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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7662

FusionGeneSummary for CNKSR3_GDE1

check button Fusion gene summary
Fusion gene informationFusion gene name: CNKSR3_GDE1
Fusion gene ID: 7662
HgeneTgene
Gene symbol

CNKSR3

GDE1

Gene ID

154043

51573

Gene nameCNKSR family member 3glycerophosphodiester phosphodiesterase 1
SynonymsCNK3|CNK3/IPCEF1|MAGI1363E6.2|MIR16
Cytomap

6q25.2

16p12.3

Type of geneprotein-codingprotein-coding
Descriptionconnector enhancer of kinase suppressor of ras 3CNK homolog protein 3connector enhancer of KSR 3maguin-like proteinmembrane associated guanylate kinase, WW and PDZ domain containing 1membrane-associated guanylate kinase-interacting protein-like 1glycerophosphodiester phosphodiesterase 1RGS16-interacting membrane proteinmembrane interacting protein of RGS16
Modification date2018052220180519
UniProtAcc

Q6P9H4

Q9NZC3

Ensembl transtripts involved in fusion geneENST00000607772, ENST00000479339, 
ENST00000433165, 
ENST00000353258, 
Fusion gene scores* DoF score6 X 8 X 2=964 X 3 X 1=12
# samples 84
** MAII scorelog2(8/96*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/12*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CNKSR3 [Title/Abstract] AND GDE1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BQ360698CNKSR3chr6

154693997

+GDE1chr16

19513902

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000607772ENST00000353258CNKSR3chr6

154693997

+GDE1chr16

19513902

-
intron-3UTRENST00000479339ENST00000353258CNKSR3chr6

154693997

+GDE1chr16

19513902

-
intron-3UTRENST00000433165ENST00000353258CNKSR3chr6

154693997

+GDE1chr16

19513902

-

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FusionProtFeatures for CNKSR3_GDE1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNKSR3

Q6P9H4

GDE1

Q9NZC3

Involved in transepithelial sodium transport. Regulatesaldosterone-induced and epithelial sodium channel (ENaC)-mediatedsodium transport through regulation of ENaC cell surfaceexpression. Acts as a scaffold protein coordinating the assemblyof an ENaC-regulatory complex (ERC).{ECO:0000269|PubMed:22851176}. Has glycerophosphoinositol phosphodiesterase activity.Hydrolyzes lysoglycerophospholipids to produce lysophosphatidicacid (LPA) and the corresponding amines. Has little or no activitytowards glycerophosphocholine. GDE1 activity can be modulated byG-protein signaling pathways (By similarity).{ECO:0000250|UniProtKB:Q9JL55, ECO:0000250|UniProtKB:Q9JL56}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CNKSR3_GDE1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CNKSR3_GDE1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CNKSR3_GDE1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CNKSR3_GDE1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneGDE1C0041696Unipolar Depression1PSYGENET
TgeneGDE1C1269683Major Depressive Disorder1PSYGENET