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Fusion gene ID: 7910 |
FusionGeneSummary for COL24A1_TMEM181 |
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Fusion gene information | Fusion gene name: COL24A1_TMEM181 | Fusion gene ID: 7910 | Hgene | Tgene | Gene symbol | COL24A1 | TMEM181 | Gene ID | 255631 | 57583 |
Gene name | collagen type XXIV alpha 1 chain | transmembrane protein 181 | |
Synonyms | - | GPR178|KIAA1423 | |
Cytomap | 1p22.3 | 6q25.3 | |
Type of gene | protein-coding | protein-coding | |
Description | collagen alpha-1(XXIV) chaincollagen, type XXIV, alpha 1 | transmembrane protein 181G protein-coupled receptor 178 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q17RW2 | Q9P2C4 | |
Ensembl transtripts involved in fusion gene | ENST00000436319, ENST00000370571, ENST00000485434, | ENST00000367090, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 3 X 3 X 1=9 |
# samples | 1 | 4 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(4/9*10)=2.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: COL24A1 [Title/Abstract] AND TMEM181 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AY203961 | COL24A1 | chr1 | 86351677 | + | TMEM181 | chr6 | 158971044 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000436319 | ENST00000367090 | COL24A1 | chr1 | 86351677 | + | TMEM181 | chr6 | 158971044 | + |
intron-intron | ENST00000370571 | ENST00000367090 | COL24A1 | chr1 | 86351677 | + | TMEM181 | chr6 | 158971044 | + |
intron-intron | ENST00000485434 | ENST00000367090 | COL24A1 | chr1 | 86351677 | + | TMEM181 | chr6 | 158971044 | + |
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FusionProtFeatures for COL24A1_TMEM181 |
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Hgene | Tgene |
COL24A1 | TMEM181 |
May participate in regulating type I collagenfibrillogenesis at specific anatomical locations during fetaldevelopment. {ECO:0000269|PubMed:12874293}. | Mediates action of cytolethal distending toxins (CDT),which are secreted by many pathogenic bacteria. Expression levelof TMEM181 is rate-limiting for intoxication.{ECO:0000269|PubMed:19965467}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for COL24A1_TMEM181 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for COL24A1_TMEM181 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COL24A1_TMEM181 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COL24A1_TMEM181 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |