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Fusion gene ID: 774 |
FusionGeneSummary for ADAP1_METTL2B |
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Fusion gene information | Fusion gene name: ADAP1_METTL2B | Fusion gene ID: 774 | Hgene | Tgene | Gene symbol | ADAP1 | METTL2B | Gene ID | 11033 | 55798 |
Gene name | ArfGAP with dual PH domains 1 | methyltransferase like 2B | |
Synonyms | CENTA1|GCS1L|p42IP4 | METL|METTL2|METTL2A|PSENIP1 | |
Cytomap | 7p22.3 | 7q32.1 | |
Type of gene | protein-coding | protein-coding | |
Description | arf-GAP with dual PH domain-containing protein 1centaurin-alphacentaurin-alpha-1cnt-a1putative MAPK-activating protein PM25 | methyltransferase-like protein 2B | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | O75689 | Q6P1Q9 | |
Ensembl transtripts involved in fusion gene | ENST00000265846, ENST00000449296, ENST00000539900, ENST00000463358, | ENST00000262432, ENST00000480046, ENST00000473488, | |
Fusion gene scores | * DoF score | 8 X 5 X 7=280 | 3 X 3 X 3=27 |
# samples | 9 | 3 | |
** MAII score | log2(9/280*10)=-1.63742992061529 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: ADAP1 [Title/Abstract] AND METTL2B [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | LD | LIHC | TCGA-XR-A8TD-01A | ADAP1 | chr7 | 994032 | - | METTL2B | chr7 | 128141816 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000265846 | ENST00000262432 | ADAP1 | chr7 | 994032 | - | METTL2B | chr7 | 128141816 | + |
In-frame | ENST00000265846 | ENST00000480046 | ADAP1 | chr7 | 994032 | - | METTL2B | chr7 | 128141816 | + |
5CDS-intron | ENST00000265846 | ENST00000473488 | ADAP1 | chr7 | 994032 | - | METTL2B | chr7 | 128141816 | + |
intron-3CDS | ENST00000449296 | ENST00000262432 | ADAP1 | chr7 | 994032 | - | METTL2B | chr7 | 128141816 | + |
intron-3CDS | ENST00000449296 | ENST00000480046 | ADAP1 | chr7 | 994032 | - | METTL2B | chr7 | 128141816 | + |
intron-intron | ENST00000449296 | ENST00000473488 | ADAP1 | chr7 | 994032 | - | METTL2B | chr7 | 128141816 | + |
intron-3CDS | ENST00000539900 | ENST00000262432 | ADAP1 | chr7 | 994032 | - | METTL2B | chr7 | 128141816 | + |
intron-3CDS | ENST00000539900 | ENST00000480046 | ADAP1 | chr7 | 994032 | - | METTL2B | chr7 | 128141816 | + |
intron-intron | ENST00000539900 | ENST00000473488 | ADAP1 | chr7 | 994032 | - | METTL2B | chr7 | 128141816 | + |
intron-3CDS | ENST00000463358 | ENST00000262432 | ADAP1 | chr7 | 994032 | - | METTL2B | chr7 | 128141816 | + |
intron-3CDS | ENST00000463358 | ENST00000480046 | ADAP1 | chr7 | 994032 | - | METTL2B | chr7 | 128141816 | + |
intron-intron | ENST00000463358 | ENST00000473488 | ADAP1 | chr7 | 994032 | - | METTL2B | chr7 | 128141816 | + |
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FusionProtFeatures for ADAP1_METTL2B |
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Hgene | Tgene |
ADAP1 | METTL2B |
GTPase-activating protein for the ADP ribosylationfactor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate(InsP4). {ECO:0000269|PubMed:10448098,ECO:0000303|PubMed:10333475, ECO:0000305}. | Probable S-adenosyl-L-methionine-dependentmethyltransferase that mediates 3-methylcytidine modification ofsome tRNAs. {ECO:0000269|PubMed:21518805}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | >ADAP1 | chr7:994032 | chr7:128141816 | ENST00000265846 | - | 1 | 11 | 129_230 | 27 | 375 | Domain | PH 1 |
Hgene | >ADAP1 | chr7:994032 | chr7:128141816 | ENST00000265846 | - | 1 | 11 | 252_356 | 27 | 375 | Domain | PH 2 |
Hgene | >ADAP1 | chr7:994032 | chr7:128141816 | ENST00000265846 | - | 1 | 11 | 7_126 | 27 | 375 | Domain | Arf-GAP |
Hgene | >ADAP1 | chr7:994032 | chr7:128141816 | ENST00000265846 | - | 1 | 11 | 21_44 | 27 | 375 | Zinc finger | C4-type |
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FusionGeneSequence for ADAP1_METTL2B |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_ADAP1_ENST00000265846_chr7_994032_-_METTL2B_ENST00000262432_chr7_128141816_+_79aa >In-frame_ADAP1_ENST00000265846_chr7_994032_-_METTL2B_ENST00000480046_chr7_128141816_+_79aa |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_ADAP1_ENST00000265846_chr7_994032_-_METTL2B_ENST00000262432_chr7_128141816_+_237nt ATGGCCAAGGAGCGGCGCAGGGCGGTCCTGGAGCTGCTGCAGCGGCCGGGGAACGCGCGCTGCGCGGACTGCGGCGCCCCGGAGGAACTG GACACGCTTTTCACCACTGCTGGACTGGAAAAAGTTCAGAATCTGGTGGACCGCCGACTGCAGGTGAACCGAGGGAAGCAACTGACAATG >In-frame_ADAP1_ENST00000265846_chr7_994032_-_METTL2B_ENST00000480046_chr7_128141816_+_237nt ATGGCCAAGGAGCGGCGCAGGGCGGTCCTGGAGCTGCTGCAGCGGCCGGGGAACGCGCGCTGCGCGGACTGCGGCGCCCCGGAGGAACTG GACACGCTTTTCACCACTGCTGGACTGGAAAAAGTTCAGAATCTGGTGGACCGCCGACTGCAGGTGAACCGAGGGAAGCAACTGACAATG |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_ADAP1_ENST00000265846_chr7_994032_-_METTL2B_ENST00000262432_chr7_128141816_+_1465nt CCGGGCCCCGCGCCGGCACTCGCTCAGCGACCGCGGCGGAGACACGAGCGGCGGCGGCGGAGCCCAGAGGGCGGCGGGAATGCGGAACCG GCGCGCGGGCTGAGGCCGCCCGGGATGGCGCAGGGGCGGCGGCGGCGGGCGGCCTGCGCGGGGCCCTAGCGAGCCGGGCTGACGCTCCCG GCCCCGGCCCCGGCATCGGCATCGCGGGCGCATCGCGGCCATGGCCAAGGAGCGGCGCAGGGCGGTCCTGGAGCTGCTGCAGCGGCCGGG GAACGCGCGCTGCGCGGACTGCGGCGCCCCGGAGGAACTGGACACGCTTTTCACCACTGCTGGACTGGAAAAAGTTCAGAATCTGGTGGA CCGCCGACTGCAGGTGAACCGAGGGAAGCAACTGACAATGTACCGGGTTTGGATTCAGTGCAAATACTGCAAGCCCCTTCTGTCCAGCAC CAGCTAAGAGGCACCTGCTGCCAACACGATGCAAGCCCGTTGTGTTTCCGAGCTTTTTTAAAAAAAAATTTGTAGCACCGGGCATGGTGC ATGCCTGTAATCCCAGCCACTCAGGAGGCTGAGGCAGGGAGGATCCATTGAGCCCAGGAGTCCAGCCTGGGCAAAATAGCGAGAGACCCT GAATCTGAAAGTAATGATAAAATAAAAAGAATATAAATGAGGTCTCGTTGATGCTGGACAATTCAAGAATTCAGACTTGAACCTTAAACC TAGGAAAAGTTACTTTGTATCAGGATTCTAACAATTATGCTTCATATTTGTGAAGTCCTTTAAAACATAATTTTCTCAAGTTCTTTCTTT GAGACCTCAATCTGTCTTAGCATTTTGTAACTAATAACTGAAATTTTATTCAAAGGAATTGTAAACCTTAAACCACCATTTATTTCCATG TGAAAAAGTGTTATATATGACAAGTGTTTTTTGATTGTAATTGCGTTAAATCTTTTGAGAGTGTAAATGCCGGGCTAGGCAATTGCAGTT AATACATACAGGGGTTAGTGAAGGGCTTATTAAGTTGTAGGGGAAGCAAGCTGGGAAGAATCAGATCAGATATTTTCCTGACAAGAAAAA AATGACCCTGTAGACAGCATCAAAATGTGGTGTTCTTGTTAAGTAATTGATCGTGGTCTTTGCTTTAATCTTAGTTCCGCCAGGCACGGT GGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCGTGGCCAACATGGT GAAACCCCGTCTCTACTAAAGATAAAAAAATTAGCTGGGTGTGTTGGTGGGTGCCTGTAATCCAGCTACTCGGGAGGCTGAGGCAGGAGA ATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGCCACTGTACTCCAGCCTGGGCAACAAAGCAAGACTCTGTCTCAA >In-frame_ADAP1_ENST00000265846_chr7_994032_-_METTL2B_ENST00000480046_chr7_128141816_+_5143nt CCGGGCCCCGCGCCGGCACTCGCTCAGCGACCGCGGCGGAGACACGAGCGGCGGCGGCGGAGCCCAGAGGGCGGCGGGAATGCGGAACCG GCGCGCGGGCTGAGGCCGCCCGGGATGGCGCAGGGGCGGCGGCGGCGGGCGGCCTGCGCGGGGCCCTAGCGAGCCGGGCTGACGCTCCCG GCCCCGGCCCCGGCATCGGCATCGCGGGCGCATCGCGGCCATGGCCAAGGAGCGGCGCAGGGCGGTCCTGGAGCTGCTGCAGCGGCCGGG GAACGCGCGCTGCGCGGACTGCGGCGCCCCGGAGGAACTGGACACGCTTTTCACCACTGCTGGACTGGAAAAAGTTCAGAATCTGGTGGA CCGCCGACTGCAGGTGAACCGAGGGAAGCAACTGACAATGTACCGGGTTTGGATTCAGTGCAAATACTGCAAGCCCCTTCTGTCCAGCAC CAGCTAAGAGGCACCTGCTGCCAACACGATGCAAGCCCGTTGTGTTTCCGAGCTTTTTTAAAAAAAAATTTGTAGCACCGGGCATGGTGC ATGCCTGTAATCCCAGCCACTCAGGAGGCTGAGGCAGGGAGGATCCATTGAGCCCAGGAGTCCAGCCTGGGCAAAATAGCGAGAGACCCT GAATCTGAAAGTAATGATAAAATAAAAAGAATATAAATGAGGTCTCGTTGATGCTGGACAATTCAAGAATTCAGACTTGAACCTTAAACC TAGGAAAAGTTACTTTGTATCAGGATTCTAACAATTATGCTTCATATTTGTGAAGTCCTTTAAAACATAATTTTCTCAAGTTCTTTCTTT GAGACCTCAATCTGTCTTAGCATTTTGTAACTAATAACTGAAATTTTATTCAAAGGAATTGTAAACCTTAAACCACCATTTATTTCCATG TGAAAAAGTGTTATATATGACAAGTGTTTTTTGATTGTAATTGCGTTAAATCTTTTGAGAGTGTAAATGCCGGGCTAGGCAATTGCAGTT AATACATACAGGGGTTAGTGAAGGGCTTATTAAGTTGTAGGGGAAGCAAGCTGGGAAGAATCAGATCAGATATTTTCCTGACAAGAAAAA AATGACCCTGTAGACAGCATCAAAATGTGGTGTTCTTGTTAAGTAATTGATCGTGGTCTTTGCTTTAATCTTAGTTCCGCCAGGCACGGT GGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCGTGGCCAACATGGT GAAACCCCGTCTCTACTAAAGATAAAAAAATTAGCTGGGTGTGTTGGTGGGTGCCTGTAATCCAGCTACTCGGGAGGCTGAGGCAGGAGA ATCACTTGAACCCAGGAGGCAGAGGTTGCAGTGAGCTGAGATTGCGCCACTGTACTCCAGCCTGGGCAACAAAGCAAGACTCTGTCTCAA AAAAATAAAAATAAAAAAAATCTTAGTTCCATGGAATTTTAAGCACTGTTCCCCCTCTAACCTATGTCTAAAGAATTAAAAGAATTTGGC TGGGTGCGGTAGCTCATGCCTGTAATCCCAACACTTTGGGAGGCTGAGGCAGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCT AACACGGTGAAACCTCGTCTCCACTAAAAATACCAAAAAAAATAGCTGGGCATGGTGGCATGCGCCTGTAGTCCCCTGTAGTCCCAGCTA CTCGGGAGGCTAAGGCAGGAGAATCGTTTGAACCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATCATGTCACTGCATTCCAGCCTGGGCA ACAGAGGAAGACTCTGTCTCAAAAAAATAAAAGAAAAGAATTTTCACTTTTTGCAAAATTATCTTTTTTTACTGCACCCTTAAGTGTTTG ACACAAAAGGAATTGAGAGAACTTCTTAATTTTAACCACATCATCACTTCACTTCTGAATGTGATCACTGTCAGTGTTAGATGCTTTTTT TTTTTTTTTTTAGGAGACAGGGCTCTCACTTTGTTGCCCAGGCTGGAGTTCAGTGGTGCAATGATAGCTCATTATCACCTCGAACTTCTG GCTTGAGCCATCGCTCCACCTCAGCCTCCTGAGTAGCTAGGACTGCAGGTGGGCACCATCATGCCTAGCTAATTGTTAGATCCTTTTTTT TTATGTTCTGCATTTTTTCAATTATTTTTACATATTTCTGTCTTGATCCATGCAGTTATAGGATATATCCTTAATTTTAGAAAGTAAGGA CTTTTCGACCAGGCATGGCGGCTCACGCCTATAATCCCAGCACTTTGGGAGGCTGAGGTGGGCAGATCACTTGAGGTCAGGAGTTCCAGT CCAGCCCGGCTAACATAGTGAAACCCCGTCTCCACTAAAAAATAAAAAATCAGCCCGGCATGGTTGTGGGCGCCTGTAATCCCAGCTACT CAGGAGGCTGAGGTAGGAGAATTGCTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCTGAGATGGTGCCATTGCACTCCAGCCTGGGCGAC AAGAGCGAAACTGCATCTCAAAAACAAAGATGCCTAGCTTTCACCTTGTTGATGTTTTTCTAAATTTTGGAATAATAAATTTATATAGGA ATACTGCAAGAATAGTCCATTTTTTTCTGATGTCCCAACATCAGCAAATATATTACCAAATATATCCATCACAAGTAGGAATACATGGAA ACATTAATGCCAGCCACTAACCATTCATGTTTACCCAGTAGTCCCAATAATAGCTTTGTCACACAAAAACATGATTATGTTGGCTGGGCA CAGTGGCTCCTGTAATCTTAGCATTTTGGGAGCCCAAGGCAGGAGGATGACTTGAGGCCAGGAGTTCAAGACCAGGCTGGGTAATGTAGC AAGACCCTGACTTTTTTTTTTTTTTTTTTTGAGATGGAGTTTCGCTCTTGTTGCCCAGGCTGGAGTACAATGGCACGATCTCGGCTCACT GCAATCTCCACCTCCCAAGTTTAAGTGATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGAATTACAGGCATGCAGCACCATTCCCAGCTAA ATTTTTTGTATTTTTAGTAGAGACAAGGTTTCTCCATGTTGGTCAGGCTGATCTCGAACTCCCGACCTCAGGTGATCTGCCCGCCTCAGC CTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCACGCCCGGCCAAGACCCTGACTTTTTAAAAAATGTTAAACATAGGCCGGGTGCAG TGGCTCACGCCTGTAATCCCAGCACTTTGGGAGGCCGAGGTGGGCGGATCATTTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACTTAA TGAAACCCCATCTCTGCTAACAATACAGACCAGGCATGGTGGCTCACACCTGTAATCCCAGCACTTTGAGAGACCGAGGCAGGTGGATCA CCTGAGGTCGGGAGTTCGAGACCAGCCTGACCAACATGGAGAAACCCCGTCTCTACTAAAAATACAAAATAGCCAGGTGTGATGGCGCAT GCCTGTAACCCCATCTACTTGGAAGGCTGAGGCAGGAGAATCACTTGAATCTGGGAGGCAGAGGTTGCAGTGAGCCGAGATGGCGCCATT GCACTCCAGCCTGGGCAACAAGAGTGAAACTCCGTCTCAAAAAAAAAAAAAAAAAAAAATTAGCTGGGCATGGTGGTGGGCGCCTGTAAT CCCAGCTATCTGGGAGGCTGAGTCTAGAGAATCATTTGAACCTGGGAGGCGGAGGTTGCAGTGAGCCGAGATCGCACCATTGCACTCCAG CCTGGGCAACAGTGAGACTCCGTCTCAAAATAAAAAAACAAAAAAAATGTAAAAAATAAATAATTGTATTGAATTTATTAGTTGTGTCTC AGTCTCCTTCAGTCTACAGTTTAGGCTTGCTTTTGCACCTTTGCATTTTAAGGTAAGAGGCTATTGTGTAAACTCGAATTGGGTTTGTTG GTGTTTCTTCATGATTTGGTTCAGGCTCTGCATTTTGGGCAGGAATATTCAGAGGTGATGCTGTGTTCCTCCCATAGGATCGTATCAGGC GACACATGATTATGAATTTCCCCATTATTGGTGATGTCACTTAGTTGTGTTGTCTGCCAGGTTCTGCCACTGTAAAGTTAATAAGTATTT TGTAGGGAAGTGCTTTGAGACTAAATATCCTGTTCCTCATCAAACTTCTACCCCCTAGTTTCAGTATCTATTGCTGTTTTTTGTCTGAAT AACTATGATAGTTGCCAAATAGTGGTTTCTGATCCTTCCATTCCTTCTACACTGATTGGTTGGTATTTTGTACAGAAAAGCTTTCTCATA TCTGATTTACTTGTCTCAATATGGACCCATGGGTATTTGAGTTTCTTGTGGGGTTATTTGTTGTTGTTTTTGAGACAGGCTCACCCAGGC TGGAGTGCAGCAGCACGATCACTGCTTACTGCTTACTGCAGCCTCGACCTCCCATGCTCAAGTGATTCTCCCACCCCAGCCTCCCAAGTA GATGGGACTACAGGCATGTGCCACCAAGCCTAATTTTTGTATTTTTTGTAGAGACAGGGTTTCACCATGTGTCCCAGGCTGGTCTTGAGC TCCTGAGCTCAAGCAATCCTCCCACCTCGGCCTCCCAAAGTGCTGGGATGAGCCACCGTGACTGGCCCCACTTAATGGGTTTTCAGAGGT GGGAGCAAAGAATGAAGGGAGGAAGAGAGCTCCCATCTTTTCCATTACCGTATTTACTTAAAACTGGAAAAAACTGAATCACTGGGATGG TATTTCATTTATCTTTTGAAATGAAGAATAGATACATTAATTTAAATGATTCTCTAAAGACTGTCCTTCAGCATCCCTAAAGCATTGCAA AACTATAGGCACAGTTTTTATTTTATCTTTCTGGCACCTGGTTTGGGCTTTGGCTTAGATTAAAAAGACGAGCCTTCTCCTGCCCCTGCT CCCTTTTATTCCCTGCCATCTGCTAAGCTCGACTTTTTATCTCTCAGGCCAAATTTGACTCTGTAAGGGACTTTGCATAACGTTTCATCC TCAGAATCGCTAATGATGGGCAGAGGACTGTTACATGTGTTGGGAGGGATTAAAGTATATGACCTCAGTGCCACTTAAAAAATAAATACT 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FusionGenePPI for ADAP1_METTL2B |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
ADAP1 | PRKCI, PRKCZ, PIK3CA, PRKD1, PRKCE, PSME3, CSNK1A1, NCL, ANP32A, GSK3B, GADD45A, RANBP9, DVL3, GOLGA2, SDCBP2, ARF6 | METTL2B | APP, MAPK3, CENPU, METTL2A, NAT16, TPM3 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADAP1_METTL2B |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ADAP1_METTL2B |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |