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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 787

FusionGeneSummary for ADAR_KRTCAP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAR_KRTCAP2
Fusion gene ID: 787
HgeneTgene
Gene symbol

ADAR

KRTCAP2

Gene ID

103

200185

Gene nameadenosine deaminase, RNA specifickeratinocyte associated protein 2
SynonymsADAR1|AGS6|DRADA|DSH|DSRAD|G1P1|IFI-4|IFI4|K88DSRBP|P136KCP2
Cytomap

1q21.3

1q22

Type of geneprotein-codingprotein-coding
Descriptiondouble-stranded RNA-specific adenosine deaminase136 kDa double-stranded RNA-binding proteinadenosine deaminase acting on RNA 1-AdsRNA adenosine deaminasedsRNA adeonosine deaminaseinterferon-induced protein 4interferon-inducible protein 4keratinocyte-associated protein 2KCP-2keratinocytes associated protein 2
Modification date2018052420180519
UniProtAcc

P55265

Q8N6L1

Ensembl transtripts involved in fusion geneENST00000292205, ENST00000368474, 
ENST00000368471, ENST00000471068, 
ENST00000295682, ENST00000490672, 
Fusion gene scores* DoF score7 X 6 X 6=2521 X 1 X 1=1
# samples 71
** MAII scorelog2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: ADAR [Title/Abstract] AND KRTCAP2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneADAR

GO:0006382

adenosine to inosine editing

15858013|19651874|21289159

HgeneADAR

GO:0016553

base conversion or substitution editing

9020165

HgeneADAR

GO:0031054

pre-miRNA processing

23622242

HgeneADAR

GO:0035280

miRNA loading onto RISC involved in gene silencing by miRNA

23622242

HgeneADAR

GO:0035455

response to interferon-alpha

16475990

HgeneADAR

GO:0044387

negative regulation of protein kinase activity by regulation of protein phosphorylation

19651874

HgeneADAR

GO:0045070

positive regulation of viral genome replication

19651874


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-RC-A6M4-01AADARchr1

154580468

-KRTCAP2chr1

155142333

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000292205ENST00000295682ADARchr1

154580468

-KRTCAP2chr1

155142333

-
intron-5UTRENST00000292205ENST00000490672ADARchr1

154580468

-KRTCAP2chr1

155142333

-
Frame-shitENST00000368474ENST00000295682ADARchr1

154580468

-KRTCAP2chr1

155142333

-
5CDS-5UTRENST00000368474ENST00000490672ADARchr1

154580468

-KRTCAP2chr1

155142333

-
intron-3CDSENST00000368471ENST00000295682ADARchr1

154580468

-KRTCAP2chr1

155142333

-
intron-5UTRENST00000368471ENST00000490672ADARchr1

154580468

-KRTCAP2chr1

155142333

-
intron-3CDSENST00000471068ENST00000295682ADARchr1

154580468

-KRTCAP2chr1

155142333

-
intron-5UTRENST00000471068ENST00000490672ADARchr1

154580468

-KRTCAP2chr1

155142333

-

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FusionProtFeatures for ADAR_KRTCAP2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAR

P55265

KRTCAP2

Q8N6L1

Acts as accessory component of the N-oligosaccharyltransferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donorto an asparagine residue within an Asn-X-Ser/Thr consensus motifin nascent polypeptide chains. Required for efficient substrate-specific N-glycosylation probably involving the STT3A-containingOST complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage ofAPP by enhancing endoprotelysis of PSEN1.{ECO:0000269|PubMed:21768116, ECO:0000269|PubMed:22467853,ECO:0000305}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ADAR_KRTCAP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ADAR_KRTCAP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADARXPO1, HDLBP, HDAC5, ELAVL1, HNRNPA1, CUL3, CAND1, DDX17, HNRNPM, UPF1, SNRPN, SNRPB, DHX9, HDAC9, TGM2, UBE2I, FBXO6, TARDBP, RPA1, RPA2, RPA3, ERG, STAU2, STAU1, CUL7, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, EGFR, USP38, FBXW11, NTRK1, SMC2, SCARNA22, IFI16, MYC, XRCC3, MATR3, THOC1, TACC3, EXOSC4, THOC2, THOC7, MMGT1, ZFC3H1, RBPJ, FOXA2, FOXA3, FOXB1, FOXG1, FOXH1, FOXI2, CRY2, FOXL1, FOXP3, FOXS1, MEX3C, COX15, PDHA1, FOXA1, G3BP1, UBE2AKRTCAP2DDOST, APP, STT3A, STT3B, SHD, TCTN2, TCTN3, SCLT1, CREB3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADAR_KRTCAP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADAR_KRTCAP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneADARC0406775Symmetrical dyschromatosis of extremities3CTD_human;ORPHANET;UNIPROT
HgeneADARC0796126AICARDI-GOUTIERES SYNDROME 11CTD_human
HgeneADARC3539013AICARDI-GOUTIERES SYNDROME 61UNIPROT