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Fusion gene ID: 7825 |
FusionGeneSummary for COG5_CEP41 |
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Fusion gene information | Fusion gene name: COG5_CEP41 | Fusion gene ID: 7825 | Hgene | Tgene | Gene symbol | COG5 | CEP41 | Gene ID | 10466 | 95681 |
Gene name | component of oligomeric golgi complex 5 | centrosomal protein 41 | |
Synonyms | CDG2I|GOLTC1|GTC90 | JBTS15|TSGA14 | |
Cytomap | 7q22.3 | 7q32.2 | |
Type of gene | protein-coding | protein-coding | |
Description | conserved oligomeric Golgi complex subunit 513S golgi transport complex 1 90 kDa subunitCOG complex subunit 5conserved oligomeric Golgi complex protein 5 | centrosomal protein of 41 kDacentrosomal protein 41 kDacentrosomal protein 41kDatestis specific protein A14testis specific, 14testis-specific gene A14 protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q9UP83 | Q9BYV8 | |
Ensembl transtripts involved in fusion gene | ENST00000347053, ENST00000297135, ENST00000393603, ENST00000475638, | ENST00000223208, ENST00000541543, ENST00000343969, ENST00000489512, ENST00000495702, | |
Fusion gene scores | * DoF score | 8 X 5 X 5=200 | 4 X 4 X 4=64 |
# samples | 9 | 4 | |
** MAII score | log2(9/200*10)=-1.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: COG5 [Title/Abstract] AND CEP41 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | BRCA | TCGA-BH-A0HI-01A | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-3UTR | ENST00000347053 | ENST00000223208 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-intron | ENST00000347053 | ENST00000541543 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-intron | ENST00000347053 | ENST00000343969 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-intron | ENST00000347053 | ENST00000489512 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-intron | ENST00000347053 | ENST00000495702 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-3UTR | ENST00000297135 | ENST00000223208 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-intron | ENST00000297135 | ENST00000541543 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-intron | ENST00000297135 | ENST00000343969 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-intron | ENST00000297135 | ENST00000489512 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-intron | ENST00000297135 | ENST00000495702 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-3UTR | ENST00000393603 | ENST00000223208 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-intron | ENST00000393603 | ENST00000541543 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-intron | ENST00000393603 | ENST00000343969 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-intron | ENST00000393603 | ENST00000489512 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5CDS-intron | ENST00000393603 | ENST00000495702 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5UTR-3UTR | ENST00000475638 | ENST00000223208 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5UTR-intron | ENST00000475638 | ENST00000541543 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5UTR-intron | ENST00000475638 | ENST00000343969 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5UTR-intron | ENST00000475638 | ENST00000489512 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
5UTR-intron | ENST00000475638 | ENST00000495702 | COG5 | chr7 | 107052947 | - | CEP41 | chr7 | 130034807 | - |
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FusionProtFeatures for COG5_CEP41 |
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Hgene | Tgene |
COG5 | CEP41 |
Required for normal Golgi function. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for COG5_CEP41 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for COG5_CEP41 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
COG5 | MEFV, COG4, COG7, APC, RAC1, TRAF5, COG1, COG6, COG8, COG2, COG3, VCP, EGFR, COMTD1, BSG, CD274, PARP16, VSIG2, DTNBP1, STK24, NTRK1, FOXB1, FOXL1, PTAR1, RAB1A, TSSC1, CCDC136, ATP7A, NIN, COMMD8, PCM1, IFFO1, VSIG1, STX4 | CEP41 | HIP1R, MVB12A, WARS, DCTN1, XPO1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COG5_CEP41 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COG5_CEP41 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | CEP41 | C1510586 | Autism Spectrum Disorders | 1 | CTD_human |