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Fusion gene ID: 7706 |
FusionGeneSummary for CNOT2_CEP290 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: CNOT2_CEP290 | Fusion gene ID: 7706 | Hgene | Tgene | Gene symbol | CNOT2 | CEP290 | Gene ID | 4848 | 80184 |
| Gene name | CCR4-NOT transcription complex subunit 2 | centrosomal protein 290 | |
| Synonyms | CDC36|HSPC131|NOT2|NOT2H | 3H11Ag|BBS14|CT87|JBTS5|LCA10|MKS4|NPHP6|POC3|SLSN6|rd16 | |
| Cytomap | 12q15 | 12q21.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | CCR4-NOT transcription complex subunit 2CCR4-associated factor 2negative regulator of transcription 2 | centrosomal protein of 290 kDaBardet-Biedl syndrome 14 proteinCTCL tumor antigen se2-2Meckel syndrome, type 4POC3 centriolar protein homologcancer/testis antigen 87centrosomal protein 290kDamonoclonal antibody 3H11 antigennephrocytsin-6prostate c | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9NZN8 | O15078 | |
| Ensembl transtripts involved in fusion gene | ENST00000229195, ENST00000418359, ENST00000548230, ENST00000551483, | ENST00000547691, ENST00000552810, ENST00000397838, ENST00000309041, | |
| Fusion gene scores | * DoF score | 26 X 8 X 9=1872 | 5 X 5 X 3=75 |
| # samples | 25 | 5 | |
| ** MAII score | log2(25/1872*10)=-2.90458043492132 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: CNOT2 [Title/Abstract] AND CEP290 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | CNOT2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 14707134|16712523 |
| Tgene | CEP290 | GO:0045893 | positive regulation of transcription, DNA-templated | 16682973 |
| Tgene | CEP290 | GO:0060271 | cilium assembly | 26386044 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | SARC | TCGA-WK-A8XO-01A | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000229195 | ENST00000547691 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| In-frame | ENST00000229195 | ENST00000552810 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| In-frame | ENST00000229195 | ENST00000397838 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| In-frame | ENST00000229195 | ENST00000309041 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| In-frame | ENST00000418359 | ENST00000547691 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| In-frame | ENST00000418359 | ENST00000552810 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| In-frame | ENST00000418359 | ENST00000397838 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| In-frame | ENST00000418359 | ENST00000309041 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| intron-3CDS | ENST00000548230 | ENST00000547691 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| intron-3CDS | ENST00000548230 | ENST00000552810 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| intron-3CDS | ENST00000548230 | ENST00000397838 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| intron-3CDS | ENST00000548230 | ENST00000309041 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| intron-3CDS | ENST00000551483 | ENST00000547691 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| intron-3CDS | ENST00000551483 | ENST00000552810 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| intron-3CDS | ENST00000551483 | ENST00000397838 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
| intron-3CDS | ENST00000551483 | ENST00000309041 | CNOT2 | chr12 | 70672054 | + | CEP290 | chr12 | 88483264 | - |
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FusionProtFeatures for CNOT2_CEP290 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| CNOT2 | CEP290 |
| Component of the CCR4-NOT complex which is one of themajor cellular mRNA deadenylases and is linked to various cellularprocesses including bulk mRNA degradation, miRNA-mediatedrepression, translational repression during translationalinitiation and general transcription regulation. Additionalcomplex functions may be a consequence of its influence on mRNAexpression. Required for the CCR4-NOT complex structuralintegrity. Can repress transcription and may link the CCR4-NOTcomplex to transcriptional regulation; the repressive function mayspecifically involve the N-Cor repressor complex containing HDAC3,NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES)cell identity. {ECO:0000269|PubMed:14707134,ECO:0000269|PubMed:16712523, ECO:0000269|PubMed:21299754,ECO:0000269|PubMed:22367759}. | Involved in early and late steps in cilia formation. Itsassociation with CCP110 is required for inhibition of primarycilia formation by CCP110 (PubMed:18694559). May play a role inearly ciliogenesis in the disappearance of centriolar satellitesand in the transition of primary ciliar vesicles (PCVs) to cappedciliary vesicles (CCVs). Required for the centrosomal recruitmentof RAB8A and for the targeting of centriole satellite proteins tocentrosomes such as of PCM1 (PubMed:24421332). Required for thecorrect localization of ciliary and phototransduction proteins inretinal photoreceptor cells; may play a role in ciliary transportprocesses (By similarity). Required for efficient recruitment ofRAB8A to primary cilium (PubMed:17705300). In the ciliarytransition zone is part of the tectonic-like complex which isrequired for tissue-specific ciliogenesis and may regulate ciliarymembrane composition (By similarity). Involved in regulation ofthe BBSome complex integrity, specifically for presence of BBS2,BBS5 and BBS8/TTC8 in the complex, and in ciliary targeting ofselected BBSome cargos. May play a role in controlling entry ofthe BBSome complex to cilia possibly implicating IQCB1/NPHP5(PubMed:25552655). Activates ATF4-mediated transcription(PubMed:16682973). {ECO:0000250|UniProtKB:Q6A078,ECO:0000269|PubMed:16682973, ECO:0000269|PubMed:17705300,ECO:0000269|PubMed:18694559, ECO:0000269|PubMed:24421332,ECO:0000269|PubMed:25552655}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000397838 | - | 21 | 46 | 1071_1498 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000397838 | - | 21 | 46 | 1533_1584 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000397838 | - | 21 | 46 | 1635_2452 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000397838 | - | 21 | 46 | 598_664 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000397838 | - | 21 | 46 | 697_931 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000397838 | - | 21 | 46 | 958_1027 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000547691 | - | 4 | 29 | 1071_1498 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000547691 | - | 4 | 29 | 1533_1584 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000547691 | - | 4 | 29 | 1635_2452 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000547691 | - | 4 | 29 | 598_664 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000547691 | - | 4 | 29 | 697_931 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000547691 | - | 4 | 29 | 958_1027 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000552810 | - | 29 | 54 | 1533_1584 | 1191 | 2480 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000552810 | - | 29 | 54 | 1635_2452 | 1191 | 2480 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000397838 | - | 21 | 46 | 1966_2479 | 251 | 1540 | Region | Self-association (with itself or N-terminus) |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000547691 | - | 4 | 29 | 1966_2479 | 251 | 1540 | Region | Self-association (with itself or N-terminus) |
| Tgene | >CEP290 | chr12:70672054 | chr12:88483264 | ENST00000552810 | - | 29 | 54 | 1966_2479 | 1191 | 2480 | Region | Self-association (with itself or N-terminus) |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >CNOT2 | chr12:70672054 | chr12:88483264 | ENST00000229195 | + | 2 | 16 | 437_540 | 16 | 541 | Region | Note=Repressor domain |
| Hgene | >CNOT2 | chr12:70672054 | chr12:88483264 | ENST00000418359 | + | 3 | 17 | 437_540 | 16 | 541 | Region | Note=Repressor domain |
| Hgene | >CNOT2 | chr12:70672054 | chr12:88483264 | ENST00000551483 | + | 1 | 7 | 437_540 | -1385 | 192 | Region | Note=Repressor domain |
| Tgene | CEP290 | chr12:70672054 | chr12:88483264 | ENST00000397838 | - | 21 | 46 | 59_565 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CEP290 | chr12:70672054 | chr12:88483264 | ENST00000547691 | - | 4 | 29 | 59_565 | 251 | 1540 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CEP290 | chr12:70672054 | chr12:88483264 | ENST00000552810 | - | 29 | 54 | 1071_1498 | 1191 | 2480 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CEP290 | chr12:70672054 | chr12:88483264 | ENST00000552810 | - | 29 | 54 | 598_664 | 1191 | 2480 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CEP290 | chr12:70672054 | chr12:88483264 | ENST00000552810 | - | 29 | 54 | 59_565 | 1191 | 2480 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CEP290 | chr12:70672054 | chr12:88483264 | ENST00000552810 | - | 29 | 54 | 697_931 | 1191 | 2480 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CEP290 | chr12:70672054 | chr12:88483264 | ENST00000552810 | - | 29 | 54 | 958_1027 | 1191 | 2480 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | CEP290 | chr12:70672054 | chr12:88483264 | ENST00000397838 | - | 21 | 46 | 1_695 | 251 | 1540 | Region | Self-association (with itself or C-terminus) |
| Tgene | CEP290 | chr12:70672054 | chr12:88483264 | ENST00000547691 | - | 4 | 29 | 1_695 | 251 | 1540 | Region | Self-association (with itself or C-terminus) |
| Tgene | CEP290 | chr12:70672054 | chr12:88483264 | ENST00000552810 | - | 29 | 54 | 1_695 | 1191 | 2480 | Region | Self-association (with itself or C-terminus) |
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FusionGeneSequence for CNOT2_CEP290 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_CNOT2_ENST00000229195_chr12_70672054_+_CEP290_ENST00000547691_chr12_88483264_-_1305aa MVRTDGHTLSEKRNYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQ TIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELR LQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDP SLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTL KIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE MEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEAN SRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEAL KTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKE LEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIEL KFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMAN IEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRG PQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLR LANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEV >In-frame_CNOT2_ENST00000229195_chr12_70672054_+_CEP290_ENST00000552810_chr12_88483264_-_1305aa MVRTDGHTLSEKRNYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQ TIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELR LQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDP SLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTL KIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE MEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEAN SRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEAL KTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKE LEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIEL KFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMAN IEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRG PQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLR LANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEV >In-frame_CNOT2_ENST00000229195_chr12_70672054_+_CEP290_ENST00000397838_chr12_88483264_-_1305aa MVRTDGHTLSEKRNYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQ TIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELR LQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDP SLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTL KIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE MEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEAN SRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEAL KTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKE LEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIEL KFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMAN IEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRG PQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLR LANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEV >In-frame_CNOT2_ENST00000229195_chr12_70672054_+_CEP290_ENST00000309041_chr12_88483264_-_1305aa MVRTDGHTLSEKRNYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQ TIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELR LQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDP SLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTL KIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE MEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEAN SRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEAL KTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKE LEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIEL KFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMAN IEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRG PQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLR LANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEV >In-frame_CNOT2_ENST00000418359_chr12_70672054_+_CEP290_ENST00000547691_chr12_88483264_-_1305aa MVRTDGHTLSEKRNYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQ TIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELR LQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDP SLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTL KIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE MEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEAN SRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEAL KTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKE LEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIEL KFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMAN IEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRG PQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLR LANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEV >In-frame_CNOT2_ENST00000418359_chr12_70672054_+_CEP290_ENST00000552810_chr12_88483264_-_1305aa MVRTDGHTLSEKRNYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQ TIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELR LQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDP SLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTL KIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE MEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEAN SRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEAL KTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKE LEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIEL KFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMAN IEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRG PQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLR LANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEV >In-frame_CNOT2_ENST00000418359_chr12_70672054_+_CEP290_ENST00000397838_chr12_88483264_-_1305aa MVRTDGHTLSEKRNYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQ TIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELR LQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDP SLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTL KIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE MEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEAN SRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEAL KTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKE LEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIEL KFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMAN IEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRG PQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLR LANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEV >In-frame_CNOT2_ENST00000418359_chr12_70672054_+_CEP290_ENST00000309041_chr12_88483264_-_1305aa MVRTDGHTLSEKRNYQAQSDEKSLIAKLHQHNVSLQLSEATALGKLESITSKLQKMEAYNLRLEQKLDEKEQALYYARLEGRNRAKHLRQ TIQSLRRQFSGALPLAQQEKFSKTMIQLQNDKLKIMQEMKNSQQEHRNMENKTLEMELKLKGLEELISTLKDTKGAQKVINWHMKIEELR LQELKLNRELVKDKEEIKYLNNIISEYERTISSLEEEIVQQNKFHEERQMAWDQREVDLERQLDIFDRQQNEILNAAQKFEEATGSIPDP SLPLPNQLEIALRKIKENIRIILETRATCKSLEEKLKEKESALRLAEQNILSRDKVINELRLRLPATAEREKLIAELGRKEMEPKSHHTL KIAHQTIANMQARLNQKEEVLKKYQRLLEKAREEQREIVKKHEEDLHILHHRLELQADSSLNKFKQTAWDLMKQSPTPVPTNKHFIRLAE MEQTVAEQDDSLSSLLVKLKKVSQDLERQREITELKVKEFENIKLQLQENHEDEVKKVKAEVEDLKYLLDQSQKESQCLKSELQAQKEAN SRAPTTTMRNLVERLKSQLALKEKQQKALSRALLELRAEMTAAAEERIISATSQKEAHLNVQQIVDRHTRELKTQVEDLNENLLKLKEAL KTSKNRENSLTDNLNDLNNELQKKQKAYNKILREKEEIDQENDELKRQIKRLTSGLQGKPLTDNKQSLIEELQRKVKKLENQLEGKVEEV DLKPMKEKNAKEELIRWEEGKKWQAKIEGIRNKLKEKEGEVFTLTKQLNTLKDLFAKADKEKLTLQRKLKTTGMTVDQVLGIRALESEKE LEELKKRNLDLENDILYMRAHQALPRDSVVEDLHLQNRYLQEKLHALEKQFSKDTYSKPSISGIESDDHCQREQELQKENLKLSSENIEL KFQLEQANKDLPRLKNQVRDLKEMCEFLKKEKAEVQRKLGHVRGSGRSGKTIPELEKTIGLMKKVVEKVQRENEQLKKASGILTSEKMAN IEQENEKLKAELEKLKAHLGHQLSMHYESKTKGTEKIIAENERLRKELKKETDAAEKLRIAKNNLEILNEKMTVQLEETGKRLQFAESRG PQLEGADSKSWKSIVVTRMYETKLKELETDIAKKNQSITDLKQLVKEATEREQKVNKYNEDLEQQIKILKHVPEGAETEQGLKRELQVLR LANHQLDKEKAELIHQIEANKDQSGAESTIPDADQLKEKIKDLETQLKMSDLEKQHLKEEIKKLKKELENFDPSFFEEIEDLKYNYKEEV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_CNOT2_ENST00000229195_chr12_70672054_+_CEP290_ENST00000547691_chr12_88483264_-_3915nt ATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCACAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCAA CATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAGTCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAAC TTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCTCGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCAA ACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAACAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAAT GACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGAAATATGGAGAACAAAACATTGGAGATGGAATTAAAATTA AAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAAAAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCGT CTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATAAAATATTTGAATAACATAATTTCTGAATATGAACGTACA ATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAAAGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGAA CGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCACAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCCT AGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAGAACATTCGAATAATTCTAGAAACACGGGCAACTTGCAAA TCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAACAAAATATACTGTCAAGAGACAAAGTAATCAATGAACTG AGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTAGGCAGAAAAGAGATGGAACCAAAATCTCACCACACATTG AAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAAGAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAAA GCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCATATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTCA CTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACTCCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGAG ATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTCAAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAGA GAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTTCAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGCG GAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAGTGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAAT TCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGCCAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAGT CGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGTATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAAT GTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAAGATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACTT AAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTAAATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAAA ATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGGCAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACCC CTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAAAAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGTA GACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGGGAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAATT CGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAGTTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAAA GAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGATCAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGAA TTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTATATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGTA GAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTAGAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTCA ATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAGAAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACTG AAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAAGTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAAA GAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGAAGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGGT TTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAAAAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAAT ATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCTCATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAAG ACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAACTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGATA GCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGGT CCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGAT ATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGAA GACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAGA TTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCATA CCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGAA ATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGTG AAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGAG >In-frame_CNOT2_ENST00000229195_chr12_70672054_+_CEP290_ENST00000552810_chr12_88483264_-_3915nt ATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCACAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCAA CATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAGTCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAAC TTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCTCGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCAA ACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAACAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAAT GACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGAAATATGGAGAACAAAACATTGGAGATGGAATTAAAATTA AAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAAAAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCGT CTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATAAAATATTTGAATAACATAATTTCTGAATATGAACGTACA ATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAAAGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGAA CGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCACAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCCT AGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAGAACATTCGAATAATTCTAGAAACACGGGCAACTTGCAAA TCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAACAAAATATACTGTCAAGAGACAAAGTAATCAATGAACTG AGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTAGGCAGAAAAGAGATGGAACCAAAATCTCACCACACATTG AAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAAGAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAAA GCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCATATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTCA CTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACTCCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGAG ATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTCAAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAGA GAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTTCAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGCG GAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAGTGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAAT TCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGCCAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAGT CGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGTATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAAT GTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAAGATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACTT AAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTAAATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAAA ATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGGCAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACCC CTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAAAAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGTA GACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGGGAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAATT CGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAGTTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAAA GAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGATCAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGAA TTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTATATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGTA GAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTAGAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTCA ATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAGAAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACTG AAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAAGTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAAA GAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGAAGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGGT TTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAAAAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAAT ATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCTCATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAAG ACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAACTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGATA GCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGGT CCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGAT ATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGAA GACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAGA TTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCATA CCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGAA ATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGTG AAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGAG >In-frame_CNOT2_ENST00000229195_chr12_70672054_+_CEP290_ENST00000397838_chr12_88483264_-_3915nt ATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCACAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCAA CATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAGTCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAAC TTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCTCGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCAA ACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAACAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAAT GACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGAAATATGGAGAACAAAACATTGGAGATGGAATTAAAATTA AAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAAAAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCGT CTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATAAAATATTTGAATAACATAATTTCTGAATATGAACGTACA ATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAAAGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGAA CGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCACAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCCT AGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAGAACATTCGAATAATTCTAGAAACACGGGCAACTTGCAAA TCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAACAAAATATACTGTCAAGAGACAAAGTAATCAATGAACTG AGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTAGGCAGAAAAGAGATGGAACCAAAATCTCACCACACATTG AAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAAGAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAAA GCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCATATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTCA CTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACTCCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGAG ATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTCAAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAGA GAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTTCAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGCG GAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAGTGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAAT TCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGCCAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAGT CGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGTATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAAT GTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAAGATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACTT AAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTAAATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAAA ATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGGCAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACCC CTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAAAAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGTA GACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGGGAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAATT CGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAGTTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAAA GAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGATCAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGAA TTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTATATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGTA GAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTAGAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTCA ATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAGAAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACTG AAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAAGTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAAA GAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGAAGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGGT TTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAAAAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAAT ATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCTCATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAAG ACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAACTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGATA GCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGGT CCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGAT ATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGAA GACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAGA TTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCATA CCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGAA ATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGTG AAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGAG >In-frame_CNOT2_ENST00000229195_chr12_70672054_+_CEP290_ENST00000309041_chr12_88483264_-_3915nt ATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCACAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCAA CATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAGTCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAAC TTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCTCGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCAA ACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAACAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAAT GACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGAAATATGGAGAACAAAACATTGGAGATGGAATTAAAATTA AAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAAAAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCGT CTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATAAAATATTTGAATAACATAATTTCTGAATATGAACGTACA ATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAAAGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGAA CGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCACAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCCT AGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAGAACATTCGAATAATTCTAGAAACACGGGCAACTTGCAAA TCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAACAAAATATACTGTCAAGAGACAAAGTAATCAATGAACTG AGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTAGGCAGAAAAGAGATGGAACCAAAATCTCACCACACATTG AAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAAGAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAAA GCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCATATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTCA CTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACTCCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGAG ATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTCAAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAGA GAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTTCAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGCG GAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAGTGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAAT TCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGCCAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAGT CGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGTATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAAT GTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAAGATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACTT AAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTAAATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAAA ATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGGCAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACCC CTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAAAAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGTA GACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGGGAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAATT CGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAGTTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAAA GAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGATCAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGAA TTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTATATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGTA GAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTAGAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTCA ATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAGAAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACTG AAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAAGTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAAA GAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGAAGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGGT TTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAAAAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAAT ATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCTCATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAAG ACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAACTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGATA GCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGGT CCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGAT ATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGAA GACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAGA TTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCATA CCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGAA ATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGTG AAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGAG >In-frame_CNOT2_ENST00000418359_chr12_70672054_+_CEP290_ENST00000547691_chr12_88483264_-_3915nt ATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCACAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCAA CATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAGTCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAAC TTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCTCGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCAA ACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAACAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAAT GACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGAAATATGGAGAACAAAACATTGGAGATGGAATTAAAATTA AAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAAAAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCGT CTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATAAAATATTTGAATAACATAATTTCTGAATATGAACGTACA ATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAAAGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGAA CGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCACAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCCT AGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAGAACATTCGAATAATTCTAGAAACACGGGCAACTTGCAAA TCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAACAAAATATACTGTCAAGAGACAAAGTAATCAATGAACTG AGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTAGGCAGAAAAGAGATGGAACCAAAATCTCACCACACATTG AAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAAGAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAAA GCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCATATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTCA CTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACTCCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGAG ATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTCAAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAGA GAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTTCAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGCG GAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAGTGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAAT TCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGCCAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAGT CGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGTATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAAT GTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAAGATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACTT AAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTAAATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAAA ATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGGCAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACCC CTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAAAAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGTA GACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGGGAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAATT CGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAGTTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAAA GAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGATCAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGAA TTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTATATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGTA GAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTAGAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTCA ATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAGAAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACTG AAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAAGTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAAA GAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGAAGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGGT TTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAAAAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAAT ATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCTCATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAAG ACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAACTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGATA GCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGGT CCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGAT ATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGAA GACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAGA TTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCATA CCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGAA ATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGTG AAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGAG >In-frame_CNOT2_ENST00000418359_chr12_70672054_+_CEP290_ENST00000552810_chr12_88483264_-_3915nt ATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCACAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCAA CATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAGTCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAAC TTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCTCGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCAA ACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAACAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAAT GACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGAAATATGGAGAACAAAACATTGGAGATGGAATTAAAATTA AAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAAAAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCGT CTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATAAAATATTTGAATAACATAATTTCTGAATATGAACGTACA ATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAAAGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGAA CGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCACAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCCT AGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAGAACATTCGAATAATTCTAGAAACACGGGCAACTTGCAAA TCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAACAAAATATACTGTCAAGAGACAAAGTAATCAATGAACTG AGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTAGGCAGAAAAGAGATGGAACCAAAATCTCACCACACATTG AAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAAGAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAAA GCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCATATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTCA CTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACTCCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGAG ATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTCAAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAGA GAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTTCAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGCG GAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAGTGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAAT TCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGCCAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAGT CGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGTATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAAT GTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAAGATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACTT AAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTAAATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAAA ATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGGCAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACCC CTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAAAAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGTA GACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGGGAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAATT CGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAGTTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAAA GAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGATCAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGAA TTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTATATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGTA GAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTAGAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTCA ATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAGAAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACTG AAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAAGTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAAA GAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGAAGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGGT TTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAAAAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAAT ATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCTCATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAAG ACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAACTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGATA GCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGGT CCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGAT ATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGAA GACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAGA TTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCATA CCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGAA ATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGTG AAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGAG >In-frame_CNOT2_ENST00000418359_chr12_70672054_+_CEP290_ENST00000397838_chr12_88483264_-_3915nt ATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCACAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCAA CATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAGTCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAAC TTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCTCGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCAA ACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAACAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAAT GACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGAAATATGGAGAACAAAACATTGGAGATGGAATTAAAATTA AAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAAAAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCGT CTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATAAAATATTTGAATAACATAATTTCTGAATATGAACGTACA ATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAAAGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGAA CGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCACAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCCT AGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAGAACATTCGAATAATTCTAGAAACACGGGCAACTTGCAAA TCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAACAAAATATACTGTCAAGAGACAAAGTAATCAATGAACTG AGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTAGGCAGAAAAGAGATGGAACCAAAATCTCACCACACATTG AAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAAGAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAAA GCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCATATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTCA CTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACTCCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGAG ATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTCAAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAGA GAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTTCAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGCG GAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAGTGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAAT TCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGCCAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAGT CGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGTATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAAT GTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAAGATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACTT AAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTAAATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAAA ATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGGCAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACCC CTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAAAAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGTA GACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGGGAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAATT CGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAGTTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAAA GAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGATCAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGAA TTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTATATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGTA GAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTAGAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTCA ATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAGAAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACTG AAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAAGTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAAA GAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGAAGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGGT TTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAAAAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAAT ATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCTCATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAAG ACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAACTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGATA GCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGGT CCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGAT ATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGAA GACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAGA TTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCATA CCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGAA ATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGTG AAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGAG >In-frame_CNOT2_ENST00000418359_chr12_70672054_+_CEP290_ENST00000309041_chr12_88483264_-_3915nt ATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCACAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCAA CATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAGTCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAAC TTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCTCGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCAA ACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAACAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAAT GACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGAAATATGGAGAACAAAACATTGGAGATGGAATTAAAATTA AAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAAAAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCGT CTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATAAAATATTTGAATAACATAATTTCTGAATATGAACGTACA ATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAAAGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGAA CGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCACAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCCT AGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAGAACATTCGAATAATTCTAGAAACACGGGCAACTTGCAAA TCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAACAAAATATACTGTCAAGAGACAAAGTAATCAATGAACTG AGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTAGGCAGAAAAGAGATGGAACCAAAATCTCACCACACATTG AAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAAGAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAAA GCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCATATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTCA CTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACTCCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGAG ATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTCAAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAGA GAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTTCAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGCG GAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAGTGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAAT TCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGCCAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAGT CGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGTATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAAT GTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAAGATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACTT AAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTAAATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAAA ATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGGCAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACCC CTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAAAAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGTA GACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGGGAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAATT CGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAGTTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAAA GAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGATCAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGAA TTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTATATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGTA GAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTAGAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTCA ATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAGAAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACTG AAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAAGTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAAA GAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGAAGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGGT TTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAAAAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAAT ATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCTCATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAAG ACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAACTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGATA GCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGGT CCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGAT ATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGAA GACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAGA TTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCATA CCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGAA ATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGTG AAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGAG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_CNOT2_ENST00000229195_chr12_70672054_+_CEP290_ENST00000547691_chr12_88483264_-_4662nt AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCA CAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCAACATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAG TCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAACTTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCT CGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCAAACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAA CAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAATGACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGA AATATGGAGAACAAAACATTGGAGATGGAATTAAAATTAAAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAA AAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCGTCTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATA AAATATTTGAATAACATAATTTCTGAATATGAACGTACAATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAA AGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGAACGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCA CAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCCTAGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAG AACATTCGAATAATTCTAGAAACACGGGCAACTTGCAAATCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAA CAAAATATACTGTCAAGAGACAAAGTAATCAATGAACTGAGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTA GGCAGAAAAGAGATGGAACCAAAATCTCACCACACATTGAAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAA GAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAAAGCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCAT ATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTCACTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACT CCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGAGATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTC AAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAGAGAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTT CAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGCGGAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAG TGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAATTCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGC CAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAGTCGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGT ATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAATGTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAA GATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACTTAAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTA AATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAAAATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGG CAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACCCCTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAA AAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGTAGACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGG GAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAATTCGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAG TTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAAAGAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGAT CAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGAATTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTAT ATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGTAGAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTA GAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTCAATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAG AAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACTGAAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAA GTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAAAGAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGA AGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGGTTTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAA AAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAATATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCT CATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAAGACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAA CTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGATAGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAA GAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGGTCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACA AGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGATATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAA GCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGAAGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAG ACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAGATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATA GAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCATACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTC AAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGAAATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAA GAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGTGAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTG GGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGAGTTTGAAGATGAAGAAGAAAGTCCTGTTAATTTCCCCATTTACTAAAGGTCA CCTATAAACTTTGTTTCATTTAACTATTTATTAACTTTATAAGTTAAATATACTTGGAAATAAGCAGTTCTCCGAACTGTAGTATTTCCT >In-frame_CNOT2_ENST00000229195_chr12_70672054_+_CEP290_ENST00000552810_chr12_88483264_-_4658nt AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCA CAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCAACATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAG TCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAACTTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCT CGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCAAACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAA CAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAATGACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGA AATATGGAGAACAAAACATTGGAGATGGAATTAAAATTAAAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAA AAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCGTCTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATA AAATATTTGAATAACATAATTTCTGAATATGAACGTACAATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAA AGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGAACGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCA CAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCCTAGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAG AACATTCGAATAATTCTAGAAACACGGGCAACTTGCAAATCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAA CAAAATATACTGTCAAGAGACAAAGTAATCAATGAACTGAGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTA GGCAGAAAAGAGATGGAACCAAAATCTCACCACACATTGAAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAA GAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAAAGCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCAT ATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTCACTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACT CCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGAGATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTC AAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAGAGAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTT CAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGCGGAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAG TGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAATTCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGC CAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAGTCGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGT ATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAATGTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAA GATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACTTAAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTA AATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAAAATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGG CAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACCCCTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAA AAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGTAGACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGG GAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAATTCGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAG TTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAAAGAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGAT CAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGAATTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTAT ATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGTAGAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTA GAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTCAATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAG AAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACTGAAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAA GTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAAAGAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGA AGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGGTTTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAA AAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAATATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCT CATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAAGACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAA CTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGATAGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAA GAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGGTCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACA AGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGATATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAA GCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGAAGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAG ACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAGATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATA GAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCATACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTC AAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGAAATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAA GAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGTGAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTG GGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGAGTTTGAAGATGAAGAAGAAAGTCCTGTTAATTTCCCCATTTACTAAAGGTCA CCTATAAACTTTGTTTCATTTAACTATTTATTAACTTTATAAGTTAAATATACTTGGAAATAAGCAGTTCTCCGAACTGTAGTATTTCCT >In-frame_CNOT2_ENST00000229195_chr12_70672054_+_CEP290_ENST00000397838_chr12_88483264_-_4494nt AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCA CAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCAACATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAG TCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAACTTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCT CGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCAAACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAA CAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAATGACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGA AATATGGAGAACAAAACATTGGAGATGGAATTAAAATTAAAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAA AAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCGTCTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATA AAATATTTGAATAACATAATTTCTGAATATGAACGTACAATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAA AGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGAACGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCA CAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCCTAGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAG AACATTCGAATAATTCTAGAAACACGGGCAACTTGCAAATCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAA CAAAATATACTGTCAAGAGACAAAGTAATCAATGAACTGAGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTA GGCAGAAAAGAGATGGAACCAAAATCTCACCACACATTGAAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAA GAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAAAGCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCAT ATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTCACTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACT CCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGAGATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTC AAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAGAGAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTT CAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGCGGAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAG TGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAATTCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGC CAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAGTCGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGT ATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAATGTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAA GATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACTTAAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTA AATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAAAATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGG CAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACCCCTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAA AAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGTAGACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGG GAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAATTCGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAG TTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAAAGAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGAT CAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGAATTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTAT ATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGTAGAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTA GAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTCAATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAG AAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACTGAAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAA GTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAAAGAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGA AGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGGTTTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAA AAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAATATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCT CATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAAGACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAA CTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGATAGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAA GAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGGTCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACA AGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGATATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAA GCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGAAGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAG ACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAGATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATA GAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCATACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTC AAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGAAATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAA GAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGTGAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTG >In-frame_CNOT2_ENST00000229195_chr12_70672054_+_CEP290_ENST00000309041_chr12_88483264_-_4494nt AACACAAACACAAACACGAACACGAACACGCTCAGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCC GCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTCTGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGT AACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTGAGTCGGTGGGAGACAAGACGGAGCGGCGGTAAGGGCGGTAGGGAAGTGAAGCGCCTC TCTCCACCTTGTTAGAAGCGCGCTGAAAGCGGCCTGCCTACCCACCCCATCGCTGCCGTTTTGCAGTCGTCGCTCCCACCTTCCGCTGCC GCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGCGGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGC CATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGGAGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTAT TTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTCTATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCA CAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCAACATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAG TCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAACTTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCT CGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCAAACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAA CAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAATGACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGA AATATGGAGAACAAAACATTGGAGATGGAATTAAAATTAAAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAA AAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCGTCTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATA AAATATTTGAATAACATAATTTCTGAATATGAACGTACAATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAA AGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGAACGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCA CAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCCTAGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAG AACATTCGAATAATTCTAGAAACACGGGCAACTTGCAAATCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAA CAAAATATACTGTCAAGAGACAAAGTAATCAATGAACTGAGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTA GGCAGAAAAGAGATGGAACCAAAATCTCACCACACATTGAAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAA GAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAAAGCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCAT ATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTCACTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACT CCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGAGATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTC AAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAGAGAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTT CAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGCGGAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAG TGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAATTCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGC CAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAGTCGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGT ATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAATGTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAA GATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACTTAAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTA AATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAAAATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGG CAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACCCCTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAA AAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGTAGACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGG GAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAATTCGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAG TTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAAAGAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGAT CAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGAATTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTAT ATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGTAGAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTA GAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTCAATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAG AAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACTGAAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAA GTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAAAGAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGA AGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGGTTTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAA AAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAATATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCT CATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAAGACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAA CTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGATAGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAA GAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGGTCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACA AGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGATATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAA GCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGAAGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAG ACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAGATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATA GAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCATACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTC AAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGAAATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAA GAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGTGAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTG >In-frame_CNOT2_ENST00000418359_chr12_70672054_+_CEP290_ENST00000547691_chr12_88483264_-_4534nt AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCACAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCA ACATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAGTCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAA CTTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCTCGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCA AACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAACAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAA TGACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGAAATATGGAGAACAAAACATTGGAGATGGAATTAAAATT AAAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAAAAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCG TCTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATAAAATATTTGAATAACATAATTTCTGAATATGAACGTAC AATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAAAGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGA ACGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCACAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCC TAGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAGAACATTCGAATAATTCTAGAAACACGGGCAACTTGCAA ATCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAACAAAATATACTGTCAAGAGACAAAGTAATCAATGAACT GAGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTAGGCAGAAAAGAGATGGAACCAAAATCTCACCACACATT GAAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAAGAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAA AGCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCATATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTC ACTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACTCCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGA GATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTCAAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAG AGAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTTCAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGC GGAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAGTGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAA TTCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGCCAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAG TCGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGTATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAA TGTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAAGATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACT TAAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTAAATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAA AATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGGCAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACC CCTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAAAAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGT AGACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGGGAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAAT TCGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAGTTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAA AGAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGATCAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGA ATTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTATATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGT AGAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTAGAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTC AATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAGAAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACT GAAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAAGTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAA AGAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGAAGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGG TTTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAAAAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAA TATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCTCATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAA GACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAACTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGAT AGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGG TCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGA TATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGA AGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAG ATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCAT ACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGA AATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGT GAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGA GTTTGAAGATGAAGAAGAAAGTCCTGTTAATTTCCCCATTTACTAAAGGTCACCTATAAACTTTGTTTCATTTAACTATTTATTAACTTT ATAAGTTAAATATACTTGGAAATAAGCAGTTCTCCGAACTGTAGTATTTCCTTCTCACTACCTTGTACCTTTATACTTAGATTGGAATTC >In-frame_CNOT2_ENST00000418359_chr12_70672054_+_CEP290_ENST00000552810_chr12_88483264_-_4530nt AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCACAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCA ACATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAGTCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAA CTTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCTCGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCA AACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAACAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAA TGACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGAAATATGGAGAACAAAACATTGGAGATGGAATTAAAATT AAAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAAAAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCG TCTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATAAAATATTTGAATAACATAATTTCTGAATATGAACGTAC AATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAAAGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGA ACGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCACAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCC TAGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAGAACATTCGAATAATTCTAGAAACACGGGCAACTTGCAA ATCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAACAAAATATACTGTCAAGAGACAAAGTAATCAATGAACT GAGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTAGGCAGAAAAGAGATGGAACCAAAATCTCACCACACATT GAAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAAGAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAA AGCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCATATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTC ACTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACTCCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGA GATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTCAAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAG AGAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTTCAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGC GGAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAGTGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAA TTCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGCCAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAG TCGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGTATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAA TGTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAAGATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACT TAAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTAAATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAA AATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGGCAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACC CCTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAAAAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGT AGACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGGGAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAAT TCGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAGTTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAA AGAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGATCAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGA ATTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTATATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGT AGAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTAGAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTC AATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAGAAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACT GAAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAAGTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAA AGAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGAAGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGG TTTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAAAAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAA TATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCTCATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAA GACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAACTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGAT AGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGG TCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGA TATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGA AGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAG ATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCAT ACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGA AATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGT GAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGA GTTTGAAGATGAAGAAGAAAGTCCTGTTAATTTCCCCATTTACTAAAGGTCACCTATAAACTTTGTTTCATTTAACTATTTATTAACTTT ATAAGTTAAATATACTTGGAAATAAGCAGTTCTCCGAACTGTAGTATTTCCTTCTCACTACCTTGTACCTTTATACTTAGATTGGAATTC >In-frame_CNOT2_ENST00000418359_chr12_70672054_+_CEP290_ENST00000397838_chr12_88483264_-_4366nt AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCACAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCA ACATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAGTCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAA CTTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCTCGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCA AACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAACAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAA TGACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGAAATATGGAGAACAAAACATTGGAGATGGAATTAAAATT AAAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAAAAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCG TCTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATAAAATATTTGAATAACATAATTTCTGAATATGAACGTAC AATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAAAGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGA ACGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCACAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCC TAGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAGAACATTCGAATAATTCTAGAAACACGGGCAACTTGCAA ATCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAACAAAATATACTGTCAAGAGACAAAGTAATCAATGAACT GAGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTAGGCAGAAAAGAGATGGAACCAAAATCTCACCACACATT GAAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAAGAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAA AGCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCATATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTC ACTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACTCCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGA GATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTCAAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAG AGAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTTCAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGC GGAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAGTGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAA TTCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGCCAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAG TCGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGTATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAA TGTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAAGATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACT TAAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTAAATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAA AATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGGCAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACC CCTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAAAAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGT AGACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGGGAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAAT TCGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAGTTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAA AGAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGATCAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGA ATTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTATATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGT AGAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTAGAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTC AATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAGAAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACT GAAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAAGTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAA AGAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGAAGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGG TTTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAAAAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAA TATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCTCATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAA GACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAACTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGAT AGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGG TCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGA TATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGA AGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAG ATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCAT ACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGA AATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGT GAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGA >In-frame_CNOT2_ENST00000418359_chr12_70672054_+_CEP290_ENST00000309041_chr12_88483264_-_4366nt AGCGTCCCCGGGGAGGGCGGACTGAAGCCACCTCACCATTCATCGCCCCTGGACCCCGCAGTCCCCCTCGGACTCAGGGCCAGAGCCTTC TGCGAAGCAACCTAGCCCCAGGGAAACGGTAGCGGCCGCAGAAGCCCCGCTCTCTGTAACGGCCGCGGAGGAGCAGCAAGCCTCCCTGTG AGTCGGTGGGAGACAAGACGGAGCGGCGTCGTCGCTCCCACCTTCCGCTGCCGCCTGGAGGGAAGCCGGAGCGACGGGGGTCACGGCGGC GGTCAGAGGGTAAAGGTCTTGCTCCCAGCAGCCTCCGCGGTGGATACGTCGCCATCTTGGATCCGCGGGACAAGAAAATTCATGCGAGGG AGACGTGGTGGGCGGTCCTTCCTGTGACACGACCCTTGAGTGACAGTTCTATTTGATTGCCTCCGGTACTGTGAGGAAAGGACACGACTC TATGGTGAGGACTGATGGACATACATTATCTGAGAAAAGAAACTACCAGGCACAGTCTGATGAAAAGTCGCTCATTGCCAAGTTGCACCA ACATAATGTCTCTCTTCAACTGAGTGAGGCTACTGCTCTTGGTAAGTTGGAGTCAATTACATCTAAACTGCAGAAGATGGAGGCCTACAA CTTGCGCTTAGAGCAGAAACTTGATGAAAAAGAACAGGCTCTCTATTATGCTCGTTTGGAGGGAAGAAACAGAGCAAAACATCTGCGCCA AACAATTCAGTCTCTACGACGACAGTTTAGTGGAGCTTTACCCTTGGCACAACAGGAAAAGTTCTCCAAAACAATGATTCAACTACAAAA TGACAAACTTAAGATAATGCAAGAAATGAAAAATTCTCAACAAGAACATAGAAATATGGAGAACAAAACATTGGAGATGGAATTAAAATT AAAGGGCCTGGAAGAGTTAATAAGCACTTTAAAGGATACCAAAGGAGCCCAAAAGGTAATCAACTGGCATATGAAAATAGAAGAACTTCG TCTTCAAGAACTTAAACTAAATCGGGAATTAGTCAAGGATAAAGAAGAAATAAAATATTTGAATAACATAATTTCTGAATATGAACGTAC AATCAGCAGTCTTGAAGAAGAAATTGTGCAACAGAACAAGTTTCATGAAGAAAGACAAATGGCCTGGGATCAAAGAGAAGTTGACCTGGA ACGCCAACTAGACATTTTTGACCGTCAGCAAAATGAAATACTAAATGCGGCACAAAAGTTTGAAGAAGCTACAGGATCAATCCCTGACCC TAGTTTGCCCCTTCCAAATCAACTTGAGATCGCTCTAAGGAAAATTAAGGAGAACATTCGAATAATTCTAGAAACACGGGCAACTTGCAA ATCACTAGAAGAGAAACTAAAAGAGAAAGAATCTGCTTTAAGGTTAGCAGAACAAAATATACTGTCAAGAGACAAAGTAATCAATGAACT GAGGCTTCGATTGCCTGCCACTGCAGAAAGAGAAAAGCTCATAGCTGAGCTAGGCAGAAAAGAGATGGAACCAAAATCTCACCACACATT GAAAATTGCTCATCAAACCATTGCAAACATGCAAGCAAGGTTAAATCAAAAAGAAGAAGTATTAAAGAAGTATCAACGTCTTCTAGAAAA AGCCAGAGAGGAGCAAAGAGAAATTGTGAAGAAACATGAGGAAGACCTTCATATTCTTCATCACAGATTAGAACTACAGGCTGATAGTTC ACTAAATAAATTCAAACAAACGGCTTGGGATTTAATGAAACAGTCTCCCACTCCAGTTCCTACCAACAAGCATTTTATTCGTCTGGCTGA GATGGAACAGACAGTAGCAGAACAAGATGACTCTCTTTCCTCACTCTTGGTCAAACTAAAGAAAGTATCACAAGATTTGGAGAGACAAAG AGAAATCACTGAATTAAAAGTAAAAGAATTTGAAAATATCAAATTACAGCTTCAAGAAAACCATGAAGATGAAGTGAAAAAAGTAAAAGC GGAAGTAGAGGATTTAAAGTATCTTCTGGACCAGTCACAAAAGGAGTCACAGTGTTTAAAATCTGAACTTCAGGCTCAAAAAGAAGCAAA TTCAAGAGCTCCAACAACTACAATGAGAAATCTAGTAGAACGGCTAAAGAGCCAATTAGCCTTGAAGGAGAAACAACAGAAAGCACTTAG TCGGGCACTTTTAGAACTCCGGGCAGAAATGACAGCAGCTGCTGAAGAACGTATTATTTCTGCAACTTCTCAAAAAGAGGCCCATCTCAA TGTTCAACAAATCGTTGATCGACATACTAGAGAGCTAAAGACACAAGTTGAAGATTTAAATGAAAATCTTTTAAAATTGAAAGAAGCACT TAAAACAAGTAAAAACAGAGAAAACTCACTAACTGATAATTTGAATGACTTAAATAATGAACTGCAAAAGAAACAAAAAGCCTATAATAA AATACTTAGAGAGAAAGAGGAAATTGATCAAGAGAATGATGAACTGAAAAGGCAAATTAAAAGACTAACCAGTGGATTACAGGGCAAACC CCTGACAGATAATAAACAAAGTCTAATTGAAGAACTCCAAAGGAAAGTTAAAAAACTAGAGAACCAATTAGAGGGAAAGGTGGAGGAAGT AGACCTAAAACCTATGAAAGAAAAGAATGCTAAAGAAGAATTAATTAGGTGGGAAGAAGGTAAAAAGTGGCAAGCCAAAATAGAAGGAAT TCGAAACAAGTTAAAAGAGAAAGAGGGGGAAGTCTTTACTTTAACAAAGCAGTTGAATACTTTGAAGGATCTTTTTGCCAAAGCCGATAA AGAGAAACTTACTTTGCAGAGGAAACTAAAAACAACTGGCATGACTGTTGATCAGGTTTTGGGAATACGAGCTTTGGAGTCAGAAAAAGA ATTGGAAGAATTAAAAAAGAGAAATCTTGACTTAGAAAATGATATATTGTATATGAGGGCCCACCAAGCTCTTCCTCGAGATTCTGTTGT AGAAGATTTACATTTACAAAATAGATACCTCCAAGAAAAACTTCATGCTTTAGAAAAACAGTTTTCAAAGGATACATATTCTAAGCCTTC AATTTCAGGAATAGAGTCAGATGATCATTGTCAGAGAGAACAGGAGCTTCAGAAGGAAAACTTGAAGTTGTCATCTGAAAATATTGAACT GAAATTTCAGCTTGAACAAGCAAATAAAGATTTGCCAAGATTAAAGAATCAAGTCAGAGATTTGAAGGAAATGTGTGAATTTCTTAAGAA AGAAAAAGCAGAAGTTCAGCGGAAACTTGGCCATGTTAGAGGGTCTGGTAGAAGTGGAAAGACAATCCCAGAACTGGAAAAAACCATTGG TTTAATGAAAAAAGTAGTTGAAAAAGTCCAGAGAGAAAATGAACAGTTGAAAAAAGCATCAGGAATATTGACTAGTGAAAAAATGGCTAA TATTGAGCAGGAAAATGAAAAATTGAAGGCTGAATTAGAAAAACTTAAAGCTCATCTTGGGCATCAGTTGAGCATGCACTATGAATCCAA GACCAAAGGCACAGAAAAAATTATTGCTGAAAATGAAAGGCTTCGTAAAGAACTTAAAAAAGAAACTGATGCTGCAGAGAAATTACGGAT AGCAAAGAATAATTTAGAGATATTAAATGAGAAGATGACAGTTCAACTAGAAGAGACTGGTAAGAGATTGCAGTTTGCAGAAAGCAGAGG TCCACAGCTTGAAGGTGCTGACAGTAAGAGCTGGAAATCCATTGTGGTTACAAGAATGTATGAAACCAAGTTAAAAGAATTGGAAACTGA TATTGCCAAAAAAAATCAAAGCATTACTGACCTTAAACAGCTTGTAAAAGAAGCAACAGAGAGAGAACAAAAAGTTAACAAATACAATGA AGACCTTGAACAACAGATTAAGATTCTTAAACATGTTCCTGAAGGTGCTGAGACAGAGCAAGGCCTTAAACGGGAGCTTCAAGTTCTTAG ATTAGCTAATCATCAGCTGGATAAAGAGAAAGCAGAATTAATCCATCAGATAGAAGCTAACAAGGACCAAAGTGGAGCTGAAAGCACCAT ACCTGATGCTGATCAACTAAAGGAAAAAATAAAAGATCTAGAGACACAGCTCAAAATGTCAGATCTAGAAAAGCAGCATTTGAAGGAGGA AATAAAGAAGCTGAAAAAAGAACTGGAAAATTTTGATCCTTCATTTTTTGAAGAAATTGAAGATCTTAAGTATAATTACAAGGAAGAAGT GAAGAAGAATATTCTCTTAGAAGAGAAGGTAAAAAAACTTTCAGAACAATTGGGAGTTGAATTAACTAGCCCTGTTGCTGCTTCTGAAGA |
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FusionGenePPI for CNOT2_CEP290 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| CNOT2 | CNOT3, CNOT1, DDB1, HDAC3, NCOR2, NCOR1, GPS2, VCP, CNOT6L, CNOT6, NLK, RNF219, CNOT8, MMP7, CAPZA2, CNOT7, WRAP73, AURKA, TNRC6C, TNRC6A, TNRC6B, AGO2, CAPZB, XPO1, CACNA2D1, DDX11, FHL2, EIF6, POLD1, UPF1, RPL12, MRPS12, RQCD1, USP24, LARP1, CNOT10, SS18L2, CNOT11, KANSL3, TMEM165, AKIP1, DDX24, WDR26, LCOR, TNKS1BP1, CNKSR3, RC3H1, NANOS2, TOB1, RIBC1, GADD45B, GPBP1L1, TEX13A, BTRC, KLKB1, GLA, NFKB1 | CEP290 | MAPK10, CCP110, CEP76, CEP97, NEURL4, IQCB1, ZNF423, ESR1, CDKN1A, CEP57, C9orf16, CCDC8, PEG10, DTNBP1, MCM7, MED4, CEP170, FGFR1OP, OFD1, CEP131, CCDC138, CEP72, FKBP4, HERC2, CEP162, MIB1, PTPRR, PCNT, PIBF1, SSX2IP, CCDC77, CSNK1E, ECH1, SREK1, SUPT5H, LDHA, TARDBP, MAPRE1, AKAP12, EMG1, KIF7, PNMA2, SSBP1, CAND1, UBA1, PGD, USO1, CEP104, AHCY, AK2, ANP32A, ARPC3, BCAP31, C11orf49, C21orf2, CSPP1, CYB5R3, GYS1, HAUS7, HAUS8, ISOC1, KDELR2, LRRC49, LUZP1, MIF, MPHOSPH9, MTPN, NEK1, PAWR, PCM1, PLP2, PMPCB, PTGES3, RAB2A, TPGS1, WRAP73, YWHAH, CALM2, CCDC61, CEP350, CHTOP, DDX47, FOPNL, GPATCH1, HAUS1, HAUS3, HAUS4, HAUS6, HMGN1, KIAA0753, KIF14, NEDD1, NME7, TCHP, TBC1D31, WDR83, CEP128, LGALS3BP, CEP135, CCDC14, HYPK, CDC14A, TPTE2, LZTS2, CALM1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| Tgene | CEP290 | chr12:70672054 | chr12:88483264 | ENST00000397838 | - | 21 | 46 | 696_896 | 251 | 1540 | IQCB1 |
| Tgene | CEP290 | chr12:70672054 | chr12:88483264 | ENST00000547691 | - | 4 | 29 | 696_896 | 251 | 1540 | IQCB1 |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Tgene | CEP290 | chr12:70672054 | chr12:88483264 | ENST00000552810 | - | 29 | 54 | 696_896 | 1191 | 2480 | IQCB1 |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CNOT2_CEP290 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CNOT2_CEP290 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | CEP290 | C1857780 | JOUBERT SYNDROME 5 | 3 | CTD_human;UNIPROT |
| Tgene | CEP290 | C0752166 | Bardet-Biedl Syndrome | 1 | CTD_human;ORPHANET |
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