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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 789

FusionGeneSummary for ADAR_SUMO3

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAR_SUMO3
Fusion gene ID: 789
HgeneTgene
Gene symbol

ADAR

SUMO3

Gene ID

103

6613

Gene nameadenosine deaminase, RNA specificsmall ubiquitin-like modifier 2
SynonymsADAR1|AGS6|DRADA|DSH|DSRAD|G1P1|IFI-4|IFI4|K88DSRBP|P136HSMT3|SMT3B|SMT3H2|SUMO3|Smt3A
Cytomap

1q21.3

17q25.1

Type of geneprotein-codingprotein-coding
Descriptiondouble-stranded RNA-specific adenosine deaminase136 kDa double-stranded RNA-binding proteinadenosine deaminase acting on RNA 1-AdsRNA adenosine deaminasedsRNA adeonosine deaminaseinterferon-induced protein 4interferon-inducible protein 4small ubiquitin-related modifier 2SMT3 homolog 2SMT3 suppressor of mif two 3 homolog 2sentrin 2ubiquitin-like protein SMT3Aubiquitin-like protein SMT3B
Modification date2018052420180523
UniProtAcc

P55265

P55854

Ensembl transtripts involved in fusion geneENST00000292205, ENST00000368474, 
ENST00000368471, ENST00000471068, 
ENST00000397898, ENST00000332859, 
ENST00000479153, ENST00000411651, 
ENST00000397893, 
Fusion gene scores* DoF score7 X 6 X 6=2525 X 5 X 2=50
# samples 75
** MAII scorelog2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/50*10)=0
Context

PubMed: ADAR [Title/Abstract] AND SUMO3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAR

GO:0006382

adenosine to inosine editing

15858013|19651874|21289159

HgeneADAR

GO:0016553

base conversion or substitution editing

9020165

HgeneADAR

GO:0031054

pre-miRNA processing

23622242

HgeneADAR

GO:0035280

miRNA loading onto RISC involved in gene silencing by miRNA

23622242

HgeneADAR

GO:0035455

response to interferon-alpha

16475990

HgeneADAR

GO:0044387

negative regulation of protein kinase activity by regulation of protein phosphorylation

19651874

HgeneADAR

GO:0045070

positive regulation of viral genome replication

19651874

TgeneSUMO3

GO:0016925

protein sumoylation

17081986|17696781|21965678|24105744

TgeneSUMO3

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

18408734


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-3B-A9HO-01AADARchr1

154600331

-SUMO3chr21

46229033

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000292205ENST00000397898ADARchr1

154600331

-SUMO3chr21

46229033

-
In-frameENST00000292205ENST00000332859ADARchr1

154600331

-SUMO3chr21

46229033

-
5CDS-5UTRENST00000292205ENST00000479153ADARchr1

154600331

-SUMO3chr21

46229033

-
5CDS-5UTRENST00000292205ENST00000411651ADARchr1

154600331

-SUMO3chr21

46229033

-
5CDS-5UTRENST00000292205ENST00000397893ADARchr1

154600331

-SUMO3chr21

46229033

-
intron-3CDSENST00000368474ENST00000397898ADARchr1

154600331

-SUMO3chr21

46229033

-
intron-3CDSENST00000368474ENST00000332859ADARchr1

154600331

-SUMO3chr21

46229033

-
intron-5UTRENST00000368474ENST00000479153ADARchr1

154600331

-SUMO3chr21

46229033

-
intron-5UTRENST00000368474ENST00000411651ADARchr1

154600331

-SUMO3chr21

46229033

-
intron-5UTRENST00000368474ENST00000397893ADARchr1

154600331

-SUMO3chr21

46229033

-
5UTR-3CDSENST00000368471ENST00000397898ADARchr1

154600331

-SUMO3chr21

46229033

-
5UTR-3CDSENST00000368471ENST00000332859ADARchr1

154600331

-SUMO3chr21

46229033

-
5UTR-5UTRENST00000368471ENST00000479153ADARchr1

154600331

-SUMO3chr21

46229033

-
5UTR-5UTRENST00000368471ENST00000411651ADARchr1

154600331

-SUMO3chr21

46229033

-
5UTR-5UTRENST00000368471ENST00000397893ADARchr1

154600331

-SUMO3chr21

46229033

-
intron-3CDSENST00000471068ENST00000397898ADARchr1

154600331

-SUMO3chr21

46229033

-
intron-3CDSENST00000471068ENST00000332859ADARchr1

154600331

-SUMO3chr21

46229033

-
intron-5UTRENST00000471068ENST00000479153ADARchr1

154600331

-SUMO3chr21

46229033

-
intron-5UTRENST00000471068ENST00000411651ADARchr1

154600331

-SUMO3chr21

46229033

-
intron-5UTRENST00000471068ENST00000397893ADARchr1

154600331

-SUMO3chr21

46229033

-

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FusionProtFeatures for ADAR_SUMO3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAR

P55265

SUMO3

P55854

Ubiquitin-like protein which can be covalently attachedto target lysines either as a monomer or as a lysine-linkedpolymer. Does not seem to be involved in protein degradation andmay function as an antagonist of ubiquitin in the degradationprocess. Plays a role in a number of cellular processes such asnuclear transport, DNA replication and repair, mitosis and signaltransduction. Covalent attachment to its substrates requires prioractivation by the E1 complex SAE1-SAE2 and linkage to the E2enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4,RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659,PubMed:21965678). Plays a role in the regulation of sumoylationstatus of SETX (PubMed:24105744). {ECO:0000269|PubMed:11451954,ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADARchr1:154600331chr21:46229033ENST00000368471-115503_571-290932DomainDRBM 1
HgeneADARchr1:154600331chr21:46229033ENST00000368471-115614_682-290932DomainDRBM 2
HgeneADARchr1:154600331chr21:46229033ENST00000368471-115726_794-290932DomainDRBM 3
HgeneADARchr1:154600331chr21:46229033ENST00000368471-115886_1221-290932DomainA to I editase
HgeneADARchr1:154600331chr21:46229033ENST00000368474-115503_571-671227DomainDRBM 1
HgeneADARchr1:154600331chr21:46229033ENST00000368474-115614_682-671227DomainDRBM 2
HgeneADARchr1:154600331chr21:46229033ENST00000368474-115726_794-671227DomainDRBM 3
HgeneADARchr1:154600331chr21:46229033ENST00000368474-115886_1221-671227DomainA to I editase
HgeneADARchr1:154600331chr21:46229033ENST00000368471-115716_725-290932RegionN-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signal
HgeneADARchr1:154600331chr21:46229033ENST00000368471-115795_801-290932RegionC-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signal
HgeneADARchr1:154600331chr21:46229033ENST00000368474-115716_725-671227RegionN-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signal
HgeneADARchr1:154600331chr21:46229033ENST00000368474-115795_801-671227RegionC-terminal extension of DRBM 3 and constituent of a bi-partite nuclear localization signal
HgeneADARchr1:154600331chr21:46229033ENST00000368471-115293_360-290932RepeatDRADA 2
HgeneADARchr1:154600331chr21:46229033ENST00000368474-115293_360-671227RepeatDRADA 2
TgeneSUMO3chr1:154600331chr21:46229033ENST00000332859-1415_9250104DomainUbiquitin-like


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FusionGeneSequence for ADAR_SUMO3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ADAR_ENST00000292205_chr1_154600331_-_SUMO3_ENST00000397898_chr21_46229033_-_134aa
MMSPICDQTIDSRLKVEKATWWGRVGGGSRPHWQSPGVRPCPEEVQDPGLSMRQIRFRFDGQPINETDTPAQVRSWLRVVPGRLPICAGW

>In-frame_ADAR_ENST00000292205_chr1_154600331_-_SUMO3_ENST00000332859_chr21_46229033_-_102aa
MMSPICDQTIDSRLKVEKATWWGRVGGGSRPHWQSPGVRPCPEEVQDPGLSMRQIRFRFDGQPINETDTPAQLEMEDEDTIDVFQQQTGG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ADAR_ENST00000292205_chr1_154600331_-_SUMO3_ENST00000397898_chr21_46229033_-_402nt
ATGATGTCACCAATCTGCGACCAGACCATTGATTCCCGACTGAAGGTAGAGAAGGCTACGTGGTGGGGGAGGGTGGGGGGAGGGTCGCGG
CCGCACTGGCAGTCTCCGGGTGTCCGGCCGTGTCCCGAGGAAGTGCAAGACCCGGGCTTGTCAATGAGGCAGATCAGATTCAGGTTCGAC
GGGCAGCCAATCAATGAAACTGACACTCCAGCACAGGTACGGAGCTGGCTTCGCGTGGTTCCAGGGCGACTTCCGATTTGTGCGGGCTGG
AGATGGAGGACGAGGACACCATCGACGTGTTCCAGCAGCAGACGGGAGGTGTGCCGGAGAGCAGCCTGGCAGGGCACAGTTTCTAGAGGG

>In-frame_ADAR_ENST00000292205_chr1_154600331_-_SUMO3_ENST00000332859_chr21_46229033_-_306nt
ATGATGTCACCAATCTGCGACCAGACCATTGATTCCCGACTGAAGGTAGAGAAGGCTACGTGGTGGGGGAGGGTGGGGGGAGGGTCGCGG
CCGCACTGGCAGTCTCCGGGTGTCCGGCCGTGTCCCGAGGAAGTGCAAGACCCGGGCTTGTCAATGAGGCAGATCAGATTCAGGTTCGAC
GGGCAGCCAATCAATGAAACTGACACTCCAGCACAGCTGGAGATGGAGGACGAGGACACCATCGACGTGTTCCAGCAGCAGACGGGAGGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_ADAR_ENST00000292205_chr1_154600331_-_SUMO3_ENST00000397898_chr21_46229033_-_1690nt
ATGATGTCACCAATCTGCGACCAGACCATTGATTCCCGACTGAAGGTAGAGAAGGCTACGTGGTGGGGGAGGGTGGGGGGAGGGTCGCGG
CCGCACTGGCAGTCTCCGGGTGTCCGGCCGTGTCCCGAGGAAGTGCAAGACCCGGGCTTGTCAATGAGGCAGATCAGATTCAGGTTCGAC
GGGCAGCCAATCAATGAAACTGACACTCCAGCACAGGTACGGAGCTGGCTTCGCGTGGTTCCAGGGCGACTTCCGATTTGTGCGGGCTGG
AGATGGAGGACGAGGACACCATCGACGTGTTCCAGCAGCAGACGGGAGGTGTGCCGGAGAGCAGCCTGGCAGGGCACAGTTTCTAGAGGG
CCCGTCCCCAGCCCGGGCCGTCCATCCTCGCATTGCTGTTGAATGGTGAGCACGTGACCATGCCGACCACAAAGGTGTCTGCGGAAACTC
GAGGACATTCACCACGATGATTTTCCTCTCTTTGATGTACTTCAAGTGCAACTCAAAACTATATCTGCAGGGATGAATCTGTAACTTAAA
TTGGGCCAATCAGAATTGTTATCTTTGTTCAGGTAAAATGAGTTGCAAGATATTGTGGGTACTTTTGTGTGCTCATTTGTGTTTTCCCCC
CCTCCTACAACATTTTTTTAACCCCAAAATTATAGCCTGAATGTTCGCTTTTAGTCTGGCCAGGGATCTGACTCCTGAGTTGGTTGCCTC
TCCCCTGCTCACTCCAGTCACATAGAGAATTGGTGTTTCCCGCAGTGGGGATGCAGCTGTTGGACAGGTATTGGGGGCAAGGTTGGTAGG
GAGGACAGACTGTCACTTGCTGTTACAGGCACAGGTGATTAAAATGCTAAATATTGCAAATTTAAGCTTTGTCAGTATATGGAAAAGTTG
AAGGGAAAATACTGGAATGCTTCTTCAAAGGTTAAAAAATAACCGAGTCTTTTGGTAATTTGACCCCACGTGCTCTCTGGCCCTCAAGCA
TGTAACCTCGGGGTCTGAGGCCCAGGACCCACCCCCCTGCCACCCCTCCCACCCCACTCCCTGCTCAGTACCTGGCGTTGGTACACAGGC
AAGGATTGGCACAACCAAAATTGGCCTTTTTCTCCCTCTTAATATTGAAGAAATTCCCACATTTCTCATTTGGTAATGGTGTTGTGGCCT
CAGATTTCTTCTAGTATTTGCTTCTGATGAATGATTATGGTCTATACATAAAAAAGTAAGACTAAGTATTGCTGAATTTGCAGTTATGTT
GTCGTGTATAAGAGCTACTTCCAAGTGTGGTTACAAATGAACCCATGGAATGATGACTTCATGTTCTTCTCGTGGGTTTGTGCCGTGCTG
CTTTCCAAATAGGTATTGAATTTATGCATTAGTCTGGTGATTTCAGTTCTGTGAAATATTTTGGGATCTATACCAATTAAACATTTTCAT
AGTTCTGCCTATTGTCCTTCCCTGAGGCTCCATTGCTGCTTGGTGGCCATTCTCTGCCTTTTTACAGTCACCTGAACAATGACCCATCAT
CTCTTGCTTGCTTGAAATCTTGCTGAAATGTTCTCATTTCCTGTTTGCTGTATGGGCTCGGGTGGGATGTTTGTTGGCTCTGTTGTGTTT

>In-frame_ADAR_ENST00000292205_chr1_154600331_-_SUMO3_ENST00000332859_chr21_46229033_-_1640nt
ATGATGTCACCAATCTGCGACCAGACCATTGATTCCCGACTGAAGGTAGAGAAGGCTACGTGGTGGGGGAGGGTGGGGGGAGGGTCGCGG
CCGCACTGGCAGTCTCCGGGTGTCCGGCCGTGTCCCGAGGAAGTGCAAGACCCGGGCTTGTCAATGAGGCAGATCAGATTCAGGTTCGAC
GGGCAGCCAATCAATGAAACTGACACTCCAGCACAGCTGGAGATGGAGGACGAGGACACCATCGACGTGTTCCAGCAGCAGACGGGAGGT
GTGCCGGAGAGCAGCCTGGCAGGGCACAGTTTCTAGAGGGCCCGTCCCCAGCCCGGGCCGTCCATCCTCGCATTGCTGTTGAATGGTGAG
CACGTGACCATGCCGACCACAAAGGTGTCTGCGGAAACTCGAGGACATTCACCACGATGATTTTCCTCTCTTTGATGTACTTCAAGTGCA
ACTCAAAACTATATCTGCAGGGATGAATCTGTAACTTAAATTGGGCCAATCAGAATTGTTATCTTTGTTCAGGTAAAATGAGTTGCAAGA
TATTGTGGGTACTTTTGTGTGCTCATTTGTGTTTTCCCCCCCTCCTACAACATTTTTTTAACCCCAAAATTATAGCCTGAATGTTCGCTT
TTAGTCTGGCCAGGGATCTGACTCCTGAGTTGGTTGCCTCTCCCCTGCTCACTCCAGTCACATAGAGAATTGGTGTTTCCCGCAGTGGGG
ATGCAGCTGTTGGACAGGTATTGGGGGCAAGGTTGGTAGGGAGGACAGACTGTCACTTGCTGTTACAGGCACAGGTGATTAAAATGCTAA
ATATTGCAAATTTAAGCTTTGTCAGTATATGGAAAAGTTGAAGGGAAAATACTGGAATGCTTCTTCAAAGGTTAAAAAATAACCGAGTCT
TTTGGTAATTTGACCCCACGTGCTCTCTGGCCCTCAAGCATGTAACCTCGGGGTCTGAGGCCCAGGACCCACCCCCCTGCCACCCCTCCC
ACCCCACTCCCTGCTCAGTACCTGGCGTTGGTACACAGGCAAGGATTGGCACAACCAAAATTGGCCTTTTTCTCCCTCTTAATATTGAAG
AAATTCCCACATTTCTCATTTGGTAATGGTGTTGTGGCCTCAGATTTCTTCTAGTATTTGCTTCTGATGAATGATTATGGTCTATACATA
AAAAAGTAAGACTAAGTATTGCTGAATTTGCAGTTATGTTGTCGTGTATAAGAGCTACTTCCAAGTGTGGTTACAAATGAACCCATGGAA
TGATGACTTCATGTTCTTCTCGTGGGTTTGTGCCGTGCTGCTTTCCAAATAGGTATTGAATTTATGCATTAGTCTGGTGATTTCAGTTCT
GTGAAATATTTTGGGATCTATACCAATTAAACATTTTCATAGTTCTGCCTATTGTCCTTCCCTGAGGCTCCATTGCTGCTTGGTGGCCAT
TCTCTGCCTTTTTACAGTCACCTGAACAATGACCCATCATCTCTTGCTTGCTTGAAATCTTGCTGAAATGTTCTCATTTCCTGTTTGCTG
TATGGGCTCGGGTGGGATGTTTGTTGGCTCTGTTGTGTTTATTCACCAATTTGTACATTATTTGTTGTCCTTTACTACTGTAAACAGTAA


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FusionGenePPI for ADAR_SUMO3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADARXPO1, HDLBP, HDAC5, ELAVL1, HNRNPA1, CUL3, CAND1, DDX17, HNRNPM, UPF1, SNRPN, SNRPB, DHX9, HDAC9, TGM2, UBE2I, FBXO6, TARDBP, RPA1, RPA2, RPA3, ERG, STAU2, STAU1, CUL7, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, EGFR, USP38, FBXW11, NTRK1, SMC2, SCARNA22, IFI16, MYC, XRCC3, MATR3, THOC1, TACC3, EXOSC4, THOC2, THOC7, MMGT1, ZFC3H1, RBPJ, FOXA2, FOXA3, FOXB1, FOXG1, FOXH1, FOXI2, CRY2, FOXL1, FOXP3, FOXS1, MEX3C, COX15, PDHA1, FOXA1, G3BP1, UBE2ASUMO3SAE1, UBE2I, VIM, SENP2, TDG, UBA2, CHAF1A, UBE3A, MAPKAPK3, TK1, CDKN1A, SMN1, TTR, ANXA7, PFDN1, PML, USP25, USPL1, PIAS1, PIAS2, TDP2, PIAS3, SP100, UPF2, DRAP1, IRF7, SENP1, SENP5, ENO1, MOV10, NXF1, RNF111, DAXX, UBC, HIPK2, ALDOB, ECHS1, ISYNA1, MAPRE1, PROSC, SEC23B, ARHGDIA, DYNLT1, ENO2, FKBP2, MTAP, PFKM, PGD, RAD23A, RAD23B, SEC23A, STIP1, UFD1L, TAGLN2, TAGLN3, UCHL3, EWSR1, SLX4, RNF168, RNF8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneADARchr1:154600331chr21:46229033ENST00000368471-115133_202-290932Z-DNA
HgeneADARchr1:154600331chr21:46229033ENST00000368474-115133_202-671227Z-DNA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADAR_SUMO3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADAR_SUMO3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADARC0406775Symmetrical dyschromatosis of extremities3CTD_human;ORPHANET;UNIPROT
HgeneADARC0796126AICARDI-GOUTIERES SYNDROME 11CTD_human
HgeneADARC3539013AICARDI-GOUTIERES SYNDROME 61UNIPROT