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Fusion gene ID: 7739 |
FusionGeneSummary for CNOT8_PROL1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CNOT8_PROL1 | Fusion gene ID: 7739 | Hgene | Tgene | Gene symbol | CNOT8 | PROL1 | Gene ID | 9337 | 58503 |
| Gene name | CCR4-NOT transcription complex subunit 8 | opiorphin prepropeptide | |
| Synonyms | CAF1|CALIF|Caf1b|POP2|hCAF1 | BPLP|PRL1|PROL1|opiorphin | |
| Cytomap | 5q33.2 | 4q13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CCR4-NOT transcription complex subunit 8CAF1-like proteinCAF2CALIFpCCR4-associated factor 8PGK promoter directed over production | opiorphin prepropeptidebasic proline-rich lacrimal proteinbasic proline-rich proteinproline rich, lacrimal 1proline-rich 1proline-rich protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UFF9 | ||
| Ensembl transtripts involved in fusion gene | ENST00000523698, ENST00000517876, ENST00000521450, ENST00000403027, ENST00000524105, ENST00000285896, ENST00000520671, ENST00000521583, ENST00000519404, ENST00000521402, | ENST00000399575, ENST00000514338, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 1 X 1 X 1=1 |
| # samples | 2 | 1 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: CNOT8 [Title/Abstract] AND PROL1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CNOT8 | GO:0043928 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 20065043 |
| Tgene | PROL1 | GO:0051930 | regulation of sensory perception of pain | 17101991 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | UCS | TCGA-NA-A4QW-01A | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000523698 | ENST00000399575 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| intron-3UTR | ENST00000523698 | ENST00000514338 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| Frame-shift | ENST00000517876 | ENST00000399575 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| 5CDS-3UTR | ENST00000517876 | ENST00000514338 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| intron-3CDS | ENST00000521450 | ENST00000399575 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| intron-3UTR | ENST00000521450 | ENST00000514338 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| Frame-shift | ENST00000403027 | ENST00000399575 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| 5CDS-3UTR | ENST00000403027 | ENST00000514338 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| 5UTR-3CDS | ENST00000524105 | ENST00000399575 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| 5UTR-3UTR | ENST00000524105 | ENST00000514338 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| Frame-shift | ENST00000285896 | ENST00000399575 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| 5CDS-3UTR | ENST00000285896 | ENST00000514338 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| 5UTR-3CDS | ENST00000520671 | ENST00000399575 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| 5UTR-3UTR | ENST00000520671 | ENST00000514338 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| 5UTR-3CDS | ENST00000521583 | ENST00000399575 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| 5UTR-3UTR | ENST00000521583 | ENST00000514338 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| Frame-shift | ENST00000519404 | ENST00000399575 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| 5CDS-3UTR | ENST00000519404 | ENST00000514338 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| 3UTR-3CDS | ENST00000521402 | ENST00000399575 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
| 3UTR-3UTR | ENST00000521402 | ENST00000514338 | CNOT8 | chr5 | 154244945 | + | PROL1 | chr4 | 71275097 | + |
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FusionProtFeatures for CNOT8_PROL1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CNOT8 | PROL1 |
| Has 3'-5' poly(A) exoribonuclease activity for syntheticpoly(A) RNA substrate. Its function seems to be partiallyredundant with that of CNOT7. Catalytic component of the CCR4-NOTcomplex which is linked to various cellular processes includingbulk mRNA degradation, miRNA-mediated repression, translationalrepression during translational initiation and generaltranscription regulation. During miRNA-mediated repression thecomplex seems also to act as translational repressor duringtranslational initiation. Additional complex functions may be aconsequence of its influence on mRNA expression. Associates withmembers of the BTG family such as TOB1 and BTG2 and is requiredfor their anti-proliferative activity.{ECO:0000269|PubMed:12771185, ECO:0000269|PubMed:19605561,ECO:0000269|PubMed:20065043, ECO:0000269|PubMed:23236473}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CNOT8_PROL1 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CNOT8_PROL1 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CNOT8 | BTG1, CNOT1, CNOT10, MCM7, BTG2, CNOT3, PRMT1, ELAVL1, VCP, TOB2, TNRC6C, CNOT2, FCGR3B, CT55, MMP7, CAPZA2, AURKA, TNRC6A, TNRC6B, AGO2, UNK, USP11, LDHD, RC3H1, ZFP36, NANOS2, CNOT11, TEX13A, TOB1, RIBC1, GADD45B, GPBP1L1 | PROL1 | DDX31, RNGTT |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CNOT8_PROL1 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CNOT8_PROL1 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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