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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 7641

FusionGeneSummary for CNBD1_PTPN2

check button Fusion gene summary
Fusion gene informationFusion gene name: CNBD1_PTPN2
Fusion gene ID: 7641
HgeneTgene
Gene symbol

CNBD1

PTPN2

Gene ID

168975

5771

Gene namecyclic nucleotide binding domain containing 1protein tyrosine phosphatase, non-receptor type 2
Synonyms-PTN2|PTPT|TC-PTP|TCELLPTP|TCPTP
Cytomap

8q21.3

18p11.21

Type of geneprotein-codingprotein-coding
Descriptioncyclic nucleotide-binding domain-containing protein 1tyrosine-protein phosphatase non-receptor type 2T-cell protein tyrosine phosphatase
Modification date2018032920180519
UniProtAcc

Q8NA66

P17706

Ensembl transtripts involved in fusion geneENST00000518476, ENST00000522427, 
ENST00000327283, ENST00000591115, 
ENST00000353319, ENST00000309660, 
ENST00000589086, ENST00000591497, 
Fusion gene scores* DoF score1 X 1 X 1=13 X 3 X 3=27
# samples 13
** MAII scorelog2(1/1*10)=3.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CNBD1 [Title/Abstract] AND PTPN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationTumor suppressor gene involved fusion gene, in-frame but not retained their domain.
Tumor suppressor gene involved fusion gene, retained protein feature but frameshift.
DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBLCATCGA-FD-A3B5-01ACNBD1chr8

88366014

+PTPN2chr18

12785843

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000518476ENST00000327283CNBD1chr8

88366014

+PTPN2chr18

12785843

-
Frame-shiftENST00000518476ENST00000591115CNBD1chr8

88366014

+PTPN2chr18

12785843

-
In-frameENST00000518476ENST00000353319CNBD1chr8

88366014

+PTPN2chr18

12785843

-
5CDS-intronENST00000518476ENST00000309660CNBD1chr8

88366014

+PTPN2chr18

12785843

-
5CDS-intronENST00000518476ENST00000589086CNBD1chr8

88366014

+PTPN2chr18

12785843

-
5CDS-intronENST00000518476ENST00000591497CNBD1chr8

88366014

+PTPN2chr18

12785843

-
intron-3CDSENST00000522427ENST00000327283CNBD1chr8

88366014

+PTPN2chr18

12785843

-
intron-3CDSENST00000522427ENST00000591115CNBD1chr8

88366014

+PTPN2chr18

12785843

-
intron-3CDSENST00000522427ENST00000353319CNBD1chr8

88366014

+PTPN2chr18

12785843

-
intron-intronENST00000522427ENST00000309660CNBD1chr8

88366014

+PTPN2chr18

12785843

-
intron-intronENST00000522427ENST00000589086CNBD1chr8

88366014

+PTPN2chr18

12785843

-
intron-intronENST00000522427ENST00000591497CNBD1chr8

88366014

+PTPN2chr18

12785843

-

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FusionProtFeatures for CNBD1_PTPN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CNBD1

Q8NA66

PTPN2

P17706

Non-receptor type tyrosine-specific phosphatase thatdephosphorylates receptor protein tyrosine kinases including INSR,EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor proteintyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1,STAT3 and STAT6 either in the nucleus or the cytoplasm. Negativelyregulates numerous signaling pathways and biological processeslike hematopoiesis, inflammatory response, cell proliferation anddifferentiation, and glucose homeostasis. Plays a multifaceted andimportant role in the development of the immune system. Functionsin T-cell receptor signaling through dephosphorylation of FYN andLCK to control T-cells differentiation and activation.Dephosphorylates CSF1R, negatively regulating its downstreamsignaling and macrophage differentiation. Negatively regulatescytokine (IL2/interleukin-2 and interferon)-mediated signalingthrough dephosphorylation of the cytoplasmic kinases JAK1, JAK3and their substrate STAT1, that propagate signaling downstream ofthe cytokine receptors. Also regulates the IL6/interleukin-6 andIL4/interleukin-4 cytokine signaling through dephosphorylation ofSTAT3 and STAT6 respectively. In addition to the immune system, itis involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, itdephosphorylates EGFR and negatively regulates EGF signaling.Dephosphorylates PDGFRB and negatively regulates platelet-derivedgrowth factor receptor-beta signaling pathway and therefore cellproliferation. Negatively regulates tumor necrosis factor-mediatedsignaling downstream via MAPK through SRC dephosphorylation. Mayalso regulate the hepatocyte growth factor receptor signalingpathway through dephosphorylation of the hepatocyte growth factorreceptor MET. Plays also an important role in glucose homeostasis.For instance, negatively regulates the insulin receptor signalingpathway through the dephosphorylation of INSR and controlgluconeogenesis and liver glucose production through negativeregulation of the IL6 signaling pathways. May also bind DNA.{ECO:0000269|PubMed:10734133, ECO:0000269|PubMed:11909529,ECO:0000269|PubMed:12138178, ECO:0000269|PubMed:12612081,ECO:0000269|PubMed:14966296, ECO:0000269|PubMed:15592458,ECO:0000269|PubMed:18819921, ECO:0000269|PubMed:22080863,ECO:0000269|PubMed:9488479}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCNBD1chr8:88366014chr18:12785843ENST00000518476+101121_24434437Compositional biasNote=Poly-Pro
HgeneCNBD1chr8:88366014chr18:12785843ENST00000518476+1011322_436434437Nucleotide bindingNote=cNMP
TgenePTPN2chr8:88366014chr18:12785843ENST00000309660-095_275-32416DomainTyrosine-protein phosphatase
TgenePTPN2chr8:88366014chr18:12785843ENST00000309660-09216_222-32416RegionSubstrate binding
TgenePTPN2chr8:88366014chr18:12785843ENST00000309660-09346_415-32416RegionNote=Endoplasmic reticulum location
TgenePTPN2chr8:88366014chr18:12785843ENST00000353319-79346_415346354RegionNote=Endoplasmic reticulum location

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePTPN2chr8:88366014chr18:12785843ENST00000327283-8105_275380388DomainTyrosine-protein phosphatase
TgenePTPN2chr8:88366014chr18:12785843ENST00000353319-795_275346354DomainTyrosine-protein phosphatase
TgenePTPN2chr8:88366014chr18:12785843ENST00000327283-810216_222380388RegionSubstrate binding
TgenePTPN2chr8:88366014chr18:12785843ENST00000327283-810346_415380388RegionNote=Endoplasmic reticulum location
TgenePTPN2chr8:88366014chr18:12785843ENST00000353319-79216_222346354RegionSubstrate binding


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FusionGeneSequence for CNBD1_PTPN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_CNBD1_ENST00000518476_chr8_88366014_+_PTPN2_ENST00000327283_chr18_12785843_-_441aa
MPMSSLPAAILSHMTAINNVPPPPLHSIPNLKKSKHINYGQLNALCHIRGQHSRSMSNILSAHDTFMKQYPKVFLHQKPRLPKLFKQEEQ
RELNEGKEESQHQQPDDSNNIAVHVQRAHGGHILYRPKRATEKFEEFLAILKKLPIHRTPYEHKTVWKFLKTIPDLTFQLNDKHLKTLSK
TVFSETWLKGSTVVANDGFYVILKGLARPQTNVYKNLIEGSDSPDSFISQSFHSFIWSEEFKNSTLAEMYLPSYDSMLSKWSTFGTLEVM
PQNESETQMFSVVTEDDCEILKIPAKGYAKIKEEKIKLENMQKLKLIRMCPYYEEWPTLSIYELIALLKWKKFPPGHVIVESGNIISFVG

>In-frame_CNBD1_ENST00000518476_chr8_88366014_+_PTPN2_ENST00000353319_chr18_12785843_-_441aa
MPMSSLPAAILSHMTAINNVPPPPLHSIPNLKKSKHINYGQLNALCHIRGQHSRSMSNILSAHDTFMKQYPKVFLHQKPRLPKLFKQEEQ
RELNEGKEESQHQQPDDSNNIAVHVQRAHGGHILYRPKRATEKFEEFLAILKKLPIHRTPYEHKTVWKFLKTIPDLTFQLNDKHLKTLSK
TVFSETWLKGSTVVANDGFYVILKGLARPQTNVYKNLIEGSDSPDSFISQSFHSFIWSEEFKNSTLAEMYLPSYDSMLSKWSTFGTLEVM
PQNESETQMFSVVTEDDCEILKIPAKGYAKIKEEKIKLENMQKLKLIRMCPYYEEWPTLSIYELIALLKWKKFPPGHVIVESGNIISFVG


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_CNBD1_ENST00000518476_chr8_88366014_+_PTPN2_ENST00000327283_chr18_12785843_-_1325nt
ATGCCGATGTCTTCTCTTCCAGCAGCTATTTTGTCTCACATGACAGCTATTAACAATGTGCCTCCTCCTCCACTTCACAGTATACCAAAC
TTGAAAAAGTCTAAGCACATTAATTATGGCCAGTTGAATGCATTATGCCACATTAGAGGACAACACAGCCGGAGTATGAGCAATATCTTA
TCAGCTCACGATACATTTATGAAGCAATATCCTAAAGTATTCCTGCACCAAAAACCCAGACTTCCTAAACTTTTCAAACAGGAGGAACAA
AGGGAACTCAATGAAGGCAAAGAGGAAAGTCAACATCAACAACCTGATGATTCTAACAATATAGCTGTCCATGTTCAGAGAGCACATGGT
GGCCATATTTTATATAGACCAAAAAGAGCCACAGAGAAATTTGAAGAATTCCTAGCTATCTTAAAGAAATTGCCCATTCACAGGACGCCA
TATGAACACAAAACTGTGTGGAAGTTCCTGAAAACAATTCCAGATTTAACCTTTCAGCTAAATGATAAGCATCTGAAAACACTTAGTAAG
ACTGTCTTTTCCGAAACCTGGTTGAAAGGCAGCACAGTGGTTGCAAATGATGGATTTTATGTAATACTGAAAGGCCTAGCTCGACCTCAA
ACAAACGTGTATAAAAATCTGATTGAAGGAAGTGATTCACCAGACTCGTTCATATCTCAGAGTTTCCACAGCTTCATTTGGAGTGAAGAA
TTCAAAAACTCTACACTTGCTGAGATGTACCTACCTTCATATGACTCAATGCTTAGCAAATGGAGTACCTTTGGGACTCTGGAAGTTATG
CCTCAGAATGAATCGGAAACACAGATGTTCTCGGTGGTGACAGAAGACGATTGTGAAATTCTTAAAATCCCAGCAAAGGGATATGCAAAG
ATAAAGGAGGAAAAAATAAAACTTGAAAATATGCAAAAGTTGAAATTAATCCGTATGTGTCCTTATTATGAGGAATGGCCTACTTTATCC
ATATATGAGCTAATTGCACTCCTTAAATGGAAAAAATTTCCTCCAGGTCATGTGATAGTGGAAAGTGGAAATATAATTTCTTTTGTGGGT
TATATTAACTCTGGATGCTGTAACATTTATAGAAGTATTATAGGATTTGTGAAACTACGATCAAATAAAGTGAAAAGATCTCAAAAACTT
GTTTATATGGGGAAACTTAAGGAGAAGGAGTCCTTTGGTGAGATTAGCGTCCTTCTTCAAGTTCCTTTCACGTGCACAATCATTACCAAA

>In-frame_CNBD1_ENST00000518476_chr8_88366014_+_PTPN2_ENST00000353319_chr18_12785843_-_1325nt
ATGCCGATGTCTTCTCTTCCAGCAGCTATTTTGTCTCACATGACAGCTATTAACAATGTGCCTCCTCCTCCACTTCACAGTATACCAAAC
TTGAAAAAGTCTAAGCACATTAATTATGGCCAGTTGAATGCATTATGCCACATTAGAGGACAACACAGCCGGAGTATGAGCAATATCTTA
TCAGCTCACGATACATTTATGAAGCAATATCCTAAAGTATTCCTGCACCAAAAACCCAGACTTCCTAAACTTTTCAAACAGGAGGAACAA
AGGGAACTCAATGAAGGCAAAGAGGAAAGTCAACATCAACAACCTGATGATTCTAACAATATAGCTGTCCATGTTCAGAGAGCACATGGT
GGCCATATTTTATATAGACCAAAAAGAGCCACAGAGAAATTTGAAGAATTCCTAGCTATCTTAAAGAAATTGCCCATTCACAGGACGCCA
TATGAACACAAAACTGTGTGGAAGTTCCTGAAAACAATTCCAGATTTAACCTTTCAGCTAAATGATAAGCATCTGAAAACACTTAGTAAG
ACTGTCTTTTCCGAAACCTGGTTGAAAGGCAGCACAGTGGTTGCAAATGATGGATTTTATGTAATACTGAAAGGCCTAGCTCGACCTCAA
ACAAACGTGTATAAAAATCTGATTGAAGGAAGTGATTCACCAGACTCGTTCATATCTCAGAGTTTCCACAGCTTCATTTGGAGTGAAGAA
TTCAAAAACTCTACACTTGCTGAGATGTACCTACCTTCATATGACTCAATGCTTAGCAAATGGAGTACCTTTGGGACTCTGGAAGTTATG
CCTCAGAATGAATCGGAAACACAGATGTTCTCGGTGGTGACAGAAGACGATTGTGAAATTCTTAAAATCCCAGCAAAGGGATATGCAAAG
ATAAAGGAGGAAAAAATAAAACTTGAAAATATGCAAAAGTTGAAATTAATCCGTATGTGTCCTTATTATGAGGAATGGCCTACTTTATCC
ATATATGAGCTAATTGCACTCCTTAAATGGAAAAAATTTCCTCCAGGTCATGTGATAGTGGAAAGTGGAAATATAATTTCTTTTGTGGGT
TATATTAACTCTGGATGCTGTAACATTTATAGAAGTATTATAGGATTTGTGAAACTACGATCAAATAAAGTGAAAAGATCTCAAAAACTT
GTTTATATGGGGAAACTTAAGGAGAAGGAGTCCTTTGGTGAGATTAGCGTCCTTCTTCAAGTTCCTTTCACGTGCACAATCATTACCAAA


* Fusion transcript sequences (Full-length transcript).
>In-frame_CNBD1_ENST00000518476_chr8_88366014_+_PTPN2_ENST00000327283_chr18_12785843_-_1721nt
ATTTGCCTCTCAAGCAGCCTCTGGTCATCTATCTGCCTTTGAGCCATCAAGATGCCGATGTCTTCTCTTCCAGCAGCTATTTTGTCTCAC
ATGACAGCTATTAACAATGTGCCTCCTCCTCCACTTCACAGTATACCAAACTTGAAAAAGTCTAAGCACATTAATTATGGCCAGTTGAAT
GCATTATGCCACATTAGAGGACAACACAGCCGGAGTATGAGCAATATCTTATCAGCTCACGATACATTTATGAAGCAATATCCTAAAGTA
TTCCTGCACCAAAAACCCAGACTTCCTAAACTTTTCAAACAGGAGGAACAAAGGGAACTCAATGAAGGCAAAGAGGAAAGTCAACATCAA
CAACCTGATGATTCTAACAATATAGCTGTCCATGTTCAGAGAGCACATGGTGGCCATATTTTATATAGACCAAAAAGAGCCACAGAGAAA
TTTGAAGAATTCCTAGCTATCTTAAAGAAATTGCCCATTCACAGGACGCCATATGAACACAAAACTGTGTGGAAGTTCCTGAAAACAATT
CCAGATTTAACCTTTCAGCTAAATGATAAGCATCTGAAAACACTTAGTAAGACTGTCTTTTCCGAAACCTGGTTGAAAGGCAGCACAGTG
GTTGCAAATGATGGATTTTATGTAATACTGAAAGGCCTAGCTCGACCTCAAACAAACGTGTATAAAAATCTGATTGAAGGAAGTGATTCA
CCAGACTCGTTCATATCTCAGAGTTTCCACAGCTTCATTTGGAGTGAAGAATTCAAAAACTCTACACTTGCTGAGATGTACCTACCTTCA
TATGACTCAATGCTTAGCAAATGGAGTACCTTTGGGACTCTGGAAGTTATGCCTCAGAATGAATCGGAAACACAGATGTTCTCGGTGGTG
ACAGAAGACGATTGTGAAATTCTTAAAATCCCAGCAAAGGGATATGCAAAGATAAAGGAGGAAAAAATAAAACTTGAAAATATGCAAAAG
TTGAAATTAATCCGTATGTGTCCTTATTATGAGGAATGGCCTACTTTATCCATATATGAGCTAATTGCACTCCTTAAATGGAAAAAATTT
CCTCCAGGTCATGTGATAGTGGAAAGTGGAAATATAATTTCTTTTGTGGGTTATATTAACTCTGGATGCTGTAACATTTATAGAAGTATT
ATAGGATTTGTGAAACTACGATCAAATAAAGTGAAAAGATCTCAAAAACTTGTTTATATGGGGAAACTTAAGGAGAAGGAGTCCTTTGGT
GAGATTAGCGTCCTTCTTCAAGTTCCTTTCACGTGCACAATCATTACCAAAAAAGAAGTTGAGATGGCAATCATTGAAGATAAGGACCTA
TTTGGCCAAGATTGACAGACACCTAATATTCATGACTTGAGAATATTCTGCAGCTATAAATTTTGAACCATTGATGTGCAAAGCAAGACC
TGAAGCCCACTCCGGAAACTAAAGTGAGGCTCGCTAACCCTCTAGATTGCCTCACAGTTGTTTGTTTACAAAGTAAACTTTACATCCAGG
GGATGAAGAGCACCCACCAGCAGAAGACTTTGCAGAACCTTTAATTGGATGTGTTAAGTGTTTTTAATGAGTGTATGAAATGTAGAAAGA
TGTACAAGAAATAAATTAGGGGAGATTACTTTGTATTGTACTGCCATTCCTACTGTATTTTTATACTTTTTGGCAGCATTAAATATTTTT

>In-frame_CNBD1_ENST00000518476_chr8_88366014_+_PTPN2_ENST00000353319_chr18_12785843_-_1716nt
ATTTGCCTCTCAAGCAGCCTCTGGTCATCTATCTGCCTTTGAGCCATCAAGATGCCGATGTCTTCTCTTCCAGCAGCTATTTTGTCTCAC
ATGACAGCTATTAACAATGTGCCTCCTCCTCCACTTCACAGTATACCAAACTTGAAAAAGTCTAAGCACATTAATTATGGCCAGTTGAAT
GCATTATGCCACATTAGAGGACAACACAGCCGGAGTATGAGCAATATCTTATCAGCTCACGATACATTTATGAAGCAATATCCTAAAGTA
TTCCTGCACCAAAAACCCAGACTTCCTAAACTTTTCAAACAGGAGGAACAAAGGGAACTCAATGAAGGCAAAGAGGAAAGTCAACATCAA
CAACCTGATGATTCTAACAATATAGCTGTCCATGTTCAGAGAGCACATGGTGGCCATATTTTATATAGACCAAAAAGAGCCACAGAGAAA
TTTGAAGAATTCCTAGCTATCTTAAAGAAATTGCCCATTCACAGGACGCCATATGAACACAAAACTGTGTGGAAGTTCCTGAAAACAATT
CCAGATTTAACCTTTCAGCTAAATGATAAGCATCTGAAAACACTTAGTAAGACTGTCTTTTCCGAAACCTGGTTGAAAGGCAGCACAGTG
GTTGCAAATGATGGATTTTATGTAATACTGAAAGGCCTAGCTCGACCTCAAACAAACGTGTATAAAAATCTGATTGAAGGAAGTGATTCA
CCAGACTCGTTCATATCTCAGAGTTTCCACAGCTTCATTTGGAGTGAAGAATTCAAAAACTCTACACTTGCTGAGATGTACCTACCTTCA
TATGACTCAATGCTTAGCAAATGGAGTACCTTTGGGACTCTGGAAGTTATGCCTCAGAATGAATCGGAAACACAGATGTTCTCGGTGGTG
ACAGAAGACGATTGTGAAATTCTTAAAATCCCAGCAAAGGGATATGCAAAGATAAAGGAGGAAAAAATAAAACTTGAAAATATGCAAAAG
TTGAAATTAATCCGTATGTGTCCTTATTATGAGGAATGGCCTACTTTATCCATATATGAGCTAATTGCACTCCTTAAATGGAAAAAATTT
CCTCCAGGTCATGTGATAGTGGAAAGTGGAAATATAATTTCTTTTGTGGGTTATATTAACTCTGGATGCTGTAACATTTATAGAAGTATT
ATAGGATTTGTGAAACTACGATCAAATAAAGTGAAAAGATCTCAAAAACTTGTTTATATGGGGAAACTTAAGGAGAAGGAGTCCTTTGGT
GAGATTAGCGTCCTTCTTCAAGTTCCTTTCACGTGCACAATCATTACCAAAAAAGAAGTTGAGATGGCAATCATTGAAGATAAGGACCTA
TTTGGCCAAGATTGACAGACACCTAATATTCATGACTTGAGAATATTCTGCAGCTATAAATTTTGAACCATTGATGTGCAAAGCAAGACC
TGAAGCCCACTCCGGAAACTAAAGTGAGGCTCGCTAACCCTCTAGATTGCCTCACAGTTGTTTGTTTACAAAGTAAACTTTACATCCAGG
GGATGAAGAGCACCCACCAGCAGAAGACTTTGCAGAACCTTTAATTGGATGTGTTAAGTGTTTTTAATGAGTGTATGAAATGTAGAAAGA
TGTACAAGAAATAAATTAGGGGAGATTACTTTGTATTGTACTGCCATTCCTACTGTATTTTTATACTTTTTGGCAGCATTAAATATTTTT


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FusionGenePPI for CNBD1_PTPN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
CNBD1PTPN2SFN, STAT3, UCHL5, STAT1, GHR, TRAF2, SRC, KATNB1, HSPD1, STAT6, BAG3, SLC39A4, COL5A1, METTL13, PTPN6, VARS, TCTN2, TMEM17, TMEM216, PSMC1, PSMD14, APLP2, APP, CALU, CASC4, CSPG5, GOLIM4, HADHA, HARS, HMGN5, KPNA1, KPNA6, NUP50, PSMC2, PSMC4, PSMC5, PSMC6, PSMD1, PSMD10, PSMD2, PSMD4, PSMD6, SETD7, OCLN, C5AR2, B4GAT1, C3AR1, ASGR1, TNFSF8, SLC39A5, PTPN20B, KPNA5, ANP32C, ANP32B, TXNDC5, NMNAT1, ANP32E, TRMT61B, RCL1, BRIX1, GAR1, PNO1, GADD45GIP1, ZC3HAV1L, DIMT1, NSUN5, ADARB2-AS1, DNAJC10, C8orf33, RNMTL1, G3BP1, FTSJ3, EIF2S1, BYSL, PSMD13, RBM34, CASKIN1, PSMC3IP, GTPBP10, PSMD8, RPL3L, TFB1M, RPP30, DUSP10, EXOSC4, GRSF1, UBC, EGFR


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for CNBD1_PTPN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for CNBD1_PTPN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTPN2C0003873Rheumatoid Arthritis1CTD_human
TgenePTPN2C0009324Ulcerative Colitis1CTD_human
TgenePTPN2C0010346Crohn Disease1CTD_human
TgenePTPN2C0023492Leukemia, T-Cell1CTD_human
TgenePTPN2C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human