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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7648

FusionGeneSummary for CNDP2_FRYL

check button Fusion gene summary
Fusion gene informationFusion gene name: CNDP2_FRYL
Fusion gene ID: 7648
HgeneTgene
Gene symbol

CNDP2

FRYL

Gene ID

55748

285527

Gene namecarnosine dipeptidase 2FRY like transcription coactivator
SynonymsCN2|CPGL|HEL-S-13|HsT2298|PEPAAF4p12|KIAA0826|MOR2
Cytomap

18q22.3

4p11

Type of geneprotein-codingprotein-coding
Descriptioncytosolic non-specific dipeptidaseCNDP dipeptidase 2 (metallopeptidase M20 family)carnosinase-2carnosine dipeptidase IIcytosolic nonspecific dipeptidaseepididymis secretory protein Li 13glutamate carboxypeptidase-like protein 1peptidase Aprotein furry homolog-likeALL1-fused gene from chromosome 4p12 proteinFRY-likefurry homolog-likefurry-likemor2 cell polarity protein homolog
Modification date2018051920180523
UniProtAcc

Q96KP4

O94915

Ensembl transtripts involved in fusion geneENST00000324262, ENST00000579847, 
ENST00000580229, ENST00000324301, 
ENST00000503238, ENST00000358350, 
ENST00000537810, ENST00000264319, 
ENST00000507711, ENST00000514783, 
ENST00000507873, ENST00000506685, 
Fusion gene scores* DoF score6 X 6 X 2=725 X 6 X 2=60
# samples 79
** MAII scorelog2(7/72*10)=-0.0406419844973459
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/60*10)=0.584962500721156
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CNDP2 [Title/Abstract] AND FRYL [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI010777CNDP2chr18

72176440

+FRYLchr4

48741196

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000324262ENST00000503238CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324262ENST00000358350CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324262ENST00000537810CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324262ENST00000264319CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324262ENST00000507711CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324262ENST00000514783CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324262ENST00000507873CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324262ENST00000506685CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000579847ENST00000503238CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000579847ENST00000358350CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000579847ENST00000537810CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000579847ENST00000264319CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000579847ENST00000507711CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000579847ENST00000514783CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000579847ENST00000507873CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000579847ENST00000506685CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000580229ENST00000503238CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000580229ENST00000358350CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000580229ENST00000537810CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000580229ENST00000264319CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000580229ENST00000507711CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000580229ENST00000514783CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000580229ENST00000507873CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000580229ENST00000506685CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324301ENST00000503238CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324301ENST00000358350CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324301ENST00000537810CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324301ENST00000264319CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324301ENST00000507711CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324301ENST00000514783CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324301ENST00000507873CNDP2chr18

72176440

+FRYLchr4

48741196

-
intron-intronENST00000324301ENST00000506685CNDP2chr18

72176440

+FRYLchr4

48741196

-

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FusionProtFeatures for CNDP2_FRYL


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNDP2

Q96KP4

FRYL

O94915

Hydrolyzes a variety of dipeptides including L-carnosinebut has a strong preference for Cys-Gly (PubMed:19346245). Acts asa functional tumor suppressor in gastric cancer via activation ofthe mitogen-activated protein kinase (MAPK) pathway. An elevatedlevel of CNDP2 activates the p38 and JNK MAPK pathways to inducecell apoptosis, and a lower level of CNDP2 activates the ERK MAPKpathway to promote cell proliferation (PubMed:24395568). Isoform 2may play a role as tumor suppressor in hepatocellular carcinoma(HCC) cells (PubMed:17121880). Catalyzes the production of N-lactoyl-amino acids from lactate and amino acids by reverseproteolysis (PubMed:25964343). {ECO:0000269|PubMed:17121880,ECO:0000269|PubMed:19346245, ECO:0000269|PubMed:24395568,ECO:0000269|PubMed:25964343}. Plays a key role in maintaining the integrity ofpolarized cell extensions during morphogenesis, regulates theactin cytoskeleton and plays a key role in patterning sensoryneuron dendritic fields by promoting avoidance between homologousdendrites as well as by limiting dendritic branching (Bysimilarity). May function as a transcriptional activator.{ECO:0000250, ECO:0000269|PubMed:16061630}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for CNDP2_FRYL


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for CNDP2_FRYL


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CNDP2_FRYL


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CNDP2_FRYL


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCNDP2C0011881Diabetic Nephropathy1CTD_human
HgeneCNDP2C0015695Fatty Liver1CTD_human