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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7814

FusionGeneSummary for COG3_AGA

check button Fusion gene summary
Fusion gene informationFusion gene name: COG3_AGA
Fusion gene ID: 7814
HgeneTgene
Gene symbol

COG3

AGA

Gene ID

83548

175

Gene namecomponent of oligomeric golgi complex 3aspartylglucosaminidase
SynonymsSEC34AGU|ASRG|GA
Cytomap

13q14.13

4q34.3

Type of geneprotein-codingprotein-coding
Descriptionconserved oligomeric Golgi complex subunit 3COG complex subunit 3p94tethering factor SEC34vesicle-docking protein SEC34 homologN(4)-(beta-N-acetylglucosaminyl)-L-asparaginaseN4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidaseaspartylglucosylamine deaspartylaseglycosylasparaginase
Modification date2018052320180523
UniProtAcc

Q96JB2

P20933

Ensembl transtripts involved in fusion geneENST00000349995, ENST00000465942, 
ENST00000264595, ENST00000506853, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: COG3 [Title/Abstract] AND AGA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCOG3

GO:0006888

ER to Golgi vesicle-mediated transport

11929878

HgeneCOG3

GO:0006891

intra-Golgi vesicle-mediated transport

11929878

TgeneAGA

GO:0006517

protein deglycosylation

1281977


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI904994COG3chr13

46109519

+AGAchr4

178357154

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000349995ENST00000264595COG3chr13

46109519

+AGAchr4

178357154

-
3UTR-intronENST00000349995ENST00000506853COG3chr13

46109519

+AGAchr4

178357154

-
intron-intronENST00000465942ENST00000264595COG3chr13

46109519

+AGAchr4

178357154

-
intron-intronENST00000465942ENST00000506853COG3chr13

46109519

+AGAchr4

178357154

-

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FusionProtFeatures for COG3_AGA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
COG3

Q96JB2

AGA

P20933

Involved in ER-Golgi transport.{ECO:0000269|PubMed:11929878}. Cleaves the GlcNAc-Asn bond which joins oligosaccharidesto the peptide of asparagine-linked glycoproteins.{ECO:0000269|PubMed:1703489, ECO:0000269|PubMed:1904874,ECO:0000269|PubMed:2401370}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for COG3_AGA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for COG3_AGA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for COG3_AGA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for COG3_AGA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneAGAC0268225Aspartylglucosaminuria4CTD_human;HPO;ORPHANET;UNIPROT
TgeneAGAC0036341Schizophrenia1PSYGENET