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Fusion gene ID: 7816 |
FusionGeneSummary for COG4_AARS |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: COG4_AARS | Fusion gene ID: 7816 | Hgene | Tgene | Gene symbol | COG4 | AARS | Gene ID | 25839 | 16 |
| Gene name | component of oligomeric golgi complex 4 | alanyl-tRNA synthetase | |
| Synonyms | CDG2J|COD1 | CMT2N|EIEE29 | |
| Cytomap | 16q22.1 | 16q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | conserved oligomeric Golgi complex subunit 4COG complex subunit 4complexed with Dor1pconserved oligomeric Golgi complex protein 4 | alanine--tRNA ligase, cytoplasmicalaRSalanine tRNA ligase 1, cytoplasmicalanyl-tRNA synthetase, cytoplasmicrenal carcinoma antigen NY-REN-42 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9H9E3 | P49588 | |
| Ensembl transtripts involved in fusion gene | ENST00000323786, ENST00000393612, ENST00000564653, | ENST00000261772, ENST00000564359, | |
| Fusion gene scores | * DoF score | 6 X 7 X 5=210 | 7 X 6 X 4=168 |
| # samples | 8 | 7 | |
| ** MAII score | log2(8/210*10)=-1.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: COG4 [Title/Abstract] AND AARS [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | AARS | GO:0006419 | alanyl-tRNA aminoacylation | 27622773|28493438 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-VQ-A94O-01A | COG4 | chr16 | 70530169 | - | AARS | chr16 | 70311057 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000323786 | ENST00000261772 | COG4 | chr16 | 70530169 | - | AARS | chr16 | 70311057 | - |
| 5CDS-intron | ENST00000323786 | ENST00000564359 | COG4 | chr16 | 70530169 | - | AARS | chr16 | 70311057 | - |
| intron-3CDS | ENST00000393612 | ENST00000261772 | COG4 | chr16 | 70530169 | - | AARS | chr16 | 70311057 | - |
| intron-intron | ENST00000393612 | ENST00000564359 | COG4 | chr16 | 70530169 | - | AARS | chr16 | 70311057 | - |
| intron-3CDS | ENST00000564653 | ENST00000261772 | COG4 | chr16 | 70530169 | - | AARS | chr16 | 70311057 | - |
| intron-intron | ENST00000564653 | ENST00000564359 | COG4 | chr16 | 70530169 | - | AARS | chr16 | 70311057 | - |
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FusionProtFeatures for COG4_AARS |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| COG4 | AARS |
| Required for normal Golgi function. Plays a role inSNARE-pin assembly and Golgi-to-ER retrograde transport via itsinteraction with SCFD1. {ECO:0000269|PubMed:19536132}. | Catalyzes the attachment of alanine to tRNA(Ala) in atwo-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala)(PubMed:27622773, PubMed:27911835, PubMed:28493438). Also editsincorrectly charged tRNA(Ala) via its editing domain(PubMed:27622773, PubMed:27911835, PubMed:28493438).{ECO:0000255|HAMAP-Rule:MF_03133, ECO:0000269|PubMed:27622773,ECO:0000269|PubMed:27911835, ECO:0000269|PubMed:28493438}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >AARS | chr16:70530169 | chr16:70311057 | ENST00000261772 | - | 1 | 21 | 214_216 | 48 | 969 | Nucleotide binding | ATP |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >COG4 | chr16:70530169 | chr16:70311057 | ENST00000393612 | - | 1 | 8 | 618_740 | -1 | 338 | Region | Note=D domain |
| Hgene | >COG4 | chr16:70530169 | chr16:70311057 | ENST00000393612 | - | 1 | 8 | 741_785 | -1 | 338 | Region | Note=E domain%3B essential for proper cell surface glycosylation |
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FusionGeneSequence for COG4_AARS |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_COG4_ENST00000323786_chr16_70530169_-_AARS_ENST00000261772_chr16_70311057_-_1470aa MGTKMADLDSPPKLSGVQQPSEGVGGGRCSEISAELIRSLTELQELEAVYERLCGEEKVVERELDALLEQQNTIESKMVTLHRMGPNLQL IEGDAKQLAGMITFTCNLAENVSSKVRQLDLAKNRLYQAIQRADDILDLKFCMDGVQTALRSEDYEQAAAHTHRYLCLDKSVIELSRQGK EGSMIDANLKLLQEAEQRLKAIVAEKFAIATKEGDLPQVERFFKIFPLLGLHEEGLRKFSEYLCKQVASKAEENLLMVLGTDMSDRRAAV IFADTLTLLFEGIARIVETHQPIVETYYGPGRLYTLIKYLQVECDRQVEKVVDKFIKQRDYHQQFRHVQNNLMRNSTTEKIEPRELDPIL TEVTLMNARSELYLRFLKKRISSDFEVGDSMASEEVKQEHQKCLDKLLNNCLLSCTMQELIGLYVTMEEYFMRETVNKAVALDTYEKGQL TSSMVDDVFYIVKKCIGRALSSSSIDCLCAMINLATTELESDFRDVLCNKLRMGFPATTFQDIQRGVTSAVNIMHSSLQQGKFDTKGIES TDEAKMSFLFKPIFLNTIDPSHPMAKLSRAANTQKCIRAGGKHNDLDDVGKDVYHHTFFEMLGSWSFGDYFKELACKMALELLTQEFGIP IERLYVTYFGGDEAAGLEADLECKQIWQNLGLDDTKILPGNMKDNFWEMGDTGPCGPCSEIHYDRIGGRDAAHLVNQDDPNVLEIWNLVF IQYNREADGILKPLPKKSIDTGMGLERLVSVLQNKMSNYDTDLFVPYFEAIQKGTGARPYTGKVGAEDADGIDMAYRVLADHARTITVAL ADGGRPDNTGRGYVLRRILRRAVRYAHEKLNASRGFFATLVDVVVQSLGDAFPELKKDPDMVKDIINEEEVQFLKTLSRGRRILDRKIQS LGDSKTIPGDTAWLLYDTYGFPVDLTGLIAEEKGLVVDMDGFEEERKLAQLKSQGKGAGGEDLIMLDIYAIEELRARGLEVTDDSPKYNY HLDSSGSYVFENTVATVMALRREKMFVEEVSTGQECGVVLDKTCFYAEQGGQIYDEGYLVKVDDSSEDKTEFTVKNAQVRGGYVLHIGTI YGDLKVGDQVWLFIDEPRRRPIMSNHTATHILNFALRSVLGEADQKGSLVAPDRLRFDFTAKGAMSTQQIKKAEEIANEMIEAAKAVYTQ DCPLAAAKAIQGLRAVFDETYPDPVRVVSIGVPVSELLDDPSGPAGSLTSVEFCGGTHLRNSSHAGAFVIVTEEAIAKGIRRIVAVTGAE AQKALRKAESLKKCLSVMEAKVKAQTAPNKDVQREIADLGEALATAVIPQWQKDELRETLKSLKKVMDDLDRASKADVQKRVLEKTKQFI DSNPNQPLVILEMESGASAKALNEALKLFKMHSPQTSAMLFTVDNEAGKITCLCQVPQNAANRGLKASEWVQQVSGLMDGKGGGKDVSAQ |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_COG4_ENST00000323786_chr16_70530169_-_AARS_ENST00000261772_chr16_70311057_-_4410nt ATGGGGACCAAGATGGCGGACCTTGATTCGCCTCCGAAGCTGTCAGGGGTGCAGCAGCCGTCTGAGGGGGTGGGAGGTGGCCGCTGCTCC GAAATCTCCGCTGAGCTCATTCGCTCCCTGACAGAGCTGCAGGAGCTGGAGGCTGTATACGAACGGCTCTGCGGCGAGGAGAAAGTGGTG GAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTCCACCGAATGGGTCCTAATCTGCAGCTG ATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAATGTGTCCAGCAAAGTTCGTCAGCTTGAC CTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTCTGCATGGATGGAGTTCAGACTGCTTTG AGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCGGTCATTGAGCTCAGCCGACAGGGCAAA GAGGGGAGCATGATTGATGCCAACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTCAAAGCCATTGTGGCAGAGAAGTTTGCCATTGCC ACCAAGGAAGGTGATCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTGGGTTTGCATGAGGAGGGATTAAGAAAGTTCTCG GAGTACCTTTGCAAGCAGGTGGCCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTGGGGACAGACATGAGTGATCGGAGAGCTGCAGTC ATCTTTGCAGATACACTTACTCTTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACCCACCAGCCAATAGTGGAGACCTATTATGGGCCA GGGAGACTCTATACCCTGATCAAATATCTGCAGGTGGAATGTGACAGACAGGTGGAGAAGGTGGTAGACAAGTTCATCAAGCAAAGGGAC TACCACCAGCAGTTCCGGCATGTTCAGAACAACCTGATGAGAAATTCTACAACAGAAAAAATCGAACCAAGAGAACTGGACCCCATCCTG ACTGAGGTCACCCTGATGAATGCCCGCAGTGAGCTATACTTACGCTTCCTCAAGAAGAGGATTAGCTCTGATTTTGAGGTGGGAGACTCC ATGGCCTCAGAGGAAGTAAAGCAAGAGCACCAGAAGTGTCTGGACAAACTCCTCAATAACTGCCTTTTGAGCTGTACCATGCAGGAGCTA ATTGGCTTATATGTTACCATGGAGGAGTACTTCATGAGGGAGACTGTCAATAAGGCTGTGGCTCTGGACACCTATGAGAAGGGCCAGCTG ACATCCAGCATGGTGGATGATGTCTTCTACATTGTTAAGAAGTGCATTGGGCGGGCTCTGTCCAGCTCCAGCATTGACTGTCTCTGTGCC ATGATCAACCTCGCCACCACAGAGCTGGAGTCTGACTTCAGGGATGTTCTGTGTAATAAGCTGCGGATGGGCTTTCCTGCCACCACCTTC CAGGACATCCAGCGCGGGGTGACAAGTGCCGTGAACATCATGCACAGCAGCCTCCAGCAAGGCAAATTTGACACAAAAGGCATCGAGAGT ACTGACGAGGCGAAGATGTCCTTCCTGTTTAAACCCATTTTCCTGAACACAATTGACCCATCTCACCCCATGGCAAAGCTGAGCAGAGCT GCCAATACCCAGAAGTGCATCCGGGCTGGGGGCAAACATAATGACCTGGACGATGTGGGCAAGGATGTCTATCATCACACCTTCTTCGAG ATGCTGGGCTCTTGGTCTTTTGGAGATTACTTTAAGGAATTGGCATGTAAGATGGCTCTGGAACTCCTCACCCAAGAGTTTGGCATTCCC ATTGAAAGACTTTATGTTACTTACTTTGGCGGGGATGAAGCAGCTGGCTTAGAAGCAGATCTGGAATGCAAACAGATCTGGCAAAATTTG GGGCTGGATGACACCAAAATCCTCCCAGGCAACATGAAGGATAACTTCTGGGAGATGGGTGACACGGGCCCCTGTGGTCCTTGCAGTGAG ATCCACTACGACCGGATTGGTGGTCGGGACGCCGCACATCTTGTCAACCAGGACGACCCTAATGTGCTGGAGATCTGGAACCTTGTGTTC ATCCAGTATAACAGGGAAGCTGATGGCATTCTGAAACCTCTTCCCAAGAAAAGCATTGACACAGGGATGGGCCTGGAACGACTGGTATCT GTGCTGCAGAATAAGATGTCCAACTATGACACTGACCTTTTTGTCCCTTACTTTGAAGCCATTCAGAAGGGCACAGGTGCCCGACCATAC ACTGGGAAAGTTGGTGCTGAGGATGCCGATGGGATTGACATGGCCTACCGGGTGCTGGCTGACCACGCTCGGACCATCACTGTGGCACTG GCTGATGGTGGCCGGCCTGACAACACAGGGCGTGGATATGTGTTGAGACGGATTCTCCGCCGAGCTGTCCGATACGCCCATGAAAAGCTC AATGCCAGCAGGGGCTTCTTTGCTACGTTAGTGGATGTTGTCGTCCAGTCCCTGGGAGATGCATTTCCTGAGCTGAAGAAGGACCCAGAC ATGGTGAAGGACATCATTAATGAAGAAGAGGTGCAGTTTCTCAAGACTCTCAGCAGAGGGCGTCGCATCCTGGACAGGAAAATTCAGAGC CTGGGAGACAGCAAGACCATTCCCGGAGACACTGCTTGGCTCCTCTATGACACCTATGGGTTTCCAGTGGATCTGACTGGACTGATTGCT GAAGAGAAGGGCCTGGTGGTAGACATGGATGGCTTTGAAGAGGAGAGGAAACTGGCCCAGCTGAAATCACAGGGCAAGGGAGCTGGTGGG GAAGACCTCATTATGCTGGACATTTACGCTATCGAAGAGCTCCGGGCACGGGGTCTGGAGGTCACAGATGATTCCCCAAAGTACAATTAC CATTTGGACTCCAGTGGTAGCTATGTATTTGAGAACACAGTGGCTACGGTGATGGCTCTGCGCAGGGAGAAGATGTTCGTGGAAGAGGTG TCCACAGGCCAGGAGTGTGGAGTGGTGCTGGACAAGACCTGTTTCTATGCTGAGCAAGGAGGCCAGATCTATGACGAAGGCTACCTGGTG AAGGTGGATGACAGCAGTGAAGATAAAACAGAGTTTACAGTGAAGAATGCTCAGGTCCGAGGAGGGTATGTGCTACACATTGGAACCATC TACGGTGACCTGAAAGTGGGGGATCAGGTCTGGCTGTTTATTGATGAGCCCCGACGAAGACCCATCATGAGCAACCACACAGCTACGCAC ATTCTGAACTTCGCCCTGCGCTCAGTGCTTGGGGAAGCTGACCAGAAAGGCTCATTGGTTGCTCCTGACCGCCTCAGATTTGACTTTACT GCCAAGGGAGCCATGTCCACCCAACAGATCAAGAAGGCTGAAGAGATTGCTAATGAGATGATTGAGGCAGCCAAGGCCGTCTATACCCAG GATTGCCCCCTGGCAGCAGCGAAAGCCATCCAGGGCCTACGGGCTGTGTTTGATGAGACCTATCCTGACCCTGTGCGAGTCGTCTCCATT GGGGTCCCGGTGTCCGAGTTGCTGGATGACCCCTCTGGGCCTGCTGGCTCCCTGACTTCTGTTGAGTTCTGTGGGGGAACGCACCTGCGG AACTCGAGTCATGCAGGAGCTTTTGTGATCGTGACGGAAGAAGCCATTGCCAAGGGTATCCGGAGGATTGTGGCTGTCACAGGTGCCGAG GCCCAGAAGGCCCTCAGGAAAGCAGAGAGCTTGAAGAAATGTCTCTCTGTCATGGAAGCCAAAGTGAAGGCTCAGACTGCTCCAAACAAG GATGTGCAGAGGGAGATCGCTGACCTTGGAGAGGCCCTGGCCACTGCAGTCATCCCCCAGTGGCAGAAGGATGAATTGCGGGAGACTCTC AAATCCCTAAAGAAGGTCATGGATGACTTGGACCGAGCCAGCAAAGCCGATGTCCAGAAACGAGTGTTAGAGAAGACGAAGCAGTTCATC GACAGCAACCCCAACCAGCCTCTTGTCATCCTGGAGATGGAGAGCGGCGCCTCAGCCAAGGCCCTGAATGAAGCCTTGAAGCTCTTCAAG ATGCACTCCCCTCAGACTTCTGCCATGCTCTTCACGGTGGACAATGAGGCTGGCAAGATCACGTGCCTGTGTCAAGTTCCCCAGAATGCA GCCAATCGGGGCTTAAAAGCCAGCGAGTGGGTGCAGCAGGTGTCAGGCTTGATGGACGGTAAAGGTGGTGGCAAGGATGTGTCTGCACAG GCCACAGGCAAGAACGTTGGCTGCCTGCAGGAGGCGCTGCAGCTGGCCACTTCCTTCGCCCAGCTGCGCCTCGGGGATGTAAAGAACTGA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_COG4_ENST00000323786_chr16_70530169_-_AARS_ENST00000261772_chr16_70311057_-_4858nt CTCGCGGGACCGGAAGTGCCGAATGGGGACCAAGATGGCGGACCTTGATTCGCCTCCGAAGCTGTCAGGGGTGCAGCAGCCGTCTGAGGG GGTGGGAGGTGGCCGCTGCTCCGAAATCTCCGCTGAGCTCATTCGCTCCCTGACAGAGCTGCAGGAGCTGGAGGCTGTATACGAACGGCT CTGCGGCGAGGAGAAAGTGGTGGAGAGAGAGCTGGATGCTCTTTTGGAACAGCAAAACACCATTGAAAGTAAGATGGTCACTCTCCACCG AATGGGTCCTAATCTGCAGCTGATTGAGGGAGATGCAAAGCAGCTGGCTGGAATGATCACCTTTACCTGCAACCTGGCTGAGAATGTGTC CAGCAAAGTTCGTCAGCTTGACCTGGCCAAGAACCGCCTCTATCAGGCCATTCAGAGAGCTGATGACATCTTGGACCTGAAGTTCTGCAT GGATGGAGTTCAGACTGCTTTGAGGAGTGAAGATTATGAGCAGGCTGCAGCACATACTCATCGCTACTTGTGCCTGGACAAGTCGGTCAT TGAGCTCAGCCGACAGGGCAAAGAGGGGAGCATGATTGATGCCAACCTGAAATTGCTGCAGGAAGCTGAGCAACGTCTCAAAGCCATTGT GGCAGAGAAGTTTGCCATTGCCACCAAGGAAGGTGATCTGCCCCAGGTGGAGCGCTTCTTCAAGATCTTCCCACTGCTGGGTTTGCATGA GGAGGGATTAAGAAAGTTCTCGGAGTACCTTTGCAAGCAGGTGGCCAGTAAAGCTGAGGAGAATCTGCTCATGGTGCTGGGGACAGACAT GAGTGATCGGAGAGCTGCAGTCATCTTTGCAGATACACTTACTCTTCTGTTTGAAGGGATTGCCCGCATTGTGGAGACCCACCAGCCAAT AGTGGAGACCTATTATGGGCCAGGGAGACTCTATACCCTGATCAAATATCTGCAGGTGGAATGTGACAGACAGGTGGAGAAGGTGGTAGA CAAGTTCATCAAGCAAAGGGACTACCACCAGCAGTTCCGGCATGTTCAGAACAACCTGATGAGAAATTCTACAACAGAAAAAATCGAACC AAGAGAACTGGACCCCATCCTGACTGAGGTCACCCTGATGAATGCCCGCAGTGAGCTATACTTACGCTTCCTCAAGAAGAGGATTAGCTC TGATTTTGAGGTGGGAGACTCCATGGCCTCAGAGGAAGTAAAGCAAGAGCACCAGAAGTGTCTGGACAAACTCCTCAATAACTGCCTTTT GAGCTGTACCATGCAGGAGCTAATTGGCTTATATGTTACCATGGAGGAGTACTTCATGAGGGAGACTGTCAATAAGGCTGTGGCTCTGGA CACCTATGAGAAGGGCCAGCTGACATCCAGCATGGTGGATGATGTCTTCTACATTGTTAAGAAGTGCATTGGGCGGGCTCTGTCCAGCTC CAGCATTGACTGTCTCTGTGCCATGATCAACCTCGCCACCACAGAGCTGGAGTCTGACTTCAGGGATGTTCTGTGTAATAAGCTGCGGAT GGGCTTTCCTGCCACCACCTTCCAGGACATCCAGCGCGGGGTGACAAGTGCCGTGAACATCATGCACAGCAGCCTCCAGCAAGGCAAATT TGACACAAAAGGCATCGAGAGTACTGACGAGGCGAAGATGTCCTTCCTGTTTAAACCCATTTTCCTGAACACAATTGACCCATCTCACCC CATGGCAAAGCTGAGCAGAGCTGCCAATACCCAGAAGTGCATCCGGGCTGGGGGCAAACATAATGACCTGGACGATGTGGGCAAGGATGT CTATCATCACACCTTCTTCGAGATGCTGGGCTCTTGGTCTTTTGGAGATTACTTTAAGGAATTGGCATGTAAGATGGCTCTGGAACTCCT CACCCAAGAGTTTGGCATTCCCATTGAAAGACTTTATGTTACTTACTTTGGCGGGGATGAAGCAGCTGGCTTAGAAGCAGATCTGGAATG CAAACAGATCTGGCAAAATTTGGGGCTGGATGACACCAAAATCCTCCCAGGCAACATGAAGGATAACTTCTGGGAGATGGGTGACACGGG CCCCTGTGGTCCTTGCAGTGAGATCCACTACGACCGGATTGGTGGTCGGGACGCCGCACATCTTGTCAACCAGGACGACCCTAATGTGCT GGAGATCTGGAACCTTGTGTTCATCCAGTATAACAGGGAAGCTGATGGCATTCTGAAACCTCTTCCCAAGAAAAGCATTGACACAGGGAT GGGCCTGGAACGACTGGTATCTGTGCTGCAGAATAAGATGTCCAACTATGACACTGACCTTTTTGTCCCTTACTTTGAAGCCATTCAGAA GGGCACAGGTGCCCGACCATACACTGGGAAAGTTGGTGCTGAGGATGCCGATGGGATTGACATGGCCTACCGGGTGCTGGCTGACCACGC TCGGACCATCACTGTGGCACTGGCTGATGGTGGCCGGCCTGACAACACAGGGCGTGGATATGTGTTGAGACGGATTCTCCGCCGAGCTGT CCGATACGCCCATGAAAAGCTCAATGCCAGCAGGGGCTTCTTTGCTACGTTAGTGGATGTTGTCGTCCAGTCCCTGGGAGATGCATTTCC TGAGCTGAAGAAGGACCCAGACATGGTGAAGGACATCATTAATGAAGAAGAGGTGCAGTTTCTCAAGACTCTCAGCAGAGGGCGTCGCAT CCTGGACAGGAAAATTCAGAGCCTGGGAGACAGCAAGACCATTCCCGGAGACACTGCTTGGCTCCTCTATGACACCTATGGGTTTCCAGT GGATCTGACTGGACTGATTGCTGAAGAGAAGGGCCTGGTGGTAGACATGGATGGCTTTGAAGAGGAGAGGAAACTGGCCCAGCTGAAATC ACAGGGCAAGGGAGCTGGTGGGGAAGACCTCATTATGCTGGACATTTACGCTATCGAAGAGCTCCGGGCACGGGGTCTGGAGGTCACAGA TGATTCCCCAAAGTACAATTACCATTTGGACTCCAGTGGTAGCTATGTATTTGAGAACACAGTGGCTACGGTGATGGCTCTGCGCAGGGA GAAGATGTTCGTGGAAGAGGTGTCCACAGGCCAGGAGTGTGGAGTGGTGCTGGACAAGACCTGTTTCTATGCTGAGCAAGGAGGCCAGAT CTATGACGAAGGCTACCTGGTGAAGGTGGATGACAGCAGTGAAGATAAAACAGAGTTTACAGTGAAGAATGCTCAGGTCCGAGGAGGGTA TGTGCTACACATTGGAACCATCTACGGTGACCTGAAAGTGGGGGATCAGGTCTGGCTGTTTATTGATGAGCCCCGACGAAGACCCATCAT GAGCAACCACACAGCTACGCACATTCTGAACTTCGCCCTGCGCTCAGTGCTTGGGGAAGCTGACCAGAAAGGCTCATTGGTTGCTCCTGA CCGCCTCAGATTTGACTTTACTGCCAAGGGAGCCATGTCCACCCAACAGATCAAGAAGGCTGAAGAGATTGCTAATGAGATGATTGAGGC AGCCAAGGCCGTCTATACCCAGGATTGCCCCCTGGCAGCAGCGAAAGCCATCCAGGGCCTACGGGCTGTGTTTGATGAGACCTATCCTGA CCCTGTGCGAGTCGTCTCCATTGGGGTCCCGGTGTCCGAGTTGCTGGATGACCCCTCTGGGCCTGCTGGCTCCCTGACTTCTGTTGAGTT CTGTGGGGGAACGCACCTGCGGAACTCGAGTCATGCAGGAGCTTTTGTGATCGTGACGGAAGAAGCCATTGCCAAGGGTATCCGGAGGAT TGTGGCTGTCACAGGTGCCGAGGCCCAGAAGGCCCTCAGGAAAGCAGAGAGCTTGAAGAAATGTCTCTCTGTCATGGAAGCCAAAGTGAA GGCTCAGACTGCTCCAAACAAGGATGTGCAGAGGGAGATCGCTGACCTTGGAGAGGCCCTGGCCACTGCAGTCATCCCCCAGTGGCAGAA GGATGAATTGCGGGAGACTCTCAAATCCCTAAAGAAGGTCATGGATGACTTGGACCGAGCCAGCAAAGCCGATGTCCAGAAACGAGTGTT AGAGAAGACGAAGCAGTTCATCGACAGCAACCCCAACCAGCCTCTTGTCATCCTGGAGATGGAGAGCGGCGCCTCAGCCAAGGCCCTGAA TGAAGCCTTGAAGCTCTTCAAGATGCACTCCCCTCAGACTTCTGCCATGCTCTTCACGGTGGACAATGAGGCTGGCAAGATCACGTGCCT GTGTCAAGTTCCCCAGAATGCAGCCAATCGGGGCTTAAAAGCCAGCGAGTGGGTGCAGCAGGTGTCAGGCTTGATGGACGGTAAAGGTGG TGGCAAGGATGTGTCTGCACAGGCCACAGGCAAGAACGTTGGCTGCCTGCAGGAGGCGCTGCAGCTGGCCACTTCCTTCGCCCAGCTGCG CCTCGGGGATGTAAAGAACTGAGTGGGGAAGGAGGAGGCTCCCACTGGATCCATCCGTCCAGCCAAGAGCTCTTCATCTGCTACAAGAAC ATTTGAATCTTGGGACCTTTAAAGAGCCCCTCCTAACCCAGCAGTAACTGGAACACACTTGGGAGCAGTCCTATGTCTCAGTGCCCCTTA AATTTCTGCCCTGAGCCCTCCACGTCAGTGCCATCGGTCTAGAACCACTAACCCCGCATTGCTGTTGATCGTCACGCTCGCATCTATAGA TAACGGCTCTCCAGACCTGAGCTTTCCGCGTCAGCAAGTAGGAATCGTTTTTGCTGCAGAGAATAAAAGGACCACGTGCAATACTTAATG |
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FusionGenePPI for COG4_AARS |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| COG4 | COG1, COG2, COG5, COG7, COG3, APC, SEPT2, CUL4B, COG8, RPS20, VCP, COG6, EGFR, BSG, CD274, VSIG2, CA14, TEKT4, SCN2B, NTRK1, HDAC1, PDK1, SMEK1, CCDC40, PSMC5, TMCO3, NUP54, CCDC59, COMMD8, VSIG1, OPRM1, SIGLECL1, RAB30, MTNR1B | AARS | SIRT7, CDK2, UBA1, IARS, GARS, NARS, LARS, ACTA2, DARS, ASNS, NSUN2, FARSB, QARS, HSP90AA1, HSP90AB1, VCAM1, FN1, ITGA4, ANKMY2, ARPC1B, CALU, HSF1, IPO11, METTL1, PPP2R5E, SAE1, STAT5B, TOM1L1, CACYBP, DPP8, DPP9, EEF2K, EIF4A3, NIF3L1, SRP9, TPD52, TPD52L2, WARS, ENO1, MOV10, NXF1, ABCE1, CIAPIN1, TARSL2, MSH2, NMD3, PDIA3, SBDS, STAT1, NTRK1, AURKB, MICU1, HSD17B10, SOD1, BRCA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | COG4 | chr16:70530169 | chr16:70311057 | ENST00000393612 | - | 1 | 8 | 2_84 | -1 | 338 | SCFD1 |
| Hgene | COG4 | chr16:70530169 | chr16:70311057 | ENST00000393612 | - | 1 | 8 | 85_153 | -1 | 338 | STX5 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COG4_AARS |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COG4_AARS |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | COG4 | C0032927 | Precancerous Conditions | 1 | CTD_human |
| Hgene | COG4 | C3150736 | CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIj | 1 | CTD_human;ORPHANET;UNIPROT |
| Tgene | AARS | C2750090 | Charcot-Marie-Tooth Disease, Axonal, Type 2n | 3 | CTD_human;ORPHANET;UNIPROT |
| Tgene | AARS | C4225361 | EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 29 | 1 | UNIPROT |
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