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Fusion gene ID: 7734 |
FusionGeneSummary for CNOT6L_AKT3 |
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Fusion gene information | Fusion gene name: CNOT6L_AKT3 | Fusion gene ID: 7734 | Hgene | Tgene | Gene symbol | CNOT6L | AKT3 | Gene ID | 246175 | 10000 |
Gene name | CCR4-NOT transcription complex subunit 6 like | AKT serine/threonine kinase 3 | |
Synonyms | CCR4b | MPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2 | |
Cytomap | 4q21.1 | 1q43-q44 | |
Type of gene | protein-coding | protein-coding | |
Description | CCR4-NOT transcription complex subunit 6-likecarbon catabolite repressor protein 4 homolog B | RAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma) | |
Modification date | 20180519 | 20180523 | |
UniProtAcc | Q96LI5 | Q9Y243 | |
Ensembl transtripts involved in fusion gene | ENST00000504123, ENST00000264903, ENST00000506166, | ENST00000336199, ENST00000366540, ENST00000366539, ENST00000263826, ENST00000492957, | |
Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 8 X 7 X 4=224 |
# samples | 1 | 9 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(9/224*10)=-1.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CNOT6L [Title/Abstract] AND AKT3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | AKT3 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 28254819 |
Tgene | AKT3 | GO:1905564 | positive regulation of vascular endothelial cell proliferation | 28254819 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA479228 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-intron | ENST00000504123 | ENST00000336199 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000504123 | ENST00000366540 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000504123 | ENST00000366539 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000504123 | ENST00000263826 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000504123 | ENST00000492957 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000264903 | ENST00000336199 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000264903 | ENST00000366540 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000264903 | ENST00000366539 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000264903 | ENST00000263826 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000264903 | ENST00000492957 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000506166 | ENST00000336199 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000506166 | ENST00000366540 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000506166 | ENST00000366539 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000506166 | ENST00000263826 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
intron-intron | ENST00000506166 | ENST00000492957 | CNOT6L | chr4 | 78636227 | - | AKT3 | chr1 | 244013430 | - |
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FusionProtFeatures for CNOT6L_AKT3 |
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Hgene | Tgene |
CNOT6L | AKT3 |
Has 3'-5' poly(A) exoribonuclease activity for syntheticpoly(A) RNA substrate. Catalytic component of the CCR4-NOT complexwhich is one of the major cellular mRNA deadenylases and is linkedto various cellular processes including bulk mRNA degradation,miRNA-mediated repression, translational repression duringtranslational initiation and general transcription regulation.Additional complex functions may be a consequence of its influenceon mRNA expression. May be involved in the deadenylation-dependentdegradation of mRNAs through the 3'-UTR AU-rich element-mediatedmechanism. Involved in deadenylation-dependent degradation ofCDKN1B mRNA. Its mRNA deadenylase activity can be inhibited byTOB1. Mediates cell proliferation and cell survival and preventscellular senescence. {ECO:0000269|PubMed:17452450,ECO:0000269|PubMed:21233283}. | AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, andwhich regulate many processes including metabolism, proliferation,cell survival, growth and angiogenesis. This is mediated throughserine and/or threonine phosphorylation of a range of downstreamsubstrates. Over 100 substrate candidates have been reported sofar, but for most of them, no isoform specificity has beenreported. AKT3 is the least studied AKT isoform. It plays animportant role in brain development and is crucial for theviability of malignant glioma cells. AKT3 isoform may also be thekey molecule in up-regulation and down-regulation of MMP13 viaIL13. Required for the coordination of mitochondrial biogenesiswith growth factor-induced increases in cellular energy demands.Down-regulation by RNA interference reduces the expression of thephosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868,ECO:0000269|PubMed:21191416}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CNOT6L_AKT3 |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CNOT6L_AKT3 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CNOT6L_AKT3 |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CNOT6L_AKT3 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | AKT3 | C4014738 | MEGALENCEPHALY-POLYMICROGYRIA-POLYDACTYLY-HYDROCEPHALUS SYNDROME 2 | 3 | UNIPROT |
Tgene | AKT3 | C1863924 | Megalanecephaly Polymicrogyria-Polydactyly Hydrocephalus Syndrome | 1 | CTD_human |
Tgene | AKT3 | C1955869 | Malformations of Cortical Development | 1 | CTD_human |