingerC2H2-type 4
TgeneZNF827chr13:110801311chr4:146859787ENST00000379448-015845_867-22995Zinc fingerC2H2-type 5
TgeneZNF827chr13:110801311chr4:146859787ENST00000379448-015897_919-22995Zinc fingerC2H2-type 6
TgeneZNF827chr13:110801311chr4:146859787ENST00000379448-015929_952-22995Zinc fingerC2H2-type 7
TgeneZNF827chr13:110801311chr4:146859787ENST00000508784--1151019_1041141976Zinc fingerC2H2-type 8
TgeneZNF827chr13:110801311chr4:146859787ENST00000508784--1151047_1069141976Zinc fingerC2H2-type 9
TgeneZNF827chr13:110801311chr4:146859787ENST00000508784--115374_396141976Zinc fingerC2H2-type 1
TgeneZNF827chr13:110801311chr4:146859787ENST00000508784--115402_424141976Zinc fingerC2H2-type 2
TgeneZNF827chr13:110801311chr4:146859787ENST00000508784--115433_455141976Zinc fingerC2H2-type 3
TgeneZNF827chr13:110801311chr4:146859787ENST00000508784--115817_839141976Zinc fingerC2H2-type 4
TgeneZNF827chr13:110801311chr4:146859787ENST00000508784--115845_867141976Zinc fingerC2H2-type 5
TgeneZNF827chr13:110801311chr4:146859787ENST00000508784--115897_919141976Zinc fingerC2H2-type 6
TgeneZNF827chr13:110801311chr4:146859787ENST00000508784--115929_952141976Zinc fingerC2H2-type 7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COL4A1_ZNF827


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_COL4A1_ENST00000375820_chr13_110801311_-_ZNF827_ENST00000508784_chr4_146859787_-_0aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_COL4A1_ENST00000375820_chr13_110801311_-_ZNF827_ENST00000508784_chr4_146859787_-_0nt


* Fusion transcript sequences (Full-length transcript).
>In-frame_COL4A1_ENST00000375820_chr13_110801311_-_ZNF827_ENST00000508784_chr4_146859787_-_13987nt
GCTTGGAGCCGCCGCACCCGGGACGGTGCGTAGCGCTGGAAGTCCGGCCTTCCGAGAGCTAGCTGTCCGCCGCGGCCCCCGCACGCCGGG
CAGCCGTCCCTCGCCGCCTCGGGCGCGCCACCATGGGGCCCCGGCTCAGCGTCTGGCTGCTGCTGCTGCCCGCCGCCCTTCTGCTCCACG
AGGAGCACAGCCGGGCCGCTGCGAAGGGTGGCTGTGCTGGCTCTGGCTGTGGCAAATGTGACTGCCATGGAGTGAAGGGACAAAAGGGTG
AAAGAGGCCTCCCGGGGTTACAAGGTGTCATTGGGTTTCCTGGAATGCAAGGACCTGAGGGGCCACAGGGACCACCAGGACAAAAGGGTG
ATACTGGAGAACCAGGACTACCTGGAACAAAAGGGACAAGAGGACCTCCGGGAGCATCTGGCTACCCTGGAAACCCAGGACTTCCCGGAA
TTCCTGGCCAAGACGGCCCGCCAGGCCCCCCAGGTATTCCAGGATGCAATGGCACAAAGGGGGAGAGAGGGCCGCTCGGGCCTCCTGGCT
TGCCTGGTTTCGCTGGAAATCCCGGACCACCAGGCTTACCAGGGATGAAGGGTGATCCAGGTGAGATACTTGGCCATGTGCCCGGGATGC
TGTTGAAAGGTGAAAGAGGATTTCCCGGAATCCCAGGGACTCCAGGCCCACCAGGACTGCCAGGGCTTCAAGGTCCTGTTGGGCCTCCAG
GATTTACCGGACCACCAGGTCCCCCAGGCCCTCCCGGCCCTCCAGGTGAAAAGGGACAAATGGGCTTAAGTTTTCAAGGACCAAAAGGTG
ACAAGGGTGACCAAGGGGTCAGTGGGCCTCCAGGAGTACCAGGACAAGCTCAAGTTCAAGAAAAAGGAGACTTCGCCACCAAGGGAGAAA
AGGGCCAAAAAGGTGAACCTGGATTTCAGGGGATGCCAGGGGTCGGAGAGAAAGGTGAACCCGGAAAACCAGGACCCAGAGGCAAACCCG
GAAAAGATGGTGACAAAGGGGAAAAAGGGAGTCCCGGTTTTCCTGGTGAACCCGGGTACCCAGGACTCATAGGCCGCCAGGGCCCGCAGG
GAGAAAAGGGTGAAGCAGGTCCTCCTGGCCCACCTGGAATTGTTATAGGCACAGGACCTTTGGGAGAAAAAGGAGAGAGGGGCTACCCTG
GAACTCCGGGGCCAAGAGGAGAGCCAGGCCCAAAAGGTTTCCCAGGACTACCAGGCCAACCCGGACCTCCAGGCCTCCCTGTACCTGGGC
AGGCTGGTGCCCCTGGCTTCCCTGGTGAAAGAGGAGAAAAAGGTGACCGAGGATTTCCTGGTACATCTCTGCCAGGACCAAGTGGAAGAG
ATGGGCTCCCGGGTCCTCCTGGTTCCCCTGGGCCCCCTGGGCAGCCTGGCTACACAAATGGAATTGTGGAATGTCAGCCCGGACCTCCAG
GTGACCAGGGTCCTCCTGGAATTCCAGGGCAGCCAGGATTTATAGGCGAAATTGGAGAGAAAGGTCAAAAAGGAGAGAGTTGCCTCATCT
GTGATATAGACGGATATCGGGGGCCTCCCGGGCCACAGGGACCCCCGGGAGAAATAGGTTTCCCAGGGCAGCCAGGGGCCAAGGGCGACA
GAGGTTTGCCTGGCAGAGATGGTGTTGCAGGAGTGCCAGGCCCTCAAGGTACACCAGGGCTGATAGGCCAGCCAGGAGCCAAGGGGGAGC
CTGGTGAGTTTTATTTCGACTTGCGGCTCAAAGGTGACAAAGGAGACCCAGGCTTTCCAGGACAGCCCGGCATGACAGGGAGAGCGGGTT
CTCCTGGAAGAGATGGCCATCCGGGTCTTCCTGGCCCCAAGGGCTCGCCGGGTTCTGTAGGATTGAAAGGAGAGCGTGGCCCCCCTGGAG
GAGTTGGATTCCCAGGCAGTCGTGGTGACACCGGCCCCCCTGGGCCTCCAGGATATGGTCCTGCTGGTCCCATTGGTGACAAAGGACAAG
CAGGCTTTCCTGGAGGCCCTGGATCCCCAGGCCTGCCAGGTCCAAAGGGTGAACCAGGAAAAATTGTTCCTTTACCAGGCCCCCCTGGAG
CAGAAGGACTGCCGGGGTCCCCAGGCTTCCCAGGTCCCCAAGGAGACCGAGGCTTTCCCGGAACCCCAGGAAGGCCAGGCCTGCCAGGAG
AGAAGGGCGCTGTGGGCCAGCCAGGCATTGGATTTCCAGGGCCCCCCGGCCCCAAAGGTGTTGACGGCTTACCTGGAGACATGGGGCCAC
CGGGGACTCCAGGTCGCCCGGGATTTAATGGCTTACCTGGGAACCCAGGTGTGCAGGGCCAGAAGGGAGAGCCTGGAGTTGGTCTACCGG
GACTCAAAGGTTTGCCAGGTCTTCCCGGCATTCCTGGCACACCCGGGGAGAAGGGGAGCATTGGGGTACCAGGCGTTCCTGGAGAACATG
GAGCGATCGGACCCCCTGGGCTTCAGGGGATCAGAGGTGAACCGGGACCTCCTGGATTGCCAGGCTCCGTGGGGTCTCCAGGAGTTCCAG
GAATAGGCCCCCCTGGAGCTAGGGGTCCCCCTGGAGGACAGGGACCACCGGGGTTGTCAGGCCCTCCTGGAATAAAAGGAGAGAAGGGTT
TCCCCGGATTCCCTGGACTGGACATGCCGGGCCCTAAAGGAGATAAAGGGGCTCAAGGACTCCCTGGCATAACGGGACAGTCGGGGCTCC
CTGGCCTTCCTGGACAGCAGGGGGCTCCTGGGATTCCTGGGTTTCCAGGTTCCAAGGGAGAAATGGGCGTCATGGGGACCCCCGGGCAGC
CGGGCTCACCAGGACCAGTGGGTGCTCCTGGATTACCGGGTGAAAAAGGGGACCATGGCTTTCCGGGCTCCTCAGGACCCAGGGGAGACC
CTGGCTTGAAAGGTGATAAGGGGGATGTCGGTCTCCCTGGCAAGCCTGGCTCCATGGATAAGGTGGACATGGGCAGCATGAAGGGCCAGA
AAGGAGACCAAGGAGAGAAAGGACAAATTGGACCAATTGGTGAGAAGGGATCCCGAGGAGACCCTGGGACCCCAGGAGTGCCTGGAAAGG
ACGGGCAGGCAGGACAGCCTGGGCAGCCAGGACCTAAAGGTGATCCAGGTATAAGTGGAACCCCAGGTGCTCCAGGACTTCCGGGACCAA
AAGGATCTGTTGGTGGAATGGGCTTGCCAGGAACACCTGGAGAGAAAGGTGTGCCTGGCATCCCTGGCCCACAAGGTTCACCTGGCTTAC
CTGGAGACAAAGGTGCAAAAGGAGAGAAAGGGCAGGCAGGCCCACCTGGCATAGGCATCCCAGGGCTGCGAGGTGAAAAGGGAGATCAAG
GGATAGCGGGTTTCCCAGGAAGCCCTGGAGAGAAGGGAGAAAAAGGAAGCATTGGGATCCCAGGAATGCCAGGGTCCCCAGGCCTTAAAG
GGTCTCCCGGGAGTGTTGGCTATCCAGGAAGTCCTGGGCTACCTGGAGAAAAAGGTGACAAAGGCCTCCCAGGATTGGATGGCATCCCTG
GTGTCAAAGGAGAAGCAGGTCTTCCTGGGACTCCTGGCCCCACAGGCCCAGCTGGCCAGAAAGGGGAGCCAGGCAGTGATGGAATCCCGG
GGTCAGCAGGAGAGAAGGGTGAACCAGGTCTACCAGGAAGAGGATTCCCAGGGTTTCCAGGGGCCAAAGGAGACAAAGGTTCAAAGGGTG
AGGTGGGTTTCCCAGGATTAGCCGGGAGCCCAGGAATTCCTGGATCCAAAGGAGAGCAAGGATTCATGGGTCCTCCGGGGCCCCAGGGAC
AGCCGGGGTTACCGGGATCCCCAGGCCATGCCACGGAGGGGCCCAAAGGAGACCGCGGACCTCAGGGCCAGCCTGGCCTGCCAGGACTTC
CGGGACCCATGGGGCCTCCAGGGCTTCCTGGGATTGATGGAGTTAAAGGTGACAAAGGAAATCCAGGCTGGCCAGGAGCACCCGGTGTCC
CAGGGCCCAAGGGAGACCCTGGATTCCAGGGCATGCCTGGTATTGGTGGCTCTCCAGGAATCACAGGCTCTAAGGGTGATATGGGGCCTC
CAGGAGTTCCAGGATTTCAAGGTCCAAAAGGTCTTCCTGGCCTCCAGGGAATTAAAGGTGATCAAGGCGATCAAGGCGTCCCGGGAGCTA
AAGGTCTCCCGGGTCCTCCTGGCCCCCCAGGTCCTTACGACATCATCAAAGGGGAGCCCGGGCTCCCTGGTCCTGAGGGCCCCCCAGGGC
TGAAAGGGCTTCAGGGACTGCCAGGCCCGAAAGGCCAGCAAGGTGTTACAGGATTGGTGGGTATACCTGGACCTCCAGGTATTCCTGGGT
TTGACGGTGCCCCTGGCCAGAAAGGAGAGATGGGACCTGCCGGGCCTACTGGTCCAAGAGGATTTCCAGGTCCACCAGGCCCCGATGGGT
TGCCAGGATCCATGGGGCCCCCAGGCACCCCATCTGTTGATCACGGCTTCCTTGTGACCAGGCATAGTCAAACAATAGATGACCCACAGT
GTCCTTCTGGGACCAAAATTCTTTACCACGGGTACTCTTTGCTCTACGTGCAAGGCAATGAACGGGCCCATGGCCAGGACTTGGGCACGG
CCGGCAGCTGCCTGCGCAAGTTCAGCACAATGCCCTTCCTGTTCTGCAATATTAACAACGTGTGCAACTTTGCATCACGAAATGACTACT
CGTACTGGCTGTCCACCCCTGAGCCCATGCCCATGTCAATGGCACCCATCACGGGGGAAAACATAAGACCATTTATTAGTAGGTGTGCTG
TGTGTGAGGCGCCTGCCATGGTGATGGCCGTGCACAGCCAGACCATTCAGATCCCACCGTGCCCCAGCGGGTGGTCCTCGCTGTGGATCG
GCTACTCTTTTGTGATGCACACCAGCGCTGGTGCAGAAGGCTCTGGCCAAGCCCTGGCGTCCCCCGGCTCCTGCCTGGAGGAGTTTAGAA
GTGCGCCATTCATCGAGTGTCACGGCCGTGGGACCTGCAATTACTACGCAAACGCTTACAGCTTTTGGCTCGCCACCATAGAGAGGAGCG
AGATGTTCAAGAAGCCTACGCCGTCCACCTTGAAGGCAGGGGAGCTGCGCACGCACGTCAGCCGCTGCCAAGTCTGTATGAGAAGAACAT
AATGAAGCCTGACTCAGCTAATGTCACAACATGGTGCTACTTCTTCTTCTTTTTGTTAACAGCAACGAACCCTAGAAATATATCCTGTGT
ACCTCACTGTCCAATATGAAAACCGTAAAGTGCCTTATAGGAATTTGCGTAACTAACACACCCTGCTTCATTGACCTCTACTTGCTGAAG
GAGAAAAAGACAGCGATAAGCTTTCAATAGTGGCATACCAAATGGCACTTTTGATGAAATAAAATATCAATATTTTCTGCAATCCAATGC
ACTGATGTGTGAAGTGAGAACTCCATCAGAAAACCAAAGGGTGCTAGGAGGTGTGGGTGCCTTCCATACTGTTTGCCCATTTTCATTCTT
GTATTATAATTAATTTTCTACCCCCAGAGATAAATGTTTGTTTATATCACTGTCTAGCTGTTTCAAAATTTAGGTCCCTTGGTCTGTACA
AATAATAGCAATGTAAAAATGGTTTTTTGAACCTCCAAATGGAATTACAGACTCAGTAGCCATATCTTCCAACCCCCCAGTATAAATTTC
TGTCTTTCTGCTATGTGTGGTACTTTGCAGCTGCTTTTGCAGAAATCACAATTTTCCTGTGGAATAAAGATGGTCCAAAAATAGTCAAAA
ATTAAATATATATATATATTAGTAATTTATATAGATGTCAGCAATTAGGCAGATCAAGGTTTAGTTTAACTTCCACTGTTAAAATAAAGC
TTACATAGTTTTCTTCCTTTGAAAGACTGTGCTGTCCTTTAACATAGGTTTTTAAAGACTAGGATATTGAATGTGAAACATCCGTTTTCA
TTGTTCACTTCTAAACCAAAAATTATGTGTTGCCAAAACCAAACCCAGGTTCATGAATATGGTGTCTATTATAGTGAAACATGTACTTTG
AGCTTATTGTTTTTATTCTGTATTAAATATTTTCAGGGTTTTAAACACTAATCACAAACTGAATGACTTGACTTCAAAAGCAACAACCTT
AAAGGCCGTCATTTCATTAGTATTCCTCATTCTGCATCCTGGCTTGAAAAACAGCTCTGTTGAATCACAGTATCAGTATTTTCACACGTA
AGCACATTCGGGCCATTTCCGTGGTTTCTCATGAGCTGTGTTCACAGACCTCAGCAGGGCATCGCATGGACCGCAGGAGGGCAGATTCGG
ACCACTAGGCCTGAAATGACATTTCACTAAAAGTCTCCAAAACATTTCTAAGACTACTAAGGCCTTTTATGTAATTTCTTTAAATGTGTA
TTTCTTAAGAATTCAAATTTGTAATAAAACTATTTGTATAAAAATTAAGCTTTTATTAATTTGTTGCTAGTATTGCCACAGACGCATTAA
AAGAAACTTACTGCACAAGCTGCTAATAAATTTGTAAGCTTTGCAAAAAAAAAAAAAGGAAAAAAGAAAGGAAAGAAAAGAAGAAAACCC
CTCTTCTGGCTCCAGGAAACAAGCTTCAACCCATTGCACACACCGGAGAAGGGGTTTCCCCCTGCCCGCCCGCCCGCCCCCCAACTACCT
CCCCGCTCCTGCCAGTGTCTGCCTCTCTGCCCCCACGGGGGTTTATTTGATCTCACATTAACCAAGGAGGAGAATGTGAGAAAAGGGGGA
AAATGCCCAGGAGGAAGCAGGAGCAGCCCAAGCGCCTTCCCTCACATGTTAGTAGGCAGGAAGAGGCGGAGGGAGAGCTCAGTGAAGGAG
AACACTGGTATGGAAACTCTTCAGAGACTCCGTCAGAAGCATCCTATGGGGAAGTCCAGGAGAACTATAAGTTGTCTCTGGAGGACCGGA
TCCAGGAGCAGTCCACGTCCCCGGACACCTCCTTGGGAAGCACGACTCCCAGCAGCCACACGTTGGAGCTGGTGGCACTGGACAGTGAGG
TCCTGCGAGACTCACTGCAGTGTCAAGATCACCTTTCCCCGGGAGTGTCTTCTTTGTGTGACGATGACCCAGGCTCCAACAAGCCCCTGA
GCAGCAATTTGAGGCGGCTGCTGGAGGCTGGTTCCCTCAAACTCGATGCTGCAGCCACGGCTAATGGCAGAGTGGAGTCCCCCGTAAACG
TTGGCTCGAACCTCTCCTTTTCCCCGCCTTCCCACCACGCCCAGCAGCTCAGTGTTCTGGCCAGGAAGTTGGCCGAGAAGCAGGAACAGA
ATGACCAATACACTCCAAGTAACCGTTTTATATGGAATCAAGGTAAGTGGTTGCCAAACTCAACCACCACCTGCAGCTTGTCTCCGGATT
CAGCCATCCTAAAACTGAAAGCTGCAGCCAATGCCGTTCTGCAGGACAAATCTCTCACCAGGACTGAGGAGACCATGCGATTTGAGTCCT
TTTCCTCCCCTTTTAGCTCCCAGTCTGCCAGTTCTACCTTGGCCGCTTTGTCCAAGAAGGTCAGTGAAAGAAGTTTGACTCCTGGTCAGG
AGCACCCTCCACCGGCCAGCTCCTTCCTTTCCCTGGCTTCTATGACCTCCTCAGCGGCCCTTCTGAAGGAGGTGGCCGCAAGGGCTGCGG
GCAGTCTTCTGGCTGAGAAATCATCGCTGCTGCCTGAGGACCCTCTACCGCCCCCGCCTTCAGAGAAGAAACCAGAAAAAGTCACTCCGC
CACCTCCACCGCCACCTCCACCACCTCCACCACCACCACCACAATCCCTGGAATTATTATTACTCCCAGTTCCTAAGGGAAGAGTTTCTA
AACCCTCCAATTCAGCCTCAGAAGAGGAAAGTGGAAAGCCTTTCCAGTGTCCAATATGTGGTTTGGTTATTAAAAGGAAGAGTTACTGGA
AGCGGCACATGGTGATTCACACAGGTTTAAAAAGTCATCAGTGTCCGCTCTGTCCATTCCGGTGTGCTCGCAAGGACAATCTCAAATCCC
ACATGAAGGTTCATCAGCACCAGGATCGGGGAGAGACCTTTCAGTGCCAGCTGTGCCCTTTTACTTCCTCACGCCACTTCAGCCTGAAAC
TCCACATGCGTTGCCATCAGCACTTCCTGAGGACAGAAGCCAAGGTGAAGGAGGAGATCCCAGACCCAGATGTCAAGGGATCTCCCCACC
TCAGTGACAGTGCCTGCCTGGGGCAGCAAAGGGAAGGAGGAGGGACAGAGCTAGTGGGGACCATGATGACGTCTAACACTCCAGAGAGGA
CTAGCCAGGGAGGGGCTGGCGTCTCGCCTTTGCTGGTGAAGGAGGAACCCAAGGAAGATAACGGCCTGCCCACCTCCTTTACTTTGAATG
CTGCCGACAGGCCCGCCAACCACACAAAGCTGAAAGACCCCTCCGAGTATGTGGCCAACAGTGCGTCAGCATTGTTCAGCCAGGACATCT
CTGTTAAGATGGCGTCTGATTTTCTCATGAAGCTGTCAGCTGCAAATCAGAAGGAGCCCATGAATCTTAATTTTAAAGTGAAAGAGGAGC
CTAAGGAAGGGGAGTCCCTAAGCACGACTTTGCCTCGGTCCAGCTATGTGTTCAGCCCGGAATCTGAAGTGTCAGCCCCAGGCGTCTCTG
AGGACGCACTAAAGCCCCAGGAAGGGAAGGGAAGTGTGCTAAGGCGGGATGTGTCAGTCAAAGCAGCCTCTGAACTTCTCATGAAACTCT
CAGCGGAAAGCTACAAGGAAACACAGATGGTGAAGATTAAAGAGGAACCCATGGAGGTTGACATCCAGGACTCCCATGTCTCGATATCAC
CCAGCCGGAATGTTGGCTACAGCACTTTAATCGGGCGAGAGAAAACCGAACCCTTACAGAAGATGCCAGAGGGCAGAGTACCCCCAGAGA
GAAACCTCTTCAGTCAGGATATCTCTGTGAAAATGGCTTCCGAGCTCCTCTTTCAACTGTCAGAAAAAGTGAGCAAAGAGCACAATCATA
CAAAAGAAAACACCATCCGGACCACGACCAGCCCTTTCTTTTCAGAAGACACATTTAGACAATCACCATTCACCTCCAATTCAAAAGAAC
TGCTGCCCAGTGACTCCGTGCTGCACGGAAGAATATCAGCTCCAGAAACAGAAAAGATAGTCCTAGAGGCAGGAAATGGATTACCATCCT
GGAAATTCAATGACCAGCTTTTTCCCTGTGACGTGTGTGGGAAAGTGTTTGGCCGACAGCAGACATTGTCCCGACACCTCTCGCTGCACA
CAGAGGAAAGAAAATACAAATGCCACTTGTGCCCCTATGCTGCTAAGTGCCGTGCAAATCTGAACCAGCACTTGACCGTCCATTCCGTGA
AGCTGGTGAGTACAGACACCGAGGACATTGTCAGCGCCGTCACCTCTGAAGGCAGTGATGGGAAGAAACATCCTTATTATTACAGTTGTC
ACGTGTGTGGATTTGAGACCGAGCTCAATGTCCAGTTTGTCAGCCACATGTCACTCCACGTGGACAAGGAGCAGTGGATGTTTTCGATCT
GCTGCACTGCCTGCGACTTCGTCACCATGGAGGAAGCAGAGATAAAGACTCACATTGGCACCAAGCACACAGGGGAAGACAGGAAGACCC
CCAGCGAATCAAATAGCCCCTCTTCATCCTCCCTCTCAGCTCTGAGTGATTCAGCCAACAGCAAAGATGATTCAGATGGCTCCCAGAAAA
ACAAGGGCGGGAACAATCTGCTGGTCATCTCTGTCATGCCTGGGAGCCAGCCCTCACTGAACAGTGAGGAAAAGCCAGAGAAAGGGTTCG
AATGTGTTTTTTGCAACTTTGTCTGCAAGACGAAGAACATGTTTGAGCGTCATCTGCAGATACACCTCATCACCCGGATGTTTGAGTGTG
ATGTGTGCCACAAGTTCATGAAGACCCCCGAACAGCTGCTGGAGCATAAGAAATGCCACACTGTCCCCACCGGTGGGCTCAACTCAGGAC
AGTGGTGAGTTTCAGACTCCTCTAGGTGCCCATTCTGCATTTATTCCACCAACCGCCCCGCTGCCATGGAGTGCCACCTCAAGACCCACT
ACAAGATGGAGTACAAGTGCCGGATCTGCCAGACGGTGAAGGCCAACCAGCTGGAGCTGGAGACGCACACCCGGGAGCACCGCCTGGGCA
ACCACTACAAGTGCGACCAGTGCGGCTACCTGTCCAAGACCGCCAACAAGCTCATCGAGCACGTGCGCGTCCACACCGGGGAGCGGCCCT
TCCACTGTGACCAGTGCAGCTACAGCTGCAAGCGCAAGGACAATCTCAACCTGCACAAGAAGCTGAAGCACGCCCCACGCCAGACCTTCA
GCTGCGAAGAGTGCCTGTTCAAGACCACACACCCTTTCGTCTTCAGCCGCCACGTCAAGAAGCACCAGAGTGGGGACTGCCCCGAGGAGG
ACAAGAAGGGCCTGTGTCCAGCCCCCAAGGAACCGGCCGGCCCGGGGGCCCCGCTCCTGGTGGTCGGGAGCTCCCGGAATCTCCTGTCTC
CCCTGTCAGTTATGTCTGCCTCCCAGGCTCTGCAGACCGTGGCCCTGTCGGCAGCCCACGGCAGCAGCTCAGAGCCCAACCTGGCACTCA
AGGCTTTGGCCTTCAACGGCTCCCCTTTGCGCTTTGACAAGTACCGGAACTCAGATTTTGCCCATCTCATTCCCTTGACAATGTTATACC
CCAAGAACCACTTGGATCTCACATTCCACCCTCCCCGACCTCAGACTGCGCCTCCCAGCATCCCCTCACCCAAACACTCCTTCCTGGCCT
ATCTCGGACTGAGAGAAAGAGCAGAGACTGTCTGAGGGCAGCCATGTTCTGTACCAAAAACAGAGAGACAAAAGACAAAAAAAAAAAAAA
AAACCACAAAACTTAAACACAACCCCAGCAGGTGTATGTTGCTGCAAAACCTACAGACCCCGATGGGTCTGGAACATGTGTACTGTATAT
CTTTAGTAAGGAATAGAAAATTGGCTCTGTGTGTATACCTATTGCATTGACCTGAAAGCTGCTTTATCCAATCTTCAGAGAGGTGACCTA
CTGCATACTTCTACCTTCAGAGGCATGCCTCCCCAGCCACCCACTCCCACTCTCAGCCCTTCTCCGTACTTTTCTCTGAAAGGAATCTTG
TCTTGTTAAACCCTAAAGAGAGTGTCCTTAATAGCAATCAGCACTTGTAAGCTTATATACTGGTGCATTTGGTTTTCTGTTGGGTGAATG
CGGTGTGTGGGCGTTTGTGGATTCTGAAAGAGAAAGCCGTGTGTCGTGTGCCATGACATTTCTATTGCACATTCTTTGTACTGGCTTCTT
TAACAGCGATGAACGTTCTTTTCCCTCCTGGGTTGTTCATCCACGACAGTCTCTCCCTGTGCTCCTTCATCACCTTTCCCTCTCTCTTTG
ATGGCTACAGAGTGGTAGGGCCTGGTGCTTAGTCGATGAAGGAATGGTAGCCATCTACAGTGCTGCTGGAGATTTCCGCCAGAGCGCTGG
AGACCTTGCGCTCAGATCTTCTCTGGTGATGAAGAGGCGAGGAATCAAGTGACTGATCTGGAAGAAATATCTCGCAGCACTGCAGCTAAC
ATCACAGAACTTAAGTGTGTTTTGTGTGTGTGCCCACACGTAGACAAATGTGTACGGTGCACACACACAGTGCATCATTTTTTAAGGGCA
GATTATATATATATATGAGATGTATTAATTCAGTGGTTACCATTTGTTTGCAGGAAAAAGAAATGTATGGGTGAAAAAATTTATGGTTGA
TAAATCCAGCCAAGGAGATTAAAAGGGGTTTGGATAAATTCTGGGTATAAATGCTCAGACTAAAAAAAAGAAATGGCAGTTTTGCACAGT
GCTATGGTCTTGCACTAGTTTTTGTTTCTCATCTGAAAAAAAAAAAGTAAAATAAAAGGAAGAAAATGTACCTTTTTTATGGAATGAGTA
GACTGTATGTTTGAAGATTTAGCCACAACCTCTTTGACATATAATGACGCAACAAAAAGGTGCTGTTTAGTCCTATGGTTCAGTTTATGC
CCCTGACAAGTTTCCATTGTGTTTTGCCGATCTTCTGGCTAATCGTGGTATCCTCCATGTTATTAGTAATTCTGTATTCCATTTTGTTAA
CGCCTGGTAGATGTAACCTGCTAGGAGGCTAACTTTATACTTATTTAAAAGCTCTTATTTTGTGGTCATTAAAATGGCAATTTATGTGCA
GCACTTTATTGCAGCAGGAAGCAGGTGTGGGTTGGTTGTAAAGCTCTTTGCTAATCTTAAAAAGTAATGGGTGATTTAAAAAGAAAAAAG
GAAAAAAATCTTTGGCTGAATATGTTCATTGCTTGTATTTTTAAAACAACAGAATTTCCAGTATGAAACAGGCTGAAAGAGCAGGAAGAA
ATGTTCTTTGTATAATAATGGGAAGTTTGGAATATAAAAGTTTATATATTATTTATCTATTGGAGAACTGGTGTACAGGAGGAACATTTT
CTTACTGTGTTGCTGTTTTCCATCATGTGTTATCCTAAGAGTTGGGGTTTTTTAAAATCTGTTTCACCAGGGGAAAATAAAAGCATCCCT
AATGTTCTTCCTCTAGTCAGTTTGCTTTGCTGAAAGCTCCCTGGAAATTAGTACAGTTCTACAGGAAGCCAGAAGACTGTACTGTCTGTC
CACACCATGGTCTCCTCAGTCCCCTCCACGCCAGCCCCTCTTCCCCACACCTAGTAGGTGTGCTACACCTCCCTTTGCCAGTCATCCCGC
CATGGATGGGGAGCCTACTTGGTGCCCTGGCAAACCTGTTTACACTAAGGAGATGCCCACAGGGAGCGGGAAGCTCCCAAACCCTCAGTC
ATTCTCCAGCAGAGACCTTTGCTCTTGGCCAGGTTTGAAACGATGTTCAACCTCGCCACGTCAATGTCTCAGTAAAAGACACTATAGATA
GTTATGGACAATACACTCCAAGAATACTGGGCTTATGGGTGGGTTGGTTTTTTGTTTTGTTTTGTTTTGTTTTCAAGTCATGTCTTTATC
CCCATATAATGGAGAATGTGCCACTTGGCTAATAATGTGTTTTCAAAACTACAAGTTCAGTGATGACAGGAAAGAGGGCTAAAGTAGTCC
CACAGAGGCTGGTAGAAAAGGCGAATCACACTTAAGCACCAGCAGGTTAAAAACCTGAAAGGGTGGCCCTGACAATTCAGACTATAGGTT
TTACAGCATGCCACTTGTGCAATAGGAGGTCTAGGGTTGAAACTTTCAAGAACGAGAGGAGGTGAAGGAAGGAGACGTTTACTGCTCAAA
TGCCATGCATTTCACTGCTTGCCACTGAACTTGTATTTGAATGACTTAGTAATGCTTAATATAATTGGGCAACTTTTTTAGCACTTTGGA
AAGAGTCATCAATCTTTCTGGTAAATTATAAAAGTTTTCTGAGTGAGAAAAGGTGTGTTTGGAGTTTGTTTGACTTTTTATATTATTATT
GTTATTAATAAAGAAAAAAATCTACAGCATTTTTCAGACTCCACCCTAGAAAATATGTACCCCTGAATTTGGTTTGCAGTTTGATACTCA
GGGAAGGATGTATTCCATAGATATCCTTTCCGTATAAAACACTAACATCTTTGAGAAATTCACCTACCAACTAACTTCAATTGTTGTCAC
TATGCATTCTTCAATGAAAACTAGCTTATTTTTCCATATAGTAATGCAGTTAGGGTTCTCAGCACTTTCTTTCTTCTATCCTTTTTTTAA
CTCTTCATATTATGTTCAGATGATCATACTGTCAAGGTTTGTGTACATTACTGAAAATTTGTATTGTATAAAGCTTTTTGCATTACGAGG
CTGTACAGGGTCATTTTGACAGTAACTGGTATATTCCTTTGCATCTTATGTTGCATTGCCAATTTCTAGTGTATCCAGTTTGAAAGTATA


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FusionGenePPI for COL4A1_ZNF827


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
COL4A1DISC1, NID1, NID2, COL4A2, COL4A1, THBS1, COL7A1, MAG, VHL, PDGFA, PDGFB, ACHE, KIFAP3, PLOD1, COLGALT2, MMP9, MMP2, TINAGZNF827PPP1CA, UBE2E1, ATP6V1E1, CHERP, VPS45, UNC80, HDAC1, GATAD2A, GATAD2B, RBBP7, RBBP4, CHD3, CHD4, MTA1, MTA2, MTA3, HDAC2, MCPH1, BRCA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COL4A1_ZNF827


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COL4A1_ZNF827


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCOL4A1C4013035BRAIN SMALL VESSEL DISEASE WITH OR WITHOUT OCULAR ANOMALIES8ORPHANET;UNIPROT
HgeneCOL4A1C1867983PORENCEPHALY, FAMILIAL3ORPHANET;UNIPROT
HgeneCOL4A1C2673195Angiopathy, Hereditary, With Nephropathy, Aneurysms, And Muscle Cramps3CTD_human;ORPHANET;UNIPROT
HgeneCOL4A1C0017668Focal glomerulosclerosis2CTD_human
HgeneCOL4A1C0011881Diabetic Nephropathy1CTD_human
HgeneCOL4A1C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCOL4A1C0027726Nephrotic Syndrome1CTD_human
HgeneCOL4A1C0266484Schizencephaly1HPO;ORPHANET;UNIPROT
HgeneCOL4A1C3281105HEMORRHAGE, INTRACEREBRAL, SUSCEPTIBILITY TO1UNIPROT