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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 774

FusionGeneSummary for ADAP1_METTL2B

check button Fusion gene summary
Fusion gene informationFusion gene name: ADAP1_METTL2B
Fusion gene ID: 774
HgeneTgene
Gene symbol

ADAP1

METTL2B

Gene ID

11033

55798

Gene nameArfGAP with dual PH domains 1methyltransferase like 2B
SynonymsCENTA1|GCS1L|p42IP4METL|METTL2|METTL2A|PSENIP1
Cytomap

7p22.3

7q32.1

Type of geneprotein-codingprotein-coding
Descriptionarf-GAP with dual PH domain-containing protein 1centaurin-alphacentaurin-alpha-1cnt-a1putative MAPK-activating protein PM25methyltransferase-like protein 2B
Modification date2018052320180523
UniProtAcc

O75689

Q6P1Q9

Ensembl transtripts involved in fusion geneENST00000265846, ENST00000449296, 
ENST00000539900, ENST00000463358, 
ENST00000262432, ENST00000480046, 
ENST00000473488, 
Fusion gene scores* DoF score8 X 5 X 7=2803 X 3 X 3=27
# samples 93
** MAII scorelog2(9/280*10)=-1.63742992061529
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ADAP1 [Title/Abstract] AND METTL2B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLIHCTCGA-XR-A8TD-01AADAP1chr7

994032

-METTL2Bchr7

128141816

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000265846ENST00000262432ADAP1chr7

994032

-METTL2Bchr7

128141816

+
In-frameENST00000265846ENST00000480046ADAP1chr7

994032

-METTL2Bchr7

128141816

+
5CDS-intronENST00000265846ENST00000473488ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-3CDSENST00000449296ENST00000262432ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-3CDSENST00000449296ENST00000480046ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-intronENST00000449296ENST00000473488ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-3CDSENST00000539900ENST00000262432ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-3CDSENST00000539900ENST00000480046ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-intronENST00000539900ENST00000473488ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-3CDSENST00000463358ENST00000262432ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-3CDSENST00000463358ENST00000480046ADAP1chr7

994032

-METTL2Bchr7

128141816

+
intron-intronENST00000463358ENST00000473488ADAP1chr7

994032

-METTL2Bchr7

128141816

+

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FusionProtFeatures for ADAP1_METTL2B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ADAP1

O75689

METTL2B

Q6P1Q9

GTPase-activating protein for the ADP ribosylationfactor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate(InsP4). {ECO:0000269|PubMed:10448098,ECO:0000303|PubMed:10333475, ECO:0000305}. Probable S-adenosyl-L-methionine-dependentmethyltransferase that mediates 3-methylcytidine modification ofsome tRNAs. {ECO:0000269|PubMed:21518805}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADAP1chr7:994032chr7:128141816ENST00000265846-111129_23027375DomainPH 1
HgeneADAP1chr7:994032chr7:128141816ENST00000265846-111252_35627375DomainPH 2
HgeneADAP1chr7:994032chr7:128141816ENST00000265846-1117_12627375DomainArf-GAP
HgeneADAP1chr7:994032chr7:128141816ENST00000265846-11121_4427375Zinc fingerC4-type


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FusionGeneSequence for ADAP1_METTL2B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_ADAP1_ENST00000265846_chr7_994032_-_METTL2B_ENST00000262432_chr7_128141816_+_79aa

>In-frame_ADAP1_ENST00000265846_chr7_994032_-_METTL2B_ENST00000480046_chr7_128141816_+_79aa


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_ADAP1_ENST00000265846_chr7_994032_-_METTL2B_ENST00000262432_chr7_128141816_+_237nt
ATGGCCAAGGAGCGGCGCAGGGCGGTCCTGGAGCTGCTGCAGCGGCCGGGGAACGCGCGCTGCGCGGACTGCGGCGCCCCGGAGGAACTG
GACACGCTTTTCACCACTGCTGGACTGGAAAAAGTTCAGAATCTGGTGGACCGCCGACTGCAGGTGAACCGAGGGAAGCAACTGACAATG

>In-frame_ADAP1_ENST00000265846_chr7_994032_-_METTL2B_ENST00000480046_chr7_128141816_+_237nt
ATGGCCAAGGAGCGGCGCAGGGCGGTCCTGGAGCTGCTGCAGCGGCCGGGGAACGCGCGCTGCGCGGACTGCGGCGCCCCGGAGGAACTG
GACACGCTTTTCACCACTGCTGGACTGGAAAAAGTTCAGAATCTGGTGGACCGCCGACTGCAGGTGAACCGAGGGAAGCAACTGACAATG


* Fusion transcript sequences (Full-length transcript).
>In-frame_ADAP1_ENST00000265846_chr7_994032_-_METTL2B_ENST00000262432_chr7_128141816_+_1465nt
CCGGGCCCCGCGCCGGCACTCGCTCAGCGACCGCGGCGGAGACACGAGCGGCGGCGGCGGAGCCCAGAGGGCGGCGGGAATGCGGAACCG
GCGCGCGGGCTGAGGCCGCCCGGGATGGCGCAGGGGCGGCGGCGGCGGGCGGCCTGCGCGGGGCCCTAGCGAGCCGGGCTGACGCTCCCG
GCCCCGGCCCCGGCATCGGCATCGCGGGCGCATCGCGGCCATGGCCAAGGAGCGGCGCAGGGCGGTCCTGGAGCTGCTGCAGCGGCCGGG
GAACGCGCGCTGCGCGGACTGCGGCGCCCCGGAGGAACTGGACACGCTTTTCACCACTGCTGGACTGGAAAAAGTTCAGAATCTGGTGGA
CCGCCGACTGCAGGTGAACCGAGGGAAGCAACTGACAATGTACCGGGTTTGGATTCAGTGCAAATACTGCAAGCCCCTTCTGTCCAGCAC
CAGCTAAGAGGCACCTGCTGCCAACACGATGCAAGCCCGTTGTGTTTCCGAGCTTTTTTAAAAAAAAATTTGTAGCACCGGGCATGGTGC
ATGCCTGTAATCCCAGCCACTCAGGAGGCTGAGGCAGGGAGGATCCATTGAGCCCAGGAGTCCAGCCTGGGCAAAATAGCGAGAGACCCT
GAATCTGAAAGTAATGATAAAATAAAAAGAATATAAATGAGGTCTCGTTGATGCTGGACAATTCAAGAATTCAGACTTGAACCTTAAACC
TAGGAAAAGTTACTTTGTATCAGGATTCTAACAATTATGCTTCATATTTGTGAAGTCCTTTAAAACATAATTTTCTCAAGTTCTTTCTTT
GAGACCTCAATCTGTCTTAGCATTTTGTAACTAATAACTGAAATTTTATTCAAAGGAATTGTAAACCTTAAACCACCATTTATTTCCATG
TGAAAAAGTGTTATATATGACAAGTGTTTTTTGATTGTAATTGCGTTAAATCTTTTGAGAGTGTAAATGCCGGGCTAGGCAATTGCAGTT
AATACATACAGGGGTTAGTGAAGGGCTTATTAAGTTGTAGGGGAAGCAAGCTGGGAAGAATCAGATCAGATATTTTCCTGACAAGAAAAA
AATGACCCTGTAGACAGCATCAAAATGTGGTGTTCTTGTTAAGTAATTGATCGTGGTCTTTGCTTTAATCTTAGTTCCGCCAGGCACGGT
GGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCGTGGCCAACATGGT
GAAACCCCGTCTCTACTAAAGATAAAAAAATTAGCTGGGTGTGTTGGTGGGTGCCTGTAATCCAGCTACTCGGGAGGCTGAGGCAGGAGA
ATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGCCACTGTACTCCAGCCTGGGCAACAAAGCAAGACTCTGTCTCAA

>In-frame_ADAP1_ENST00000265846_chr7_994032_-_METTL2B_ENST00000480046_chr7_128141816_+_5143nt
CCGGGCCCCGCGCCGGCACTCGCTCAGCGACCGCGGCGGAGACACGAGCGGCGGCGGCGGAGCCCAGAGGGCGGCGGGAATGCGGAACCG
GCGCGCGGGCTGAGGCCGCCCGGGATGGCGCAGGGGCGGCGGCGGCGGGCGGCCTGCGCGGGGCCCTAGCGAGCCGGGCTGACGCTCCCG
GCCCCGGCCCCGGCATCGGCATCGCGGGCGCATCGCGGCCATGGCCAAGGAGCGGCGCAGGGCGGTCCTGGAGCTGCTGCAGCGGCCGGG
GAACGCGCGCTGCGCGGACTGCGGCGCCCCGGAGGAACTGGACACGCTTTTCACCACTGCTGGACTGGAAAAAGTTCAGAATCTGGTGGA
CCGCCGACTGCAGGTGAACCGAGGGAAGCAACTGACAATGTACCGGGTTTGGATTCAGTGCAAATACTGCAAGCCCCTTCTGTCCAGCAC
CAGCTAAGAGGCACCTGCTGCCAACACGATGCAAGCCCGTTGTGTTTCCGAGCTTTTTTAAAAAAAAATTTGTAGCACCGGGCATGGTGC
ATGCCTGTAATCCCAGCCACTCAGGAGGCTGAGGCAGGGAGGATCCATTGAGCCCAGGAGTCCAGCCTGGGCAAAATAGCGAGAGACCCT
GAATCTGAAAGTAATGATAAAATAAAAAGAATATAAATGAGGTCTCGTTGATGCTGGACAATTCAAGAATTCAGACTTGAACCTTAAACC
TAGGAAAAGTTACTTTGTATCAGGATTCTAACAATTATGCTTCATATTTGTGAAGTCCTTTAAAACATAATTTTCTCAAGTTCTTTCTTT
GAGACCTCAATCTGTCTTAGCATTTTGTAACTAATAACTGAAATTTTATTCAAAGGAATTGTAAACCTTAAACCACCATTTATTTCCATG
TGAAAAAGTGTTATATATGACAAGTGTTTTTTGATTGTAATTGCGTTAAATCTTTTGAGAGTGTAAATGCCGGGCTAGGCAATTGCAGTT
AATACATACAGGGGTTAGTGAAGGGCTTATTAAGTTGTAGGGGAAGCAAGCTGGGAAGAATCAGATCAGATATTTTCCTGACAAGAAAAA
AATGACCCTGTAGACAGCATCAAAATGTGGTGTTCTTGTTAAGTAATTGATCGTGGTCTTTGCTTTAATCTTAGTTCCGCCAGGCACGGT
GGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCGTGGCCAACATGGT
GAAACCCCGTCTCTACTAAAGATAAAAAAATTAGCTGGGTGTGTTGGTGGGTGCCTGTAATCCAGCTACTCGGGAGGCTGAGGCAGGAGA
ATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGCCACTGTACTCCAGCCTGGGCAACAAAGCAAGACTCTGTCTCAA
AAAAATAAAAATAAAAAAAATCTTAGTTCCATGGAATTTTAAGCACTGTTCCCCCTCTAACCTATGTCTAAAGAATTAAAAGAATTTGGC
TGGGTGCGGTAGCTCATGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCAGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCT
AACACGGTGAAACCTCGTCTCCACTAAAAATACCAAAAAAAATAGCTGGGCATGGTGGCATGCGCCTGTAGTCCCCTGTAGTCCCAGCTA
CTCGGGAGGCTAAGGCAGGAGAATCGTTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGTCACTGCATTCCAGCCTGGGCA
ACAGAGGAAGACTCTGTCTCAAAAAAATAAAAGAAAAGAATTTTCACTTTTTGCAAAATTATCTTTTTTTACTGCACCCTTAAGTGTTTG
ACACAAAAGGAATTGAGAGAACTTCTTAATTTTAACCACATCATCACTTCACTTCTGAATGTGATCACTGTCAGTGTTAGATGCTTTTTT
TTTTTTTTTTTAGGAGACAGGGCTCTCACTTTGTTGCCCAGGCTGGAGTTCAGTGGTGCAATGATAGCTCATTATCACCTCGAACTTCTG
GCTTGAGCCATCGCTCCACCTCAGCCTCCTGAGTAGCTAGGACTGCAGGTGGGCACCATCATGCCTAGCTAATTGTTAGATCCTTTTTTT
TTATGTTCTGCATTTTTTCAATTATTTTTACATATTTCTGTCTTGATCCATGCAGTTATAGGATATATCCTTAATTTTAGAAAGTAAGGA
CTTTTCGACCAGGCATGGCGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCCAGT
CCAGCCCGGCTAACATAGTGAAACCCCGTCTCCACTAAAAAATAAAAAATCAGCCCGGCATGGTTGTGGGCGCCTGTAATCCCAGCTACT
CAGGAGGCTGAGGTAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATGGTGCCATTGCACTCCAGCCTGGGCGAC
AAGAGCGAAACTGCATCTCAAAAACAAAGATGCCTAGCTTTCACCTTGTTGATGTTTTTCTAAATTTTGGAATAATAAATTTATATAGGA
ATACTGCAAGAATAGTCCATTTTTTTCTGATGTCCCAACATCAGCAAATATATTACCAAATATATCCATCACAAGTAGGAATACATGGAA
ACATTAATGCCAGCCACTAACCATTCATGTTTACCCAGTAGTCCCAATAATAGCTTTGTCACACAAAAACATGATTATGTTGGCTGGGCA
CAGTGGCTCCTGTAATCTTAGCATTTTGGGAGCCCAAGGCAGGAGGATGACTTGAGGCCAGGAGTTCAAGACCAGGCTGGGTAATGTAGC
AAGACCCTGACTTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTACAATGGCACGATCTCGGCTCACT
GCAATCTCCACCTCCCAAGTTTAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGAATTACAGGCATGCAGCACCATTCCCAGCTAA
ATTTTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCAGGCTGATCTCGAACTCCCGACCTCAGGTGATCTGCCCGCCTCAGC
CTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCGGCCAAGACCCTGACTTTTTAAAAAATGTTAAACATAGGCCGGGTGCAG
TGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCATTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACTTAA
TGAAACCCCATCTCTGCTAACAATACAGACCAGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGTGGATCA
CCTGAGGTCGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATAGCCAGGTGTGATGGCGCAT
GCCTGTAACCCCATCTACTTGGAAGGCTGAGGCAGGAGAATCACTTGAATCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATGGCGCCATT
GCACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCAAAAAAAAAAAAAAAAAAAAATTAGCTGGGCATGGTGGTGGGCGCCTGTAAT
CCCAGCTATCTGGGAGGCTGAGTCTAGAGAATCATTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAG
CCTGGGCAACAGTGAGACTCCGTCTCAAAATAAAAAAACAAAAAAAATGTAAAAAATAAATAATTGTATTGAATTTATTAGTTGTGTCTC
AGTCTCCTTCAGTCTACAGTTTAGGCTTGCTTTTGCACCTTTGCATTTTAAGGTAAGAGGCTATTGTGTAAACTCGAATTGGGTTTGTTG
GTGTTTCTTCATGATTTGGTTCAGGCTCTGCATTTTGGGCAGGAATATTCAGAGGTGATGCTGTGTTCCTCCCATAGGATCGTATCAGGC
GACACATGATTATGAATTTCCCCATTATTGGTGATGTCACTTAGTTGTGTTGTCTGCCAGGTTCTGCCACTGTAAAGTTAATAAGTATTT
TGTAGGGAAGTGCTTTGAGACTAAATATCCTGTTCCTCATCAAACTTCTACCCCCTAGTTTCAGTATCTATTGCTGTTTTTTGTCTGAAT
AACTATGATAGTTGCCAAATAGTGGTTTCTGATCCTTCCATTCCTTCTACACTGATTGGTTGGTATTTTGTACAGAAAAGCTTTCTCATA
TCTGATTTACTTGTCTCAATATGGACCCATGGGTATTTGAGTTTCTTGTGGGGTTATTTGTTGTTGTTTTTGAGACAGGCTCACCCAGGC
TGGAGTGCAGCAGCACGATCACTGCTTACTGCTTACTGCAGCCTCGACCTCCCATGCTCAAGTGATTCTCCCACCCCAGCCTCCCAAGTA
GATGGGACTACAGGCATGTGCCACCAAGCCTAATTTTTGTATTTTTTGTAGAGACAGGGTTTCACCATGTGTCCCAGGCTGGTCTTGAGC
TCCTGAGCTCAAGCAATCCTCCCACCTCGGCCTCCCAAAGTGCTGGGATGAGCCACCGTGACTGGCCCCACTTAATGGGTTTTCAGAGGT
GGGAGCAAAGAATGAAGGGAGGAAGAGAGCTCCCATCTTTTCCATTACCGTATTTACTTAAAACTGGAAAAAACTGAATCACTGGGATGG
TATTTCATTTATCTTTTGAAATGAAGAATAGATACATTAATTTAAATGATTCTCTAAAGACTGTCCTTCAGCATCCCTAAAGCATTGCAA
AACTATAGGCACAGTTTTTATTTTATCTTTCTGGCACCTGGTTTGGGCTTTGGCTTAGATTAAAAAGACGAGCCTTCTCCTGCCCCTGCT
CCCTTTTATTCCCTGCCATCTGCTAAGCTCGACTTTTTATCTCTCAGGCCAAATTTGACTCTGTAAGGGACTTTGCATAACGTTTCATCC
TCAGAATCGCTAATGATGGGCAGAGGACTGTTACATGTGTTGGGAGGGATTAAAGTATATGACCTCAGTGCCACTTAAAAAATAAATACT


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FusionGenePPI for ADAP1_METTL2B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ADAP1PRKCI, PRKCZ, PIK3CA, PRKD1, PRKCE, PSME3, CSNK1A1, NCL, ANP32A, GSK3B, GADD45A, RANBP9, DVL3, GOLGA2, SDCBP2, ARF6METTL2BAPP, MAPK3, CENPU, METTL2A, NAT16, TPM3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ADAP1_METTL2B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ADAP1_METTL2B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource