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Fusion gene ID: 788 |
FusionGeneSummary for ADAR_PLS3 |
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Fusion gene information | Fusion gene name: ADAR_PLS3 | Fusion gene ID: 788 | Hgene | Tgene | Gene symbol | ADAR | PLS3 | Gene ID | 103 | 5358 |
Gene name | adenosine deaminase, RNA specific | plastin 3 | |
Synonyms | ADAR1|AGS6|DRADA|DSH|DSRAD|G1P1|IFI-4|IFI4|K88DSRBP|P136 | BMND18|T-plastin | |
Cytomap | 1q21.3 | Xq23 | |
Type of gene | protein-coding | protein-coding | |
Description | double-stranded RNA-specific adenosine deaminase136 kDa double-stranded RNA-binding proteinadenosine deaminase acting on RNA 1-AdsRNA adenosine deaminasedsRNA adeonosine deaminaseinterferon-induced protein 4interferon-inducible protein 4 | plastin-3T fimbrinT plastin | |
Modification date | 20180524 | 20180523 | |
UniProtAcc | P55265 | P13797 | |
Ensembl transtripts involved in fusion gene | ENST00000292205, ENST00000368474, ENST00000368471, ENST00000471068, | ENST00000355899, ENST00000537301, ENST00000289290, ENST00000420625, ENST00000539310, ENST00000543070, | |
Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 1 X 1 X 1=1 |
# samples | 7 | 1 | |
** MAII score | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ADAR [Title/Abstract] AND PLS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ADAR | GO:0006382 | adenosine to inosine editing | 15858013|19651874|21289159 |
Hgene | ADAR | GO:0016553 | base conversion or substitution editing | 9020165 |
Hgene | ADAR | GO:0031054 | pre-miRNA processing | 23622242 |
Hgene | ADAR | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA | 23622242 |
Hgene | ADAR | GO:0035455 | response to interferon-alpha | 16475990 |
Hgene | ADAR | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation | 19651874 |
Hgene | ADAR | GO:0045070 | positive regulation of viral genome replication | 19651874 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | BE177612 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000292205 | ENST00000355899 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000292205 | ENST00000537301 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000292205 | ENST00000289290 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000292205 | ENST00000420625 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000292205 | ENST00000539310 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-5UTR | ENST00000292205 | ENST00000543070 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000368474 | ENST00000355899 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000368474 | ENST00000537301 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000368474 | ENST00000289290 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000368474 | ENST00000420625 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000368474 | ENST00000539310 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-5UTR | ENST00000368474 | ENST00000543070 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000368471 | ENST00000355899 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000368471 | ENST00000537301 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000368471 | ENST00000289290 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000368471 | ENST00000420625 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000368471 | ENST00000539310 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-5UTR | ENST00000368471 | ENST00000543070 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000471068 | ENST00000355899 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000471068 | ENST00000537301 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000471068 | ENST00000289290 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000471068 | ENST00000420625 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-3CDS | ENST00000471068 | ENST00000539310 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
intron-5UTR | ENST00000471068 | ENST00000543070 | ADAR | chr1 | 154555930 | - | PLS3 | chrX | 114874787 | - |
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FusionProtFeatures for ADAR_PLS3 |
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Hgene | Tgene |
ADAR | PLS3 |
Actin-bundling protein found in intestinal microvilli,hair cell stereocilia, and fibroblast filopodia. May play a rolein the regulation of bone development. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ADAR_PLS3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ADAR_PLS3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADAR_PLS3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADAR_PLS3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ADAR | C0406775 | Symmetrical dyschromatosis of extremities | 3 | CTD_human;ORPHANET;UNIPROT |
Hgene | ADAR | C0796126 | AICARDI-GOUTIERES SYNDROME 1 | 1 | CTD_human |
Hgene | ADAR | C3539013 | AICARDI-GOUTIERES SYNDROME 6 | 1 | UNIPROT |
Tgene | PLS3 | C0029408 | Degenerative polyarthritis | 1 | CTD_human |