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Fusion gene ID: 787 |
FusionGeneSummary for ADAR_KRTCAP2 |
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Fusion gene information | Fusion gene name: ADAR_KRTCAP2 | Fusion gene ID: 787 | Hgene | Tgene | Gene symbol | ADAR | KRTCAP2 | Gene ID | 103 | 200185 |
Gene name | adenosine deaminase, RNA specific | keratinocyte associated protein 2 | |
Synonyms | ADAR1|AGS6|DRADA|DSH|DSRAD|G1P1|IFI-4|IFI4|K88DSRBP|P136 | KCP2 | |
Cytomap | 1q21.3 | 1q22 | |
Type of gene | protein-coding | protein-coding | |
Description | double-stranded RNA-specific adenosine deaminase136 kDa double-stranded RNA-binding proteinadenosine deaminase acting on RNA 1-AdsRNA adenosine deaminasedsRNA adeonosine deaminaseinterferon-induced protein 4interferon-inducible protein 4 | keratinocyte-associated protein 2KCP-2keratinocytes associated protein 2 | |
Modification date | 20180524 | 20180519 | |
UniProtAcc | P55265 | Q8N6L1 | |
Ensembl transtripts involved in fusion gene | ENST00000292205, ENST00000368474, ENST00000368471, ENST00000471068, | ENST00000295682, ENST00000490672, | |
Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 1 X 1 X 1=1 |
# samples | 7 | 1 | |
** MAII score | log2(7/252*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
Context | PubMed: ADAR [Title/Abstract] AND KRTCAP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ADAR | GO:0006382 | adenosine to inosine editing | 15858013|19651874|21289159 |
Hgene | ADAR | GO:0016553 | base conversion or substitution editing | 9020165 |
Hgene | ADAR | GO:0031054 | pre-miRNA processing | 23622242 |
Hgene | ADAR | GO:0035280 | miRNA loading onto RISC involved in gene silencing by miRNA | 23622242 |
Hgene | ADAR | GO:0035455 | response to interferon-alpha | 16475990 |
Hgene | ADAR | GO:0044387 | negative regulation of protein kinase activity by regulation of protein phosphorylation | 19651874 |
Hgene | ADAR | GO:0045070 | positive regulation of viral genome replication | 19651874 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-RC-A6M4-01A | ADAR | chr1 | 154580468 | - | KRTCAP2 | chr1 | 155142333 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000292205 | ENST00000295682 | ADAR | chr1 | 154580468 | - | KRTCAP2 | chr1 | 155142333 | - |
intron-5UTR | ENST00000292205 | ENST00000490672 | ADAR | chr1 | 154580468 | - | KRTCAP2 | chr1 | 155142333 | - |
Frame-shift | ENST00000368474 | ENST00000295682 | ADAR | chr1 | 154580468 | - | KRTCAP2 | chr1 | 155142333 | - |
5CDS-5UTR | ENST00000368474 | ENST00000490672 | ADAR | chr1 | 154580468 | - | KRTCAP2 | chr1 | 155142333 | - |
intron-3CDS | ENST00000368471 | ENST00000295682 | ADAR | chr1 | 154580468 | - | KRTCAP2 | chr1 | 155142333 | - |
intron-5UTR | ENST00000368471 | ENST00000490672 | ADAR | chr1 | 154580468 | - | KRTCAP2 | chr1 | 155142333 | - |
intron-3CDS | ENST00000471068 | ENST00000295682 | ADAR | chr1 | 154580468 | - | KRTCAP2 | chr1 | 155142333 | - |
intron-5UTR | ENST00000471068 | ENST00000490672 | ADAR | chr1 | 154580468 | - | KRTCAP2 | chr1 | 155142333 | - |
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FusionProtFeatures for ADAR_KRTCAP2 |
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Hgene | Tgene |
ADAR | KRTCAP2 |
Acts as accessory component of the N-oligosaccharyltransferase (OST) complex which catalyzes the transfer of a highmannose oligosaccharide from a lipid-linked oligosaccharide donorto an asparagine residue within an Asn-X-Ser/Thr consensus motifin nascent polypeptide chains. Required for efficient substrate-specific N-glycosylation probably involving the STT3A-containingOST complex. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage ofAPP by enhancing endoprotelysis of PSEN1.{ECO:0000269|PubMed:21768116, ECO:0000269|PubMed:22467853,ECO:0000305}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ADAR_KRTCAP2 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ADAR_KRTCAP2 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ADAR | XPO1, HDLBP, HDAC5, ELAVL1, HNRNPA1, CUL3, CAND1, DDX17, HNRNPM, UPF1, SNRPN, SNRPB, DHX9, HDAC9, TGM2, UBE2I, FBXO6, TARDBP, RPA1, RPA2, RPA3, ERG, STAU2, STAU1, CUL7, OBSL1, EZH2, SUZ12, EED, RNF2, BMI1, EGFR, USP38, FBXW11, NTRK1, SMC2, SCARNA22, IFI16, MYC, XRCC3, MATR3, THOC1, TACC3, EXOSC4, THOC2, THOC7, MMGT1, ZFC3H1, RBPJ, FOXA2, FOXA3, FOXB1, FOXG1, FOXH1, FOXI2, CRY2, FOXL1, FOXP3, FOXS1, MEX3C, COX15, PDHA1, FOXA1, G3BP1, UBE2A | KRTCAP2 | DDOST, APP, STT3A, STT3B, SHD, TCTN2, TCTN3, SCLT1, CREB3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADAR_KRTCAP2 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADAR_KRTCAP2 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | ADAR | C0406775 | Symmetrical dyschromatosis of extremities | 3 | CTD_human;ORPHANET;UNIPROT |
Hgene | ADAR | C0796126 | AICARDI-GOUTIERES SYNDROME 1 | 1 | CTD_human |
Hgene | ADAR | C3539013 | AICARDI-GOUTIERES SYNDROME 6 | 1 | UNIPROT |