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Fusion gene ID: 7814 |
FusionGeneSummary for COG3_AGA |
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Fusion gene information | Fusion gene name: COG3_AGA | Fusion gene ID: 7814 | Hgene | Tgene | Gene symbol | COG3 | AGA | Gene ID | 83548 | 175 |
Gene name | component of oligomeric golgi complex 3 | aspartylglucosaminidase | |
Synonyms | SEC34 | AGU|ASRG|GA | |
Cytomap | 13q14.13 | 4q34.3 | |
Type of gene | protein-coding | protein-coding | |
Description | conserved oligomeric Golgi complex subunit 3COG complex subunit 3p94tethering factor SEC34vesicle-docking protein SEC34 homolog | N(4)-(beta-N-acetylglucosaminyl)-L-asparaginaseN4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidaseaspartylglucosylamine deaspartylaseglycosylasparaginase | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96JB2 | P20933 | |
Ensembl transtripts involved in fusion gene | ENST00000349995, ENST00000465942, | ENST00000264595, ENST00000506853, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 2=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: COG3 [Title/Abstract] AND AGA [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | COG3 | GO:0006888 | ER to Golgi vesicle-mediated transport | 11929878 |
Hgene | COG3 | GO:0006891 | intra-Golgi vesicle-mediated transport | 11929878 |
Tgene | AGA | GO:0006517 | protein deglycosylation | 1281977 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AI904994 | COG3 | chr13 | 46109519 | + | AGA | chr4 | 178357154 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
3UTR-intron | ENST00000349995 | ENST00000264595 | COG3 | chr13 | 46109519 | + | AGA | chr4 | 178357154 | - |
3UTR-intron | ENST00000349995 | ENST00000506853 | COG3 | chr13 | 46109519 | + | AGA | chr4 | 178357154 | - |
intron-intron | ENST00000465942 | ENST00000264595 | COG3 | chr13 | 46109519 | + | AGA | chr4 | 178357154 | - |
intron-intron | ENST00000465942 | ENST00000506853 | COG3 | chr13 | 46109519 | + | AGA | chr4 | 178357154 | - |
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FusionProtFeatures for COG3_AGA |
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Hgene | Tgene |
COG3 | AGA |
Involved in ER-Golgi transport.{ECO:0000269|PubMed:11929878}. | Cleaves the GlcNAc-Asn bond which joins oligosaccharidesto the peptide of asparagine-linked glycoproteins.{ECO:0000269|PubMed:1703489, ECO:0000269|PubMed:1904874,ECO:0000269|PubMed:2401370}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for COG3_AGA |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for COG3_AGA |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for COG3_AGA |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for COG3_AGA |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | AGA | C0268225 | Aspartylglucosaminuria | 4 | CTD_human;HPO;ORPHANET;UNIPROT |
Tgene | AGA | C0036341 | Schizophrenia | 1 | PSYGENET |