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Fusion gene ID: 769 |
FusionGeneSummary for ADAMTSL4_MAT2A |
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Fusion gene information | Fusion gene name: ADAMTSL4_MAT2A | Fusion gene ID: 769 | Hgene | Tgene | Gene symbol | ADAMTSL4 | MAT2A | Gene ID | 54507 | 4144 |
Gene name | ADAMTS like 4 | methionine adenosyltransferase 2A | |
Synonyms | ADAMTSL-4|ECTOL2|TSRC1 | MATA2|MATII|SAMS2 | |
Cytomap | 1q21.2 | 2p11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | ADAMTS-like protein 4thrombospondin repeat-containing protein 1 | S-adenosylmethionine synthase isoform type-2MAT 2MAT-IIadoMet synthase 2adoMet synthetase 2methionine adenosyltransferase 2methionine adenosyltransferase II, alphatesticular tissue protein Li 121 | |
Modification date | 20180527 | 20180523 | |
UniProtAcc | Q6UY14 | P31153 | |
Ensembl transtripts involved in fusion gene | ENST00000369041, ENST00000483335, ENST00000271643, ENST00000369039, ENST00000369038, | ENST00000306434, ENST00000409017, ENST00000490878, | |
Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 2 X 2 X 1=4 |
# samples | 2 | 2 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: ADAMTSL4 [Title/Abstract] AND MAT2A [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | ADAMTSL4 | GO:0043065 | positive regulation of apoptotic process | 16364318 |
Tgene | MAT2A | GO:0006556 | S-adenosylmethionine biosynthetic process | 10644686|25075345 |
Tgene | MAT2A | GO:0034214 | protein hexamerization | 25075345 |
Tgene | MAT2A | GO:0051291 | protein heterooligomerization | 25075345 |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChiTaRS3.1 | AA992625 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
intron-3CDS | ENST00000369041 | ENST00000306434 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
intron-3CDS | ENST00000369041 | ENST00000409017 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
intron-intron | ENST00000369041 | ENST00000490878 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
intron-3CDS | ENST00000483335 | ENST00000306434 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
intron-3CDS | ENST00000483335 | ENST00000409017 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
intron-intron | ENST00000483335 | ENST00000490878 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
3UTR-3CDS | ENST00000271643 | ENST00000306434 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
3UTR-3CDS | ENST00000271643 | ENST00000409017 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
3UTR-intron | ENST00000271643 | ENST00000490878 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
3UTR-3CDS | ENST00000369039 | ENST00000306434 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
3UTR-3CDS | ENST00000369039 | ENST00000409017 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
3UTR-intron | ENST00000369039 | ENST00000490878 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
3UTR-3CDS | ENST00000369038 | ENST00000306434 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
3UTR-3CDS | ENST00000369038 | ENST00000409017 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
3UTR-intron | ENST00000369038 | ENST00000490878 | ADAMTSL4 | chr1 | 150533101 | - | MAT2A | chr2 | 85769334 | - |
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FusionProtFeatures for ADAMTSL4_MAT2A |
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Hgene | Tgene |
ADAMTSL4 | MAT2A |
Positive regulation of apoptosis. May facilitate FBN1microfibril biogenesis. {ECO:0000269|PubMed:16364318,ECO:0000269|PubMed:21989719}. | Catalyzes the formation of S-adenosylmethionine frommethionine and ATP. The reaction comprises two steps that are bothcatalyzed by the same enzyme: formation of S-adenosylmethionine(AdoMet) and triphosphate, and subsequent hydrolysis of thetriphosphate. {ECO:0000269|PubMed:10644686,ECO:0000269|PubMed:23189196, ECO:0000269|PubMed:25075345}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ADAMTSL4_MAT2A |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ADAMTSL4_MAT2A |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ADAMTSL4_MAT2A |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | MAT2A | P31153 | DB00118 | Ademetionine | S-adenosylmethionine synthase isoform type-2 | small molecule | approved|investigational|nutraceutical |
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RelatedDiseases for ADAMTSL4_MAT2A |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |