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Fusion gene ID: 7627 |
FusionGeneSummary for CMTM8_GPD1L |
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Fusion gene information | Fusion gene name: CMTM8_GPD1L | Fusion gene ID: 7627 | Hgene | Tgene | Gene symbol | CMTM8 | GPD1L | Gene ID | 152189 | 23171 |
Gene name | CKLF like MARVEL transmembrane domain containing 8 | glycerol-3-phosphate dehydrogenase 1 like | |
Synonyms | CKLFSF8|CKLFSF8-V2 | GPD1-L | |
Cytomap | 3p22.3 | 3p22.3 | |
Type of gene | protein-coding | protein-coding | |
Description | CKLF-like MARVEL transmembrane domain-containing protein 8chemokine-like factor superfamily member 8 | glycerol-3-phosphate dehydrogenase 1-like protein | |
Modification date | 20180523 | 20180519 | |
UniProtAcc | Q8IZV2 | Q8N335 | |
Ensembl transtripts involved in fusion gene | ENST00000458535, ENST00000307526, | ENST00000282541, | |
Fusion gene scores | * DoF score | 6 X 1 X 4=24 | 6 X 3 X 6=108 |
# samples | 6 | 7 | |
** MAII score | log2(6/24*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(7/108*10)=-0.625604485218502 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: CMTM8 [Title/Abstract] AND GPD1L [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LIHC | TCGA-2Y-A9H0-01A | CMTM8 | chr3 | 32280611 | + | GPD1L | chr3 | 32169568 | + |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
Frame-shift | ENST00000458535 | ENST00000282541 | CMTM8 | chr3 | 32280611 | + | GPD1L | chr3 | 32169568 | + |
Frame-shift | ENST00000307526 | ENST00000282541 | CMTM8 | chr3 | 32280611 | + | GPD1L | chr3 | 32169568 | + |
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FusionProtFeatures for CMTM8_GPD1L |
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Hgene | Tgene |
CMTM8 | GPD1L |
Plays a role in regulating cardiac sodium current;decreased enzymatic activity with resulting increased levels ofglycerol 3-phosphate activating the DPD1L-dependent SCN5Aphosphorylation pathway, may ultimately lead to decreased sodiumcurrent; cardiac sodium current may also be reduced due toalterations of NAD(H) balance induced by DPD1L.{ECO:0000269|PubMed:19666841, ECO:0000269|PubMed:19745168}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for CMTM8_GPD1L |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for CMTM8_GPD1L |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
CMTM8 | TRIM25 | GPD1L | ELAVL1, BSG, FAS, PALM2, ART3, ISLR, TGOLN2, ALDOA, ALDOC, CYCS, GNPNAT1, ACO2, CKMT1A, CKMT1B, FH, GAPDH, GPT2, MYH7B, PHGDH, PYCRL, PGM1, TPI1, UPP1, GPD1, LAMP2, FAM174A, C1orf85, CCL5, DKKL1 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for CMTM8_GPD1L |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for CMTM8_GPD1L |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | GPD1L | C2673193 | Brugada Syndrome 2 | 3 | CTD_human;UNIPROT |
Tgene | GPD1L | C0038644 | Sudden infant death syndrome | 2 | UNIPROT |
Tgene | GPD1L | C0015695 | Fatty Liver | 1 | CTD_human |