|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 7893 |
FusionGeneSummary for COL1A2_FSTL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COL1A2_FSTL1 | Fusion gene ID: 7893 | Hgene | Tgene | Gene symbol | COL1A2 | FSTL1 | Gene ID | 1278 | 11167 |
| Gene name | collagen type I alpha 2 chain | follistatin like 1 | |
| Synonyms | EDSARTH2|EDSCV|OI4 | FRP|FSL1|MIR198|OCC-1|OCC1|tsc36 | |
| Cytomap | 7q21.3 | 3q13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | collagen alpha-2(I) chainalpha 2 type I procollagenalpha 2(I) procollagenalpha 2(I)-collagenalpha-2 type I collagencollagen I, alpha-2 polypeptidecollagen of skin, tendon and bone, alpha-2 chaincollagen, type I, alpha 2type I procollagen | follistatin-related protein 1follistatin-like protein 1 | |
| Modification date | 20180527 | 20180519 | |
| UniProtAcc | P08123 | Q12841 | |
| Ensembl transtripts involved in fusion gene | ENST00000297268, | ENST00000295633, ENST00000424703, ENST00000485968, | |
| Fusion gene scores | * DoF score | 15 X 20 X 5=1500 | 10 X 8 X 6=480 |
| # samples | 21 | 12 | |
| ** MAII score | log2(21/1500*10)=-2.83650126771712 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/480*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: COL1A2 [Title/Abstract] AND FSTL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | COL1A2 | GO:0007179 | transforming growth factor beta receptor signaling pathway | 17217948 |
| Hgene | COL1A2 | GO:0007266 | Rho protein signal transduction | 17217948 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | UCS | TCGA-NA-A4QV-01A | COL1A2 | chr7 | 94054975 | + | FSTL1 | chr3 | 120134874 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000297268 | ENST00000295633 | COL1A2 | chr7 | 94054975 | + | FSTL1 | chr3 | 120134874 | - |
| 5CDS-intron | ENST00000297268 | ENST00000424703 | COL1A2 | chr7 | 94054975 | + | FSTL1 | chr3 | 120134874 | - |
| 5CDS-intron | ENST00000297268 | ENST00000485968 | COL1A2 | chr7 | 94054975 | + | FSTL1 | chr3 | 120134874 | - |
Top |
FusionProtFeatures for COL1A2_FSTL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COL1A2 | FSTL1 |
| May modulate the action of some growth factors on cellproliferation and differentiation. Binds heparin (By similarity).{ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >FSTL1 | chr7:94054975 | chr3:120134874 | ENST00000295633 | - | 1 | 11 | 144_178 | 21 | 309 | Domain | EF-hand 1 |
| Tgene | >FSTL1 | chr7:94054975 | chr3:120134874 | ENST00000295633 | - | 1 | 11 | 193_228 | 21 | 309 | Domain | EF-hand 2 |
| Tgene | >FSTL1 | chr7:94054975 | chr3:120134874 | ENST00000295633 | - | 1 | 11 | 233_287 | 21 | 309 | Domain | Note=VWFC |
| Tgene | >FSTL1 | chr7:94054975 | chr3:120134874 | ENST00000295633 | - | 1 | 11 | 30_53 | 21 | 309 | Domain | Note=Follistatin-like |
| Tgene | >FSTL1 | chr7:94054975 | chr3:120134874 | ENST00000295633 | - | 1 | 11 | 48_100 | 21 | 309 | Domain | Kazal-like |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >COL1A2 | chr7:94054975 | chr3:120134874 | ENST00000297268 | + | 43 | 52 | 1133_1366 | 945 | 1367 | Domain | Fibrillar collagen NC1 |
Top |
FusionGeneSequence for COL1A2_FSTL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_COL1A2_ENST00000297268_chr7_94054975_+_FSTL1_ENST00000295633_chr3_120134874_-_1233aa MLSFVDTRTLLLLAVTLCLATCQSLQEETVRKGPAGDRGPRGERGPPGPPGRDGEDGPTGPPGPPGPPGPPGLGGNFAAQYDGKGVGLGP GPMGLMGPRGPPGAAGAPGPQGFQGPAGEPGEPGQTGPAGARGPAGPPGKAGEDGHPGKPGRPGERGVVGPQGARGFPGTPGLPGFKGIR GHNGLDGLKGQPGAPGVKGEPGAPGENGTPGQTGARGLPGERGRVGAPGPAGARGSDGSVGPVGPAGPIGSAGPPGFPGAPGPKGEIGAV GNAGPAGPAGPRGEVGLPGLSGPVGPPGNPGANGLTGAKGAAGLPGVAGAPGLPGPRGIPGPVGAAGATGARGLVGEPGPAGSKGESGNK GEPGSAGPQGPPGPSGEEGKRGPNGEAGSAGPPGPPGLRGSPGSRGLPGADGRAGVMGPPGSRGASGPAGVRGPNGDAGRPGEPGLMGPR GLPGSPGNIGPAGKEGPVGLPGIDGRPGPIGPAGARGEPGNIGFPGPKGPTGDPGKNGDKGHAGLAGARGAPGPDGNNGAQGPPGPQGVQ GGKGEQGPPGPPGFQGLPGPSGPAGEVGKPGERGLHGEFGLPGPAGPRGERGPPGESGAAGPTGPIGSRGPSGPPGPDGNKGEPGVVGAV GTAGPSGPSGLPGERGAAGIPGGKGEKGEPGLRGEIGNPGRDGARGAPGAVGAPGPAGATGDRGEAGAAGPAGPAGPRGSPGERGEVGPA GPNGFAGPAGAAGQPGAKGERGAKGPKGENGVVGPTGPVGAAGPAGPNGPPGPAGSRGDGGPPGMTGFPGAAGRTGPPGPSGISGPPGPP GPAGKEGLRGPRGDQGPVGRTGEVGAVGPPGFAGEKGPSGEAGTAGPPGTPGPQGLLGAPGILGLPGSRGERGLPGVAGAVGEPGPLGIA GPPGARGPPGAVGSPGVNGAPGEAGRDGNPGNDGPPGRDGQPGHKEELRSKSKICANVFCGAGRECAVTEKGEPTCLCIEQCKPHKRPVC GSNGKTYLNHCELHRDACLTGSKIQVDYDGHCKEKKSVSPSASPVVCYQSNRDELRRRIIQWLEAEIIPDGWFSKGSNYSEILDKYFKNF DNGDSRLDSSEFLKFVEQNETAINITTYPDQENNKLLRGLCVDALIELSDENADWKLSFQEFLKCLNPSFNPPEKKCALEDETYADGAET |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_COL1A2_ENST00000297268_chr7_94054975_+_FSTL1_ENST00000295633_chr3_120134874_-_3699nt ATGCTCAGCTTTGTGGATACGCGGACTTTGTTGCTGCTTGCAGTAACCTTATGCCTAGCAACATGCCAATCTTTACAAGAGGAAACTGTA AGAAAGGGCCCAGCCGGAGATAGAGGACCACGTGGAGAAAGGGGTCCACCAGGCCCCCCAGGCAGAGATGGTGAAGATGGTCCCACAGGC CCTCCTGGTCCACCTGGTCCTCCTGGCCCCCCTGGTCTCGGTGGGAACTTTGCTGCTCAGTATGATGGAAAAGGAGTTGGACTTGGCCCT GGACCAATGGGCTTAATGGGACCTAGAGGCCCACCTGGTGCAGCTGGAGCCCCAGGCCCTCAAGGTTTCCAAGGACCTGCTGGTGAGCCT GGTGAACCTGGTCAAACTGGTCCTGCAGGTGCTCGTGGTCCAGCTGGCCCTCCTGGCAAGGCTGGTGAAGATGGTCACCCTGGAAAACCC GGACGACCTGGTGAGAGAGGAGTTGTTGGACCACAGGGTGCTCGTGGTTTCCCTGGAACTCCTGGACTTCCTGGCTTCAAAGGCATTAGG GGACACAATGGTCTGGATGGATTGAAGGGACAGCCCGGTGCTCCTGGTGTGAAGGGTGAACCTGGTGCCCCTGGTGAAAATGGAACTCCA GGTCAAACAGGAGCCCGTGGGCTTCCTGGTGAGAGAGGACGTGTTGGTGCCCCTGGCCCAGCTGGTGCCCGTGGCAGTGATGGAAGTGTG GGTCCCGTGGGTCCTGCTGGTCCCATTGGGTCTGCTGGCCCTCCAGGCTTCCCAGGTGCCCCTGGCCCCAAGGGTGAAATTGGAGCTGTT GGTAACGCTGGTCCTGCTGGTCCCGCCGGTCCCCGTGGTGAAGTGGGTCTTCCAGGCCTCTCCGGCCCCGTTGGACCTCCTGGTAATCCT GGAGCAAACGGCCTTACTGGTGCCAAGGGTGCTGCTGGCCTTCCCGGCGTTGCTGGGGCTCCCGGCCTCCCTGGACCCCGCGGTATTCCT GGCCCTGTTGGTGCTGCCGGTGCTACTGGTGCCAGAGGACTTGTTGGTGAGCCTGGTCCAGCTGGCTCCAAAGGAGAGAGCGGTAACAAG GGTGAGCCCGGCTCTGCTGGGCCCCAAGGTCCTCCTGGTCCCAGTGGTGAAGAAGGAAAGAGAGGCCCTAATGGGGAAGCTGGATCTGCC GGCCCTCCAGGACCTCCTGGGCTGAGAGGTAGTCCTGGTTCTCGTGGTCTTCCTGGAGCTGATGGCAGAGCTGGCGTCATGGGCCCTCCT GGTAGTCGTGGTGCAAGTGGCCCTGCTGGAGTCCGAGGACCTAATGGAGATGCTGGTCGCCCTGGGGAGCCTGGTCTCATGGGACCCAGA GGTCTTCCTGGTTCCCCTGGAAATATCGGCCCCGCTGGAAAAGAAGGTCCTGTCGGCCTCCCTGGCATCGACGGCAGGCCTGGCCCAATT GGCCCAGCTGGAGCAAGAGGAGAGCCTGGCAACATTGGATTCCCTGGACCCAAAGGCCCCACTGGTGATCCTGGCAAAAACGGTGATAAA GGTCATGCTGGTCTTGCTGGTGCTCGGGGTGCTCCAGGTCCTGATGGAAACAATGGTGCTCAGGGACCTCCTGGACCACAGGGTGTTCAA GGTGGAAAAGGTGAACAGGGTCCCCCTGGTCCTCCAGGCTTCCAGGGTCTGCCTGGCCCCTCAGGTCCCGCTGGTGAAGTTGGCAAACCA GGAGAAAGGGGTCTCCATGGTGAGTTTGGTCTCCCTGGTCCTGCTGGTCCAAGAGGGGAACGCGGTCCCCCAGGTGAGAGTGGTGCTGCC GGTCCTACTGGTCCTATTGGAAGCCGAGGTCCTTCTGGACCCCCAGGGCCTGATGGAAACAAGGGTGAACCTGGTGTGGTTGGTGCTGTG GGCACTGCTGGTCCATCTGGTCCTAGTGGACTCCCAGGAGAGAGGGGTGCTGCTGGCATACCTGGAGGCAAGGGAGAAAAGGGTGAACCT GGTCTCAGAGGTGAAATTGGTAACCCTGGCAGAGATGGTGCTCGTGGTGCTCCTGGTGCTGTAGGTGCCCCTGGTCCTGCTGGAGCCACA GGTGACCGGGGCGAAGCTGGGGCTGCTGGTCCTGCTGGTCCTGCTGGTCCTCGGGGAAGCCCTGGTGAACGTGGTGAGGTCGGTCCTGCT GGCCCCAATGGATTTGCTGGTCCTGCTGGTGCTGCTGGTCAACCTGGTGCTAAAGGAGAAAGAGGAGCCAAAGGGCCTAAGGGTGAAAAC GGTGTTGTTGGTCCCACAGGCCCCGTTGGAGCTGCTGGCCCAGCTGGTCCAAATGGTCCCCCCGGTCCTGCTGGAAGTCGTGGTGATGGA GGCCCCCCTGGTATGACTGGTTTCCCTGGTGCTGCTGGACGGACTGGTCCCCCAGGACCCTCTGGTATTTCTGGCCCTCCTGGTCCCCCT GGTCCTGCTGGGAAAGAAGGGCTTCGTGGTCCTCGTGGTGACCAAGGTCCAGTTGGCCGAACTGGAGAAGTAGGTGCAGTTGGTCCCCCT GGCTTCGCTGGTGAGAAGGGTCCCTCTGGAGAGGCTGGTACTGCTGGACCTCCTGGCACTCCAGGTCCTCAGGGTCTTCTTGGTGCTCCT GGTATTCTGGGTCTCCCTGGCTCGAGAGGTGAACGTGGTCTACCAGGTGTTGCTGGTGCTGTGGGTGAACCTGGTCCTCTTGGCATTGCC GGCCCTCCTGGGGCCCGTGGTCCTCCTGGTGCTGTGGGTAGTCCTGGAGTCAACGGTGCTCCTGGTGAAGCTGGTCGTGATGGCAACCCT GGGAACGATGGTCCCCCAGGTCGCGATGGTCAACCCGGACACAAGGAAGAGCTAAGGAGCAAATCCAAGATCTGTGCCAATGTGTTTTGT GGAGCCGGCCGGGAATGTGCAGTCACAGAGAAAGGGGAACCCACCTGTCTCTGCATTGAGCAATGCAAACCTCACAAGAGGCCTGTGTGT GGCAGTAATGGCAAGACCTACCTCAACCACTGTGAACTGCATCGAGATGCCTGCCTCACTGGATCCAAAATCCAGGTTGATTACGATGGA CACTGCAAAGAGAAGAAATCCGTAAGTCCATCTGCCAGCCCAGTTGTTTGCTATCAGTCCAACCGTGATGAGCTCCGACGTCGCATCATC CAGTGGCTGGAAGCTGAGATCATTCCAGATGGCTGGTTCTCTAAAGGCAGCAACTACAGTGAAATCCTAGACAAGTATTTTAAGAACTTT GATAATGGTGATTCTCGCCTGGACTCCAGTGAATTCCTGAAGTTTGTGGAACAGAATGAAACTGCCATCAATATTACAACGTATCCAGAC CAGGAGAACAACAAGTTGCTTAGGGGACTCTGTGTTGATGCTCTCATTGAACTGTCTGATGAAAATGCTGATTGGAAACTCAGCTTCCAA GAGTTTCTCAAGTGCCTCAACCCATCTTTCAACCCTCCTGAGAAGAAGTGTGCCCTGGAGGATGAAACGTATGCAGATGGAGCTGAGACC GAGGTGGACTGTAACCGCTGTGTCTGTGCCTGTGGAAATTGGGTCTGTACAGCCATGACCTGTGACGGAAAGAATCAGAAGGGGGCCCAG ACCCAGACAGAGGAGGAGATGACCAGATATGTCCAGGAGCTCCAAAAGCATCAGGAAACAGCTGAAAAGACCAAGAGAGTGAGCACCAAA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_COL1A2_ENST00000297268_chr7_94054975_+_FSTL1_ENST00000295633_chr3_120134874_-_8829nt GTGTCCCATAGTGTTTCCAAACTTGGAAAGGGCGGGGGAGGGCGGGAGGATGCGGAGGGCGGAGGTATGCAGACAACGAGTCAGAGTTTC CCCTTGAAAGCCTCAAAAGTGTCCACGTCCTCAAAAAGAATGGAACCAATTTAAGAAGCCAGCCCCGTGGCCACGTCCCTTCCCCCATTC GCTCCCTCCTCTGCGCCCCCGCAGGCTCCTCCCAGCTGTGGCTGCCCGGGCCCCCAGCCCCAGCCCTCCCATTGGTGGAGGCCCTTTTGG AGGCACCCTAGGGCCAGGGAAACTTTTGCCGTATAAATAGGGCAGATCCGGGCTTTATTATTTTAGCACCACGGCAGCAGGAGGTTTCGG CTAAGTTGGAGGTACTGGCCACGACTGCATGCCCGCGCCCGCCAGGTGATACCTCCGCCGGTGACCCAGGGGCTCTGCGACACAAGGAGT CTGCATGTCTAAGTGCTAGACATGCTCAGCTTTGTGGATACGCGGACTTTGTTGCTGCTTGCAGTAACCTTATGCCTAGCAACATGCCAA TCTTTACAAGAGGAAACTGTAAGAAAGGGCCCAGCCGGAGATAGAGGACCACGTGGAGAAAGGGGTCCACCAGGCCCCCCAGGCAGAGAT GGTGAAGATGGTCCCACAGGCCCTCCTGGTCCACCTGGTCCTCCTGGCCCCCCTGGTCTCGGTGGGAACTTTGCTGCTCAGTATGATGGA AAAGGAGTTGGACTTGGCCCTGGACCAATGGGCTTAATGGGACCTAGAGGCCCACCTGGTGCAGCTGGAGCCCCAGGCCCTCAAGGTTTC CAAGGACCTGCTGGTGAGCCTGGTGAACCTGGTCAAACTGGTCCTGCAGGTGCTCGTGGTCCAGCTGGCCCTCCTGGCAAGGCTGGTGAA GATGGTCACCCTGGAAAACCCGGACGACCTGGTGAGAGAGGAGTTGTTGGACCACAGGGTGCTCGTGGTTTCCCTGGAACTCCTGGACTT CCTGGCTTCAAAGGCATTAGGGGACACAATGGTCTGGATGGATTGAAGGGACAGCCCGGTGCTCCTGGTGTGAAGGGTGAACCTGGTGCC CCTGGTGAAAATGGAACTCCAGGTCAAACAGGAGCCCGTGGGCTTCCTGGTGAGAGAGGACGTGTTGGTGCCCCTGGCCCAGCTGGTGCC CGTGGCAGTGATGGAAGTGTGGGTCCCGTGGGTCCTGCTGGTCCCATTGGGTCTGCTGGCCCTCCAGGCTTCCCAGGTGCCCCTGGCCCC AAGGGTGAAATTGGAGCTGTTGGTAACGCTGGTCCTGCTGGTCCCGCCGGTCCCCGTGGTGAAGTGGGTCTTCCAGGCCTCTCCGGCCCC GTTGGACCTCCTGGTAATCCTGGAGCAAACGGCCTTACTGGTGCCAAGGGTGCTGCTGGCCTTCCCGGCGTTGCTGGGGCTCCCGGCCTC CCTGGACCCCGCGGTATTCCTGGCCCTGTTGGTGCTGCCGGTGCTACTGGTGCCAGAGGACTTGTTGGTGAGCCTGGTCCAGCTGGCTCC AAAGGAGAGAGCGGTAACAAGGGTGAGCCCGGCTCTGCTGGGCCCCAAGGTCCTCCTGGTCCCAGTGGTGAAGAAGGAAAGAGAGGCCCT AATGGGGAAGCTGGATCTGCCGGCCCTCCAGGACCTCCTGGGCTGAGAGGTAGTCCTGGTTCTCGTGGTCTTCCTGGAGCTGATGGCAGA GCTGGCGTCATGGGCCCTCCTGGTAGTCGTGGTGCAAGTGGCCCTGCTGGAGTCCGAGGACCTAATGGAGATGCTGGTCGCCCTGGGGAG CCTGGTCTCATGGGACCCAGAGGTCTTCCTGGTTCCCCTGGAAATATCGGCCCCGCTGGAAAAGAAGGTCCTGTCGGCCTCCCTGGCATC GACGGCAGGCCTGGCCCAATTGGCCCAGCTGGAGCAAGAGGAGAGCCTGGCAACATTGGATTCCCTGGACCCAAAGGCCCCACTGGTGAT CCTGGCAAAAACGGTGATAAAGGTCATGCTGGTCTTGCTGGTGCTCGGGGTGCTCCAGGTCCTGATGGAAACAATGGTGCTCAGGGACCT CCTGGACCACAGGGTGTTCAAGGTGGAAAAGGTGAACAGGGTCCCCCTGGTCCTCCAGGCTTCCAGGGTCTGCCTGGCCCCTCAGGTCCC GCTGGTGAAGTTGGCAAACCAGGAGAAAGGGGTCTCCATGGTGAGTTTGGTCTCCCTGGTCCTGCTGGTCCAAGAGGGGAACGCGGTCCC CCAGGTGAGAGTGGTGCTGCCGGTCCTACTGGTCCTATTGGAAGCCGAGGTCCTTCTGGACCCCCAGGGCCTGATGGAAACAAGGGTGAA CCTGGTGTGGTTGGTGCTGTGGGCACTGCTGGTCCATCTGGTCCTAGTGGACTCCCAGGAGAGAGGGGTGCTGCTGGCATACCTGGAGGC AAGGGAGAAAAGGGTGAACCTGGTCTCAGAGGTGAAATTGGTAACCCTGGCAGAGATGGTGCTCGTGGTGCTCCTGGTGCTGTAGGTGCC CCTGGTCCTGCTGGAGCCACAGGTGACCGGGGCGAAGCTGGGGCTGCTGGTCCTGCTGGTCCTGCTGGTCCTCGGGGAAGCCCTGGTGAA CGTGGTGAGGTCGGTCCTGCTGGCCCCAATGGATTTGCTGGTCCTGCTGGTGCTGCTGGTCAACCTGGTGCTAAAGGAGAAAGAGGAGCC AAAGGGCCTAAGGGTGAAAACGGTGTTGTTGGTCCCACAGGCCCCGTTGGAGCTGCTGGCCCAGCTGGTCCAAATGGTCCCCCCGGTCCT GCTGGAAGTCGTGGTGATGGAGGCCCCCCTGGTATGACTGGTTTCCCTGGTGCTGCTGGACGGACTGGTCCCCCAGGACCCTCTGGTATT TCTGGCCCTCCTGGTCCCCCTGGTCCTGCTGGGAAAGAAGGGCTTCGTGGTCCTCGTGGTGACCAAGGTCCAGTTGGCCGAACTGGAGAA GTAGGTGCAGTTGGTCCCCCTGGCTTCGCTGGTGAGAAGGGTCCCTCTGGAGAGGCTGGTACTGCTGGACCTCCTGGCACTCCAGGTCCT CAGGGTCTTCTTGGTGCTCCTGGTATTCTGGGTCTCCCTGGCTCGAGAGGTGAACGTGGTCTACCAGGTGTTGCTGGTGCTGTGGGTGAA CCTGGTCCTCTTGGCATTGCCGGCCCTCCTGGGGCCCGTGGTCCTCCTGGTGCTGTGGGTAGTCCTGGAGTCAACGGTGCTCCTGGTGAA GCTGGTCGTGATGGCAACCCTGGGAACGATGGTCCCCCAGGTCGCGATGGTCAACCCGGACACAAGGAAGAGCTAAGGAGCAAATCCAAG ATCTGTGCCAATGTGTTTTGTGGAGCCGGCCGGGAATGTGCAGTCACAGAGAAAGGGGAACCCACCTGTCTCTGCATTGAGCAATGCAAA CCTCACAAGAGGCCTGTGTGTGGCAGTAATGGCAAGACCTACCTCAACCACTGTGAACTGCATCGAGATGCCTGCCTCACTGGATCCAAA ATCCAGGTTGATTACGATGGACACTGCAAAGAGAAGAAATCCGTAAGTCCATCTGCCAGCCCAGTTGTTTGCTATCAGTCCAACCGTGAT GAGCTCCGACGTCGCATCATCCAGTGGCTGGAAGCTGAGATCATTCCAGATGGCTGGTTCTCTAAAGGCAGCAACTACAGTGAAATCCTA GACAAGTATTTTAAGAACTTTGATAATGGTGATTCTCGCCTGGACTCCAGTGAATTCCTGAAGTTTGTGGAACAGAATGAAACTGCCATC AATATTACAACGTATCCAGACCAGGAGAACAACAAGTTGCTTAGGGGACTCTGTGTTGATGCTCTCATTGAACTGTCTGATGAAAATGCT GATTGGAAACTCAGCTTCCAAGAGTTTCTCAAGTGCCTCAACCCATCTTTCAACCCTCCTGAGAAGAAGTGTGCCCTGGAGGATGAAACG TATGCAGATGGAGCTGAGACCGAGGTGGACTGTAACCGCTGTGTCTGTGCCTGTGGAAATTGGGTCTGTACAGCCATGACCTGTGACGGA AAGAATCAGAAGGGGGCCCAGACCCAGACAGAGGAGGAGATGACCAGATATGTCCAGGAGCTCCAAAAGCATCAGGAAACAGCTGAAAAG ACCAAGAGAGTGAGCACCAAAGAGATCTAATGAGGAGGCACAGACCAGTGTCTGGATCCCAGCATCTTCTCCACTTCAGCGCTGAGTTCA GTATACACAAGTGTCTGCTACAGTCGCCAAATCACCAGTATTTGCTTATATAGCAATGAGTTTTATTTTGTTTATTTGTTTTGCAATAAA GGATATGAAGGTGGCTGGCTAGGAAGGGAAGGGCCACAGCCTTCATTTCTAGGAGTGCTTTAAGAGAAACTGTAAATGGTGCTCTGGGGC TGGAGGCTAGTAAGGAAACTGCATCACGATTGAAAGAGGAACAGACCCAAATCTGAACCTCTTTTGAGTTTACTGCATCTGTCAGCAGGC TGCAGGGAGTGCACACGATGCCAGAGAGAACTTAGCAGGGTGTCCCCGGAGGAGAGGTTTGGGAAGCTCCACGGAGAGGAACGCTCTCTG CTTCCAGCCTCTTTCCATTGCCGTCAGCATGACAGACCTCCAGCATCCACGCATCTCTTGGTCCCAATAACTGCCTCTAGATACATAGCC ATACTGCTAGTTAACCCAGTGTCCCTCAGACTTGGATGGAGTTTCTGGGAGGGTACACCCAAATGATGCAGATACTTGTATACTTTGAGC CCCTTAGCGACCTAACCAAATTTTAAAAATACTTTTTACCAAAGGTGCTATTTCTCTGTAAAACACTTTTTTTTGGCAAGTTGACTTTAT TCTTCAATTATTATCATTATATTATTGTTTTTTAATATTTTATTTTCTTGACTAGGTATTAAGCTTTTGTAATTATTTTTCAGTAGTCCC ACCACTTCATAGGTGGAAGGAGTTTGGGGTTCTTCCTGGTGCAGGGGCTGAAATAACCCAGATGCCCCCACCCTGCCACATACTAGATGC AGCCCATAGTTGGCCCCCCTAGCTTCCAGCAGTCCACTATCTGCCAGAGGAGCAAGGGTGCCTTAGACCGAAGCCAGGGGAAGAAGCATC TTCATAAAAAACTTTCAAGATCCAAACATTAATTTGTTTTTATTTATTCTGAGAAGTTGAGGCAAATCAGTATTCCCAAGGATGGCGACA AGGGCAGCCAAGCAGGGCTTAGGATATCCCAGCCTACCAATATGCTCATTCGACTAACTAGGAGGGTGAGTTGGCCCTGTCTCTTCTTTT TTCTGGACCTCAGTTTCCTCAGTGAGCTGGTAAGAATGCACTAACCTTTTGATTTGATAAGTTATAAATTCTGTGGTTCTGATCATTGGT CCAGAGGGGAGATAGGTTCCTGTGATTTTTCCTTCTTCTCTATAGAATAAATGAAATCTTGTTACTAGAACAAGAAATGTCAGATGGCCA AAAACAAGATGACCAGATTTGATCTCAGCCTGATGACCCTACAGGTCGTGCTATGATATGGAGTCCTCATGGGTAAAGCAGGAAGAGAGT GGGAAAGAGAACCACCCCACTCTGTCTTCATATTTGCATTTCATGTTTAACCTCCGGCTGGAAATAGAAAGCATTCCCTTAGAGATGAGG ATAAAAGAAAGTTTCAGATTCAACAGGGGGAAGAAAATGGAGATTTAATCCTAAAACTGTGACTTGGGGAGGTCAGTCATTTACAGTTAG TCCTGTGTCTTTCGACTTCTGTGATTATTAACCCCACTCACTACCCTGTTTCAGATGCATTTGGAATACCAAAGATTAAATCCTTGACAT AAGATCTCATTTGCAGAAAGCAGATTAAAGACCATCAGAAGGAAATTATTTAGGTTGTAATGCACAGGCAACTGTGAGAAACTGTTGTGC CAAAAATAGAATTCCTTCTAGTTTTTCTTGTTCTCATTTGAAAGGAGAAAATTCCACTTTGTTTAGCATTTCAAGCTTTTATGTATCCAT CCCATCTAAAAACTCTTCAAACTCCACTTGTTCAGTCTGAAATGCAGCTCCCTGTCCAAGTGCCTTGGAGAACTCACAGCAGCACGCCTT AATCAAAGGTTTTACCAGCCCTTGGACACTATGGGAGGAGGGCAAGAGTACACCAATTTGTTAAAAGCAAGAAACCACAGTGTCTCTTCA CTAGTCATTTAGAACATGGTTATCATCCAAGACTACTCTACCCTGCAACATTGAACTCCCAAGAGCAAATCCACATTCCTCTTGAGTTCT GCAGCTTCTGTGTAAATAGGGCAGCTGTCGTCTATGCCGTAGAATCACATGATCTGAGGACCATTCATGGAAGCTGCTAAATAGCCTAGT CTGGGGAGTCTTCCATAAAGTTTTGCATGGAGCAAACAAACAGGATTAAACTAGGTTTGGTTCCTTCAGCCCTCTAAAAGCATAGGGCTT AGCCTGCAGGCTTCCTTGGGCTTTCTCTGTGTGTGTAGTTTTGTAAACACTATAGCATCTGTTAAGATCCAGTGTCCATGGAAACATTCC CACATGCCGTGACTCTGGACTATATCAGTTTTTGGAAAGCAGGGTTCCTCTGCCTGCTAACAAGCCCACGTGGACCAGTCTGAATGTCTT TCCTTTACACCTATGTTTTTAAGTAGTCAAACTTCAAGAAACAATCTAAACAAGTTTCTGTTGCATATGTGTTTGTGAACTTGTATTTGT ATTTAGTAGGCTTCTATATTGCATTTAACTTGTTTTTGTAACTCCTGATTCTTCCTTTTCGGATACTATTGATGAATAAAGAAATTAAAG TGATGGTTTTATTGGTTTCCTTTCCCCCAATTAAGGCCAAATAAAGTCGTGAGAACATTACCCATTTACTTCCTAAGAGTGGATTTGAGT TTCAGGAGCCTTAAAAAGGACTGAAGAGTTTCTCCTGGGACTACAGCTTGGATGGAAAGTTTACTCGGGGACTGGTAGAACAAGTTTCTT TGAAAGGATCATGGATAGTGGGTCTGGAGTAGAAGGTGATGACAAGTCAGAAAGTGTCTTAGTCCCTTCAAGTTGCTATAACAAAATGCC TCAGACTGGGTAATTATAGGCAACAGAAATGTATTGCTCACAGTTCTGAAGGCTGGGAAGCCTAAGATCAAGGTACCAGCAGATTCAGTG TCTGATGACGGCTTGTTGAAGCTTGCCTGCTTCAAAGAATGCACCTTTTTGATGCATCCCCACATGGTGAAAAGGGTGAACAAACTCCCT TAGGCCTCTTTTATAAGGGCACTTACCCATTCATGAGGGTTAAACTTTGATGACCTAATCATCTCCCAAGAGCCTCACCTCTCAATACCA TTGCTTTGGGGATTCAATTTTAACATATGAATTTTGGGGGACATAAACATTCAAACCATAGCAGGTGCATTCCTGTATTGGGAAGACATT AAATTAAATGACTCGTAAATCCCCCATATGATTTAGGAGACTAAATGGCATCCAGTGAGGCTGACTGCAGTAGCCTGTGAGAAGGCAAAT AAACATGGGAAGGTAGTACAGGGAACATGGAATCATTGCCAGGGACAGGCTAAATAACCTTAATGGCACTTCCTTGATACACACATTCCA TGGGGGTAAACAGTTCCAAGTGGGCTGAACGTTAGCTGGTTAAAACCTCTTTTGCTTGGGGACACATGACTAACGCTTTCCAACCTGCCA TTTTCATATGTATCATGCACTCTCCACCCACAATAATTCTGCCTCCCAAAAGAGCATATTATAGTCAATGAGGTTTAAGGTTTCTTCGGT TCAGTCATGTGGAAGTTTTGCTTTCCTAAAATTATAGCTGGATCACTTTGATTGGATTTGGGATATTACCCAAATGCTAATCAAATATTA AAAGGCAATCTTTTTTGTTATGTGATTGCTACAGATTACTGCTCTTACAGTTTGATTCTTCAAATTTTCATTCTCAGAAGGGAATCTTAA ACCCAGTTTGAAGGGTACCTTGTCCACAACCACTTTTAAATTTTGGCTAACTTCCCAACCTTCCACCATGTTCTGGGAAAACTTTTTCTG CTGTTATAGTATGTATGTATTCAGGAAGTGCAACATTATTAAACTAAGCATAATTCAGAAGCTAAGTTTCCTTTCATCAAAATTTAATAT TACGAATTGTGCAAAGAAGTATGTTACTTTGATCAGCTTTATTTTAGAGCTTCTTTATCAAGTTATCATCAGTCCTCTTGAATTATTTCT GAAATAAGGGGAAGGAAGGAAGGGAAAAAATATGAATGCATAGATAGATCTAAGCAGATGCCTTCAGAGCCCTGGAATAATCCTAGCTGG GATATGGGACATGAAAACAACTCTGGCCTACTGCTGCTGGGGGCTGTTGCATGGTGTGACATAGGAAGTAAAATGTTGCTGTATGAATAG GAAGGAGGGTCTTCCTGTCAATGAGAATTAATGTTTTCCTAATGATTTAACTTTTTTACTGAAAAAATAATATGTGTACATGGTAAAAAT CCAAATTGTATCACAGAAAATACAGTGAATAAAACCATCCTCTTAAGAGGGTGTGTACATTTATAAATTTGCCTATGATTGCCTATAAAG TCAAAGAAGTTGCACCAGTATGCATGACTGCCAAAAGTACATAAACTGAGCATATCCATTTCCCTACATTCTTGCAAACATTGTGCCTTC GAACTTTTTGGCCTCTGATAGAGGAAAAATGGTAACTCCTTGTTTTATTTTTTATATTCATTATTCCTTTTGTAAGATTAAATATCATCT |
Top |
FusionGenePPI for COL1A2_FSTL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| COL1A2 | SHBG, MYOC, LIG4, PAN2, COL1A1, PDGFA, PDGFB, SGTA, UBQLN1, ERAL1, CAMKMT, COMT, RAB5A, ZWINT, CDKN2AIP, FBXW7, SERPINB5, EGFR, SBF1, YAF2, TIMM44, CYLD | FSTL1 | APPBP2, DNASE2B, SGCA, WNT10B, CRK, GPR114, IL12A, LYZL2, LRRC4C, PRG3, WNT4, ADAM33, FBXO6, FBXL14, WNT5A, WNT7A, SCGB1D2, TM2D3, PRELP, INSL6, DEFA1, ZPBP2, CHST8, SCGB2A2, DEFB121, XCL1, MTNR1A, MTNR1B |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for COL1A2_FSTL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Hgene | COL1A2 | P08123 | DB00048 | Collagenase clostridium histolyticum | Collagen alpha-2(I) chain | biotech | approved|investigational |
Top |
RelatedDiseases for COL1A2_FSTL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | COL1A2 | C0268362 | Osteogenesis imperfecta type III (disorder) | 17 | CTD_human;ORPHANET;UNIPROT |
| Hgene | COL1A2 | C0268358 | Osteogenesis imperfecta, dominant perinatal lethal | 14 | CTD_human;ORPHANET;UNIPROT |
| Hgene | COL1A2 | C0268363 | Osteogenesis imperfecta type IV (disorder) | 11 | CTD_human;ORPHANET;UNIPROT |
| Hgene | COL1A2 | C0023931 | Lobstein's Disease | 6 | ORPHANET;UNIPROT |
| Hgene | COL1A2 | C0000786 | Spontaneous abortion | 1 | CTD_human |
| Hgene | COL1A2 | C0016059 | Fibrosis | 1 | CTD_human |
| Hgene | COL1A2 | C0018824 | Heart valve disease | 1 | CTD_human |
| Hgene | COL1A2 | C0023890 | Liver Cirrhosis | 1 | CTD_human |
| Hgene | COL1A2 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Hgene | COL1A2 | C0029172 | Oral Submucous Fibrosis | 1 | CTD_human |
| Hgene | COL1A2 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |
| Hgene | COL1A2 | C0036421 | Systemic Scleroderma | 1 | CTD_human |
| Hgene | COL1A2 | C1857034 | Ehlers-Danlos syndrome, cardiac valvular form | 1 | CTD_human;ORPHANET |
| Tgene | FSTL1 | C0003504 | Aortic Valve Insufficiency | 1 | CTD_human |
| Tgene | FSTL1 | C0023893 | Liver Cirrhosis, Experimental | 1 | CTD_human |
| Tgene | FSTL1 | C0036341 | Schizophrenia | 1 | PSYGENET |
| Tgene | FSTL1 | C0043094 | Weight Gain | 1 | CTD_human |
| Tgene | FSTL1 | C2609414 | Acute kidney injury | 1 | CTD_human |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|